JP2019503349A - Ｐｄ−１に対する抗体分子およびその使用 - Google Patents

Ｐｄ−１に対する抗体分子およびその使用 Download PDF

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Publication number
JP2019503349A
JP2019503349A JP2018531392A JP2018531392A JP2019503349A JP 2019503349 A JP2019503349 A JP 2019503349A JP 2018531392 A JP2018531392 A JP 2018531392A JP 2018531392 A JP2018531392 A JP 2018531392A JP 2019503349 A JP2019503349 A JP 2019503349A
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Prior art keywords
amino acid
seq
acid sequence
cancer
antibody molecule
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JP2018531392A
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Japanese (ja)
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JP2019503349A5 (https=
Inventor
サネラ・ビリック
ダニー・ローランド・ハワード・ジュニア
ジョン・スコット・キャメロン
グレン・ドラノフ
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ノバルティス アーゲー
ノバルティス アーゲー
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Publication of JP2019503349A publication Critical patent/JP2019503349A/ja
Publication of JP2019503349A5 publication Critical patent/JP2019503349A5/ja
Priority to JP2020096122A priority Critical patent/JP7569166B2/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2018531392A 2015-12-17 2016-12-16 Ｐｄ−１に対する抗体分子およびその使用 Pending JP2019503349A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2020096122A JP7569166B2 (ja) 2015-12-17 2020-06-02 Ｐｄ－１に対する抗体分子およびその使用

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
US201562269044P 2015-12-17 2015-12-17
US62/269,044 2015-12-17
US201662331371P 2016-05-03 2016-05-03
US62/331,371 2016-05-03
US201662344784P 2016-06-02 2016-06-02
US62/344,784 2016-06-02
US201662347331P 2016-06-08 2016-06-08
US62/347,331 2016-06-08
US201662359781P 2016-07-08 2016-07-08
US62/359,781 2016-07-08
US201662381384P 2016-08-30 2016-08-30
US62/381,384 2016-08-30
US201662400787P 2016-09-28 2016-09-28
US62/400,787 2016-09-28
US201662414128P 2016-10-28 2016-10-28
US62/414,128 2016-10-28
US201662431846P 2016-12-09 2016-12-09
US62/431,846 2016-12-09
PCT/US2016/067200 WO2017106656A1 (en) 2015-12-17 2016-12-16 Antibody molecules to pd-1 and uses thereof

Related Child Applications (1)

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JP2020096122A Division JP7569166B2 (ja) 2015-12-17 2020-06-02 Ｐｄ－１に対する抗体分子およびその使用

Publications (2)

Publication Number Publication Date
JP2019503349A true JP2019503349A (ja) 2019-02-07
JP2019503349A5 JP2019503349A5 (https=) 2019-10-17

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JP2018531392A Pending JP2019503349A (ja) 2015-12-17 2016-12-16 Ｐｄ−１に対する抗体分子およびその使用
JP2020096122A Active JP7569166B2 (ja) 2015-12-17 2020-06-02 Ｐｄ－１に対する抗体分子およびその使用
JP2022152739A Pending JP2022180567A (ja) 2015-12-17 2022-09-26 Ｐｄ－１に対する抗体分子およびその使用
JP2024150345A Pending JP2024174916A (ja) 2015-12-17 2024-08-30 Ｐｄ－１に対する抗体分子およびその使用

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JP2020096122A Active JP7569166B2 (ja) 2015-12-17 2020-06-02 Ｐｄ－１に対する抗体分子およびその使用
JP2022152739A Pending JP2022180567A (ja) 2015-12-17 2022-09-26 Ｐｄ－１に対する抗体分子およびその使用
JP2024150345A Pending JP2024174916A (ja) 2015-12-17 2024-08-30 Ｐｄ－１に対する抗体分子およびその使用

Country Status (13)

Country Link
US (1) US20180371093A1 (https=)
EP (2) EP3389712B1 (https=)
JP (4) JP2019503349A (https=)
KR (1) KR102833068B1 (https=)
CN (1) CN108495651A (https=)
AU (1) AU2016369537B2 (https=)
BR (1) BR112018012138A2 (https=)
CL (1) CL2018001560A1 (https=)
ES (1) ES2986067T3 (https=)
IL (1) IL259987A (https=)
MX (1) MX2018007423A (https=)
PH (1) PH12018501206A1 (https=)
WO (1) WO2017106656A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
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JP2022535816A (ja) * 2019-06-03 2022-08-10 ザ・ユニバーシティ・オブ・シカゴ コラーゲン結合薬物担体を用いてがんを処置するための方法および組成物
JP2023506958A (ja) * 2019-12-20 2023-02-20 ノバルティス アーゲー 骨髄線維症および骨髄異形成症候群を処置するための、デシタビンまたは抗ｐｄ－１抗体スパルタリズマブを伴うかまたは伴わない抗ｔｉｍ－３抗体ｍｂｇ４５３および抗ｔｇｆ－ベータ抗体ｎｉｓ７９３の組合せ
JP2024138346A (ja) * 2019-04-02 2024-10-08 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 前悪性病変を有する患者において癌を予測及び予防する方法

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