JP2019141083A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019141083A5 JP2019141083A5 JP2019084119A JP2019084119A JP2019141083A5 JP 2019141083 A5 JP2019141083 A5 JP 2019141083A5 JP 2019084119 A JP2019084119 A JP 2019084119A JP 2019084119 A JP2019084119 A JP 2019084119A JP 2019141083 A5 JP2019141083 A5 JP 2019141083A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- substitution mutation
- position corresponding
- aar polypeptide
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102220184507 rs763093375 Human genes 0.000 claims 43
- 230000035772 mutation Effects 0.000 claims 31
- 238000006467 substitution reaction Methods 0.000 claims 29
- 101710129019 Long-chain acyl-[acyl-carrier-protein] reductase Proteins 0.000 claims 28
- 229920001184 polypeptide Polymers 0.000 claims 25
- 102000004196 processed proteins & peptides Human genes 0.000 claims 25
- 108090000765 processed proteins & peptides Proteins 0.000 claims 25
- 102220535257 A disintegrin and metalloproteinase with thrombospondin motifs 9_S96T_mutation Human genes 0.000 claims 21
- 230000001580 bacterial effect Effects 0.000 claims 14
- 102220003633 rs137852506 Human genes 0.000 claims 9
- 102220105307 rs879254427 Human genes 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 150000002191 fatty alcohols Chemical class 0.000 claims 4
- 102220519085 Cytochrome P450 1A2_S18C_mutation Human genes 0.000 claims 3
- 102220508034 Mitochondrial folate transporter/carrier_R19A_mutation Human genes 0.000 claims 3
- 102220624011 Non-histone chromosomal protein HMG-14_R19S_mutation Human genes 0.000 claims 3
- 102220469615 Protein unc-13 homolog B_Y23N_mutation Human genes 0.000 claims 3
- 102220471966 Single-stranded DNA cytosine deaminase_R19V_mutation Human genes 0.000 claims 3
- 102220423687 c.53C>T Human genes 0.000 claims 3
- 102220414540 c.56G>C Human genes 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 150000002192 fatty aldehydes Chemical class 0.000 claims 3
- 102200080102 rs121908643 Human genes 0.000 claims 3
- 102200158393 rs5030732 Human genes 0.000 claims 3
- 102220222142 rs780470521 Human genes 0.000 claims 3
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 claims 2
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims 1
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 102200007298 rs587777310 Human genes 0.000 claims 1
- 102220027168 rs63749950 Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361753273P | 2013-01-16 | 2013-01-16 | |
| US61/753,273 | 2013-01-16 | ||
| JP2017174449A JP6523393B2 (ja) | 2013-01-16 | 2017-09-12 | 改良された特性を有するアシル−ａｃｐレダクターゼ |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017174449A Division JP6523393B2 (ja) | 2013-01-16 | 2017-09-12 | 改良された特性を有するアシル−ａｃｐレダクターゼ |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020178581A Division JP7094343B2 (ja) | 2013-01-16 | 2020-10-26 | 改良された特性を有するアシル－ａｃｐレダクターゼ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019141083A JP2019141083A (ja) | 2019-08-29 |
| JP2019141083A5 true JP2019141083A5 (enExample) | 2019-10-31 |
| JP6926143B2 JP6926143B2 (ja) | 2021-08-25 |
Family
ID=50473752
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015553830A Active JP6063585B2 (ja) | 2013-01-16 | 2014-01-16 | 改良された特性を有するアシル−ａｃｐレダクターゼ |
| JP2016202155A Expired - Fee Related JP6211162B2 (ja) | 2013-01-16 | 2016-10-14 | 改良された特性を有するアシル−ａｃｐレダクターゼ |
| JP2017174449A Expired - Fee Related JP6523393B2 (ja) | 2013-01-16 | 2017-09-12 | 改良された特性を有するアシル−ａｃｐレダクターゼ |
| JP2019084119A Active JP6926143B2 (ja) | 2013-01-16 | 2019-04-25 | 改良された特性を有するアシル−ａｃｐレダクターゼ |
| JP2020178581A Active JP7094343B2 (ja) | 2013-01-16 | 2020-10-26 | 改良された特性を有するアシル－ａｃｐレダクターゼ |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015553830A Active JP6063585B2 (ja) | 2013-01-16 | 2014-01-16 | 改良された特性を有するアシル−ａｃｐレダクターゼ |
| JP2016202155A Expired - Fee Related JP6211162B2 (ja) | 2013-01-16 | 2016-10-14 | 改良された特性を有するアシル−ａｃｐレダクターゼ |
| JP2017174449A Expired - Fee Related JP6523393B2 (ja) | 2013-01-16 | 2017-09-12 | 改良された特性を有するアシル−ａｃｐレダクターゼ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020178581A Active JP7094343B2 (ja) | 2013-01-16 | 2020-10-26 | 改良された特性を有するアシル－ａｃｐレダクターゼ |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US9683219B2 (enExample) |
| EP (3) | EP2946009B1 (enExample) |
| JP (5) | JP6063585B2 (enExample) |
| KR (4) | KR101746040B1 (enExample) |
| CN (3) | CN110387352A (enExample) |
| AU (3) | AU2014207522B2 (enExample) |
| BR (1) | BR112015017005A2 (enExample) |
| CA (2) | CA3143642A1 (enExample) |
| CO (1) | CO7461134A2 (enExample) |
| ES (2) | ES2675224T3 (enExample) |
| MX (2) | MX356997B (enExample) |
| MY (1) | MY167434A (enExample) |
| WO (1) | WO2014113571A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011038364A1 (en) | 2009-09-27 | 2011-03-31 | Opx Biotechnologies, Inc. | Method for producing 3-hydroxypropionic acid and other products |
| BR112015002940A2 (pt) | 2012-08-10 | 2018-04-24 | Opx Biotechnologies Inc | microorganismos e métodos para a produção de ácidos graxos e produtos derivados de ácidos graxos. |
| CN110387352A (zh) | 2013-01-16 | 2019-10-29 | Reg生命科学有限责任公司 | 具有改善特性的酰基-acp还原酶 |
| US9447438B2 (en) | 2013-03-15 | 2016-09-20 | Cargill, Incorporated | Acetyl-coA carboxylases |
| WO2015010103A2 (en) | 2013-07-19 | 2015-01-22 | Opx Biotechnologies, Inc. | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| CN106574238B (zh) * | 2014-07-18 | 2021-09-21 | 基因组股份公司 | 微生物的脂肪二醇产生 |
| EP2993228B1 (en) | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Production of fatty acid esters |
| CN110494566A (zh) | 2017-02-02 | 2019-11-22 | 嘉吉公司 | 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞 |
| KR102677413B1 (ko) | 2017-04-03 | 2024-06-24 | 게노마티카 인코포레이티드 | 중쇄 지방산 유도체의 생산을 위해 개선된 활성을 갖는 티오에스테라제 변이체 |
| WO2020047088A1 (en) * | 2018-08-31 | 2020-03-05 | Genomatica, Inc. | Production of non-native monounsaturated fatty acids in bacteria |
| EP3844179A4 (en) | 2018-08-31 | 2022-08-31 | Genomatica, Inc. | XYLR MUTANT FOR IMPROVED XYLOSE UTILIZATION OR IMPROVED CO-UTILIZATION OF GLUCOSE AND XYLOSE |
| WO2023178193A1 (en) | 2022-03-16 | 2023-09-21 | Genomatica, Inc. | Acyl-acp thioesterase variants and uses thereof |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5424202A (en) | 1988-08-31 | 1995-06-13 | The University Of Florida | Ethanol production by recombinant hosts |
| US5028539A (en) | 1988-08-31 | 1991-07-02 | The University Of Florida | Ethanol production using engineered mutant E. coli |
| US5000000A (en) | 1988-08-31 | 1991-03-19 | University Of Florida | Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes |
| US5482846A (en) | 1988-08-31 | 1996-01-09 | University Of Florida | Ethanol production in Gram-positive microbes |
| AU7791991A (en) | 1990-04-24 | 1991-11-11 | Stratagene | Methods for phenotype creation from multiple gene populations |
| US5602030A (en) | 1994-03-28 | 1997-02-11 | University Of Florida Research Foundation | Recombinant glucose uptake system |
| US6428767B1 (en) | 1995-05-12 | 2002-08-06 | E. I. Du Pont De Nemours And Company | Method for identifying the source of carbon in 1,3-propanediol |
| US5965408A (en) | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
| US5939250A (en) | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
| PL207026B1 (pl) | 2000-02-09 | 2010-10-29 | Basf Ag | Wyizolowany kwas nukleinowy, konstrukt genowy zawierający ten kwas, sekwencja aminokwasowa kodowana przez wyizolowaną sekwencję tego kwasu nukleinowego, wektor zawierający kwas nukleinowy lub konstrukt genowy, roślina transgeniczna lub mikroorganizm transgeniczny zawierający kwas nukleinowy, konstrukt genowy lub wektor, przeciwciało specyficznie wiążące się z polipeptydem kodowanym przez kwas nukleinowy, cząsteczka antysensownego kwasu nukleinowego oraz sposób wytwarzania wielonienasyconych kwasów tłuszczowych (PUFA) |
| US8110670B2 (en) | 2006-05-19 | 2012-02-07 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| JP5933909B2 (ja) | 2006-05-19 | 2016-06-15 | アールイージー ライフ サイエンシズ リミテッド ライアビリティ カンパニー | 脂肪酸およびその誘導体の生産 |
| WO2008113041A2 (en) | 2007-03-14 | 2008-09-18 | Ls9, Inc. | Process for producing low molecular weight hydrocarbons from renewable resources |
| CA3178593A1 (en) | 2007-03-28 | 2008-10-02 | Genomatica, Inc. | Enhanced production of fatty acid derivatives |
| TWI351779B (en) | 2007-12-03 | 2011-11-01 | Advance Smart Ind Ltd | Apparatus and method for correcting residual capac |
| US8183028B2 (en) | 2007-12-21 | 2012-05-22 | Ls9, Inc. | Methods and compositions for producing olefins |
| MX2010012192A (es) | 2008-05-16 | 2011-04-26 | Ls9 Inc | Metodos y composiciones para producir hidrocarburos. |
| US8232924B2 (en) | 2008-05-23 | 2012-07-31 | Alliant Techsystems Inc. | Broadband patch antenna and antenna system |
| MX2011003597A (es) | 2008-10-07 | 2011-06-20 | Ls9 Inc | Metodos y composiciones para producir aldehidos grasos. |
| EP2796559B1 (en) | 2008-10-28 | 2018-09-12 | REG Life Sciences, LLC | Microbial cell for producing fatty alcohols |
| EP2424989A2 (en) | 2009-05-01 | 2012-03-07 | The Regents of The University of California | Product of fatty acid esters from biomass polymers |
| WO2010135624A2 (en) * | 2009-05-22 | 2010-11-25 | Codexis, Inc. | Engineered biosynthesis of fatty alcohols |
| US7794969B1 (en) * | 2009-07-09 | 2010-09-14 | Joule Unlimited, Inc. | Methods and compositions for the recombinant biosynthesis of n-alkanes |
| EP2477021B1 (en) * | 2009-09-07 | 2018-03-07 | National Institute of Information and Communication Technology | Method and system for evaluating characteristic of optical modulator having mach-zehnder interferometer |
| WO2011038134A1 (en) * | 2009-09-25 | 2011-03-31 | Ls9, Inc. | Production of fatty acid derivatives |
| WO2011038364A1 (en) | 2009-09-27 | 2011-03-31 | Opx Biotechnologies, Inc. | Method for producing 3-hydroxypropionic acid and other products |
| US8530221B2 (en) | 2010-01-14 | 2013-09-10 | Ls9, Inc. | Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells |
| WO2011100667A1 (en) | 2010-02-14 | 2011-08-18 | Ls9, Inc. | Surfactant and cleaning compositions comprising microbially produced branched fatty alcohols |
| AR084377A1 (es) * | 2010-04-08 | 2013-05-15 | Ls9 Inc | Metodos y composiciones relacionados con enzimas de alcohol graso biosintetico |
| US8372610B2 (en) | 2010-09-15 | 2013-02-12 | Ls9, Inc. | Production of odd chain fatty acid derivatives in recombinant microbial cells |
| AU2011349444B2 (en) * | 2010-12-20 | 2016-06-30 | Lumen Bioscience, Inc. | Modified photosynthetic microorganisms for producing lipids |
| CA2823928C (en) * | 2011-01-14 | 2020-09-22 | Ls9, Inc. | Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells |
| CN102719467A (zh) * | 2012-07-09 | 2012-10-10 | 武汉大学 | 一种利用脂肪酰acp还原酶生物合成脂肪醇的方法 |
| CN110387352A (zh) | 2013-01-16 | 2019-10-29 | Reg生命科学有限责任公司 | 具有改善特性的酰基-acp还原酶 |
| JP7478517B2 (ja) | 2019-04-24 | 2024-05-07 | 三菱商事ライフサイエンス株式会社 | 脂質活性代謝改善組成物 |
-
2014
- 2014-01-16 CN CN201910693927.0A patent/CN110387352A/zh active Pending
- 2014-01-16 JP JP2015553830A patent/JP6063585B2/ja active Active
- 2014-01-16 CN CN201910169609.4A patent/CN109897834A/zh active Pending
- 2014-01-16 KR KR1020157021992A patent/KR101746040B1/ko active Active
- 2014-01-16 CN CN201480004992.3A patent/CN105051189B/zh active Active
- 2014-01-16 EP EP14716444.6A patent/EP2946009B1/en active Active
- 2014-01-16 AU AU2014207522A patent/AU2014207522B2/en not_active Ceased
- 2014-01-16 ES ES16181205.2T patent/ES2675224T3/es active Active
- 2014-01-16 US US14/761,299 patent/US9683219B2/en active Active
- 2014-01-16 ES ES14716444.6T patent/ES2600354T3/es active Active
- 2014-01-16 EP EP18172072.3A patent/EP3385375B1/en active Active
- 2014-01-16 KR KR1020177015121A patent/KR102082247B1/ko not_active Expired - Fee Related
- 2014-01-16 MX MX2017003816A patent/MX356997B/es unknown
- 2014-01-16 MX MX2015009138A patent/MX346830B/es active IP Right Grant
- 2014-01-16 CA CA3143642A patent/CA3143642A1/en active Pending
- 2014-01-16 MY MYPI2015001785A patent/MY167434A/en unknown
- 2014-01-16 BR BR112015017005A patent/BR112015017005A2/pt not_active IP Right Cessation
- 2014-01-16 KR KR1020207004969A patent/KR102265148B1/ko not_active Expired - Fee Related
- 2014-01-16 EP EP16181205.2A patent/EP3103867B1/en active Active
- 2014-01-16 KR KR1020217017654A patent/KR20210072147A/ko not_active Ceased
- 2014-01-16 WO PCT/US2014/011859 patent/WO2014113571A2/en not_active Ceased
- 2014-01-16 CA CA2898317A patent/CA2898317C/en active Active
-
2015
- 2015-07-28 CO CO15173779A patent/CO7461134A2/es unknown
-
2016
- 2016-07-28 US US15/222,657 patent/US10208294B2/en active Active
- 2016-10-14 JP JP2016202155A patent/JP6211162B2/ja not_active Expired - Fee Related
-
2017
- 2017-01-30 AU AU2017200596A patent/AU2017200596B2/en not_active Ceased
- 2017-06-13 US US15/621,430 patent/US9873865B2/en active Active
- 2017-09-12 JP JP2017174449A patent/JP6523393B2/ja not_active Expired - Fee Related
-
2019
- 2019-02-11 US US16/272,303 patent/US11130944B2/en not_active Expired - Fee Related
- 2019-04-18 AU AU2019202790A patent/AU2019202790A1/en not_active Abandoned
- 2019-04-25 JP JP2019084119A patent/JP6926143B2/ja active Active
-
2020
- 2020-10-26 JP JP2020178581A patent/JP7094343B2/ja active Active
-
2021
- 2021-08-18 US US17/405,685 patent/US20220090028A1/en not_active Abandoned
-
2023
- 2023-07-20 US US18/355,990 patent/US12173329B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019141083A5 (enExample) | ||
| JP2021006067A5 (enExample) | ||
| JP2016503663A5 (enExample) | ||
| JP2015512645A5 (enExample) | ||
| CN109266565B (zh) | L-乳酸生产的耐热酵母工程菌株的构建及应用 | |
| Wang et al. | Exploring fatty alcohol-producing capability of Yarrowia lipolytica | |
| JP2021520836A5 (enExample) | ||
| JP2015526105A5 (enExample) | ||
| JP2020509751A5 (enExample) | ||
| JP2016521577A5 (enExample) | ||
| JP2010524468A5 (enExample) | ||
| JP2020509755A5 (enExample) | ||
| JP2019193640A5 (enExample) | ||
| JP2013511972A (ja) | 組換え型Ｙａｒｒｏｗｉａｓｐ．を用いた発酵による超長鎖脂肪酸（ＶＬＣＦＡ）の生産方法 | |
| JP2020506723A5 (enExample) | ||
| RU2011152925A (ru) | Полипептид, обладающий активностью d-лактатдегидрогеназы, полинуклеотид, кодирующий этот полипептид, и способ получения d-молочной кислоты | |
| Sun et al. | Double Candida antarctica lipase B co-display on Pichia pastoris cell surface based on a self-processing foot-and-mouth disease virus 2A peptide | |
| JP2017507644A5 (enExample) | ||
| JP2024029002A5 (enExample) | ||
| JP2016510990A5 (enExample) | ||
| WO2013096082A1 (en) | Fatty alcohol forming acyl reductase (far) variants and methods of use | |
| AU2015218647A1 (en) | Diacylglycerol acyl transferase (DGA1) polynucleotides, and methods of increasing yeast cell lipid production by overexpression of heterologous DGA1 | |
| CN105647822B (zh) | 一株过表达来源于寄生疫霉的ω-3脱饱和酶的重组高山被孢霉、其构建方法及应用 | |
| JP2014503216A5 (enExample) | ||
| CN105483034B (zh) | 一种转换酵母交配型的方法 |