CA3143642A1 - Acyl-acp reductase with improved properties - Google Patents
Acyl-acp reductase with improved propertiesInfo
- Publication number
- CA3143642A1 CA3143642A1 CA3143642A CA3143642A CA3143642A1 CA 3143642 A1 CA3143642 A1 CA 3143642A1 CA 3143642 A CA3143642 A CA 3143642A CA 3143642 A CA3143642 A CA 3143642A CA 3143642 A1 CA3143642 A1 CA 3143642A1
- Authority
- CA
- Canada
- Prior art keywords
- mutation
- aar polypeptide
- fatty alcohol
- variant aar
- fatty
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/0108—Long-chain acyl-[acyl-carrier-protein] reductase (1.2.1.80)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361753273P | 2013-01-16 | 2013-01-16 | |
| US61/753,273 | 2013-01-16 | ||
| CA2898317A CA2898317C (en) | 2013-01-16 | 2014-01-16 | Acyl-acp reductase with improved properties |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2898317A Division CA2898317C (en) | 2013-01-16 | 2014-01-16 | Acyl-acp reductase with improved properties |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3143642A1 true CA3143642A1 (en) | 2014-07-24 |
Family
ID=50473752
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3143642A Pending CA3143642A1 (en) | 2013-01-16 | 2014-01-16 | Acyl-acp reductase with improved properties |
| CA2898317A Active CA2898317C (en) | 2013-01-16 | 2014-01-16 | Acyl-acp reductase with improved properties |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2898317A Active CA2898317C (en) | 2013-01-16 | 2014-01-16 | Acyl-acp reductase with improved properties |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US9683219B2 (enExample) |
| EP (3) | EP2946009B1 (enExample) |
| JP (5) | JP6063585B2 (enExample) |
| KR (4) | KR101746040B1 (enExample) |
| CN (3) | CN105051189B (enExample) |
| AU (3) | AU2014207522B2 (enExample) |
| BR (1) | BR112015017005A2 (enExample) |
| CA (2) | CA3143642A1 (enExample) |
| CO (1) | CO7461134A2 (enExample) |
| ES (2) | ES2600354T3 (enExample) |
| MX (2) | MX356997B (enExample) |
| MY (1) | MY167434A (enExample) |
| WO (1) | WO2014113571A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013505727A (ja) | 2009-09-27 | 2013-02-21 | オーピーエックス バイオテクノロジーズ， インコーポレイテッド | ３−ヒドロキシプロピオン酸および他の生成物を生成するための方法 |
| EP2882843A4 (en) | 2012-08-10 | 2016-04-06 | Opx Biotechnologies Inc | MICRO-ORGANISMS AND METHOD FOR THE PRODUCTION OF FATTY ACIDS AND PRODUCTS DERIVED FROM FATTY ACIDS |
| KR101746040B1 (ko) | 2013-01-16 | 2017-06-13 | 알이지 라이프 사이언시스, 엘엘씨 | 개선된 특성들을 갖는 아실-ａｃｐ 레덕타아제 |
| US20150057465A1 (en) | 2013-03-15 | 2015-02-26 | Opx Biotechnologies, Inc. | Control of growth-induction-production phases |
| CN106795483A (zh) | 2013-07-19 | 2017-05-31 | 嘉吉公司 | 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法 |
| US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| CN111748511A (zh) * | 2014-07-18 | 2020-10-09 | 基因组股份公司 | 微生物的脂肪二醇产生 |
| EP2993228B1 (en) | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Production of fatty acid esters |
| WO2018144701A2 (en) | 2017-02-02 | 2018-08-09 | Cargill Incorporated | Genetically modified cells that produce c6-c10 fatty acid derivatives |
| BR112019020784A2 (pt) | 2017-04-03 | 2020-04-28 | Genomatica, Inc. | variantes de tioesterase com atividade melhorada para a produção de derivados de ácidos graxos de cadeia média |
| EP3844269A4 (en) * | 2018-08-31 | 2022-07-27 | Genomatica, Inc. | PRODUCTION OF NON-NATIVE MONOUNSATURATED FATTY ACIDS IN BACTERIA |
| WO2020047304A1 (en) | 2018-08-31 | 2020-03-05 | Genomatica, Inc. | Xylr mutant for improved xylose utilization or improved co-utilization of glucose and xylose |
| US12649937B2 (en) | 2021-03-29 | 2026-06-09 | Genomatica, Inc. | Production of non-native monounsaturated fatty acids in bacteria |
| WO2023178193A1 (en) | 2022-03-16 | 2023-09-21 | Genomatica, Inc. | Acyl-acp thioesterase variants and uses thereof |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5424202A (en) | 1988-08-31 | 1995-06-13 | The University Of Florida | Ethanol production by recombinant hosts |
| US5482846A (en) | 1988-08-31 | 1996-01-09 | University Of Florida | Ethanol production in Gram-positive microbes |
| US5028539A (en) | 1988-08-31 | 1991-07-02 | The University Of Florida | Ethanol production using engineered mutant E. coli |
| US5000000A (en) | 1988-08-31 | 1991-03-19 | University Of Florida | Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes |
| EP0528881A4 (en) | 1990-04-24 | 1993-05-26 | Stratagene | Methods for phenotype creation from multiple gene populations |
| US5602030A (en) | 1994-03-28 | 1997-02-11 | University Of Florida Research Foundation | Recombinant glucose uptake system |
| US6428767B1 (en) | 1995-05-12 | 2002-08-06 | E. I. Du Pont De Nemours And Company | Method for identifying the source of carbon in 1,3-propanediol |
| US5965408A (en) | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
| US5939250A (en) | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
| US7544859B2 (en) * | 2000-02-09 | 2009-06-09 | Basf Aktiengesellschaft | Elongase gene and method for producing multiple-unsaturated fatty acids |
| US8110670B2 (en) | 2006-05-19 | 2012-02-07 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| AU2007254151A1 (en) | 2006-05-19 | 2007-11-29 | Ls9, Inc. | Production of fatty acids and derivatives thereof |
| US8110093B2 (en) | 2007-03-14 | 2012-02-07 | Ls9, Inc. | Process for producing low molecular weight hydrocarbons from renewable resources |
| CA3035878C (en) | 2007-03-28 | 2023-01-03 | REG Life Sciences, LLC | Enhanced production of fatty acid derivatives |
| TWI351779B (en) | 2007-12-03 | 2011-11-01 | Advance Smart Ind Ltd | Apparatus and method for correcting residual capac |
| US8183028B2 (en) | 2007-12-21 | 2012-05-22 | Ls9, Inc. | Methods and compositions for producing olefins |
| JP2011522525A (ja) | 2008-05-16 | 2011-08-04 | エルエス９・インコーポレイテッド | 炭化水素を製造するための方法および組成物 |
| WO2009142983A1 (en) | 2008-05-23 | 2009-11-26 | Alliant Techsystems Inc. | Broadband patch antenna and antenna system |
| CA3038491A1 (en) | 2008-10-07 | 2010-04-15 | REG Life Sciences, LLC | Bacterial host cells engineered to express a carboxylic acid reductase and a thioesterase |
| WO2010062480A2 (en) * | 2008-10-28 | 2010-06-03 | Ls9, Inc. | Methods and compositions for producing fatty alcohols |
| EP2424989A2 (en) | 2009-05-01 | 2012-03-07 | The Regents of The University of California | Product of fatty acid esters from biomass polymers |
| WO2010135624A2 (en) * | 2009-05-22 | 2010-11-25 | Codexis, Inc. | Engineered biosynthesis of fatty alcohols |
| US7794969B1 (en) * | 2009-07-09 | 2010-09-14 | Joule Unlimited, Inc. | Methods and compositions for the recombinant biosynthesis of n-alkanes |
| JP5622154B2 (ja) * | 2009-09-07 | 2014-11-12 | 独立行政法人情報通信研究機構 | 複数のマッハツェンダー干渉計を有する光変調器の特性評価方法 |
| CN102656273B (zh) * | 2009-09-25 | 2016-05-25 | Reg生命科学有限责任公司 | 脂肪酸衍生物的产生 |
| JP2013505727A (ja) | 2009-09-27 | 2013-02-21 | オーピーエックス バイオテクノロジーズ， インコーポレイテッド | ３−ヒドロキシプロピオン酸および他の生成物を生成するための方法 |
| US8530221B2 (en) | 2010-01-14 | 2013-09-10 | Ls9, Inc. | Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells |
| WO2011100667A1 (en) | 2010-02-14 | 2011-08-18 | Ls9, Inc. | Surfactant and cleaning compositions comprising microbially produced branched fatty alcohols |
| WO2011127409A2 (en) * | 2010-04-08 | 2011-10-13 | Ls9, Inc. | Methods and compositions related to fatty alcohol biosynthetic enzymes |
| US8372610B2 (en) | 2010-09-15 | 2013-02-12 | Ls9, Inc. | Production of odd chain fatty acid derivatives in recombinant microbial cells |
| AU2011349444B2 (en) | 2010-12-20 | 2016-06-30 | Lumen Bioscience, Inc. | Modified photosynthetic microorganisms for producing lipids |
| EP3456814A3 (en) * | 2011-01-14 | 2019-05-29 | REG Life Sciences, LLC | Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells |
| CN102719467A (zh) * | 2012-07-09 | 2012-10-10 | 武汉大学 | 一种利用脂肪酰acp还原酶生物合成脂肪醇的方法 |
| KR101746040B1 (ko) | 2013-01-16 | 2017-06-13 | 알이지 라이프 사이언시스, 엘엘씨 | 개선된 특성들을 갖는 아실-ａｃｐ 레덕타아제 |
| JP7478517B2 (ja) | 2019-04-24 | 2024-05-07 | 三菱商事ライフサイエンス株式会社 | 脂質活性代謝改善組成物 |
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2014
- 2014-01-16 KR KR1020157021992A patent/KR101746040B1/ko active Active
- 2014-01-16 CA CA3143642A patent/CA3143642A1/en active Pending
- 2014-01-16 JP JP2015553830A patent/JP6063585B2/ja active Active
- 2014-01-16 MX MX2017003816A patent/MX356997B/es unknown
- 2014-01-16 EP EP14716444.6A patent/EP2946009B1/en active Active
- 2014-01-16 CN CN201480004992.3A patent/CN105051189B/zh active Active
- 2014-01-16 CA CA2898317A patent/CA2898317C/en active Active
- 2014-01-16 US US14/761,299 patent/US9683219B2/en active Active
- 2014-01-16 WO PCT/US2014/011859 patent/WO2014113571A2/en not_active Ceased
- 2014-01-16 KR KR1020207004969A patent/KR102265148B1/ko not_active Expired - Fee Related
- 2014-01-16 CN CN201910169609.4A patent/CN109897834A/zh active Pending
- 2014-01-16 MY MYPI2015001785A patent/MY167434A/en unknown
- 2014-01-16 KR KR1020177015121A patent/KR102082247B1/ko not_active Expired - Fee Related
- 2014-01-16 AU AU2014207522A patent/AU2014207522B2/en not_active Ceased
- 2014-01-16 KR KR1020217017654A patent/KR20210072147A/ko not_active Ceased
- 2014-01-16 ES ES14716444.6T patent/ES2600354T3/es active Active
- 2014-01-16 ES ES16181205.2T patent/ES2675224T3/es active Active
- 2014-01-16 MX MX2015009138A patent/MX346830B/es active IP Right Grant
- 2014-01-16 EP EP18172072.3A patent/EP3385375B1/en active Active
- 2014-01-16 EP EP16181205.2A patent/EP3103867B1/en not_active Not-in-force
- 2014-01-16 CN CN201910693927.0A patent/CN110387352A/zh active Pending
- 2014-01-16 BR BR112015017005A patent/BR112015017005A2/pt not_active IP Right Cessation
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2015
- 2015-07-28 CO CO15173779A patent/CO7461134A2/es unknown
-
2016
- 2016-07-28 US US15/222,657 patent/US10208294B2/en active Active
- 2016-10-14 JP JP2016202155A patent/JP6211162B2/ja not_active Expired - Fee Related
-
2017
- 2017-01-30 AU AU2017200596A patent/AU2017200596B2/en not_active Ceased
- 2017-06-13 US US15/621,430 patent/US9873865B2/en active Active
- 2017-09-12 JP JP2017174449A patent/JP6523393B2/ja not_active Expired - Fee Related
-
2019
- 2019-02-11 US US16/272,303 patent/US11130944B2/en not_active Expired - Fee Related
- 2019-04-18 AU AU2019202790A patent/AU2019202790A1/en not_active Abandoned
- 2019-04-25 JP JP2019084119A patent/JP6926143B2/ja active Active
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2020
- 2020-10-26 JP JP2020178581A patent/JP7094343B2/ja active Active
-
2021
- 2021-08-18 US US17/405,685 patent/US20220090028A1/en not_active Abandoned
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2023
- 2023-07-20 US US18/355,990 patent/US12173329B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20211221 |