BR112015017005A2 - Acil-acp redutase com propriedades melhoradas - Google Patents

Acil-acp redutase com propriedades melhoradas

Info

Publication number
BR112015017005A2
BR112015017005A2 BR112015017005A BR112015017005A BR112015017005A2 BR 112015017005 A2 BR112015017005 A2 BR 112015017005A2 BR 112015017005 A BR112015017005 A BR 112015017005A BR 112015017005 A BR112015017005 A BR 112015017005A BR 112015017005 A2 BR112015017005 A2 BR 112015017005A2
Authority
BR
Brazil
Prior art keywords
acp
redutase
aar
fatty alcohol
acil
Prior art date
Application number
BR112015017005A
Other languages
English (en)
Portuguese (pt)
Inventor
Rude Mathew
Trinh Na
Schirmer Andreas
Gano Jacob
Original Assignee
Reg Life Sciences Llc
Genomatica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reg Life Sciences Llc, Genomatica Inc filed Critical Reg Life Sciences Llc
Priority to BR122017000832A priority Critical patent/BR122017000832A2/pt
Priority to BR122017000806A priority patent/BR122017000806A2/pt
Publication of BR112015017005A2 publication Critical patent/BR112015017005A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/0108—Long-chain acyl-[acyl-carrier-protein] reductase (1.2.1.80)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Fats And Perfumes (AREA)
BR112015017005A 2013-01-16 2014-01-16 Acil-acp redutase com propriedades melhoradas BR112015017005A2 (pt)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BR122017000832A BR122017000832A2 (pt) 2013-01-16 2014-01-16 polipeptídeo da variante acil-acp redutase (aar), célula hospedeira recombinante, cultura celular, método de produção de composição de álcool graxo tendo aumento do título
BR122017000806A BR122017000806A2 (pt) 2013-01-16 2014-01-16 polipeptídeo da variante acil-acp redutase (aar), célula hospedeira recombinante, cultura celular, método de produção de composição de álcool graxo tendo aumento do título

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361753273P 2013-01-16 2013-01-16
PCT/US2014/011859 WO2014113571A2 (en) 2013-01-16 2014-01-16 Acyl-acp reductase with improved properties

Publications (1)

Publication Number Publication Date
BR112015017005A2 true BR112015017005A2 (pt) 2017-08-15

Family

ID=50473752

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015017005A BR112015017005A2 (pt) 2013-01-16 2014-01-16 Acil-acp redutase com propriedades melhoradas

Country Status (13)

Country Link
US (6) US9683219B2 (enExample)
EP (3) EP2946009B1 (enExample)
JP (5) JP6063585B2 (enExample)
KR (4) KR101746040B1 (enExample)
CN (3) CN110387352A (enExample)
AU (3) AU2014207522B2 (enExample)
BR (1) BR112015017005A2 (enExample)
CA (2) CA3143642A1 (enExample)
CO (1) CO7461134A2 (enExample)
ES (2) ES2675224T3 (enExample)
MX (2) MX356997B (enExample)
MY (1) MY167434A (enExample)
WO (1) WO2014113571A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011038364A1 (en) 2009-09-27 2011-03-31 Opx Biotechnologies, Inc. Method for producing 3-hydroxypropionic acid and other products
BR112015002940A2 (pt) 2012-08-10 2018-04-24 Opx Biotechnologies Inc microorganismos e métodos para a produção de ácidos graxos e produtos derivados de ácidos graxos.
CN110387352A (zh) 2013-01-16 2019-10-29 Reg生命科学有限责任公司 具有改善特性的酰基-acp还原酶
US9447438B2 (en) 2013-03-15 2016-09-20 Cargill, Incorporated Acetyl-coA carboxylases
WO2015010103A2 (en) 2013-07-19 2015-01-22 Opx Biotechnologies, Inc. Microorganisms and methods for the production of fatty acids and fatty acid derived products
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
CN106574238B (zh) * 2014-07-18 2021-09-21 基因组股份公司 微生物的脂肪二醇产生
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
CN110494566A (zh) 2017-02-02 2019-11-22 嘉吉公司 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞
KR102677413B1 (ko) 2017-04-03 2024-06-24 게노마티카 인코포레이티드 중쇄 지방산 유도체의 생산을 위해 개선된 활성을 갖는 티오에스테라제 변이체
WO2020047088A1 (en) * 2018-08-31 2020-03-05 Genomatica, Inc. Production of non-native monounsaturated fatty acids in bacteria
EP3844179A4 (en) 2018-08-31 2022-08-31 Genomatica, Inc. XYLR MUTANT FOR IMPROVED XYLOSE UTILIZATION OR IMPROVED CO-UTILIZATION OF GLUCOSE AND XYLOSE
WO2023178193A1 (en) 2022-03-16 2023-09-21 Genomatica, Inc. Acyl-acp thioesterase variants and uses thereof

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5424202A (en) 1988-08-31 1995-06-13 The University Of Florida Ethanol production by recombinant hosts
US5028539A (en) 1988-08-31 1991-07-02 The University Of Florida Ethanol production using engineered mutant E. coli
US5000000A (en) 1988-08-31 1991-03-19 University Of Florida Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes
US5482846A (en) 1988-08-31 1996-01-09 University Of Florida Ethanol production in Gram-positive microbes
AU7791991A (en) 1990-04-24 1991-11-11 Stratagene Methods for phenotype creation from multiple gene populations
US5602030A (en) 1994-03-28 1997-02-11 University Of Florida Research Foundation Recombinant glucose uptake system
US6428767B1 (en) 1995-05-12 2002-08-06 E. I. Du Pont De Nemours And Company Method for identifying the source of carbon in 1,3-propanediol
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
US5939250A (en) 1995-12-07 1999-08-17 Diversa Corporation Production of enzymes having desired activities by mutagenesis
PL207026B1 (pl) 2000-02-09 2010-10-29 Basf Ag Wyizolowany kwas nukleinowy, konstrukt genowy zawierający ten kwas, sekwencja aminokwasowa kodowana przez wyizolowaną sekwencję tego kwasu nukleinowego, wektor zawierający kwas nukleinowy lub konstrukt genowy, roślina transgeniczna lub mikroorganizm transgeniczny zawierający kwas nukleinowy, konstrukt genowy lub wektor, przeciwciało specyficznie wiążące się z polipeptydem kodowanym przez kwas nukleinowy, cząsteczka antysensownego kwasu nukleinowego oraz sposób wytwarzania wielonienasyconych kwasów tłuszczowych (PUFA)
US8110670B2 (en) 2006-05-19 2012-02-07 Ls9, Inc. Enhanced production of fatty acid derivatives
JP5933909B2 (ja) 2006-05-19 2016-06-15 アールイージー ライフ サイエンシズ リミテッド ライアビリティ カンパニー 脂肪酸およびその誘導体の生産
WO2008113041A2 (en) 2007-03-14 2008-09-18 Ls9, Inc. Process for producing low molecular weight hydrocarbons from renewable resources
CA3178593A1 (en) 2007-03-28 2008-10-02 Genomatica, Inc. Enhanced production of fatty acid derivatives
TWI351779B (en) 2007-12-03 2011-11-01 Advance Smart Ind Ltd Apparatus and method for correcting residual capac
US8183028B2 (en) 2007-12-21 2012-05-22 Ls9, Inc. Methods and compositions for producing olefins
MX2010012192A (es) 2008-05-16 2011-04-26 Ls9 Inc Metodos y composiciones para producir hidrocarburos.
US8232924B2 (en) 2008-05-23 2012-07-31 Alliant Techsystems Inc. Broadband patch antenna and antenna system
MX2011003597A (es) 2008-10-07 2011-06-20 Ls9 Inc Metodos y composiciones para producir aldehidos grasos.
EP2796559B1 (en) 2008-10-28 2018-09-12 REG Life Sciences, LLC Microbial cell for producing fatty alcohols
EP2424989A2 (en) 2009-05-01 2012-03-07 The Regents of The University of California Product of fatty acid esters from biomass polymers
WO2010135624A2 (en) * 2009-05-22 2010-11-25 Codexis, Inc. Engineered biosynthesis of fatty alcohols
US7794969B1 (en) * 2009-07-09 2010-09-14 Joule Unlimited, Inc. Methods and compositions for the recombinant biosynthesis of n-alkanes
EP2477021B1 (en) * 2009-09-07 2018-03-07 National Institute of Information and Communication Technology Method and system for evaluating characteristic of optical modulator having mach-zehnder interferometer
WO2011038134A1 (en) * 2009-09-25 2011-03-31 Ls9, Inc. Production of fatty acid derivatives
WO2011038364A1 (en) 2009-09-27 2011-03-31 Opx Biotechnologies, Inc. Method for producing 3-hydroxypropionic acid and other products
US8530221B2 (en) 2010-01-14 2013-09-10 Ls9, Inc. Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells
WO2011100667A1 (en) 2010-02-14 2011-08-18 Ls9, Inc. Surfactant and cleaning compositions comprising microbially produced branched fatty alcohols
AR084377A1 (es) * 2010-04-08 2013-05-15 Ls9 Inc Metodos y composiciones relacionados con enzimas de alcohol graso biosintetico
US8372610B2 (en) 2010-09-15 2013-02-12 Ls9, Inc. Production of odd chain fatty acid derivatives in recombinant microbial cells
AU2011349444B2 (en) * 2010-12-20 2016-06-30 Lumen Bioscience, Inc. Modified photosynthetic microorganisms for producing lipids
CA2823928C (en) * 2011-01-14 2020-09-22 Ls9, Inc. Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells
CN102719467A (zh) * 2012-07-09 2012-10-10 武汉大学 一种利用脂肪酰acp还原酶生物合成脂肪醇的方法
CN110387352A (zh) 2013-01-16 2019-10-29 Reg生命科学有限责任公司 具有改善特性的酰基-acp还原酶
JP7478517B2 (ja) 2019-04-24 2024-05-07 三菱商事ライフサイエンス株式会社 脂質活性代謝改善組成物

Also Published As

Publication number Publication date
ES2675224T3 (es) 2018-07-09
MX346830B (es) 2017-04-03
ES2600354T3 (es) 2017-02-08
KR20200020998A (ko) 2020-02-26
KR20170066694A (ko) 2017-06-14
JP2017042170A (ja) 2017-03-02
CN110387352A (zh) 2019-10-29
CA2898317C (en) 2022-03-01
JP6523393B2 (ja) 2019-05-29
KR20210072147A (ko) 2021-06-16
AU2014207522B2 (en) 2016-12-15
EP3103867B1 (en) 2018-05-16
CA3143642A1 (en) 2014-07-24
MX356997B (es) 2018-06-22
WO2014113571A2 (en) 2014-07-24
US20200010813A1 (en) 2020-01-09
JP2017209118A (ja) 2017-11-30
US20160348080A1 (en) 2016-12-01
US20240117324A1 (en) 2024-04-11
CN105051189A (zh) 2015-11-11
KR20150105471A (ko) 2015-09-16
CN105051189B (zh) 2019-08-06
JP2016503663A (ja) 2016-02-08
US12173329B2 (en) 2024-12-24
US20150361454A1 (en) 2015-12-17
AU2017200596B2 (en) 2019-01-24
KR102082247B1 (ko) 2020-02-28
JP6063585B2 (ja) 2017-01-18
EP3385375B1 (en) 2021-06-16
US9873865B2 (en) 2018-01-23
AU2017200596A1 (en) 2017-02-23
EP3103867A1 (en) 2016-12-14
JP2019141083A (ja) 2019-08-29
EP2946009B1 (en) 2016-07-27
JP6926143B2 (ja) 2021-08-25
US9683219B2 (en) 2017-06-20
JP2021006067A (ja) 2021-01-21
KR101746040B1 (ko) 2017-06-13
MX2015009138A (es) 2015-11-06
AU2014207522A1 (en) 2015-05-07
JP6211162B2 (ja) 2017-10-11
MY167434A (en) 2018-08-28
EP2946009A2 (en) 2015-11-25
CN109897834A (zh) 2019-06-18
CO7461134A2 (es) 2015-11-30
AU2019202790A1 (en) 2019-05-16
US10208294B2 (en) 2019-02-19
WO2014113571A3 (en) 2014-11-13
CA2898317A1 (en) 2014-07-24
JP7094343B2 (ja) 2022-07-01
EP3385375A1 (en) 2018-10-10
US20220090028A1 (en) 2022-03-24
US20170342388A1 (en) 2017-11-30
US11130944B2 (en) 2021-09-28
KR102265148B1 (ko) 2021-06-15

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B25A Requested transfer of rights approved

Owner name: GENOMATICA, INC. (US)

B350 Update of information on the portal [chapter 15.35 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 11A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2810 DE 12-11-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.