JP6063585B2 - 改良された特性を有するアシル−acpレダクターゼ - Google Patents

改良された特性を有するアシル−acpレダクターゼ Download PDF

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JP6063585B2
JP6063585B2 JP2015553830A JP2015553830A JP6063585B2 JP 6063585 B2 JP6063585 B2 JP 6063585B2 JP 2015553830 A JP2015553830 A JP 2015553830A JP 2015553830 A JP2015553830 A JP 2015553830A JP 6063585 B2 JP6063585 B2 JP 6063585B2
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mutation
fatty
polypeptide
aar
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JP2016503663A5 (enExample
JP2016503663A (ja
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マシュー リュード
マシュー リュード
ナ トリン
ナ トリン
アンドレアス シルマー
アンドレアス シルマー
ジェーコブ ガーノ
ジェーコブ ガーノ
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アールイージー ライフ サイエンシズ リミテッド ライアビリティ カンパニー
アールイージー ライフ サイエンシズ リミテッド ライアビリティ カンパニー
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0008Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/24Preparation of oxygen-containing organic compounds containing a carbonyl group
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409Fatty acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y102/00Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/0108Long-chain acyl-[acyl-carrier-protein] reductase (1.2.1.80)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02EREDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00Technologies for the production of fuel of non-fossil origin
    • Y02E50/10Biofuels, e.g. bio-diesel
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/52Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Fats And Perfumes (AREA)
JP2015553830A 2013-01-16 2014-01-16 改良された特性を有するアシル−acpレダクターゼ Active JP6063585B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361753273P 2013-01-16 2013-01-16
US61/753,273 2013-01-16
PCT/US2014/011859 WO2014113571A2 (en) 2013-01-16 2014-01-16 Acyl-acp reductase with improved properties

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JP2016202155A Division JP6211162B2 (ja) 2013-01-16 2016-10-14 改良された特性を有するアシル−acpレダクターゼ

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JP2016503663A JP2016503663A (ja) 2016-02-08
JP2016503663A5 JP2016503663A5 (enExample) 2016-09-29
JP6063585B2 true JP6063585B2 (ja) 2017-01-18

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JP2015553830A Active JP6063585B2 (ja) 2013-01-16 2014-01-16 改良された特性を有するアシル−acpレダクターゼ
JP2016202155A Expired - Fee Related JP6211162B2 (ja) 2013-01-16 2016-10-14 改良された特性を有するアシル−acpレダクターゼ
JP2017174449A Expired - Fee Related JP6523393B2 (ja) 2013-01-16 2017-09-12 改良された特性を有するアシル−acpレダクターゼ
JP2019084119A Active JP6926143B2 (ja) 2013-01-16 2019-04-25 改良された特性を有するアシル−acpレダクターゼ
JP2020178581A Active JP7094343B2 (ja) 2013-01-16 2020-10-26 改良された特性を有するアシル-acpレダクターゼ

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JP2017174449A Expired - Fee Related JP6523393B2 (ja) 2013-01-16 2017-09-12 改良された特性を有するアシル−acpレダクターゼ
JP2019084119A Active JP6926143B2 (ja) 2013-01-16 2019-04-25 改良された特性を有するアシル−acpレダクターゼ
JP2020178581A Active JP7094343B2 (ja) 2013-01-16 2020-10-26 改良された特性を有するアシル-acpレダクターゼ

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US (6) US9683219B2 (enExample)
EP (3) EP2946009B1 (enExample)
JP (5) JP6063585B2 (enExample)
KR (4) KR101746040B1 (enExample)
CN (3) CN110387352A (enExample)
AU (3) AU2014207522B2 (enExample)
BR (1) BR112015017005A2 (enExample)
CA (2) CA3143642A1 (enExample)
CO (1) CO7461134A2 (enExample)
ES (2) ES2675224T3 (enExample)
MX (2) MX356997B (enExample)
MY (1) MY167434A (enExample)
WO (1) WO2014113571A2 (enExample)

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US9447438B2 (en) 2013-03-15 2016-09-20 Cargill, Incorporated Acetyl-coA carboxylases
WO2015010103A2 (en) 2013-07-19 2015-01-22 Opx Biotechnologies, Inc. Microorganisms and methods for the production of fatty acids and fatty acid derived products
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
CN106574238B (zh) * 2014-07-18 2021-09-21 基因组股份公司 微生物的脂肪二醇产生
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
CN110494566A (zh) 2017-02-02 2019-11-22 嘉吉公司 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞
KR102677413B1 (ko) 2017-04-03 2024-06-24 게노마티카 인코포레이티드 중쇄 지방산 유도체의 생산을 위해 개선된 활성을 갖는 티오에스테라제 변이체
WO2020047088A1 (en) * 2018-08-31 2020-03-05 Genomatica, Inc. Production of non-native monounsaturated fatty acids in bacteria
EP3844179A4 (en) 2018-08-31 2022-08-31 Genomatica, Inc. XYLR MUTANT FOR IMPROVED XYLOSE UTILIZATION OR IMPROVED CO-UTILIZATION OF GLUCOSE AND XYLOSE
WO2023178193A1 (en) 2022-03-16 2023-09-21 Genomatica, Inc. Acyl-acp thioesterase variants and uses thereof

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Publication number Publication date
ES2675224T3 (es) 2018-07-09
MX346830B (es) 2017-04-03
ES2600354T3 (es) 2017-02-08
KR20200020998A (ko) 2020-02-26
KR20170066694A (ko) 2017-06-14
JP2017042170A (ja) 2017-03-02
CN110387352A (zh) 2019-10-29
CA2898317C (en) 2022-03-01
JP6523393B2 (ja) 2019-05-29
KR20210072147A (ko) 2021-06-16
AU2014207522B2 (en) 2016-12-15
EP3103867B1 (en) 2018-05-16
CA3143642A1 (en) 2014-07-24
MX356997B (es) 2018-06-22
WO2014113571A2 (en) 2014-07-24
US20200010813A1 (en) 2020-01-09
JP2017209118A (ja) 2017-11-30
US20160348080A1 (en) 2016-12-01
US20240117324A1 (en) 2024-04-11
CN105051189A (zh) 2015-11-11
KR20150105471A (ko) 2015-09-16
CN105051189B (zh) 2019-08-06
JP2016503663A (ja) 2016-02-08
US12173329B2 (en) 2024-12-24
US20150361454A1 (en) 2015-12-17
AU2017200596B2 (en) 2019-01-24
KR102082247B1 (ko) 2020-02-28
EP3385375B1 (en) 2021-06-16
US9873865B2 (en) 2018-01-23
AU2017200596A1 (en) 2017-02-23
EP3103867A1 (en) 2016-12-14
JP2019141083A (ja) 2019-08-29
EP2946009B1 (en) 2016-07-27
JP6926143B2 (ja) 2021-08-25
US9683219B2 (en) 2017-06-20
JP2021006067A (ja) 2021-01-21
KR101746040B1 (ko) 2017-06-13
MX2015009138A (es) 2015-11-06
AU2014207522A1 (en) 2015-05-07
JP6211162B2 (ja) 2017-10-11
MY167434A (en) 2018-08-28
EP2946009A2 (en) 2015-11-25
CN109897834A (zh) 2019-06-18
CO7461134A2 (es) 2015-11-30
AU2019202790A1 (en) 2019-05-16
US10208294B2 (en) 2019-02-19
WO2014113571A3 (en) 2014-11-13
CA2898317A1 (en) 2014-07-24
JP7094343B2 (ja) 2022-07-01
EP3385375A1 (en) 2018-10-10
US20220090028A1 (en) 2022-03-24
US20170342388A1 (en) 2017-11-30
US11130944B2 (en) 2021-09-28
BR112015017005A2 (pt) 2017-08-15
KR102265148B1 (ko) 2021-06-15

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