MX356997B - Acil-acp reductasa con propiedades mejoradas. - Google Patents

Acil-acp reductasa con propiedades mejoradas.

Info

Publication number
MX356997B
MX356997B MX2017003816A MX2017003816A MX356997B MX 356997 B MX356997 B MX 356997B MX 2017003816 A MX2017003816 A MX 2017003816A MX 2017003816 A MX2017003816 A MX 2017003816A MX 356997 B MX356997 B MX 356997B
Authority
MX
Mexico
Prior art keywords
acyl
acp reductase
improved properties
aar
production
Prior art date
Application number
MX2017003816A
Other languages
English (en)
Inventor
Trinh Na
Rude Mathew
Schirmer Andreas
Gano Jacob
Original Assignee
Reg Life Sciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reg Life Sciences Llc filed Critical Reg Life Sciences Llc
Publication of MX356997B publication Critical patent/MX356997B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/0108—Long-chain acyl-[acyl-carrier-protein] reductase (1.2.1.80)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Fats And Perfumes (AREA)

Abstract

La presente invención se refiere a variantes de la enzima acil-ACP reductasa (AAR) que da por resultado una producción de aldehído graso y alcohol graso mejorada cuando se expresa en las células hospederas recombinantes. La descripción se refiere adicionalmente a métodos para fabricar y usar tales variantes AAR para la producción de composiciones de alcohol graso que tienen características particulares.
MX2017003816A 2013-01-16 2014-01-16 Acil-acp reductasa con propiedades mejoradas. MX356997B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361753273P 2013-01-16 2013-01-16
PCT/US2014/011859 WO2014113571A2 (en) 2013-01-16 2014-01-16 Acyl-acp reductase with improved properties

Publications (1)

Publication Number Publication Date
MX356997B true MX356997B (es) 2018-06-22

Family

ID=50473752

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015009138A MX346830B (es) 2013-01-16 2014-01-16 Acil-acp reductasa con propiedades mejoradas.
MX2017003816A MX356997B (es) 2013-01-16 2014-01-16 Acil-acp reductasa con propiedades mejoradas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2015009138A MX346830B (es) 2013-01-16 2014-01-16 Acil-acp reductasa con propiedades mejoradas.

Country Status (13)

Country Link
US (6) US9683219B2 (es)
EP (3) EP3385375B1 (es)
JP (5) JP6063585B2 (es)
KR (4) KR102265148B1 (es)
CN (3) CN110387352A (es)
AU (3) AU2014207522B2 (es)
BR (1) BR112015017005A2 (es)
CA (2) CA3143642A1 (es)
CO (1) CO7461134A2 (es)
ES (2) ES2600354T3 (es)
MX (2) MX346830B (es)
MY (1) MY167434A (es)
WO (1) WO2014113571A2 (es)

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MX2012003604A (es) 2009-09-27 2012-09-12 Opx Biotechnologies Inc Metodo para producir acido 3-hidroxipropionico y otros productos.
CA2881666A1 (en) 2012-08-10 2014-02-13 Opx Biotechnologies, Inc. Microorganisms and methods for the production of fatty acids and fatty acid derived products
CN110387352A (zh) 2013-01-16 2019-10-29 Reg生命科学有限责任公司 具有改善特性的酰基-acp还原酶
US9447438B2 (en) 2013-03-15 2016-09-20 Cargill, Incorporated Acetyl-coA carboxylases
BR112016001026A2 (pt) 2013-07-19 2017-10-24 Cargill Inc organismo geneticamente modificado
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
EP3460066B1 (en) * 2014-07-18 2022-06-15 Genomatica, Inc. Microbial production of 1,3 diols
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
US11345938B2 (en) 2017-02-02 2022-05-31 Cargill, Incorporated Genetically modified cells that produce C6-C10 fatty acid derivatives
US11339384B2 (en) 2017-04-03 2022-05-24 Genomatica, Inc. Thioesterase variants having improved activity for the production of medium-chain fatty acid derivatives
WO2020047088A1 (en) * 2018-08-31 2020-03-05 Genomatica, Inc. Production of non-native monounsaturated fatty acids in bacteria
EP3844179A4 (en) 2018-08-31 2022-08-31 Genomatica, Inc. XYLR MUTANT FOR IMPROVED XYLOSE UTILIZATION OR IMPROVED CO-UTILIZATION OF GLUCOSE AND XYLOSE
WO2023178193A1 (en) 2022-03-16 2023-09-21 Genomatica, Inc. Acyl-acp thioesterase variants and uses thereof

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US5482846A (en) 1988-08-31 1996-01-09 University Of Florida Ethanol production in Gram-positive microbes
US5424202A (en) 1988-08-31 1995-06-13 The University Of Florida Ethanol production by recombinant hosts
US5028539A (en) 1988-08-31 1991-07-02 The University Of Florida Ethanol production using engineered mutant E. coli
AU7791991A (en) 1990-04-24 1991-11-11 Stratagene Methods for phenotype creation from multiple gene populations
US5602030A (en) 1994-03-28 1997-02-11 University Of Florida Research Foundation Recombinant glucose uptake system
US6428767B1 (en) 1995-05-12 2002-08-06 E. I. Du Pont De Nemours And Company Method for identifying the source of carbon in 1,3-propanediol
US5939250A (en) 1995-12-07 1999-08-17 Diversa Corporation Production of enzymes having desired activities by mutagenesis
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MX2012003604A (es) 2009-09-27 2012-09-12 Opx Biotechnologies Inc Metodo para producir acido 3-hidroxipropionico y otros productos.
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US8372610B2 (en) 2010-09-15 2013-02-12 Ls9, Inc. Production of odd chain fatty acid derivatives in recombinant microbial cells
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EP3456814A3 (en) * 2011-01-14 2019-05-29 REG Life Sciences, LLC Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells
CN102719467A (zh) * 2012-07-09 2012-10-10 武汉大学 一种利用脂肪酰acp还原酶生物合成脂肪醇的方法
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JP7478517B2 (ja) 2019-04-24 2024-05-07 三菱商事ライフサイエンス株式会社 脂質活性代謝改善組成物

Also Published As

Publication number Publication date
KR20200020998A (ko) 2020-02-26
BR112015017005A2 (pt) 2017-08-15
JP6211162B2 (ja) 2017-10-11
EP2946009A2 (en) 2015-11-25
JP2019141083A (ja) 2019-08-29
CN110387352A (zh) 2019-10-29
US9873865B2 (en) 2018-01-23
ES2675224T3 (es) 2018-07-09
JP2017209118A (ja) 2017-11-30
US9683219B2 (en) 2017-06-20
EP2946009B1 (en) 2016-07-27
EP3385375A1 (en) 2018-10-10
US10208294B2 (en) 2019-02-19
JP2021006067A (ja) 2021-01-21
AU2017200596B2 (en) 2019-01-24
US20160348080A1 (en) 2016-12-01
CN105051189B (zh) 2019-08-06
CN109897834A (zh) 2019-06-18
JP6926143B2 (ja) 2021-08-25
US20170342388A1 (en) 2017-11-30
JP2016503663A (ja) 2016-02-08
KR20170066694A (ko) 2017-06-14
EP3103867B1 (en) 2018-05-16
JP6523393B2 (ja) 2019-05-29
KR101746040B1 (ko) 2017-06-13
US20220090028A1 (en) 2022-03-24
US20200010813A1 (en) 2020-01-09
CA2898317A1 (en) 2014-07-24
EP3385375B1 (en) 2021-06-16
KR20210072147A (ko) 2021-06-16
AU2019202790A1 (en) 2019-05-16
US20150361454A1 (en) 2015-12-17
CA2898317C (en) 2022-03-01
MY167434A (en) 2018-08-28
ES2600354T3 (es) 2017-02-08
US11130944B2 (en) 2021-09-28
AU2014207522A1 (en) 2015-05-07
JP2017042170A (ja) 2017-03-02
WO2014113571A2 (en) 2014-07-24
MX2015009138A (es) 2015-11-06
KR20150105471A (ko) 2015-09-16
EP3103867A1 (en) 2016-12-14
JP7094343B2 (ja) 2022-07-01
CO7461134A2 (es) 2015-11-30
CA3143642A1 (en) 2014-07-24
KR102265148B1 (ko) 2021-06-15
AU2014207522B2 (en) 2016-12-15
KR102082247B1 (ko) 2020-02-28
US20240117324A1 (en) 2024-04-11
WO2014113571A3 (en) 2014-11-13
AU2017200596A1 (en) 2017-02-23
JP6063585B2 (ja) 2017-01-18
MX346830B (es) 2017-04-03
US12173329B2 (en) 2024-12-24
CN105051189A (zh) 2015-11-11

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