BR112015017005A2 - Acil-acp redutase com propriedades melhoradas - Google Patents

Acil-acp redutase com propriedades melhoradas

Info

Publication number
BR112015017005A2
BR112015017005A2 BR112015017005A BR112015017005A BR112015017005A2 BR 112015017005 A2 BR112015017005 A2 BR 112015017005A2 BR 112015017005 A BR112015017005 A BR 112015017005A BR 112015017005 A BR112015017005 A BR 112015017005A BR 112015017005 A2 BR112015017005 A2 BR 112015017005A2
Authority
BR
Brazil
Prior art keywords
acp
redutase
aar
fatty alcohol
acil
Prior art date
Application number
BR112015017005A
Other languages
English (en)
Inventor
Rude Mathew
Trinh Na
Schirmer Andreas
Gano Jacob
Original Assignee
Reg Life Sciences Llc
Genomatica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reg Life Sciences Llc, Genomatica Inc filed Critical Reg Life Sciences Llc
Priority to BR122017000806A priority Critical patent/BR122017000806A2/pt
Priority to BR122017000832A priority patent/BR122017000832A2/pt
Publication of BR112015017005A2 publication Critical patent/BR112015017005A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/0108—Long-chain acyl-[acyl-carrier-protein] reductase (1.2.1.80)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Fats And Perfumes (AREA)

Abstract

POLIPEPTÍDEO DA VARIANTE ACIL-ACP REDUTASE (AAR), CÉLULA HOSPEDEIRA RECOMBINANTE, CULTURA CELULAR E MÉTODO DE PRODUÇÃO DE COMPOSIÇÃO DE ÁLCOOL GRAXO TENDO AUMENTO DO TÍTULO A descrição refere-se às variantes de enzima de acil-ACP redutase (AAR) que resultam na produção de aldeído graxo melhorado e álcool graxo melhorado, quando expressa em células hospedeiras recombinantes. A descrição refere-se aos métodos para preparar e utilizar tais variantes AAR para a produção de composições de álcoois graxos tendo características particulares.
BR112015017005A 2013-01-16 2014-01-16 Acil-acp redutase com propriedades melhoradas BR112015017005A2 (pt)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BR122017000806A BR122017000806A2 (pt) 2013-01-16 2014-01-16 polipeptídeo da variante acil-acp redutase (aar), célula hospedeira recombinante, cultura celular, método de produção de composição de álcool graxo tendo aumento do título
BR122017000832A BR122017000832A2 (pt) 2013-01-16 2014-01-16 polipeptídeo da variante acil-acp redutase (aar), célula hospedeira recombinante, cultura celular, método de produção de composição de álcool graxo tendo aumento do título

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361753273P 2013-01-16 2013-01-16
PCT/US2014/011859 WO2014113571A2 (en) 2013-01-16 2014-01-16 Acyl-acp reductase with improved properties

Publications (1)

Publication Number Publication Date
BR112015017005A2 true BR112015017005A2 (pt) 2017-08-15

Family

ID=50473752

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015017005A BR112015017005A2 (pt) 2013-01-16 2014-01-16 Acil-acp redutase com propriedades melhoradas

Country Status (13)

Country Link
US (6) US9683219B2 (pt)
EP (3) EP3103867B1 (pt)
JP (5) JP6063585B2 (pt)
KR (4) KR101746040B1 (pt)
CN (3) CN110387352A (pt)
AU (3) AU2014207522B2 (pt)
BR (1) BR112015017005A2 (pt)
CA (2) CA2898317C (pt)
CO (1) CO7461134A2 (pt)
ES (2) ES2600354T3 (pt)
MX (2) MX346830B (pt)
MY (1) MY167434A (pt)
WO (1) WO2014113571A2 (pt)

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US20150119601A1 (en) 2013-03-15 2015-04-30 Opx Biotechnologies, Inc. Monofunctional mcr + 3-hp dehydrogenase
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
BR112016001026A2 (pt) 2013-07-19 2017-10-24 Cargill Inc organismo geneticamente modificado
CA2955370A1 (en) * 2014-07-18 2016-01-21 REG Life Sciences, LLC Microbial production of fatty diols
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
CN110494566A (zh) 2017-02-02 2019-11-22 嘉吉公司 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞
CN111094558A (zh) 2017-04-03 2020-05-01 基因组股份公司 对产生中链脂肪酸衍生物具有改善的活性的硫酯酶变体
US20210189373A1 (en) * 2018-08-31 2021-06-24 Genomatica, Inc. Production Of Non-Native Monounsaturated Fatty Acids In Bacteria
WO2023178193A1 (en) 2022-03-16 2023-09-21 Genomatica, Inc. Acyl-acp thioesterase variants and uses thereof
JP7374260B1 (ja) 2022-05-13 2023-11-06 チャン，ヤ－チン 駆動装置

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Also Published As

Publication number Publication date
CN105051189B (zh) 2019-08-06
MX356997B (es) 2018-06-22
ES2600354T3 (es) 2017-02-08
AU2017200596A1 (en) 2017-02-23
KR20200020998A (ko) 2020-02-26
JP2017209118A (ja) 2017-11-30
ES2675224T3 (es) 2018-07-09
US20200010813A1 (en) 2020-01-09
JP2017042170A (ja) 2017-03-02
US20240117324A1 (en) 2024-04-11
CN109897834A (zh) 2019-06-18
KR20210072147A (ko) 2021-06-16
AU2014207522B2 (en) 2016-12-15
EP2946009A2 (en) 2015-11-25
CA2898317C (en) 2022-03-01
EP2946009B1 (en) 2016-07-27
CN105051189A (zh) 2015-11-11
US9683219B2 (en) 2017-06-20
US20220090028A1 (en) 2022-03-24
EP3103867B1 (en) 2018-05-16
JP6063585B2 (ja) 2017-01-18
AU2017200596B2 (en) 2019-01-24
US20170342388A1 (en) 2017-11-30
KR20150105471A (ko) 2015-09-16
KR20170066694A (ko) 2017-06-14
JP6523393B2 (ja) 2019-05-29
WO2014113571A2 (en) 2014-07-24
JP2016503663A (ja) 2016-02-08
CN110387352A (zh) 2019-10-29
KR102265148B1 (ko) 2021-06-15
WO2014113571A3 (en) 2014-11-13
CA2898317A1 (en) 2014-07-24
KR101746040B1 (ko) 2017-06-13
MY167434A (en) 2018-08-28
US10208294B2 (en) 2019-02-19
CO7461134A2 (es) 2015-11-30
JP2021006067A (ja) 2021-01-21
JP7094343B2 (ja) 2022-07-01
CA3143642A1 (en) 2014-07-24
JP6211162B2 (ja) 2017-10-11
AU2019202790A1 (en) 2019-05-16
EP3385375B1 (en) 2021-06-16
MX346830B (es) 2017-04-03
EP3103867A1 (en) 2016-12-14
JP2019141083A (ja) 2019-08-29
US11130944B2 (en) 2021-09-28
KR102082247B1 (ko) 2020-02-28
US9873865B2 (en) 2018-01-23
US20150361454A1 (en) 2015-12-17
EP3385375A1 (en) 2018-10-10
MX2015009138A (es) 2015-11-06
AU2014207522A1 (en) 2015-05-07
JP6926143B2 (ja) 2021-08-25
US20160348080A1 (en) 2016-12-01

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Owner name: GENOMATICA, INC. (US)

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