BR112018007590A2 - método para produzir proteína de fusão que tem domínio fc de igg - Google Patents
método para produzir proteína de fusão que tem domínio fc de iggInfo
- Publication number
- BR112018007590A2 BR112018007590A2 BR112018007590-6A BR112018007590A BR112018007590A2 BR 112018007590 A2 BR112018007590 A2 BR 112018007590A2 BR 112018007590 A BR112018007590 A BR 112018007590A BR 112018007590 A2 BR112018007590 A2 BR 112018007590A2
- Authority
- BR
- Brazil
- Prior art keywords
- fusion protein
- igg
- domain
- produce fusion
- preparing
- Prior art date
Links
- 108020001507 fusion proteins Proteins 0.000 title abstract 5
- 102000037865 fusion proteins Human genes 0.000 title abstract 5
- 230000010261 cell growth Effects 0.000 abstract 1
- 230000003833 cell viability Effects 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2523/00—Culture process characterised by temperature
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
Abstract
a presente invenção refere-se a um método para preparar uma proteína de fusão que tem um domínio fc de igg e, especificamente, a um método para preparar uma proteína de fusão que tem um domínio fc de igg, sendo que o método compreende adicionalmente uma etapa de cultivar células que produzem a proteína de fusão a uma temperatura de cultura diminuída, o que aumenta, assim, o crescimento celular e a viabilidade celular de modo a aumentar a produtividade de proteína de fusão e inibir a geração de agregado de modo a aprimorar a qualidade e o rendimento de produção.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2015-0144330 | 2015-10-15 | ||
KR20150144330 | 2015-10-15 | ||
KR1020160132633A KR101936049B1 (ko) | 2015-10-15 | 2016-10-13 | IgG Fc 도메인을 가지는 융합 단백질의 생산방법 |
KR10-2016-0132633 | 2016-10-13 | ||
PCT/KR2016/011561 WO2017065559A1 (ko) | 2015-10-15 | 2016-10-14 | Igg fc 도메인을 가지는 융합 단백질의 생산방법 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018007590A2 true BR112018007590A2 (pt) | 2018-10-23 |
Family
ID=58703642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018007590-6A BR112018007590A2 (pt) | 2015-10-15 | 2016-10-14 | método para produzir proteína de fusão que tem domínio fc de igg |
Country Status (12)
Country | Link |
---|---|
US (2) | US11414476B2 (pt) |
EP (2) | EP4098659A1 (pt) |
JP (2) | JP6783305B2 (pt) |
KR (1) | KR101936049B1 (pt) |
CN (2) | CN115247196A (pt) |
AU (1) | AU2016339642B2 (pt) |
BR (1) | BR112018007590A2 (pt) |
CA (1) | CA3001977C (pt) |
ES (1) | ES2945537T3 (pt) |
MX (1) | MX2018004580A (pt) |
PL (1) | PL3363811T3 (pt) |
RU (1) | RU2732237C2 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
TW202340452A (zh) | 2015-08-04 | 2023-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
KR101936049B1 (ko) | 2015-10-15 | 2019-01-08 | (주)알테오젠 | IgG Fc 도메인을 가지는 융합 단백질의 생산방법 |
WO2018194413A1 (en) | 2017-04-21 | 2018-10-25 | Yuhan Corporation | Method for producing dual function proteins and its derivatives |
CN115197961B (zh) * | 2022-06-20 | 2024-04-16 | 岭南现代农业科学与技术广东省实验室肇庆分中心 | 一种非洲猪瘟病毒b602l重组蛋白稳定表达细胞系及其构建方法和应用 |
Family Cites Families (25)
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TR200504220T2 (tr) | 1998-12-17 | 2007-04-24 | Biogen Idec Ma Inc. | Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem. |
US7396664B2 (en) * | 1999-06-08 | 2008-07-08 | Regeneron Pharmaceuticals, Inc. | VEGF-binding fusion proteins and nucleic acids encoding the same |
NZ515913A (en) | 1999-06-08 | 2004-01-30 | Regeneron Pharma | Modified chimeric polypeptides with improved pharmacokinetic properties |
US20030064053A1 (en) * | 2001-08-31 | 2003-04-03 | Shengjiang Liu | Multivalent protein conjugate with multiple ligand-binding domains of receptors |
EP1575998A4 (en) * | 2002-12-23 | 2007-07-25 | Bristol Myers Squibb Co | PROCESS FOR CULTIVATING MAMMALIAN CELLS FOR PROTEIN PRODUCTION |
US7300773B2 (en) * | 2004-08-27 | 2007-11-27 | Wyeth Research Ireland Limited | Production of TNFR-Ig |
US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
TW200902708A (en) * | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
WO2009023562A2 (en) | 2007-08-09 | 2009-02-19 | Wyeth | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
CN101838329A (zh) * | 2009-03-18 | 2010-09-22 | 嘉和生物药业有限公司 | 抗血管新生融合蛋白 |
JP2012525415A (ja) | 2009-05-01 | 2012-10-22 | オプソテツク・コーポレイシヨン | 眼科疾患を処置または予防するための方法 |
CA2795461C (en) * | 2010-04-26 | 2018-04-24 | Novartis Ag | Improved cell cultivation process |
JO3283B1 (ar) * | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
WO2014006113A1 (en) | 2012-07-03 | 2014-01-09 | Sanofi | Method of treating cancer by effective amounts of aflibercept |
WO2014020160A1 (en) | 2012-08-02 | 2014-02-06 | Sanofi | Article of manufacture comprising aflibercept or ziv-aflibercept |
AR095196A1 (es) * | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
JP6689189B2 (ja) | 2013-03-26 | 2020-04-28 | コヒラス・バイオサイエンシズ・インコーポレイテッド | タンパク質産生方法 |
RU2639660C2 (ru) | 2013-04-15 | 2017-12-21 | Телефонактиеболагет Л М Эрикссон (Пабл) | Сигнализация системной информации к мтс-устройствам |
CN103319610B (zh) | 2013-07-05 | 2016-01-27 | 华博生物医药技术(上海)有限公司 | 重组融合蛋白及其制法和用途 |
KR102410393B1 (ko) | 2014-01-29 | 2022-06-16 | 암젠 인크 | 재조합 단백질의 글리코실화를 조절하기 위한 n-글리코실화 경로 조절자의 과발현 |
CN104974262B (zh) * | 2014-04-04 | 2019-08-09 | 华博生物医药技术(上海)有限公司 | 重组双功能融合蛋白及其制法和用途 |
RU2016152693A (ru) | 2014-06-03 | 2018-07-09 | Люпин Лимитед | Способ культивирования клеток для получения белка |
KR20160132633A (ko) | 2015-05-11 | 2016-11-21 | 주식회사 엘지화학 | 배터리 시스템 및 그 연결 제어 방법 |
KR101936049B1 (ko) | 2015-10-15 | 2019-01-08 | (주)알테오젠 | IgG Fc 도메인을 가지는 융합 단백질의 생산방법 |
TW202140776A (zh) | 2016-04-26 | 2021-11-01 | 美商美國泰福生技股份有限公司 | 細胞培養基 |
-
2016
- 2016-10-13 KR KR1020160132633A patent/KR101936049B1/ko active IP Right Grant
- 2016-10-14 MX MX2018004580A patent/MX2018004580A/es unknown
- 2016-10-14 EP EP22186197.4A patent/EP4098659A1/en active Pending
- 2016-10-14 ES ES16855776T patent/ES2945537T3/es active Active
- 2016-10-14 BR BR112018007590-6A patent/BR112018007590A2/pt active Search and Examination
- 2016-10-14 CA CA3001977A patent/CA3001977C/en active Active
- 2016-10-14 US US15/767,806 patent/US11414476B2/en active Active
- 2016-10-14 CN CN202210985550.8A patent/CN115247196A/zh active Pending
- 2016-10-14 EP EP16855776.7A patent/EP3363811B1/en active Active
- 2016-10-14 PL PL16855776.7T patent/PL3363811T3/pl unknown
- 2016-10-14 CN CN201680059726.XA patent/CN108137672B/zh active Active
- 2016-10-14 RU RU2018117705A patent/RU2732237C2/ru active
- 2016-10-14 AU AU2016339642A patent/AU2016339642B2/en active Active
- 2016-10-14 JP JP2018519736A patent/JP6783305B2/ja active Active
-
2020
- 2020-05-07 JP JP2020082131A patent/JP2020114266A/ja active Pending
-
2022
- 2022-07-07 US US17/859,466 patent/US20220348636A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN115247196A (zh) | 2022-10-28 |
RU2018117705A3 (pt) | 2019-11-15 |
EP3363811A4 (en) | 2019-03-13 |
US20220348636A1 (en) | 2022-11-03 |
RU2732237C2 (ru) | 2020-09-14 |
PL3363811T3 (pl) | 2023-07-17 |
ES2945537T3 (es) | 2023-07-04 |
JP6783305B2 (ja) | 2020-11-11 |
KR20170044594A (ko) | 2017-04-25 |
AU2016339642A1 (en) | 2018-04-12 |
EP3363811A1 (en) | 2018-08-22 |
RU2018117705A (ru) | 2019-11-15 |
KR101936049B1 (ko) | 2019-01-08 |
CA3001977A1 (en) | 2017-04-20 |
US11414476B2 (en) | 2022-08-16 |
MX2018004580A (es) | 2018-09-19 |
CA3001977C (en) | 2023-06-20 |
CN108137672B (zh) | 2022-09-06 |
JP2020114266A (ja) | 2020-07-30 |
CN108137672A (zh) | 2018-06-08 |
JP2018530344A (ja) | 2018-10-18 |
EP3363811B1 (en) | 2023-04-19 |
EP4098659A1 (en) | 2022-12-07 |
AU2016339642B2 (en) | 2019-07-25 |
US20180298078A1 (en) | 2018-10-18 |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] |