AR096839A1 - Proceso mejorado para la producción de anticuerpos monoclonales - Google Patents
Proceso mejorado para la producción de anticuerpos monoclonalesInfo
- Publication number
- AR096839A1 AR096839A1 ARP140102519A ARP140102519A AR096839A1 AR 096839 A1 AR096839 A1 AR 096839A1 AR P140102519 A ARP140102519 A AR P140102519A AR P140102519 A ARP140102519 A AR P140102519A AR 096839 A1 AR096839 A1 AR 096839A1
- Authority
- AR
- Argentina
- Prior art keywords
- improved process
- production
- monoclonal antibodies
- provides
- temperature
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente provee un proceso mejorado para obtener una cantidad sustancial de anticuerpos monoclonales con un perfil deseado de variantes cargadas. El proceso implica inicialmente cultivar células de mamíferos a una temperatura adecuada y posteriormente reducir la temperatura; opcionalmente, mediante la adición simultánea de aminoácido(s) adecuado(s) durante la producción de la molécula deseada. La presente también provee un anticuerpo que tiene un perfil deseado de glicanos, preparado con dicho proceso mejorado.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2285MU2013 IN2013MU02285A (es) | 2013-07-06 | 2014-07-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR096839A1 true AR096839A1 (es) | 2016-02-03 |
Family
ID=51794933
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140102519A AR096839A1 (es) | 2013-07-06 | 2014-07-07 | Proceso mejorado para la producción de anticuerpos monoclonales |
Country Status (18)
Country | Link |
---|---|
US (1) | US20160215319A1 (es) |
EP (1) | EP3019528A1 (es) |
JP (1) | JP2016526385A (es) |
CN (1) | CN105431454A (es) |
AR (1) | AR096839A1 (es) |
AU (1) | AU2014288811B2 (es) |
BR (1) | BR112015032800A2 (es) |
CA (1) | CA2917484A1 (es) |
EA (1) | EA201690171A1 (es) |
HK (1) | HK1218297A1 (es) |
IL (1) | IL243011A0 (es) |
IN (1) | IN2013MU02285A (es) |
MX (1) | MX2016000123A (es) |
NZ (1) | NZ715246A (es) |
SG (1) | SG11201510342VA (es) |
TW (1) | TW201514305A (es) |
WO (1) | WO2015004679A1 (es) |
ZA (1) | ZA201509334B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
CA2905010A1 (en) | 2013-03-12 | 2014-09-18 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
US10023608B1 (en) | 2013-03-13 | 2018-07-17 | Amgen Inc. | Protein purification methods to remove impurities |
WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
EP3052640A2 (en) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
WO2017122157A1 (en) * | 2016-01-14 | 2017-07-20 | Dr. Reddy’S Laboratories Limited | Cell culture process |
JP2020188737A (ja) * | 2019-05-23 | 2020-11-26 | 東ソー株式会社 | 抗体依存性細胞傷害活性が向上した抗体の製造方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5705364A (en) | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
JP4306813B2 (ja) | 1995-09-19 | 2009-08-05 | アスビオファーマ株式会社 | 動物細胞の新規培養方法 |
WO2002076578A1 (en) * | 2001-03-27 | 2002-10-03 | Smithkline Beecham Corporation | Control of glycoforms in igg |
TWI384069B (zh) * | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
KR20180114966A (ko) * | 2009-08-11 | 2018-10-19 | 제넨테크, 인크. | 글루타민-비함유 세포 배양 배지에서의 단백질의 생성 |
US9045536B2 (en) * | 2009-12-23 | 2015-06-02 | Merck Sharp & Dohme Corp. | Cell line 3M |
WO2011085095A2 (en) * | 2010-01-07 | 2011-07-14 | Dr. Reddy's Laboratories Ltd. | Enhanced protein expression |
MX2012012528A (es) * | 2010-04-26 | 2012-11-23 | Novartis Ag | Proceso de cultivo celular mejorado. |
AU2011350456B2 (en) * | 2010-12-28 | 2016-05-26 | Chugai Seiyaku Kabushiki Kaisha | Animal cell culturing method |
US9206390B2 (en) | 2012-09-02 | 2015-12-08 | Abbvie, Inc. | Methods to control protein heterogeneity |
-
2014
- 2014-07-07 CA CA2917484A patent/CA2917484A1/en not_active Abandoned
- 2014-07-07 NZ NZ715246A patent/NZ715246A/en not_active IP Right Cessation
- 2014-07-07 AR ARP140102519A patent/AR096839A1/es unknown
- 2014-07-07 US US14/903,093 patent/US20160215319A1/en not_active Abandoned
- 2014-07-07 EP EP14789418.2A patent/EP3019528A1/en not_active Withdrawn
- 2014-07-07 MX MX2016000123A patent/MX2016000123A/es unknown
- 2014-07-07 BR BR112015032800A patent/BR112015032800A2/pt not_active IP Right Cessation
- 2014-07-07 WO PCT/IN2014/000450 patent/WO2015004679A1/en active Application Filing
- 2014-07-07 TW TW103123312A patent/TW201514305A/zh unknown
- 2014-07-07 AU AU2014288811A patent/AU2014288811B2/en not_active Ceased
- 2014-07-07 SG SG11201510342VA patent/SG11201510342VA/en unknown
- 2014-07-07 EA EA201690171A patent/EA201690171A1/ru unknown
- 2014-07-07 JP JP2016522968A patent/JP2016526385A/ja active Pending
- 2014-07-07 IN IN2285MU2013 patent/IN2013MU02285A/en unknown
- 2014-07-07 CN CN201480038458.4A patent/CN105431454A/zh active Pending
-
2015
- 2015-12-21 IL IL243011A patent/IL243011A0/en unknown
- 2015-12-22 ZA ZA2015/09334A patent/ZA201509334B/en unknown
-
2016
- 2016-05-31 HK HK16106205.0A patent/HK1218297A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
US20160215319A1 (en) | 2016-07-28 |
JP2016526385A (ja) | 2016-09-05 |
BR112015032800A2 (pt) | 2017-07-25 |
AU2014288811B2 (en) | 2017-06-08 |
SG11201510342VA (en) | 2016-01-28 |
NZ715246A (en) | 2017-07-28 |
WO2015004679A1 (en) | 2015-01-15 |
ZA201509334B (en) | 2017-03-29 |
IL243011A0 (en) | 2016-03-31 |
IN2013MU02285A (es) | 2015-06-19 |
HK1218297A1 (zh) | 2017-02-10 |
EP3019528A1 (en) | 2016-05-18 |
CN105431454A (zh) | 2016-03-23 |
TW201514305A (zh) | 2015-04-16 |
CA2917484A1 (en) | 2015-01-15 |
AU2014288811A1 (en) | 2016-01-28 |
EA201690171A1 (ru) | 2016-06-30 |
MX2016000123A (es) | 2016-07-14 |
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