BR112015019343A2 - Anticorpo anti-her2, composição, método para produção de uma população de anticorpos, células epiteliais das glândulas mamárias, e, mamífero não humano transgênico - Google Patents

Anticorpo anti-her2, composição, método para produção de uma população de anticorpos, células epiteliais das glândulas mamárias, e, mamífero não humano transgênico

Info

Publication number
BR112015019343A2
BR112015019343A2 BR112015019343A BR112015019343A BR112015019343A2 BR 112015019343 A2 BR112015019343 A2 BR 112015019343A2 BR 112015019343 A BR112015019343 A BR 112015019343A BR 112015019343 A BR112015019343 A BR 112015019343A BR 112015019343 A2 BR112015019343 A2 BR 112015019343A2
Authority
BR
Brazil
Prior art keywords
antibodies
producing
composition
population
her2 antibody
Prior art date
Application number
BR112015019343A
Other languages
English (en)
Inventor
M Meade Harry
Chen Li-How
Original Assignee
Lab Francais Du Fractionnement
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lab Francais Du Fractionnement filed Critical Lab Francais Du Fractionnement
Publication of BR112015019343A2 publication Critical patent/BR112015019343A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/12—Immunoglobulins specific features characterized by their source of isolation or production isolated from milk
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

ANTICORPO ANTI-HER2, COMPOSIÇÃO, MÉTODO PARA PRODUÇÃO DE UMA POPULAÇÃO DE ANTICORPOS, CÉLULAS EPITELIAIS DAS GLÂNDULAS MAMÁRIAS, MAMÍFERO NÃO HUMANO TRANSGÊNICO, E, USO DO ANTICORPO OU DA COMPOSIÇÃO. Em um aspecto, a descrição refere-se a anticorpos anti-HER2 altamente galactosilados e composições dos mesmos. Em um aspecto, a descrição refere-se a populalações de anticorpos anti-HER2 com um alto nível de galactosilação e composições dos mesmos. Em um aspecto a descrição se refere a métodos de produção e uso de anticorpos de anti-HER2 altamente galactosilado e populações de anticorpos anti-HER2 com um alto nível de galactosilação. Em algumas modalidades o anticorpo anti-HER2 é trastuzumab.
BR112015019343A 2013-02-13 2014-02-13 Anticorpo anti-her2, composição, método para produção de uma população de anticorpos, células epiteliais das glândulas mamárias, e, mamífero não humano transgênico BR112015019343A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361764488P 2013-02-13 2013-02-13
PCT/IB2014/000711 WO2014125377A2 (en) 2013-02-13 2014-02-13 Highly galactosylated anti-her2 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
BR112015019343A2 true BR112015019343A2 (pt) 2017-08-22

Family

ID=50980322

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015019343A BR112015019343A2 (pt) 2013-02-13 2014-02-13 Anticorpo anti-her2, composição, método para produção de uma população de anticorpos, células epiteliais das glândulas mamárias, e, mamífero não humano transgênico

Country Status (13)

Country Link
US (1) US20150368357A1 (pt)
EP (1) EP2956485A2 (pt)
JP (2) JP2016509019A (pt)
KR (1) KR20160003634A (pt)
CN (1) CN105308071A (pt)
AR (1) AR094781A1 (pt)
AU (1) AU2014217564B2 (pt)
BR (1) BR112015019343A2 (pt)
CA (1) CA2900912A1 (pt)
IL (1) IL240440A0 (pt)
MX (1) MX2015010428A (pt)
TW (1) TW201444870A (pt)
WO (1) WO2014125377A2 (pt)

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JP6189751B2 (ja) 2010-12-30 2017-08-30 ラボラトワール フランセ デュ フラクショヌマン エ デ ビオテクノロジーＬａｂｏｒａｔｏｉｒｅ Ｆｒａｎｃａｉｓ ｄｕ Ｆｒａｃｔｉｏｎｎｅｍｅｎｔ ｅｔ ｄｅｓ Ｂｉｏｔｅｃｈｎｏｌｏｇｉｅｓ 病原体不活性化剤としてのグリコール
MX2015010427A (es) 2013-02-13 2016-03-17 Lab Francais Du Fractionnement Anticuerpos anti-tnf-alfa altamente galactosilados y sus usos.
EP2956003A2 (en) 2013-02-13 2015-12-23 Laboratoire Français du Fractionnement et des Biotechnologies Proteins with modified glycosylation and methods of production thereof
MX2016000063A (es) 2013-07-05 2016-03-01 Lab Francais Du Fractionnement Matriz de cromatografia de afinidad.
CN106687481B (zh) * 2014-09-10 2022-03-22 豪夫迈·罗氏有限公司 半乳糖改造的免疫球蛋白1抗体
CN105669964B (zh) * 2016-03-04 2017-11-21 博瑞生物医药（苏州）股份有限公司 卵巢癌特异靶向的生物可降解双亲性聚合物、由其制备的聚合物囊泡及应用
FR3060395B1 (fr) * 2016-12-16 2019-05-24 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Combinaison d'anticorps anti-cd303 et anti-her2
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WO2019237322A1 (en) 2018-06-15 2019-12-19 Shanghai Miracogen Inc Methods and materials for treating cancer
CN113999313A (zh) * 2020-07-28 2022-02-01 百奥泰生物制药股份有限公司 抗her2抗体及其应用

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US5843705A (en) 1995-02-21 1998-12-01 Genzyme Transgenic Corporation Transgenically produced antithrombin III
US5945577A (en) 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
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Also Published As

Publication number Publication date
IL240440A0 (en) 2015-09-24
AR094781A1 (es) 2015-08-26
US20150368357A1 (en) 2015-12-24
JP2020125286A (ja) 2020-08-20
AU2014217564B2 (en) 2018-11-08
MX2015010428A (es) 2016-04-13
CN105308071A (zh) 2016-02-03
EP2956485A2 (en) 2015-12-23
WO2014125377A2 (en) 2014-08-21
AU2014217564A1 (en) 2015-08-27
CA2900912A1 (en) 2014-08-21
JP2016509019A (ja) 2016-03-24
KR20160003634A (ko) 2016-01-11
TW201444870A (zh) 2014-12-01
WO2014125377A3 (en) 2014-12-04

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements