BR112014026308A2 - composições de cultura celular e métodos para produção de polipeptídeos - Google Patents
composições de cultura celular e métodos para produção de polipeptídeosInfo
- Publication number
- BR112014026308A2 BR112014026308A2 BR112014026308A BR112014026308A BR112014026308A2 BR 112014026308 A2 BR112014026308 A2 BR 112014026308A2 BR 112014026308 A BR112014026308 A BR 112014026308A BR 112014026308 A BR112014026308 A BR 112014026308A BR 112014026308 A2 BR112014026308 A2 BR 112014026308A2
- Authority
- BR
- Brazil
- Prior art keywords
- cell culture
- methods
- compositions
- media
- polypeptides
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 229920001184 polypeptide Polymers 0.000 title abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 238000004113 cell culture Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 239000006143 cell culture medium Substances 0.000 abstract 4
- 230000010261 cell growth Effects 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/005—Protein-free medium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
abstract cell culture media, such as chemically defined cell culture media, are provided, as are methods of using the media for cell growth (i.e., cell culture) and polypeptide (e.g., antibody) production. compositions comprising polypeptides produced by the methods are also provided. tradução do resumo resumo patente de invenção: composições de cultura celular e métodos para produção de polipeptídeos. a presente invenção se refere a meios de cultura celular, tais como meios de cultura celular quimicamente definidos, assim como se refere a métodos de utilização dos meios para crescimento celular (isto é, cultura celular) e produção de polipeptídeos (por exemplo, anticorpos). além disso a presente invenção se refere a composições compreendendo polipeptídeos produzidos pelos métodos.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261637778P | 2012-04-24 | 2012-04-24 | |
US201261637780P | 2012-04-24 | 2012-04-24 | |
US13/841,864 US20130281355A1 (en) | 2012-04-24 | 2013-03-15 | Cell culture compositions and methods for polypeptide production |
PCT/US2013/037992 WO2013163294A1 (en) | 2012-04-24 | 2013-04-24 | Cell culture compositions and methods for polypeptide production |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014026308A2 true BR112014026308A2 (pt) | 2017-06-27 |
BR112014026308A8 BR112014026308A8 (pt) | 2021-06-01 |
Family
ID=49380652
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014026308A BR112014026308A8 (pt) | 2012-04-24 | 2013-04-24 | meios de cultura celular, seu método de cultura, polipeptídeo, seu método de produção e seu uso, composições farmacêutica, e kit |
Country Status (22)
Country | Link |
---|---|
US (2) | US20130281355A1 (pt) |
EP (2) | EP3533864A1 (pt) |
JP (4) | JP6367792B2 (pt) |
KR (2) | KR102115052B1 (pt) |
CN (2) | CN104428409A (pt) |
AR (1) | AR090822A1 (pt) |
AU (2) | AU2013251647B2 (pt) |
BR (1) | BR112014026308A8 (pt) |
CA (1) | CA2871006C (pt) |
ES (1) | ES2716301T3 (pt) |
HK (1) | HK1208496A1 (pt) |
HR (1) | HRP20190484T1 (pt) |
IL (1) | IL235235A0 (pt) |
MX (2) | MX363493B (pt) |
MY (1) | MY181513A (pt) |
NZ (1) | NZ701791A (pt) |
PL (1) | PL2841561T3 (pt) |
RU (2) | RU2678142C2 (pt) |
SG (2) | SG10201810830UA (pt) |
SI (1) | SI2841561T1 (pt) |
WO (1) | WO2013163294A1 (pt) |
ZA (2) | ZA201408092B (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
KR102202476B1 (ko) * | 2013-03-15 | 2021-01-12 | 제넨테크, 인크. | 세포 배양 배지 및 항체 생산 방법 |
RU2718986C2 (ru) * | 2013-03-15 | 2020-04-15 | Дженентек, Инк. | Композиции клеточных культур с антиоксидантами и способы получения полипептидов |
EP3052640A2 (en) * | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
WO2018229802A1 (en) * | 2017-06-16 | 2018-12-20 | Ge Healthcare Bio-Sciences Ab | Method for predicting outcome of and modelling of a process in a bioreactor |
EP3492582A1 (en) | 2017-12-01 | 2019-06-05 | UCB Biopharma SPRL | Cell culture methods |
CN108823267B (zh) * | 2018-06-25 | 2020-05-08 | 深圳市菲鹏生物制药股份有限公司 | 调节cho-k1表达系统所分泌抗体的酸性峰含量的方法 |
EP4051790A4 (en) * | 2019-10-31 | 2023-11-01 | William Marsh Rice University | GENETICALLY ENGINEERED CELLS FOR CONTROLLED PRODUCTION |
TW202128744A (zh) | 2019-12-06 | 2021-08-01 | 美商再生元醫藥公司 | 抗vegf蛋白組合物及其製備方法 |
CA3163829A1 (en) | 2020-01-31 | 2021-08-05 | Takahiro Matsuo | Method for producing composition containing polypeptide with suppressed coloring |
JP7404929B2 (ja) | 2020-02-26 | 2023-12-26 | 富士フイルムビジネスイノベーション株式会社 | 発光装置、光学装置及び計測装置 |
JP7404930B2 (ja) | 2020-02-26 | 2023-12-26 | 富士フイルムビジネスイノベーション株式会社 | 発光装置、光学装置及び計測装置 |
GB202012991D0 (en) | 2020-08-20 | 2020-10-07 | Ucb Biopharma Sprl | Cell culture processes |
IL303951A (en) * | 2020-12-22 | 2023-08-01 | Novartis Ag | Methods for reducing the oxidation level of cysteine residues in recombinantly secreted protein during cell culture |
GB202105424D0 (en) | 2021-04-16 | 2021-06-02 | UCB Biopharma SRL | Cell culture processes |
CA3229424A1 (en) | 2021-09-02 | 2023-03-09 | Boehringer Ingelheim International Gmbh | Method of determining a future color value or corresponding property and arrangement therefor |
WO2023063611A1 (ko) * | 2021-10-12 | 2023-04-20 | 프레스티지바이오로직스 주식회사 | 항체 집단의 제조 방법 |
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-
2013
- 2013-03-15 US US13/841,864 patent/US20130281355A1/en not_active Abandoned
- 2013-04-24 PL PL13720203T patent/PL2841561T3/pl unknown
- 2013-04-24 WO PCT/US2013/037992 patent/WO2013163294A1/en active Application Filing
- 2013-04-24 KR KR1020147032389A patent/KR102115052B1/ko active IP Right Grant
- 2013-04-24 KR KR1020207014171A patent/KR102339106B1/ko active IP Right Grant
- 2013-04-24 CN CN201380032959.7A patent/CN104428409A/zh active Pending
- 2013-04-24 AR ARP130101367 patent/AR090822A1/es unknown
- 2013-04-24 RU RU2014147018A patent/RU2678142C2/ru active
- 2013-04-24 SI SI201331376T patent/SI2841561T1/sl unknown
- 2013-04-24 SG SG10201810830UA patent/SG10201810830UA/en unknown
- 2013-04-24 EP EP18213796.8A patent/EP3533864A1/en active Pending
- 2013-04-24 AU AU2013251647A patent/AU2013251647B2/en active Active
- 2013-04-24 MY MYPI2014003007A patent/MY181513A/en unknown
- 2013-04-24 BR BR112014026308A patent/BR112014026308A8/pt not_active Application Discontinuation
- 2013-04-24 JP JP2015509107A patent/JP6367792B2/ja active Active
- 2013-04-24 RU RU2018146497A patent/RU2018146497A/ru unknown
- 2013-04-24 ES ES13720203T patent/ES2716301T3/es active Active
- 2013-04-24 NZ NZ701791A patent/NZ701791A/en unknown
- 2013-04-24 CA CA2871006A patent/CA2871006C/en active Active
- 2013-04-24 MX MX2014012838A patent/MX363493B/es unknown
- 2013-04-24 EP EP13720203.2A patent/EP2841561B1/en not_active Revoked
- 2013-04-24 SG SG11201406903SA patent/SG11201406903SA/en unknown
- 2013-04-24 CN CN202010250367.4A patent/CN111440758A/zh active Pending
-
2014
- 2014-10-21 IL IL235235A patent/IL235235A0/en unknown
- 2014-10-23 MX MX2019003427A patent/MX2019003427A/es unknown
- 2014-11-05 ZA ZA2014/08092A patent/ZA201408092B/en unknown
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2015
- 2015-09-17 HK HK15109118.1A patent/HK1208496A1/xx unknown
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2017
- 2017-11-03 ZA ZA2017/07452A patent/ZA201707452B/en unknown
-
2018
- 2018-07-05 JP JP2018128429A patent/JP7323272B2/ja active Active
-
2019
- 2019-03-11 HR HRP20190484TT patent/HRP20190484T1/hr unknown
- 2019-04-02 AU AU2019202259A patent/AU2019202259B2/en active Active
-
2021
- 2021-03-16 JP JP2021042702A patent/JP2021104023A/ja not_active Withdrawn
-
2023
- 2023-07-28 JP JP2023123219A patent/JP2023156371A/ja active Pending
- 2023-10-30 US US18/497,162 patent/US20240093143A1/en active Pending
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