FR2861080B1 - Anticorps presentant un taux de fucose et de galactose optimise - Google Patents
Anticorps presentant un taux de fucose et de galactose optimiseInfo
- Publication number
- FR2861080B1 FR2861080B1 FR0312229A FR0312229A FR2861080B1 FR 2861080 B1 FR2861080 B1 FR 2861080B1 FR 0312229 A FR0312229 A FR 0312229A FR 0312229 A FR0312229 A FR 0312229A FR 2861080 B1 FR2861080 B1 FR 2861080B1
- Authority
- FR
- France
- Prior art keywords
- fucose
- galactose
- antibodies
- optimized
- rate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/34—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood group antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0312229A FR2861080B1 (fr) | 2003-10-20 | 2003-10-20 | Anticorps presentant un taux de fucose et de galactose optimise |
BRPI0415565-3A BRPI0415565A (pt) | 2003-10-20 | 2004-10-20 | anticorpos que aresentam uma taxa de fucose e de galactose otimizada |
PCT/FR2004/002686 WO2005040221A1 (fr) | 2003-10-20 | 2004-10-20 | Correlation du ratio taux de fucose / taux de galactose d’anticorps anti rhesus d et anti hla-dr avec l’activite adcc |
CA002542881A CA2542881A1 (fr) | 2003-10-20 | 2004-10-20 | Anticorps possedant un ratio taux de fucose / taux de galactose optimise |
EP04805250A EP1675873A1 (fr) | 2003-10-20 | 2004-10-20 | Correlation du ratio taux de fucose / taux de galactose d'anticorps anti rhesus d et anti hla-dr avec l'activite adcc |
AU2004283924A AU2004283924B2 (en) | 2003-10-20 | 2004-10-20 | Correlation between the fucose content / galactose content ratio of anti-rhesus-D and anti-HLA-DR antibodies and the ADCC activity |
JP2006534807A JP2007533299A (ja) | 2003-10-20 | 2004-10-20 | 抗rhesus−dおよび抗hla−dr抗体のフコース含量/ガラクトース含量の比とadcc活性の間の関連 |
US10/575,333 US20070015239A1 (en) | 2003-10-20 | 2004-10-20 | Correlation between the fucose content/galactose content ratio of anti-rhesus-d and anti-hla-dr antibodies and the adcc activity |
IL174896A IL174896A0 (en) | 2003-10-20 | 2006-04-10 | Correlation between the fucose conteny/galactose content ratio of anti-rhesus-d and anti-hla-dr antibodies and the adcc activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0312229A FR2861080B1 (fr) | 2003-10-20 | 2003-10-20 | Anticorps presentant un taux de fucose et de galactose optimise |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2861080A1 FR2861080A1 (fr) | 2005-04-22 |
FR2861080B1 true FR2861080B1 (fr) | 2006-02-17 |
Family
ID=34385294
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR0312229A Expired - Fee Related FR2861080B1 (fr) | 2003-10-20 | 2003-10-20 | Anticorps presentant un taux de fucose et de galactose optimise |
Country Status (9)
Country | Link |
---|---|
US (1) | US20070015239A1 (fr) |
EP (1) | EP1675873A1 (fr) |
JP (1) | JP2007533299A (fr) |
AU (1) | AU2004283924B2 (fr) |
BR (1) | BRPI0415565A (fr) |
CA (1) | CA2542881A1 (fr) |
FR (1) | FR2861080B1 (fr) |
IL (1) | IL174896A0 (fr) |
WO (1) | WO2005040221A1 (fr) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2892724B1 (fr) * | 2005-11-02 | 2008-01-04 | Lab Francais Du Fractionnement | Anticorps cytotoxiques diriges contre des anticorps inhibiteurs du facteur viii. |
US7846724B2 (en) | 2006-04-11 | 2010-12-07 | Hoffmann-La Roche Inc. | Method for selecting CHO cell for production of glycosylated antibodies |
AU2013203482B2 (en) * | 2006-09-10 | 2015-08-27 | Glycotope Gmbh | Fully human high yield production system for improved antibodies and proteins |
CN103436574B (zh) * | 2006-09-10 | 2016-08-10 | 葛莱高托普有限公司 | 骨髓白血病来源的细胞在抗体表达中的用途 |
US7846434B2 (en) | 2006-10-24 | 2010-12-07 | Trubion Pharmaceuticals, Inc. | Materials and methods for improved immunoglycoproteins |
EP1920781B1 (fr) | 2006-11-10 | 2015-03-04 | Glycotope GmbH | Compositions comprenant un microorganisme contenant core-1 et son utilisation pour le traitement des tumeurs |
US20080227669A1 (en) * | 2007-03-12 | 2008-09-18 | Halliburton Energy Services, Inc. | Corrosion-inhibiting additives, treatment fluids, and associated methods |
EP1995309A1 (fr) * | 2007-05-21 | 2008-11-26 | Vivalis | Production de protéine recombinante dans des cellules aviaires EBx |
JP2012503656A (ja) * | 2008-09-26 | 2012-02-09 | エウレカ セラピューティクス,インコーポレイテッド | 変異体グリコシル化パターンを有する細胞株およびタンパク質 |
EP2417159A1 (fr) * | 2009-04-07 | 2012-02-15 | Roche Glycart AG | Anticorps anti-erbb-3/anti-c-met bispécifiques |
AU2010311567B2 (en) | 2009-10-26 | 2015-03-26 | Chugai Seiyaku Kabushiki Kaisha | Method for the production of a glycosylated immunoglobulin |
US9441032B2 (en) | 2010-04-07 | 2016-09-13 | Agency For Science, Technology And Research | Binding molecules against Chikungunya virus and uses thereof |
EP2374816B1 (fr) | 2010-04-07 | 2016-09-28 | Agency For Science, Technology And Research | Molécules liant le virus du Chikungunya et leurs utilisations |
EP2409993A1 (fr) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anticorps Anti-CD19 doté d'une fonction ADCC et d'un profil de glycosylation amélioré |
EP2409712A1 (fr) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Anticorps Anti-CD19 doté de fonctions ADCC et CDC et d'un profil de glycosylation amélioré |
EP2409989A1 (fr) | 2010-07-19 | 2012-01-25 | International-Drug-Development-Biotech | Procédé pour améliorer le profile de glycosylation d'un anticorps |
WO2012105699A1 (fr) * | 2011-02-03 | 2012-08-09 | 株式会社イーベック | Procédé de production d'un anticorps présentant une activité biologique élevée dépendante du complément |
EP2702077A2 (fr) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Procédé de contrôle du profil de galactosylation de protéines exprimées de manière recombinante |
BR112014003110A2 (pt) * | 2011-08-10 | 2018-10-09 | Lab Francais Du Fractionnement | composição, método para produção de uma população altamente galactosilada de anticorpos, células epiteliais de glândula mamária e mamífero não humano tramsgênico |
EP2748302B1 (fr) | 2011-08-22 | 2018-08-15 | Glycotope GmbH | Microorganismes portant un antigène tumoral |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
WO2013158279A1 (fr) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Procédés de purification de protéines pour réduire des espèces acides |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
WO2014140927A2 (fr) | 2013-02-13 | 2014-09-18 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Protéines à glycosylation modifiée et leurs procédés de production |
JP2016509019A (ja) * | 2013-02-13 | 2016-03-24 | ラボラトワール フランセ デュ フラクショヌマン エ デ ビオテクノロジーLaboratoire Francais du Fractionnement et des Biotechnologies | 高ガラクトシル化抗her2抗体およびその使用 |
ES2755181T3 (es) | 2013-02-13 | 2020-04-21 | Lab Francais Du Fractionnement | Anticuerpos anti-TNF-alfa altamente galactosilados y usos de los mismos |
WO2014143205A1 (fr) | 2013-03-12 | 2014-09-18 | Abbvie Inc. | Anticorps humains qui se lient au tnf-alpha et leurs procédés de préparation |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
WO2015051293A2 (fr) | 2013-10-04 | 2015-04-09 | Abbvie, Inc. | Utilisation d'ions métalliques pour moduler les profils de glycosylation des protéines dans le cas de protéines recombinées |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
WO2015073884A2 (fr) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Compositions de protéines de liaison génétiquement glycomodifiées |
JP2017528468A (ja) * | 2014-09-10 | 2017-09-28 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ガラクトース操作型免疫グロブリン1抗体 |
FR3035879A1 (fr) | 2015-05-07 | 2016-11-11 | Lab Francais Du Fractionnement | Mutants fc a activite fonctionnelle modifiee |
US11780934B2 (en) | 2016-02-05 | 2023-10-10 | Institut Pasteur | Use of inhibitors of ADAM12 as adjuvants in tumor therapies |
EP3652206A1 (fr) | 2017-07-10 | 2020-05-20 | International-Drug-Development-Biotech | Traitement de malignités de lymphocytes b à l'aide d'anticorps anti-cd19 pro-apoptotiques afucosylés en combinaison avec des anticorps anti-cd20 ou des agents chimiothérapeutiques |
EP3508499A1 (fr) | 2018-01-08 | 2019-07-10 | iOmx Therapeutics AG | Anticorps ciblant et d'autres modulateurs d'un gène d'immunoglobuline associé à une résistance contre des réponses immunitaires antitumorales et leurs utilisations |
BR112020023373A2 (pt) | 2018-05-18 | 2021-02-09 | Daiichi Sankyo Company, Limited | conjugado, composição, e, uso de um conjugado ou de uma composição |
CN114401992A (zh) | 2019-07-05 | 2022-04-26 | 艾欧麦克斯治疗股份公司 | 结合igsf11(vsig3)的igc2的抗体及其用途 |
EP3822288A1 (fr) | 2019-11-18 | 2021-05-19 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Anticorps ciblant et autres modulateurs de l'antigène cd276 et leurs utilisations |
US20240010720A1 (en) | 2020-07-06 | 2024-01-11 | Iomx Therapeutics Ag | Antibodies binding igv of igsf11 (vsig3) and uses thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0316463A1 (fr) * | 1987-11-13 | 1989-05-24 | Northwestern University | Hybridome murin lym-1 et anticorps de diagnostic ainsi produit |
SE9203479L (sv) * | 1992-01-20 | 1993-07-21 | Rso Corp | Saett och anordning vid elektronisk identifiering |
FR2776096B1 (fr) * | 1998-03-12 | 2000-06-23 | Commissariat Energie Atomique | Procede et systeme de lecture d'un ensemble dynamique d'etiquettes portant des codes d'identification distincts |
FR2805637B1 (fr) * | 2000-02-25 | 2002-12-13 | Commissariat Energie Atomique | Procede de lecture d'etiquettes electroniques par identification simultanee de leur code |
FR2807767B1 (fr) * | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-d |
US6946292B2 (en) * | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
US7278571B2 (en) * | 2002-11-15 | 2007-10-09 | Sensitech Inc. | Methods and apparatus for communicating condition information associated with an item |
FR2859843B1 (fr) * | 2003-09-16 | 2005-12-23 | Commissariat Energie Atomique | Dispositif adressable par radiofrequence, systeme comportant une pluralite de tels dispositifs agences dans l'espace et procede d'adressage par activation d'un mode transparent |
-
2003
- 2003-10-20 FR FR0312229A patent/FR2861080B1/fr not_active Expired - Fee Related
-
2004
- 2004-10-20 BR BRPI0415565-3A patent/BRPI0415565A/pt not_active Application Discontinuation
- 2004-10-20 WO PCT/FR2004/002686 patent/WO2005040221A1/fr active Application Filing
- 2004-10-20 CA CA002542881A patent/CA2542881A1/fr not_active Abandoned
- 2004-10-20 JP JP2006534807A patent/JP2007533299A/ja active Pending
- 2004-10-20 US US10/575,333 patent/US20070015239A1/en not_active Abandoned
- 2004-10-20 AU AU2004283924A patent/AU2004283924B2/en not_active Ceased
- 2004-10-20 EP EP04805250A patent/EP1675873A1/fr not_active Withdrawn
-
2006
- 2006-04-10 IL IL174896A patent/IL174896A0/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IL174896A0 (en) | 2006-08-20 |
CA2542881A1 (fr) | 2005-05-06 |
AU2004283924B2 (en) | 2010-12-02 |
AU2004283924A1 (en) | 2005-05-06 |
FR2861080A1 (fr) | 2005-04-22 |
US20070015239A1 (en) | 2007-01-18 |
JP2007533299A (ja) | 2007-11-22 |
BRPI0415565A (pt) | 2007-01-02 |
EP1675873A1 (fr) | 2006-07-05 |
WO2005040221A1 (fr) | 2005-05-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FR2861080B1 (fr) | Anticorps presentant un taux de fucose et de galactose optimise | |
DE60239403D1 (de) | Elektromechanischer mikrosensor | |
IL158831A0 (en) | METHODS OF ADMINISTERING ANTI-TNFalpha ANTIBODIES | |
IL168304A (en) | Human monoclonal antibodies against cd25 | |
DE60232893D1 (de) | Wirbelimplantat | |
WO2002092017A8 (fr) | Anticorps anti-pneumocoques humains provenant d'animaux non humains | |
IL157142A0 (en) | Modified antibodies and methods of use | |
DE60231749D1 (de) | Supercharge-nachrichtenaustauschvorrichtung | |
EP1506286A4 (fr) | Anticorps anti-igfr humain neutralisant | |
IS6779A (is) | Mannlíkt mótefni gegn LT-beta-R | |
GB2388192B (en) | Weighted slant stack for attenuating seismic noise | |
DE60025735D1 (de) | Verbesserter soundprozessor für cochlearimplantate | |
EP1621616A4 (fr) | Anticorps humain d'interleukine-18 antihumaine, fragment de celle-ci et procede d'utilisation correspondant | |
EP1316560A4 (fr) | Nouvel antigene de type cancer-testis humain et gene de ce dernier | |
AU2003276844A8 (en) | Formulations of modified antibodies and methods of making the same | |
EP1610757A4 (fr) | Profilage de variants conformationnels, compositions anticorps et procedes d'utilisation associes | |
GB0119497D0 (en) | Expression of modified antibodies in avian cells | |
GB2389615B (en) | Retroflective device and method of manufacture thereof | |
EP1393746A4 (fr) | Compositions d'anticorps polyclonaux humains | |
GB2407158B (en) | Weighted slant stack for attenuating seismic noise | |
GB0311982D0 (en) | Method of improving the emotional development of an infant | |
FR2861732B1 (fr) | ANTICORPS scFv ANTI-CD63 ET SES UTILISATIONS | |
EP1616020A4 (fr) | Anticorps anti cr1 a immunogenicite reduite et methodes de traitement les utilisant | |
AU2002326177A1 (en) | Cage antigen | |
ES1053452Y (es) | Cortadora-formadora de piezas de masa panificable. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property | ||
ST | Notification of lapse |
Effective date: 20140630 |