JP2016503663A5 - - Google Patents
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- Publication number
- JP2016503663A5 JP2016503663A5 JP2015553830A JP2015553830A JP2016503663A5 JP 2016503663 A5 JP2016503663 A5 JP 2016503663A5 JP 2015553830 A JP2015553830 A JP 2015553830A JP 2015553830 A JP2015553830 A JP 2015553830A JP 2016503663 A5 JP2016503663 A5 JP 2016503663A5
- Authority
- JP
- Japan
- Prior art keywords
- mutation
- fatty alcohol
- alcohol composition
- amino acid
- titer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000035772 mutation Effects 0.000 claims 49
- 150000002191 fatty alcohols Chemical class 0.000 claims 19
- 101710129019 Long-chain acyl-[acyl-carrier-protein] reductase Proteins 0.000 claims 15
- 229920001184 polypeptide Polymers 0.000 claims 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 102220094196 rs876660097 Human genes 0.000 claims 8
- 102220619153 Protein RD3-like_L8A_mutation Human genes 0.000 claims 5
- 102220049163 rs35498994 Human genes 0.000 claims 5
- 102220526846 Basic salivary proline-rich protein 1_D24V_mutation Human genes 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 238000004113 cell culture Methods 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 102220279228 rs1320222638 Human genes 0.000 claims 2
- 102220517259 Signal transducing adapter molecule 1_W34F_mutation Human genes 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 150000002192 fatty aldehydes Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 102220227062 rs1064796796 Human genes 0.000 claims 1
- 102200043783 rs17850684 Human genes 0.000 claims 1
- 102220008303 rs4904 Human genes 0.000 claims 1
- 102220227358 rs748198457 Human genes 0.000 claims 1
- 102220063378 rs786201995 Human genes 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361753273P | 2013-01-16 | 2013-01-16 | |
| US61/753,273 | 2013-01-16 | ||
| PCT/US2014/011859 WO2014113571A2 (en) | 2013-01-16 | 2014-01-16 | Acyl-acp reductase with improved properties |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016202155A Division JP6211162B2 (ja) | 2013-01-16 | 2016-10-14 | 改良された特性を有するアシル−ａｃｐレダクターゼ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016503663A JP2016503663A (ja) | 2016-02-08 |
| JP2016503663A5 true JP2016503663A5 (enExample) | 2016-09-29 |
| JP6063585B2 JP6063585B2 (ja) | 2017-01-18 |
Family
ID=50473752
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015553830A Active JP6063585B2 (ja) | 2013-01-16 | 2014-01-16 | 改良された特性を有するアシル−ａｃｐレダクターゼ |
| JP2016202155A Expired - Fee Related JP6211162B2 (ja) | 2013-01-16 | 2016-10-14 | 改良された特性を有するアシル−ａｃｐレダクターゼ |
| JP2017174449A Expired - Fee Related JP6523393B2 (ja) | 2013-01-16 | 2017-09-12 | 改良された特性を有するアシル−ａｃｐレダクターゼ |
| JP2019084119A Active JP6926143B2 (ja) | 2013-01-16 | 2019-04-25 | 改良された特性を有するアシル−ａｃｐレダクターゼ |
| JP2020178581A Active JP7094343B2 (ja) | 2013-01-16 | 2020-10-26 | 改良された特性を有するアシル－ａｃｐレダクターゼ |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016202155A Expired - Fee Related JP6211162B2 (ja) | 2013-01-16 | 2016-10-14 | 改良された特性を有するアシル−ａｃｐレダクターゼ |
| JP2017174449A Expired - Fee Related JP6523393B2 (ja) | 2013-01-16 | 2017-09-12 | 改良された特性を有するアシル−ａｃｐレダクターゼ |
| JP2019084119A Active JP6926143B2 (ja) | 2013-01-16 | 2019-04-25 | 改良された特性を有するアシル−ａｃｐレダクターゼ |
| JP2020178581A Active JP7094343B2 (ja) | 2013-01-16 | 2020-10-26 | 改良された特性を有するアシル－ａｃｐレダクターゼ |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US9683219B2 (enExample) |
| EP (3) | EP2946009B1 (enExample) |
| JP (5) | JP6063585B2 (enExample) |
| KR (4) | KR20210072147A (enExample) |
| CN (3) | CN109897834A (enExample) |
| AU (3) | AU2014207522B2 (enExample) |
| BR (1) | BR112015017005A2 (enExample) |
| CA (2) | CA2898317C (enExample) |
| CO (1) | CO7461134A2 (enExample) |
| ES (2) | ES2600354T3 (enExample) |
| MX (2) | MX356997B (enExample) |
| MY (1) | MY167434A (enExample) |
| WO (1) | WO2014113571A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2775390C (en) | 2009-09-27 | 2021-06-29 | Opx Biotechnologies, Inc. | Method for producing 3-hydroxypropionic acid and other products |
| CN109182238A (zh) | 2012-08-10 | 2019-01-11 | 嘉吉有限公司 | 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法 |
| WO2014113571A2 (en) * | 2013-01-16 | 2014-07-24 | Ls9, Inc. | Acyl-acp reductase with improved properties |
| WO2014146026A1 (en) | 2013-03-15 | 2014-09-18 | Opx Biotechnologies, Inc. | Bioproduction of chemicals |
| US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| JP6603658B2 (ja) | 2013-07-19 | 2019-11-06 | カーギル インコーポレイテッド | 脂肪酸及び脂肪酸誘導体の製造のための微生物及び方法 |
| BR112017001105A2 (pt) * | 2014-07-18 | 2018-07-24 | REG Life Sciences, LLC | produção microbiana de dióis graxos |
| EP2993228B1 (en) | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Production of fatty acid esters |
| WO2018144701A2 (en) | 2017-02-02 | 2018-08-09 | Cargill Incorporated | Genetically modified cells that produce c6-c10 fatty acid derivatives |
| CN111094558A (zh) | 2017-04-03 | 2020-05-01 | 基因组股份公司 | 对产生中链脂肪酸衍生物具有改善的活性的硫酯酶变体 |
| US12098168B2 (en) | 2018-08-31 | 2024-09-24 | Genomatica, Inc. | XylR mutant for improved xylose utilization or improved co-utilization of glucose and xylose preliminary |
| EP3844269A4 (en) * | 2018-08-31 | 2022-07-27 | Genomatica, Inc. | PRODUCTION OF NON-NATIVE MONOUNSATURATED FATTY ACIDS IN BACTERIA |
| EP4493683A1 (en) | 2022-03-16 | 2025-01-22 | Genomatica, Inc. | Acyl-acp thioesterase variants and uses thereof |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5028539A (en) | 1988-08-31 | 1991-07-02 | The University Of Florida | Ethanol production using engineered mutant E. coli |
| US5482846A (en) | 1988-08-31 | 1996-01-09 | University Of Florida | Ethanol production in Gram-positive microbes |
| US5424202A (en) | 1988-08-31 | 1995-06-13 | The University Of Florida | Ethanol production by recombinant hosts |
| US5000000A (en) | 1988-08-31 | 1991-03-19 | University Of Florida | Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes |
| AU7791991A (en) | 1990-04-24 | 1991-11-11 | Stratagene | Methods for phenotype creation from multiple gene populations |
| US5602030A (en) | 1994-03-28 | 1997-02-11 | University Of Florida Research Foundation | Recombinant glucose uptake system |
| US6428767B1 (en) | 1995-05-12 | 2002-08-06 | E. I. Du Pont De Nemours And Company | Method for identifying the source of carbon in 1,3-propanediol |
| US5965408A (en) | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
| US5939250A (en) | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
| PL207026B1 (pl) * | 2000-02-09 | 2010-10-29 | Basf Ag | Wyizolowany kwas nukleinowy, konstrukt genowy zawierający ten kwas, sekwencja aminokwasowa kodowana przez wyizolowaną sekwencję tego kwasu nukleinowego, wektor zawierający kwas nukleinowy lub konstrukt genowy, roślina transgeniczna lub mikroorganizm transgeniczny zawierający kwas nukleinowy, konstrukt genowy lub wektor, przeciwciało specyficznie wiążące się z polipeptydem kodowanym przez kwas nukleinowy, cząsteczka antysensownego kwasu nukleinowego oraz sposób wytwarzania wielonienasyconych kwasów tłuszczowych (PUFA) |
| US8110670B2 (en) | 2006-05-19 | 2012-02-07 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| ES2528482T3 (es) | 2006-05-19 | 2015-02-10 | Ls9, Inc. | Producción de ácidos grasos y derivados de los mismos |
| WO2008119082A2 (en) | 2007-03-28 | 2008-10-02 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| US8110093B2 (en) | 2007-03-14 | 2012-02-07 | Ls9, Inc. | Process for producing low molecular weight hydrocarbons from renewable resources |
| TWI351779B (en) | 2007-12-03 | 2011-11-01 | Advance Smart Ind Ltd | Apparatus and method for correcting residual capac |
| US8183028B2 (en) | 2007-12-21 | 2012-05-22 | Ls9, Inc. | Methods and compositions for producing olefins |
| CA3101888A1 (en) | 2008-05-16 | 2009-11-19 | REG Life Sciences, LLC | Methods and compositions for producing hydrocarbons |
| US8232924B2 (en) | 2008-05-23 | 2012-07-31 | Alliant Techsystems Inc. | Broadband patch antenna and antenna system |
| US8097439B2 (en) | 2008-10-07 | 2012-01-17 | Ls9, Inc. | Methods and compositions for producing fatty aldehydes |
| CN105154380B (zh) * | 2008-10-28 | 2018-11-09 | Reg生命科学有限责任公司 | 用于产生脂肪醇的方法和组合物 |
| WO2010127318A2 (en) | 2009-05-01 | 2010-11-04 | The Regents Of The University Of California | Product of fatty acid esters from biomass polymers |
| BRPI1010920B1 (pt) * | 2009-05-22 | 2020-04-28 | Codexis Inc | processo para a produção biológica de álcoois graxos |
| US7794969B1 (en) * | 2009-07-09 | 2010-09-14 | Joule Unlimited, Inc. | Methods and compositions for the recombinant biosynthesis of n-alkanes |
| EP2477021B1 (en) * | 2009-09-07 | 2018-03-07 | National Institute of Information and Communication Technology | Method and system for evaluating characteristic of optical modulator having mach-zehnder interferometer |
| MX2012003472A (es) | 2009-09-25 | 2012-05-22 | Ls9 Inc | Produccion de derivados de acido graso. |
| CA2775390C (en) | 2009-09-27 | 2021-06-29 | Opx Biotechnologies, Inc. | Method for producing 3-hydroxypropionic acid and other products |
| US8530221B2 (en) | 2010-01-14 | 2013-09-10 | Ls9, Inc. | Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells |
| WO2011100667A1 (en) | 2010-02-14 | 2011-08-18 | Ls9, Inc. | Surfactant and cleaning compositions comprising microbially produced branched fatty alcohols |
| AR084377A1 (es) | 2010-04-08 | 2013-05-15 | Ls9 Inc | Metodos y composiciones relacionados con enzimas de alcohol graso biosintetico |
| US8372610B2 (en) | 2010-09-15 | 2013-02-12 | Ls9, Inc. | Production of odd chain fatty acid derivatives in recombinant microbial cells |
| EP2655605A1 (en) | 2010-12-20 | 2013-10-30 | Matrix Genetics, LLC | Modified photosynthetic microorganisms for producing lipids |
| CA2823928C (en) * | 2011-01-14 | 2020-09-22 | Ls9, Inc. | Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells |
| CN102719467A (zh) * | 2012-07-09 | 2012-10-10 | 武汉大学 | 一种利用脂肪酰acp还原酶生物合成脂肪醇的方法 |
| WO2014113571A2 (en) | 2013-01-16 | 2014-07-24 | Ls9, Inc. | Acyl-acp reductase with improved properties |
| JP7478517B2 (ja) | 2019-04-24 | 2024-05-07 | 三菱商事ライフサイエンス株式会社 | 脂質活性代謝改善組成物 |
-
2014
- 2014-01-16 WO PCT/US2014/011859 patent/WO2014113571A2/en not_active Ceased
- 2014-01-16 CN CN201910169609.4A patent/CN109897834A/zh active Pending
- 2014-01-16 CA CA2898317A patent/CA2898317C/en active Active
- 2014-01-16 US US14/761,299 patent/US9683219B2/en active Active
- 2014-01-16 CN CN201910693927.0A patent/CN110387352A/zh active Pending
- 2014-01-16 KR KR1020217017654A patent/KR20210072147A/ko not_active Ceased
- 2014-01-16 CA CA3143642A patent/CA3143642A1/en active Pending
- 2014-01-16 JP JP2015553830A patent/JP6063585B2/ja active Active
- 2014-01-16 BR BR112015017005A patent/BR112015017005A2/pt not_active IP Right Cessation
- 2014-01-16 MX MX2017003816A patent/MX356997B/es unknown
- 2014-01-16 ES ES14716444.6T patent/ES2600354T3/es active Active
- 2014-01-16 MY MYPI2015001785A patent/MY167434A/en unknown
- 2014-01-16 KR KR1020177015121A patent/KR102082247B1/ko not_active Expired - Fee Related
- 2014-01-16 AU AU2014207522A patent/AU2014207522B2/en not_active Ceased
- 2014-01-16 CN CN201480004992.3A patent/CN105051189B/zh active Active
- 2014-01-16 EP EP14716444.6A patent/EP2946009B1/en active Active
- 2014-01-16 KR KR1020207004969A patent/KR102265148B1/ko not_active Expired - Fee Related
- 2014-01-16 KR KR1020157021992A patent/KR101746040B1/ko active Active
- 2014-01-16 EP EP18172072.3A patent/EP3385375B1/en active Active
- 2014-01-16 MX MX2015009138A patent/MX346830B/es active IP Right Grant
- 2014-01-16 EP EP16181205.2A patent/EP3103867B1/en active Active
- 2014-01-16 ES ES16181205.2T patent/ES2675224T3/es active Active
-
2015
- 2015-07-28 CO CO15173779A patent/CO7461134A2/es unknown
-
2016
- 2016-07-28 US US15/222,657 patent/US10208294B2/en active Active
- 2016-10-14 JP JP2016202155A patent/JP6211162B2/ja not_active Expired - Fee Related
-
2017
- 2017-01-30 AU AU2017200596A patent/AU2017200596B2/en not_active Ceased
- 2017-06-13 US US15/621,430 patent/US9873865B2/en active Active
- 2017-09-12 JP JP2017174449A patent/JP6523393B2/ja not_active Expired - Fee Related
-
2019
- 2019-02-11 US US16/272,303 patent/US11130944B2/en not_active Expired - Fee Related
- 2019-04-18 AU AU2019202790A patent/AU2019202790A1/en not_active Abandoned
- 2019-04-25 JP JP2019084119A patent/JP6926143B2/ja active Active
-
2020
- 2020-10-26 JP JP2020178581A patent/JP7094343B2/ja active Active
-
2021
- 2021-08-18 US US17/405,685 patent/US20220090028A1/en not_active Abandoned
-
2023
- 2023-07-20 US US18/355,990 patent/US12173329B2/en active Active
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