JP2016185168A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016185168A5 JP2016185168A5 JP2016149598A JP2016149598A JP2016185168A5 JP 2016185168 A5 JP2016185168 A5 JP 2016185168A5 JP 2016149598 A JP2016149598 A JP 2016149598A JP 2016149598 A JP2016149598 A JP 2016149598A JP 2016185168 A5 JP2016185168 A5 JP 2016185168A5
- Authority
- JP
- Japan
- Prior art keywords
- mouse
- pups
- cell
- genetic modification
- generation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 28
- 241000699666 Mus <mouse, genus> Species 0.000 claims 12
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 12
- 238000012239 gene modification Methods 0.000 claims 9
- 230000005017 genetic modification Effects 0.000 claims 9
- 235000013617 genetically modified food Nutrition 0.000 claims 9
- 239000007640 basal medium Substances 0.000 claims 8
- 150000007523 nucleic acids Chemical group 0.000 claims 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 6
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 6
- 239000011780 sodium chloride Substances 0.000 claims 6
- 210000001161 mammalian embryo Anatomy 0.000 claims 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 101100204227 Homo sapiens STEAP2 gene Proteins 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 claims 1
- 210000000472 morula Anatomy 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 239000013589 supplement Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35389610P | 2010-06-11 | 2010-06-11 | |
| US61/353,896 | 2010-06-11 | ||
| US13/157,728 US9149026B2 (en) | 2010-06-11 | 2011-06-10 | Production of fertile XY animals from XY ES cells |
| US13/157,728 | 2011-06-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013514391A Division JP2013528062A (ja) | 2010-06-11 | 2011-06-10 | Ｘｙｅｓ細胞からの繁殖可能なｘｙ雌動物の生成 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016185168A JP2016185168A (ja) | 2016-10-27 |
| JP2016185168A5 true JP2016185168A5 (enExample) | 2017-03-09 |
| JP6310969B2 JP6310969B2 (ja) | 2018-04-11 |
Family
ID=45097380
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013514391A Withdrawn JP2013528062A (ja) | 2010-06-11 | 2011-06-10 | Ｘｙｅｓ細胞からの繁殖可能なｘｙ雌動物の生成 |
| JP2016149598A Active JP6310969B2 (ja) | 2010-06-11 | 2016-07-29 | Ｘｙ ｅｓ細胞からの繁殖可能なｘｙ雌動物の生成 |
| JP2016149597A Active JP6310968B2 (ja) | 2010-06-11 | 2016-07-29 | Ｘｙ ｅｓ細胞からの繁殖可能なｘｙ雌動物の生成 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013514391A Withdrawn JP2013528062A (ja) | 2010-06-11 | 2011-06-10 | Ｘｙｅｓ細胞からの繁殖可能なｘｙ雌動物の生成 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016149597A Active JP6310968B2 (ja) | 2010-06-11 | 2016-07-29 | Ｘｙ ｅｓ細胞からの繁殖可能なｘｙ雌動物の生成 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US9149026B2 (enExample) |
| EP (1) | EP2579711B1 (enExample) |
| JP (3) | JP2013528062A (enExample) |
| CN (2) | CN104711218B (enExample) |
| AU (1) | AU2011265306C1 (enExample) |
| CA (1) | CA2800534C (enExample) |
| CY (1) | CY1121955T1 (enExample) |
| DK (1) | DK2579711T3 (enExample) |
| ES (1) | ES2727738T3 (enExample) |
| MY (2) | MY172702A (enExample) |
| PL (1) | PL2579711T3 (enExample) |
| PT (1) | PT2579711T (enExample) |
| SG (1) | SG185703A1 (enExample) |
| WO (1) | WO2011156723A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104711218B (zh) | 2010-06-11 | 2018-09-25 | 瑞泽恩制药公司 | 由xy es细胞制备能育的xy雌性动物 |
| RU2645475C2 (ru) | 2012-04-25 | 2018-02-21 | Регенерон Фармасьютикалз, Инк. | Опосредованное нуклеазой нацеливание с большими нацеливающими векторами |
| DK2986729T3 (en) | 2013-04-16 | 2018-10-29 | Regeneron Pharma | TARGETED MODIFICATION OF ROOT THROUGH |
| WO2015088643A1 (en) | 2013-12-11 | 2015-06-18 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a genome |
| RU2704283C9 (ru) | 2014-06-06 | 2020-02-07 | Регенерон Фармасьютикалз, Инк. | Способы и композиции для модификации целевого локуса |
| PT3161128T (pt) * | 2014-06-26 | 2018-11-21 | Regeneron Pharma | Métodos e composições para modificações genéticas alvejadas e métodos de utilização |
| SG11201702309RA (en) | 2014-10-15 | 2017-04-27 | Regeneron Pharma | Methods and compositions for generating or maintaining pluripotent cells |
| CA2968440A1 (en) | 2014-11-21 | 2016-05-26 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modification using paired guide rnas |
| BR112017013104A2 (en) | 2014-12-19 | 2018-05-15 | Regeneron Pharmaceuticals, Inc. | methods for modifying a target genomic locus in a cell, for enhancing homologous recombination at a target genomic locus in a cell, and for producing an f0 generation from a nonhuman animal. |
| US10893666B2 (en) * | 2015-09-17 | 2021-01-19 | Regeneron Pharmaceuticals, Inc. | Production of fertile XY female animals by silencing of genes on the Y chromosome |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0907722A1 (en) | 1996-04-29 | 1999-04-14 | Leuven Research & Development V.Z.W. | Pluripotent rabbit embryonic stem (es) cell lines and their use in the generation of chimeric rabbits |
| CA2394812A1 (en) | 1999-12-20 | 2001-06-28 | Anthony C.F. Perry | A method to produce cloned embryos and adults from cultured cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| GB0031744D0 (en) | 2000-12-28 | 2001-02-07 | Pig Improvement Co Uk Ltd | Methods |
| JP2004248505A (ja) * | 2001-09-21 | 2004-09-09 | Norio Nakatsuji | 移植抗原の一部または全てを欠除したｅｓ細胞由来の未分化な体細胞融合細胞およびその製造 |
| JPWO2003071869A1 (ja) | 2002-02-27 | 2005-06-16 | 恭光 長尾 | 生殖系列キメラ動物の作製方法 |
| ATE306810T1 (de) * | 2002-03-05 | 2005-11-15 | Artemis Pharmaceuticals Gmbh | Durch inzucht erzeugte von embryonalen stammzellen abgeleitete mäuse |
| EP1516924A1 (en) * | 2003-09-17 | 2005-03-23 | Fundacion IVI para el Estudio de la reproduccion Humana (FIVIER) | Generation of human embryonic stem cells from triploid zygotes |
| KR101178786B1 (ko) | 2004-03-23 | 2012-09-07 | 다이이찌 산쿄 가부시키가이샤 | 다능성 줄기세포의 증식 방법 |
| WO2006044962A1 (en) | 2004-10-19 | 2006-04-27 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
| JP4595896B2 (ja) | 2006-07-14 | 2010-12-08 | パナソニック電工株式会社 | 静電霧化装置 |
| CN101506354B (zh) | 2006-08-09 | 2014-05-07 | 瓦内瓦公司 | 用胚胎干细胞制备转基因禽类的方法 |
| GB0623635D0 (en) * | 2006-11-27 | 2007-01-03 | Stem Cell Sciences Uk Ltd | Pluripotent cell growth media |
| AU2010306377B2 (en) | 2009-10-13 | 2015-01-22 | Stemcell Technologies Canada Inc. | Manipulation of osmolality for differentiating stem cells |
| CN104711218B (zh) | 2010-06-11 | 2018-09-25 | 瑞泽恩制药公司 | 由xy es细胞制备能育的xy雌性动物 |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| PT3161128T (pt) | 2014-06-26 | 2018-11-21 | Regeneron Pharma | Métodos e composições para modificações genéticas alvejadas e métodos de utilização |
| SG11201702309RA (en) | 2014-10-15 | 2017-04-27 | Regeneron Pharma | Methods and compositions for generating or maintaining pluripotent cells |
-
2011
- 2011-06-10 CN CN201510101534.8A patent/CN104711218B/zh active Active
- 2011-06-10 US US13/157,728 patent/US9149026B2/en active Active
- 2011-06-10 MY MYPI2012005043A patent/MY172702A/en unknown
- 2011-06-10 JP JP2013514391A patent/JP2013528062A/ja not_active Withdrawn
- 2011-06-10 DK DK11729215.1T patent/DK2579711T3/da active
- 2011-06-10 MY MYPI2018702421A patent/MY191870A/en unknown
- 2011-06-10 CA CA2800534A patent/CA2800534C/en active Active
- 2011-06-10 PL PL11729215T patent/PL2579711T3/pl unknown
- 2011-06-10 SG SG2012085916A patent/SG185703A1/en unknown
- 2011-06-10 ES ES11729215T patent/ES2727738T3/es active Active
- 2011-06-10 CN CN201180028717.1A patent/CN102933074B/zh active Active
- 2011-06-10 WO PCT/US2011/039997 patent/WO2011156723A1/en not_active Ceased
- 2011-06-10 EP EP11729215.1A patent/EP2579711B1/en active Active
- 2011-06-10 PT PT11729215T patent/PT2579711T/pt unknown
- 2011-06-10 AU AU2011265306A patent/AU2011265306C1/en active Active
-
2014
- 2014-11-11 US US14/538,209 patent/US9398762B2/en active Active
-
2016
- 2016-06-22 US US15/189,767 patent/US9655351B2/en active Active
- 2016-07-29 JP JP2016149598A patent/JP6310969B2/ja active Active
- 2016-07-29 JP JP2016149597A patent/JP6310968B2/ja active Active
-
2017
- 2017-04-12 US US15/486,210 patent/US9885058B2/en active Active
-
2019
- 2019-06-21 CY CY20191100649T patent/CY1121955T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107475300B (zh) | Ifit3-eKO1基因敲除小鼠动物模型的构建方法和应用 | |
| CN107287245B (zh) | 一种基于CRISPR/Cas9技术的Glrx1基因敲除动物模型的构建方法 | |
| BR112015019950A2 (pt) | Método para gerar linhagem de células-tronco embrionárias (es) de rato, e, cultura in vitro | |
| MY191870A (en) | Production of fertile xy female animals from xy es cells | |
| WO2012158986A3 (en) | Methods for site-specific genetic modification in stem cells using xanthomonas tal nucleases (xtn) for the creation of model organisms | |
| JP2017538428A5 (enExample) | ||
| WO2017049240A8 (en) | Selection of pluripotent cells for production of fertile xy female mice | |
| EP3052110A1 (en) | Methods and compositions for generation of developmentally-incompetent eggs in recipients of nuclear genetic transfer | |
| JP2009509555A5 (enExample) | ||
| JP2012065652A5 (enExample) | ||
| CN105505879B (zh) | 一种培养转基因动物胚胎细胞或转基因动物的方法及培养基 | |
| WO2018045727A1 (zh) | 粘多糖贮积症ii型动物模型的构建方法及应用 | |
| JP2018527005A5 (enExample) | ||
| CN108300738B (zh) | 一种nod遗传背景的中性粒细胞缺失的人源化小鼠模型的制备方法 | |
| CN108368519A (zh) | 一种孤雄单倍体胚胎干细胞及其制备与应用 | |
| JP2014516530A5 (enExample) | ||
| CN108893495A (zh) | 一种Pdzd7基因突变动物模型的构建方法 | |
| MY193790A (en) | Cloned non-human animals free of selective markers | |
| JP2018506984A5 (enExample) | ||
| CN103103160B (zh) | 牛体外胚胎两段培养方法 | |
| WO2008084566A1 (ja) | モデルマウス、その製造方法およびその用途 | |
| CN112063654B (zh) | 一种点突变血小板无力症小鼠模型的构建方法 | |
| CN114958852A (zh) | 一种Ifnar1基因敲除小鼠动物模型的构建方法及其应用 | |
| CN102492686A (zh) | Kctd10基因剔除小鼠模型、构建方法及其应用 | |
| CN104642263B (zh) | 一种现代高产型蛋鸡新品系、培育方法和应用 |