CN104711218B - 由xy es细胞制备能育的xy雌性动物 - Google Patents
由xy es细胞制备能育的xy雌性动物 Download PDFInfo
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- CN104711218B CN104711218B CN201510101534.8A CN201510101534A CN104711218B CN 104711218 B CN104711218 B CN 104711218B CN 201510101534 A CN201510101534 A CN 201510101534A CN 104711218 B CN104711218 B CN 104711218B
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- A01K2217/00—Genetically modified animals
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| CN104711218B (zh) | 2010-06-11 | 2018-09-25 | 瑞泽恩制药公司 | 由xy es细胞制备能育的xy雌性动物 |
| RU2645475C2 (ru) | 2012-04-25 | 2018-02-21 | Регенерон Фармасьютикалз, Инк. | Опосредованное нуклеазой нацеливание с большими нацеливающими векторами |
| DK2986729T3 (en) | 2013-04-16 | 2018-10-29 | Regeneron Pharma | TARGETED MODIFICATION OF ROOT THROUGH |
| WO2015088643A1 (en) | 2013-12-11 | 2015-06-18 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a genome |
| RU2704283C9 (ru) | 2014-06-06 | 2020-02-07 | Регенерон Фармасьютикалз, Инк. | Способы и композиции для модификации целевого локуса |
| PT3161128T (pt) * | 2014-06-26 | 2018-11-21 | Regeneron Pharma | Métodos e composições para modificações genéticas alvejadas e métodos de utilização |
| SG11201702309RA (en) | 2014-10-15 | 2017-04-27 | Regeneron Pharma | Methods and compositions for generating or maintaining pluripotent cells |
| CA2968440A1 (en) | 2014-11-21 | 2016-05-26 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modification using paired guide rnas |
| BR112017013104A2 (en) | 2014-12-19 | 2018-05-15 | Regeneron Pharmaceuticals, Inc. | methods for modifying a target genomic locus in a cell, for enhancing homologous recombination at a target genomic locus in a cell, and for producing an f0 generation from a nonhuman animal. |
| US10893666B2 (en) * | 2015-09-17 | 2021-01-19 | Regeneron Pharmaceuticals, Inc. | Production of fertile XY female animals by silencing of genes on the Y chromosome |
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| CA2394812A1 (en) | 1999-12-20 | 2001-06-28 | Anthony C.F. Perry | A method to produce cloned embryos and adults from cultured cells |
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| JP2004248505A (ja) * | 2001-09-21 | 2004-09-09 | Norio Nakatsuji | 移植抗原の一部または全てを欠除したｅｓ細胞由来の未分化な体細胞融合細胞およびその製造 |
| JPWO2003071869A1 (ja) | 2002-02-27 | 2005-06-16 | 恭光 長尾 | 生殖系列キメラ動物の作製方法 |
| ATE306810T1 (de) * | 2002-03-05 | 2005-11-15 | Artemis Pharmaceuticals Gmbh | Durch inzucht erzeugte von embryonalen stammzellen abgeleitete mäuse |
| EP1516924A1 (en) * | 2003-09-17 | 2005-03-23 | Fundacion IVI para el Estudio de la reproduccion Humana (FIVIER) | Generation of human embryonic stem cells from triploid zygotes |
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| WO2006044962A1 (en) | 2004-10-19 | 2006-04-27 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
| JP4595896B2 (ja) | 2006-07-14 | 2010-12-08 | パナソニック電工株式会社 | 静電霧化装置 |
| CN101506354B (zh) | 2006-08-09 | 2014-05-07 | 瓦内瓦公司 | 用胚胎干细胞制备转基因禽类的方法 |
| GB0623635D0 (en) * | 2006-11-27 | 2007-01-03 | Stem Cell Sciences Uk Ltd | Pluripotent cell growth media |
| AU2010306377B2 (en) | 2009-10-13 | 2015-01-22 | Stemcell Technologies Canada Inc. | Manipulation of osmolality for differentiating stem cells |
| CN104711218B (zh) | 2010-06-11 | 2018-09-25 | 瑞泽恩制药公司 | 由xy es细胞制备能育的xy雌性动物 |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
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| CN1531394A (zh) * | 2000-12-28 | 2004-09-22 | 猪改良英国有限公司 | 方法 |
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| US20160295841A1 (en) | 2016-10-13 |
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| JP2016185168A (ja) | 2016-10-27 |
| CA2800534A1 (en) | 2011-12-15 |
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