CN110387352A - 具有改善特性的酰基-acp还原酶 - Google Patents

具有改善特性的酰基-acp还原酶 Download PDF

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Publication number
CN110387352A
CN110387352A CN201910693927.0A CN201910693927A CN110387352A CN 110387352 A CN110387352 A CN 110387352A CN 201910693927 A CN201910693927 A CN 201910693927A CN 110387352 A CN110387352 A CN 110387352A
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CN
China
Prior art keywords
polypeptide
seq
external source
host cell
aar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910693927.0A
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English (en)
Chinese (zh)
Inventor
M·鲁德
N·特里安
A·席尔默
J·加诺
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genomatica Inc
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LS9 Inc
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Publication of CN110387352A publication Critical patent/CN110387352A/zh
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0008Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/24Preparation of oxygen-containing organic compounds containing a carbonyl group
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409Fatty acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y102/00Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/0108Long-chain acyl-[acyl-carrier-protein] reductase (1.2.1.80)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02EREDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00Technologies for the production of fuel of non-fossil origin
    • Y02E50/10Biofuels, e.g. bio-diesel
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/52Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Fats And Perfumes (AREA)
CN201910693927.0A 2013-01-16 2014-01-16 具有改善特性的酰基-acp还原酶 Pending CN110387352A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361753273P 2013-01-16 2013-01-16
US61/753,273 2013-01-16
CN201480004992.3A CN105051189B (zh) 2013-01-16 2014-01-16 具有改善特性的酰基-acp还原酶

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201480004992.3A Division CN105051189B (zh) 2013-01-16 2014-01-16 具有改善特性的酰基-acp还原酶

Publications (1)

Publication Number Publication Date
CN110387352A true CN110387352A (zh) 2019-10-29

Family

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Family Applications (3)

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CN201910693927.0A Pending CN110387352A (zh) 2013-01-16 2014-01-16 具有改善特性的酰基-acp还原酶
CN201910169609.4A Pending CN109897834A (zh) 2013-01-16 2014-01-16 具有改善特性的酰基-acp还原酶
CN201480004992.3A Active CN105051189B (zh) 2013-01-16 2014-01-16 具有改善特性的酰基-acp还原酶

Family Applications After (2)

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CN201910169609.4A Pending CN109897834A (zh) 2013-01-16 2014-01-16 具有改善特性的酰基-acp还原酶
CN201480004992.3A Active CN105051189B (zh) 2013-01-16 2014-01-16 具有改善特性的酰基-acp还原酶

Country Status (13)

Country Link
US (6) US9683219B2 (enExample)
EP (3) EP2946009B1 (enExample)
JP (5) JP6063585B2 (enExample)
KR (4) KR101746040B1 (enExample)
CN (3) CN110387352A (enExample)
AU (3) AU2014207522B2 (enExample)
BR (1) BR112015017005A2 (enExample)
CA (2) CA3143642A1 (enExample)
CO (1) CO7461134A2 (enExample)
ES (2) ES2675224T3 (enExample)
MX (2) MX356997B (enExample)
MY (1) MY167434A (enExample)
WO (1) WO2014113571A2 (enExample)

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CN110387352A (zh) 2013-01-16 2019-10-29 Reg生命科学有限责任公司 具有改善特性的酰基-acp还原酶
US9447438B2 (en) 2013-03-15 2016-09-20 Cargill, Incorporated Acetyl-coA carboxylases
WO2015010103A2 (en) 2013-07-19 2015-01-22 Opx Biotechnologies, Inc. Microorganisms and methods for the production of fatty acids and fatty acid derived products
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
CN106574238B (zh) * 2014-07-18 2021-09-21 基因组股份公司 微生物的脂肪二醇产生
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
CN110494566A (zh) 2017-02-02 2019-11-22 嘉吉公司 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞
KR102677413B1 (ko) 2017-04-03 2024-06-24 게노마티카 인코포레이티드 중쇄 지방산 유도체의 생산을 위해 개선된 활성을 갖는 티오에스테라제 변이체
WO2020047088A1 (en) * 2018-08-31 2020-03-05 Genomatica, Inc. Production of non-native monounsaturated fatty acids in bacteria
EP3844179A4 (en) 2018-08-31 2022-08-31 Genomatica, Inc. XYLR MUTANT FOR IMPROVED XYLOSE UTILIZATION OR IMPROVED CO-UTILIZATION OF GLUCOSE AND XYLOSE
WO2023178193A1 (en) 2022-03-16 2023-09-21 Genomatica, Inc. Acyl-acp thioesterase variants and uses thereof

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Also Published As

Publication number Publication date
ES2675224T3 (es) 2018-07-09
MX346830B (es) 2017-04-03
ES2600354T3 (es) 2017-02-08
KR20200020998A (ko) 2020-02-26
KR20170066694A (ko) 2017-06-14
JP2017042170A (ja) 2017-03-02
CA2898317C (en) 2022-03-01
JP6523393B2 (ja) 2019-05-29
KR20210072147A (ko) 2021-06-16
AU2014207522B2 (en) 2016-12-15
EP3103867B1 (en) 2018-05-16
CA3143642A1 (en) 2014-07-24
MX356997B (es) 2018-06-22
WO2014113571A2 (en) 2014-07-24
US20200010813A1 (en) 2020-01-09
JP2017209118A (ja) 2017-11-30
US20160348080A1 (en) 2016-12-01
US20240117324A1 (en) 2024-04-11
CN105051189A (zh) 2015-11-11
KR20150105471A (ko) 2015-09-16
CN105051189B (zh) 2019-08-06
JP2016503663A (ja) 2016-02-08
US12173329B2 (en) 2024-12-24
US20150361454A1 (en) 2015-12-17
AU2017200596B2 (en) 2019-01-24
KR102082247B1 (ko) 2020-02-28
JP6063585B2 (ja) 2017-01-18
EP3385375B1 (en) 2021-06-16
US9873865B2 (en) 2018-01-23
AU2017200596A1 (en) 2017-02-23
EP3103867A1 (en) 2016-12-14
JP2019141083A (ja) 2019-08-29
EP2946009B1 (en) 2016-07-27
JP6926143B2 (ja) 2021-08-25
US9683219B2 (en) 2017-06-20
JP2021006067A (ja) 2021-01-21
KR101746040B1 (ko) 2017-06-13
MX2015009138A (es) 2015-11-06
AU2014207522A1 (en) 2015-05-07
JP6211162B2 (ja) 2017-10-11
MY167434A (en) 2018-08-28
EP2946009A2 (en) 2015-11-25
CN109897834A (zh) 2019-06-18
CO7461134A2 (es) 2015-11-30
AU2019202790A1 (en) 2019-05-16
US10208294B2 (en) 2019-02-19
WO2014113571A3 (en) 2014-11-13
CA2898317A1 (en) 2014-07-24
JP7094343B2 (ja) 2022-07-01
EP3385375A1 (en) 2018-10-10
US20220090028A1 (en) 2022-03-24
US20170342388A1 (en) 2017-11-30
US11130944B2 (en) 2021-09-28
BR112015017005A2 (pt) 2017-08-15
KR102265148B1 (ko) 2021-06-15

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Applicant before: REG Life Sciences, LLC

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Application publication date: 20191029

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