JP2015512645A5 - - Google Patents
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- Publication number
- JP2015512645A5 JP2015512645A5 JP2015504688A JP2015504688A JP2015512645A5 JP 2015512645 A5 JP2015512645 A5 JP 2015512645A5 JP 2015504688 A JP2015504688 A JP 2015504688A JP 2015504688 A JP2015504688 A JP 2015504688A JP 2015512645 A5 JP2015512645 A5 JP 2015512645A5
- Authority
- JP
- Japan
- Prior art keywords
- mutant
- polypeptide
- car
- fatty alcohol
- host cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 73
- 102000004196 processed proteins & peptides Human genes 0.000 claims 73
- 108090000765 processed proteins & peptides Proteins 0.000 claims 73
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 42
- 230000035772 mutation Effects 0.000 claims 31
- 102220534644 Protein quaking_E20R_mutation Human genes 0.000 claims 28
- 102220289826 rs1555407420 Human genes 0.000 claims 24
- 150000002191 fatty alcohols Chemical class 0.000 claims 23
- 238000004113 cell culture Methods 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 239000002609 medium Substances 0.000 claims 3
- 108010053754 Aldehyde reductase Proteins 0.000 claims 2
- 102100027265 Aldo-keto reductase family 1 member B1 Human genes 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 108030002325 Carboxylate reductases Proteins 0.000 claims 1
- 102000005488 Thioesterase Human genes 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 150000002192 fatty aldehydes Chemical class 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 102220242995 rs1555187010 Human genes 0.000 claims 1
- 102220017029 rs187218889 Human genes 0.000 claims 1
- 102220075807 rs202025584 Human genes 0.000 claims 1
- 102220095963 rs758112386 Human genes 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 108020002982 thioesterase Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261619309P | 2012-04-02 | 2012-04-02 | |
| US61/619,309 | 2012-04-02 | ||
| PCT/US2013/035040 WO2013152052A2 (en) | 2012-04-02 | 2013-04-02 | Novel car enzymes and improved production of fatty alcohols |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015512645A JP2015512645A (ja) | 2015-04-30 |
| JP2015512645A5 true JP2015512645A5 (enExample) | 2016-09-29 |
| JP6230594B2 JP6230594B2 (ja) | 2017-11-15 |
Family
ID=49237582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015504688A Active JP6230594B2 (ja) | 2012-04-02 | 2013-04-02 | Ｃａｒ酵素、および改良された脂肪アルコール産生方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US9340801B2 (enExample) |
| EP (6) | EP3674399B1 (enExample) |
| JP (1) | JP6230594B2 (enExample) |
| KR (6) | KR101831331B1 (enExample) |
| CN (1) | CN104704113B (enExample) |
| AU (2) | AU2013243602B2 (enExample) |
| BR (2) | BR112014024674B1 (enExample) |
| CA (1) | CA2883064A1 (enExample) |
| CO (1) | CO7170148A2 (enExample) |
| ES (3) | ES2786633T3 (enExample) |
| MX (2) | MX343296B (enExample) |
| MY (1) | MY170889A (enExample) |
| SI (1) | SI3385374T1 (enExample) |
| WO (1) | WO2013152052A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2796559B1 (en) * | 2008-10-28 | 2018-09-12 | REG Life Sciences, LLC | Microbial cell for producing fatty alcohols |
| ES2786633T3 (es) * | 2012-04-02 | 2020-10-13 | Genomatica Inc | Enzimas CAR y producción mejorada de alcoholes grasos |
| BR122019026142B1 (pt) * | 2012-04-02 | 2021-12-14 | Genomatica, Inc | Célula hospedeira recombinante |
| BR112015002940A2 (pt) | 2012-08-10 | 2018-04-24 | Opx Biotechnologies Inc | microorganismos e métodos para a produção de ácidos graxos e produtos derivados de ácidos graxos. |
| US9447438B2 (en) | 2013-03-15 | 2016-09-20 | Cargill, Incorporated | Acetyl-coA carboxylases |
| WO2014145343A1 (en) * | 2013-03-15 | 2014-09-18 | Opx Biotechnologies, Inc. | Bioproduction of chemicals |
| WO2015010103A2 (en) | 2013-07-19 | 2015-01-22 | Opx Biotechnologies, Inc. | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| CN106574238B (zh) * | 2014-07-18 | 2021-09-21 | 基因组股份公司 | 微生物的脂肪二醇产生 |
| EP2993228B1 (en) | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Production of fatty acid esters |
| CN105985987B (zh) * | 2015-03-02 | 2020-01-31 | 苏州安捷生物科技有限公司 | 一种生物法制备脂肪醇的方法 |
| EP3430133A1 (en) * | 2016-03-17 | 2019-01-23 | INVISTA Textiles (U.K.) Limited | Carboxylic acid reductase polypeptides and variants having improved activity, materials and processes relating thereto |
| CN110494566A (zh) | 2017-02-02 | 2019-11-22 | 嘉吉公司 | 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞 |
| KR102677413B1 (ko) | 2017-04-03 | 2024-06-24 | 게노마티카 인코포레이티드 | 중쇄 지방산 유도체의 생산을 위해 개선된 활성을 갖는 티오에스테라제 변이체 |
| EP3844179A4 (en) | 2018-08-31 | 2022-08-31 | Genomatica, Inc. | XYLR MUTANT FOR IMPROVED XYLOSE UTILIZATION OR IMPROVED CO-UTILIZATION OF GLUCOSE AND XYLOSE |
| WO2020047088A1 (en) | 2018-08-31 | 2020-03-05 | Genomatica, Inc. | Production of non-native monounsaturated fatty acids in bacteria |
| WO2022209763A1 (ja) | 2021-03-30 | 2022-10-06 | 旭化成株式会社 | カルボン酸還元活性を有する組換えポリペプチド |
| WO2023178193A1 (en) | 2022-03-16 | 2023-09-21 | Genomatica, Inc. | Acyl-acp thioesterase variants and uses thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5482846A (en) | 1988-08-31 | 1996-01-09 | University Of Florida | Ethanol production in Gram-positive microbes |
| US5000000A (en) | 1988-08-31 | 1991-03-19 | University Of Florida | Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes |
| US5424202A (en) | 1988-08-31 | 1995-06-13 | The University Of Florida | Ethanol production by recombinant hosts |
| US5028539A (en) | 1988-08-31 | 1991-07-02 | The University Of Florida | Ethanol production using engineered mutant E. coli |
| AU7791991A (en) | 1990-04-24 | 1991-11-11 | Stratagene | Methods for phenotype creation from multiple gene populations |
| US5602030A (en) | 1994-03-28 | 1997-02-11 | University Of Florida Research Foundation | Recombinant glucose uptake system |
| US6428767B1 (en) | 1995-05-12 | 2002-08-06 | E. I. Du Pont De Nemours And Company | Method for identifying the source of carbon in 1,3-propanediol |
| US5965408A (en) | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
| US5939250A (en) | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
| US7056714B2 (en) * | 2003-03-11 | 2006-06-06 | University Of Iowa Research Foundation, Inc. | Carboxylic acid reductase polypeptide, nucleotide sequence encoding same and methods of use |
| DE102004052115A1 (de) | 2004-10-26 | 2006-04-27 | Westfälische Wilhelms-Universität Münster | Mikroorganismen zur Herstellung von Fettsäureestern, Verfahren zu deren Herstellung und deren Verwendung |
| JP5933909B2 (ja) | 2006-05-19 | 2016-06-15 | アールイージー ライフ サイエンシズ リミテッド ライアビリティ カンパニー | 脂肪酸およびその誘導体の生産 |
| CA3178593A1 (en) | 2007-03-28 | 2008-10-02 | Genomatica, Inc. | Enhanced production of fatty acid derivatives |
| BRPI0813359A2 (pt) | 2007-05-22 | 2014-10-14 | Ls9 Inc | Ácidos nucleicos isolados, vetor, células, métodos para produzir um hidrocarboneto, para produzir uma cetona alifática, para produzir um polipeptídeo purificado, para produzir um hidrocarboneto, para produzir biocombustíveis, hidrocarboneto, biocombustível, polipeptídeo isolado, ácido nucleico isolado, organismos geneticamente engenheirados, método para identificar uma enzima útil para a produção de hidrocarbonetos |
| TWI351779B (en) | 2007-12-03 | 2011-11-01 | Advance Smart Ind Ltd | Apparatus and method for correcting residual capac |
| US8183028B2 (en) | 2007-12-21 | 2012-05-22 | Ls9, Inc. | Methods and compositions for producing olefins |
| MX2011003597A (es) | 2008-10-07 | 2011-06-20 | Ls9 Inc | Metodos y composiciones para producir aldehidos grasos. |
| EP2796559B1 (en) | 2008-10-28 | 2018-09-12 | REG Life Sciences, LLC | Microbial cell for producing fatty alcohols |
| CN110129296A (zh) * | 2008-12-23 | 2019-08-16 | Reg生命科学有限责任公司 | 硫酯酶相关的方法和组合物 |
| EP2424989A2 (en) | 2009-05-01 | 2012-03-07 | The Regents of The University of California | Product of fatty acid esters from biomass polymers |
| WO2010135624A2 (en) * | 2009-05-22 | 2010-11-25 | Codexis, Inc. | Engineered biosynthesis of fatty alcohols |
| AU2010306785B2 (en) * | 2009-10-13 | 2016-01-14 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA, putrescine and related compounds, and methods related thereto |
| WO2011100667A1 (en) | 2010-02-14 | 2011-08-18 | Ls9, Inc. | Surfactant and cleaning compositions comprising microbially produced branched fatty alcohols |
| AR084377A1 (es) | 2010-04-08 | 2013-05-15 | Ls9 Inc | Metodos y composiciones relacionados con enzimas de alcohol graso biosintetico |
| RU2013148813A (ru) * | 2011-04-01 | 2015-06-10 | Дженоматика, Инк. | Микроорганизмы для получения метакриловой кислоты и сложные эфиры метакриловой кислоты и относящиеся к ним способы |
| WO2012154329A1 (en) * | 2011-04-01 | 2012-11-15 | Ls9, Inc. | Methods and compositions for improved production of fatty acids and derivatives thereof |
| US8617862B2 (en) * | 2011-06-22 | 2013-12-31 | Genomatica, Inc. | Microorganisms for producing propylene and methods related thereto |
| ES2786633T3 (es) * | 2012-04-02 | 2020-10-13 | Genomatica Inc | Enzimas CAR y producción mejorada de alcoholes grasos |
-
2013
- 2013-04-02 ES ES18160746T patent/ES2786633T3/es active Active
- 2013-04-02 MY MYPI2014002838A patent/MY170889A/en unknown
- 2013-04-02 ES ES16198810.0T patent/ES2666157T3/es active Active
- 2013-04-02 KR KR1020147030704A patent/KR101831331B1/ko active Active
- 2013-04-02 WO PCT/US2013/035040 patent/WO2013152052A2/en not_active Ceased
- 2013-04-02 SI SI201331706T patent/SI3385374T1/sl unknown
- 2013-04-02 EP EP19212944.3A patent/EP3674399B1/en active Active
- 2013-04-02 MX MX2014011903A patent/MX343296B/es active IP Right Grant
- 2013-04-02 ES ES13766728.3T patent/ES2613553T3/es active Active
- 2013-04-02 KR KR1020217023277A patent/KR20210095226A/ko not_active Ceased
- 2013-04-02 KR KR1020197017717A patent/KR102185762B1/ko not_active Expired - Fee Related
- 2013-04-02 JP JP2015504688A patent/JP6230594B2/ja active Active
- 2013-04-02 KR KR1020197005741A patent/KR102114841B1/ko not_active Expired - Fee Related
- 2013-04-02 AU AU2013243602A patent/AU2013243602B2/en not_active Ceased
- 2013-04-02 EP EP21191034.4A patent/EP3985108A1/en not_active Withdrawn
- 2013-04-02 EP EP18160746.6A patent/EP3385374B1/en active Active
- 2013-04-02 MX MX2016013852A patent/MX358177B/es unknown
- 2013-04-02 BR BR112014024674-2A patent/BR112014024674B1/pt not_active IP Right Cessation
- 2013-04-02 CN CN201380026546.8A patent/CN104704113B/zh active Active
- 2013-04-02 CA CA2883064A patent/CA2883064A1/en active Pending
- 2013-04-02 KR KR1020177026945A patent/KR20170113710A/ko not_active Ceased
- 2013-04-02 EP EP13766728.3A patent/EP2834350B1/en active Active
- 2013-04-02 US US14/390,350 patent/US9340801B2/en active Active
- 2013-04-02 KR KR1020207009760A patent/KR102282677B1/ko not_active Expired - Fee Related
- 2013-04-02 BR BR122019026987-4A patent/BR122019026987B1/pt active IP Right Grant
- 2013-04-02 EP EP22202380.6A patent/EP4186974A1/en active Pending
- 2013-04-02 EP EP16198810.0A patent/EP3153579B1/en not_active Not-in-force
-
2014
- 2014-10-29 CO CO14240039A patent/CO7170148A2/es unknown
-
2016
- 2016-05-13 US US15/154,636 patent/US9758769B2/en active Active
- 2016-09-20 AU AU2016231497A patent/AU2016231497B2/en not_active Ceased
-
2017
- 2017-09-05 US US15/695,205 patent/US10301603B2/en active Active
-
2019
- 2019-05-16 US US16/414,550 patent/US11034937B2/en active Active
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