AU2013243602B2 - Car enzymes and improved production of fatty alcohols - Google Patents

Car enzymes and improved production of fatty alcohols Download PDF

Info

Publication number
AU2013243602B2
AU2013243602B2 AU2013243602A AU2013243602A AU2013243602B2 AU 2013243602 B2 AU2013243602 B2 AU 2013243602B2 AU 2013243602 A AU2013243602 A AU 2013243602A AU 2013243602 A AU2013243602 A AU 2013243602A AU 2013243602 B2 AU2013243602 B2 AU 2013243602B2
Authority
AU
Australia
Prior art keywords
mutations
fatty
host cell
fatty alcohol
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013243602A
Other languages
English (en)
Other versions
AU2013243602A1 (en
Inventor
Vikranth Arlagadda
Elizabeth J. CLARKE
Derek L. Greenfield
Eli S. GROBAN
Zhihao Hu
Sungwon Lee
Xuezhi LI
Baolong Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genomatica Inc
Original Assignee
Genomatica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genomatica Inc filed Critical Genomatica Inc
Publication of AU2013243602A1 publication Critical patent/AU2013243602A1/en
Assigned to REG Life Sciences, LLC reassignment REG Life Sciences, LLC Request for Assignment Assignors: ARLAGADDA, VIKRANTH, CLARKE, ELIZABETH, GREENFIELD, DEREK, GROBAN, ELI, HU, ZHIHAO, LEE, SUNGWON, LI, Xuezhi, REG Life Sciences, LLC, ZHU, BAOLONG
Priority to AU2016231497A priority Critical patent/AU2016231497B2/en
Application granted granted Critical
Publication of AU2013243602B2 publication Critical patent/AU2013243602B2/en
Assigned to GENOMATICA, INC. reassignment GENOMATICA, INC. Request for Assignment Assignors: REG Life Sciences, LLC
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0008Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y102/00Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/0105Long-chain-fatty-acyl-CoA reductase (1.2.1.50)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y102/00Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/99Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with other acceptors (1.2.99)
    • C12Y102/99006Carboxylate reductase (1.2.99.6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y203/00Acyltransferases (2.3)
    • C12Y203/01Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01041Beta-ketoacyl-acyl-carrier-protein synthase I (2.3.1.41)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/02Thioester hydrolases (3.1.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P2203/00Fermentation products obtained from optionally pretreated or hydrolyzed cellulosic or lignocellulosic material as the carbon source
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409Fatty acids
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02EREDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00Technologies for the production of fuel of non-fossil origin
    • Y02E50/10Biofuels, e.g. bio-diesel
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/52Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2013243602A 2012-04-02 2013-04-02 Car enzymes and improved production of fatty alcohols Ceased AU2013243602B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2016231497A AU2016231497B2 (en) 2012-04-02 2016-09-20 Novel car enzymes and improved production of fatty alcohols

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261619309P 2012-04-02 2012-04-02
US61/619,309 2012-04-02
PCT/US2013/035040 WO2013152052A2 (en) 2012-04-02 2013-04-02 Novel car enzymes and improved production of fatty alcohols

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2016231497A Division AU2016231497B2 (en) 2012-04-02 2016-09-20 Novel car enzymes and improved production of fatty alcohols

Publications (2)

Publication Number Publication Date
AU2013243602A1 AU2013243602A1 (en) 2014-11-13
AU2013243602B2 true AU2013243602B2 (en) 2016-11-24

Family

ID=49237582

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2013243602A Ceased AU2013243602B2 (en) 2012-04-02 2013-04-02 Car enzymes and improved production of fatty alcohols
AU2016231497A Ceased AU2016231497B2 (en) 2012-04-02 2016-09-20 Novel car enzymes and improved production of fatty alcohols

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2016231497A Ceased AU2016231497B2 (en) 2012-04-02 2016-09-20 Novel car enzymes and improved production of fatty alcohols

Country Status (14)

Country Link
US (4) US9340801B2 (enExample)
EP (6) EP3674399B1 (enExample)
JP (1) JP6230594B2 (enExample)
KR (6) KR101831331B1 (enExample)
CN (1) CN104704113B (enExample)
AU (2) AU2013243602B2 (enExample)
BR (2) BR112014024674B1 (enExample)
CA (1) CA2883064A1 (enExample)
CO (1) CO7170148A2 (enExample)
ES (3) ES2786633T3 (enExample)
MX (2) MX343296B (enExample)
MY (1) MY170889A (enExample)
SI (1) SI3385374T1 (enExample)
WO (1) WO2013152052A2 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2796559B1 (en) * 2008-10-28 2018-09-12 REG Life Sciences, LLC Microbial cell for producing fatty alcohols
ES2786633T3 (es) * 2012-04-02 2020-10-13 Genomatica Inc Enzimas CAR y producción mejorada de alcoholes grasos
BR122019026142B1 (pt) * 2012-04-02 2021-12-14 Genomatica, Inc Célula hospedeira recombinante
BR112015002940A2 (pt) 2012-08-10 2018-04-24 Opx Biotechnologies Inc microorganismos e métodos para a produção de ácidos graxos e produtos derivados de ácidos graxos.
US9447438B2 (en) 2013-03-15 2016-09-20 Cargill, Incorporated Acetyl-coA carboxylases
WO2014145343A1 (en) * 2013-03-15 2014-09-18 Opx Biotechnologies, Inc. Bioproduction of chemicals
WO2015010103A2 (en) 2013-07-19 2015-01-22 Opx Biotechnologies, Inc. Microorganisms and methods for the production of fatty acids and fatty acid derived products
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
CN106574238B (zh) * 2014-07-18 2021-09-21 基因组股份公司 微生物的脂肪二醇产生
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
CN105985987B (zh) * 2015-03-02 2020-01-31 苏州安捷生物科技有限公司 一种生物法制备脂肪醇的方法
EP3430133A1 (en) * 2016-03-17 2019-01-23 INVISTA Textiles (U.K.) Limited Carboxylic acid reductase polypeptides and variants having improved activity, materials and processes relating thereto
CN110494566A (zh) 2017-02-02 2019-11-22 嘉吉公司 产生c6-c10脂肪酸衍生物的经遗传修饰的细胞
KR102677413B1 (ko) 2017-04-03 2024-06-24 게노마티카 인코포레이티드 중쇄 지방산 유도체의 생산을 위해 개선된 활성을 갖는 티오에스테라제 변이체
EP3844179A4 (en) 2018-08-31 2022-08-31 Genomatica, Inc. XYLR MUTANT FOR IMPROVED XYLOSE UTILIZATION OR IMPROVED CO-UTILIZATION OF GLUCOSE AND XYLOSE
WO2020047088A1 (en) 2018-08-31 2020-03-05 Genomatica, Inc. Production of non-native monounsaturated fatty acids in bacteria
WO2022209763A1 (ja) 2021-03-30 2022-10-06 旭化成株式会社 カルボン酸還元活性を有する組換えポリペプチド
WO2023178193A1 (en) 2022-03-16 2023-09-21 Genomatica, Inc. Acyl-acp thioesterase variants and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100105963A1 (en) * 2008-10-28 2010-04-29 Ls9, Inc. Methods and compositions for producing fatty alcohols

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5482846A (en) 1988-08-31 1996-01-09 University Of Florida Ethanol production in Gram-positive microbes
US5000000A (en) 1988-08-31 1991-03-19 University Of Florida Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes
US5424202A (en) 1988-08-31 1995-06-13 The University Of Florida Ethanol production by recombinant hosts
US5028539A (en) 1988-08-31 1991-07-02 The University Of Florida Ethanol production using engineered mutant E. coli
AU7791991A (en) 1990-04-24 1991-11-11 Stratagene Methods for phenotype creation from multiple gene populations
US5602030A (en) 1994-03-28 1997-02-11 University Of Florida Research Foundation Recombinant glucose uptake system
US6428767B1 (en) 1995-05-12 2002-08-06 E. I. Du Pont De Nemours And Company Method for identifying the source of carbon in 1,3-propanediol
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
US5939250A (en) 1995-12-07 1999-08-17 Diversa Corporation Production of enzymes having desired activities by mutagenesis
US7056714B2 (en) * 2003-03-11 2006-06-06 University Of Iowa Research Foundation, Inc. Carboxylic acid reductase polypeptide, nucleotide sequence encoding same and methods of use
DE102004052115A1 (de) 2004-10-26 2006-04-27 Westfälische Wilhelms-Universität Münster Mikroorganismen zur Herstellung von Fettsäureestern, Verfahren zu deren Herstellung und deren Verwendung
JP5933909B2 (ja) 2006-05-19 2016-06-15 アールイージー ライフ サイエンシズ リミテッド ライアビリティ カンパニー 脂肪酸およびその誘導体の生産
CA3178593A1 (en) 2007-03-28 2008-10-02 Genomatica, Inc. Enhanced production of fatty acid derivatives
BRPI0813359A2 (pt) 2007-05-22 2014-10-14 Ls9 Inc Ácidos nucleicos isolados, vetor, células, métodos para produzir um hidrocarboneto, para produzir uma cetona alifática, para produzir um polipeptídeo purificado, para produzir um hidrocarboneto, para produzir biocombustíveis, hidrocarboneto, biocombustível, polipeptídeo isolado, ácido nucleico isolado, organismos geneticamente engenheirados, método para identificar uma enzima útil para a produção de hidrocarbonetos
TWI351779B (en) 2007-12-03 2011-11-01 Advance Smart Ind Ltd Apparatus and method for correcting residual capac
US8183028B2 (en) 2007-12-21 2012-05-22 Ls9, Inc. Methods and compositions for producing olefins
MX2011003597A (es) 2008-10-07 2011-06-20 Ls9 Inc Metodos y composiciones para producir aldehidos grasos.
CN110129296A (zh) * 2008-12-23 2019-08-16 Reg生命科学有限责任公司 硫酯酶相关的方法和组合物
EP2424989A2 (en) 2009-05-01 2012-03-07 The Regents of The University of California Product of fatty acid esters from biomass polymers
WO2010135624A2 (en) * 2009-05-22 2010-11-25 Codexis, Inc. Engineered biosynthesis of fatty alcohols
AU2010306785B2 (en) * 2009-10-13 2016-01-14 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA, putrescine and related compounds, and methods related thereto
WO2011100667A1 (en) 2010-02-14 2011-08-18 Ls9, Inc. Surfactant and cleaning compositions comprising microbially produced branched fatty alcohols
AR084377A1 (es) 2010-04-08 2013-05-15 Ls9 Inc Metodos y composiciones relacionados con enzimas de alcohol graso biosintetico
RU2013148813A (ru) * 2011-04-01 2015-06-10 Дженоматика, Инк. Микроорганизмы для получения метакриловой кислоты и сложные эфиры метакриловой кислоты и относящиеся к ним способы
WO2012154329A1 (en) * 2011-04-01 2012-11-15 Ls9, Inc. Methods and compositions for improved production of fatty acids and derivatives thereof
US8617862B2 (en) * 2011-06-22 2013-12-31 Genomatica, Inc. Microorganisms for producing propylene and methods related thereto
ES2786633T3 (es) * 2012-04-02 2020-10-13 Genomatica Inc Enzimas CAR y producción mejorada de alcoholes grasos

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100105963A1 (en) * 2008-10-28 2010-04-29 Ls9, Inc. Methods and compositions for producing fatty alcohols

Also Published As

Publication number Publication date
MX2014011903A (es) 2015-05-12
KR20190022935A (ko) 2019-03-06
EP3385374A1 (en) 2018-10-10
CA2883064A1 (en) 2013-10-10
SI3385374T1 (sl) 2020-09-30
KR102114841B1 (ko) 2020-05-26
JP6230594B2 (ja) 2017-11-15
KR102185762B1 (ko) 2020-12-02
BR112014024674A2 (pt) 2018-11-21
EP3985108A1 (en) 2022-04-20
KR20150032660A (ko) 2015-03-27
EP3153579A1 (en) 2017-04-12
KR101831331B1 (ko) 2018-02-23
US9758769B2 (en) 2017-09-12
MY170889A (en) 2019-09-12
BR112014024674B1 (pt) 2022-06-07
KR102282677B1 (ko) 2021-07-28
EP2834350A2 (en) 2015-02-11
ES2786633T3 (es) 2020-10-13
KR20200038559A (ko) 2020-04-13
AU2016231497A1 (en) 2016-10-06
EP3153579B1 (en) 2018-03-14
US20200109374A1 (en) 2020-04-09
EP3385374B1 (en) 2020-01-08
WO2013152052A3 (en) 2014-03-13
AU2016231497B2 (en) 2017-08-31
BR122019026987B1 (pt) 2022-01-18
KR20190076059A (ko) 2019-07-01
US20180135028A1 (en) 2018-05-17
JP2015512645A (ja) 2015-04-30
EP4186974A1 (en) 2023-05-31
EP2834350B1 (en) 2016-11-16
KR20170113710A (ko) 2017-10-12
MX343296B (es) 2016-11-01
US10301603B2 (en) 2019-05-28
ES2613553T3 (es) 2017-05-24
AU2013243602A1 (en) 2014-11-13
US9340801B2 (en) 2016-05-17
EP3674399A1 (en) 2020-07-01
WO2013152052A2 (en) 2013-10-10
KR20210095226A (ko) 2021-07-30
US20150064757A1 (en) 2015-03-05
MX358177B (es) 2018-08-08
US11034937B2 (en) 2021-06-15
US20160326499A1 (en) 2016-11-10
CN104704113B (zh) 2018-01-23
EP3674399B1 (en) 2021-09-22
ES2666157T3 (es) 2018-05-03
CN104704113A (zh) 2015-06-10
CO7170148A2 (es) 2015-01-28

Similar Documents

Publication Publication Date Title
US11034937B2 (en) Car enzymes and improved production of fatty alcohols
US20240150774A1 (en) Production of fatty acid derivatives
AU2016225853A1 (en) Methods and compositions related to thioesterase enzymes
AU2019202790A1 (en) Acyl-ACP reductase with improved properties
EP2931742A2 (en) Acp-mediated production of fatty acid derivatives

Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: REG LIFE SCIENCES, LLC

Free format text: FORMER APPLICANT(S): HU, ZHIHAO; GREENFIELD, DEREK; CLARKE, ELIZABETH; LEE, SUNGWON; ZHU, BAOLONG; LI, XUEZHI; GROBAN, ELI; REG LIFE SCIENCES, LLC; ARLAGADDA, VIKRANTH

FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: GENOMATICA, INC.

Free format text: FORMER OWNER(S): REG LIFE SCIENCES, LLC

MK14 Patent ceased section 143(a) (annual fees not paid) or expired