AU2013243602B2 - Car enzymes and improved production of fatty alcohols - Google Patents

Car enzymes and improved production of fatty alcohols Download PDF

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Publication number
AU2013243602B2
AU2013243602B2 AU2013243602A AU2013243602A AU2013243602B2 AU 2013243602 B2 AU2013243602 B2 AU 2013243602B2 AU 2013243602 A AU2013243602 A AU 2013243602A AU 2013243602 A AU2013243602 A AU 2013243602A AU 2013243602 B2 AU2013243602 B2 AU 2013243602B2
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AU
Australia
Prior art keywords
mutations
fatty
host cell
fatty alcohol
polypeptide
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Ceased
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AU2013243602A
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AU2013243602A1 (en
Inventor
Vikranth Arlagadda
Elizabeth J. CLARKE
Derek L. Greenfield
Eli S. GROBAN
Zhihao Hu
Sungwon Lee
Xuezhi LI
Baolong Zhu
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Genomatica Inc
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Genomatica Inc
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Assigned to REG Life Sciences, LLC reassignment REG Life Sciences, LLC Request for Assignment Assignors: ARLAGADDA, VIKRANTH, CLARKE, ELIZABETH, GREENFIELD, DEREK, GROBAN, ELI, HU, ZHIHAO, LEE, SUNGWON, LI, Xuezhi, REG Life Sciences, LLC, ZHU, BAOLONG
Priority to AU2016231497A priority Critical patent/AU2016231497B2/en
Application granted granted Critical
Publication of AU2013243602B2 publication Critical patent/AU2013243602B2/en
Assigned to GENOMATICA, INC. reassignment GENOMATICA, INC. Request for Assignment Assignors: REG Life Sciences, LLC
Ceased legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/0105—Long-chain-fatty-acyl-CoA reductase (1.2.1.50)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/99—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with other acceptors (1.2.99)
    • C12Y102/99006—Carboxylate reductase (1.2.99.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01041—Beta-ketoacyl-acyl-carrier-protein synthase I (2.3.1.41)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P2203/00—Fermentation products obtained from optionally pretreated or hydrolyzed cellulosic or lignocellulosic material as the carbon source
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2013243602A 2012-04-02 2013-04-02 Car enzymes and improved production of fatty alcohols Ceased AU2013243602B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2016231497A AU2016231497B2 (en) 2012-04-02 2016-09-20 Novel car enzymes and improved production of fatty alcohols

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261619309P 2012-04-02 2012-04-02
US61/619,309 2012-04-02
PCT/US2013/035040 WO2013152052A2 (en) 2012-04-02 2013-04-02 Novel car enzymes and improved production of fatty alcohols

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2016231497A Division AU2016231497B2 (en) 2012-04-02 2016-09-20 Novel car enzymes and improved production of fatty alcohols

Publications (2)

Publication Number Publication Date
AU2013243602A1 AU2013243602A1 (en) 2014-11-13
AU2013243602B2 true AU2013243602B2 (en) 2016-11-24

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
AU2013243602A Ceased AU2013243602B2 (en) 2012-04-02 2013-04-02 Car enzymes and improved production of fatty alcohols
AU2016231497A Ceased AU2016231497B2 (en) 2012-04-02 2016-09-20 Novel car enzymes and improved production of fatty alcohols

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2016231497A Ceased AU2016231497B2 (en) 2012-04-02 2016-09-20 Novel car enzymes and improved production of fatty alcohols

Country Status (14)

Country Link
US (4) US9340801B2 (enExample)
EP (6) EP4186974A1 (enExample)
JP (1) JP6230594B2 (enExample)
KR (6) KR102185762B1 (enExample)
CN (1) CN104704113B (enExample)
AU (2) AU2013243602B2 (enExample)
BR (2) BR112014024674B1 (enExample)
CA (1) CA2883064A1 (enExample)
CO (1) CO7170148A2 (enExample)
ES (3) ES2666157T3 (enExample)
MX (2) MX358177B (enExample)
MY (1) MY170889A (enExample)
SI (1) SI3385374T1 (enExample)
WO (1) WO2013152052A2 (enExample)

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CN105154380B (zh) * 2008-10-28 2018-11-09 Reg生命科学有限责任公司 用于产生脂肪醇的方法和组合物
WO2013152052A2 (en) * 2012-04-02 2013-10-10 Ls9, Inc. Novel car enzymes and improved production of fatty alcohols
CA2883968C (en) * 2012-04-02 2022-08-23 REG Life Sciences, LLC Improved production of fatty acid derivatives
CN109182238A (zh) 2012-08-10 2019-01-11 嘉吉有限公司 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法
EP2970988A4 (en) * 2013-03-15 2016-12-07 Cargill Inc CONTROL OF PHASES OF GROWTH INDUCTION PRODUCTION
WO2014146026A1 (en) 2013-03-15 2014-09-18 Opx Biotechnologies, Inc. Bioproduction of chemicals
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
JP6603658B2 (ja) 2013-07-19 2019-11-06 カーギル インコーポレイテッド 脂肪酸及び脂肪酸誘導体の製造のための微生物及び方法
BR112017001105A2 (pt) * 2014-07-18 2018-07-24 REG Life Sciences, LLC produção microbiana de dióis graxos
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
CN105985987B (zh) * 2015-03-02 2020-01-31 苏州安捷生物科技有限公司 一种生物法制备脂肪醇的方法
EP3430133A1 (en) * 2016-03-17 2019-01-23 INVISTA Textiles (U.K.) Limited Carboxylic acid reductase polypeptides and variants having improved activity, materials and processes relating thereto
WO2018144701A2 (en) 2017-02-02 2018-08-09 Cargill Incorporated Genetically modified cells that produce c6-c10 fatty acid derivatives
CN111094558A (zh) 2017-04-03 2020-05-01 基因组股份公司 对产生中链脂肪酸衍生物具有改善的活性的硫酯酶变体
EP3844269A4 (en) 2018-08-31 2022-07-27 Genomatica, Inc. PRODUCTION OF NON-NATIVE MONOUNSATURATED FATTY ACIDS IN BACTERIA
US12098168B2 (en) 2018-08-31 2024-09-24 Genomatica, Inc. XylR mutant for improved xylose utilization or improved co-utilization of glucose and xylose preliminary
WO2022209763A1 (ja) 2021-03-30 2022-10-06 旭化成株式会社 カルボン酸還元活性を有する組換えポリペプチド
EP4493683A1 (en) 2022-03-16 2025-01-22 Genomatica, Inc. Acyl-acp thioesterase variants and uses thereof

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Also Published As

Publication number Publication date
JP6230594B2 (ja) 2017-11-15
MX343296B (es) 2016-11-01
EP3674399B1 (en) 2021-09-22
KR20210095226A (ko) 2021-07-30
JP2015512645A (ja) 2015-04-30
US9758769B2 (en) 2017-09-12
WO2013152052A2 (en) 2013-10-10
US20150064757A1 (en) 2015-03-05
EP4186974A1 (en) 2023-05-31
CN104704113B (zh) 2018-01-23
US10301603B2 (en) 2019-05-28
KR20190076059A (ko) 2019-07-01
US20160326499A1 (en) 2016-11-10
EP3985108A1 (en) 2022-04-20
US20200109374A1 (en) 2020-04-09
ES2613553T3 (es) 2017-05-24
KR20170113710A (ko) 2017-10-12
SI3385374T1 (sl) 2020-09-30
EP3674399A1 (en) 2020-07-01
AU2016231497A1 (en) 2016-10-06
ES2786633T3 (es) 2020-10-13
KR20190022935A (ko) 2019-03-06
MX2014011903A (es) 2015-05-12
CO7170148A2 (es) 2015-01-28
BR112014024674A2 (pt) 2018-11-21
KR102282677B1 (ko) 2021-07-28
BR122019026987B1 (pt) 2022-01-18
WO2013152052A3 (en) 2014-03-13
KR20150032660A (ko) 2015-03-27
US20180135028A1 (en) 2018-05-17
BR112014024674B1 (pt) 2022-06-07
KR102114841B1 (ko) 2020-05-26
EP2834350A2 (en) 2015-02-11
CA2883064A1 (en) 2013-10-10
EP3385374B1 (en) 2020-01-08
EP3153579A1 (en) 2017-04-12
EP2834350B1 (en) 2016-11-16
EP3153579B1 (en) 2018-03-14
ES2666157T3 (es) 2018-05-03
KR20200038559A (ko) 2020-04-13
US11034937B2 (en) 2021-06-15
MX358177B (es) 2018-08-08
AU2016231497B2 (en) 2017-08-31
KR101831331B1 (ko) 2018-02-23
EP3385374A1 (en) 2018-10-10
US9340801B2 (en) 2016-05-17
KR102185762B1 (ko) 2020-12-02
MY170889A (en) 2019-09-12
CN104704113A (zh) 2015-06-10
AU2013243602A1 (en) 2014-11-13

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Free format text: FORMER APPLICANT(S): HU, ZHIHAO; GREENFIELD, DEREK; CLARKE, ELIZABETH; LEE, SUNGWON; ZHU, BAOLONG; LI, XUEZHI; GROBAN, ELI; REG LIFE SCIENCES, LLC; ARLAGADDA, VIKRANTH

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