CO7170148A2 - Enzimas car novedosas y producción mejorada de alcoholes grasos - Google Patents
Enzimas car novedosas y producción mejorada de alcoholes grasosInfo
- Publication number
- CO7170148A2 CO7170148A2 CO14240039A CO14240039A CO7170148A2 CO 7170148 A2 CO7170148 A2 CO 7170148A2 CO 14240039 A CO14240039 A CO 14240039A CO 14240039 A CO14240039 A CO 14240039A CO 7170148 A2 CO7170148 A2 CO 7170148A2
- Authority
- CO
- Colombia
- Prior art keywords
- fatty alcohols
- improved production
- novel car
- car enzymes
- enzymes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/0105—Long-chain-fatty-acyl-CoA reductase (1.2.1.50)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/99—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with other acceptors (1.2.99)
- C12Y102/99006—Carboxylate reductase (1.2.99.6)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/01041—Beta-ketoacyl-acyl-carrier-protein synthase I (2.3.1.41)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/02—Thioester hydrolases (3.1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P2203/00—Fermentation products obtained from optionally pretreated or hydrolyzed cellulosic or lignocellulosic material as the carbon source
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La invención se refiere a enzimas variantes ácido carboxílico reductasa (CAR) para la producción mejorada de alcoholes grasos en células hospedadoras recombinantes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261619309P | 2012-04-02 | 2012-04-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO7170148A2 true CO7170148A2 (es) | 2015-01-28 |
Family
ID=49237582
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO14240039A CO7170148A2 (es) | 2012-04-02 | 2014-10-29 | Enzimas car novedosas y producción mejorada de alcoholes grasos |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US9340801B2 (es) |
| EP (6) | EP3674399B1 (es) |
| JP (1) | JP6230594B2 (es) |
| KR (6) | KR20210095226A (es) |
| CN (1) | CN104704113B (es) |
| AU (2) | AU2013243602B2 (es) |
| BR (2) | BR112014024674B1 (es) |
| CA (1) | CA2883064A1 (es) |
| CO (1) | CO7170148A2 (es) |
| ES (3) | ES2613553T3 (es) |
| MX (2) | MX343296B (es) |
| MY (1) | MY170889A (es) |
| SI (1) | SI3385374T1 (es) |
| WO (1) | WO2013152052A2 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3041892C (en) * | 2008-10-28 | 2022-03-15 | REG Life Sciences, LLC | Methods for producing a fatty alcohol in a host cell |
| EP3674399B1 (en) * | 2012-04-02 | 2021-09-22 | Genomatica, Inc. | Car enzymes and improved production of fatty alcohols |
| WO2013152051A2 (en) * | 2012-04-02 | 2013-10-10 | Ls9, Inc. | Improved production of fatty acid derivatives |
| US20140051136A1 (en) | 2012-08-10 | 2014-02-20 | Opx Biotechnologies, Inc. | Micoorganisms and Methods for the Production of Fatty Acids and Fatty Acid Derived Products |
| US10047383B2 (en) | 2013-03-15 | 2018-08-14 | Cargill, Incorporated | Bioproduction of chemicals |
| WO2014145332A1 (en) * | 2013-03-15 | 2014-09-18 | Opx Biotechnologies, Inc. | Monfunctional mcr + 3-hp dehydrogenase |
| US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| US10337038B2 (en) | 2013-07-19 | 2019-07-02 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| AU2015289430B2 (en) | 2014-07-18 | 2020-03-05 | Genomatica, Inc. | Microbial production of fatty diols |
| EP2993228B1 (en) | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Production of fatty acid esters |
| CN105985987B (zh) * | 2015-03-02 | 2020-01-31 | 苏州安捷生物科技有限公司 | 一种生物法制备脂肪醇的方法 |
| WO2017161112A1 (en) * | 2016-03-17 | 2017-09-21 | Invista Technologies S.A R.L. | Carboxylic acid reductase polypeptides and variants having improved activity, materials and processes relating thereto |
| JP2020506702A (ja) | 2017-02-02 | 2020-03-05 | カーギル インコーポレイテッド | Ｃ６−ｃ１０脂肪酸誘導体を生成する遺伝子組み換え細胞 |
| CA3058950A1 (en) | 2017-04-03 | 2018-10-11 | Genomatica, Inc. | Thioesterase variants having improved activity for the production of medium-chain fatty acid derivatives |
| WO2020047304A1 (en) | 2018-08-31 | 2020-03-05 | Genomatica, Inc. | Xylr mutant for improved xylose utilization or improved co-utilization of glucose and xylose |
| CN117120616A (zh) | 2021-03-30 | 2023-11-24 | 旭化成株式会社 | 具有羧酸还原活性的重组多肽 |
| WO2023178193A1 (en) | 2022-03-16 | 2023-09-21 | Genomatica, Inc. | Acyl-acp thioesterase variants and uses thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5028539A (en) | 1988-08-31 | 1991-07-02 | The University Of Florida | Ethanol production using engineered mutant E. coli |
| US5000000A (en) | 1988-08-31 | 1991-03-19 | University Of Florida | Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes |
| US5482846A (en) | 1988-08-31 | 1996-01-09 | University Of Florida | Ethanol production in Gram-positive microbes |
| US5424202A (en) | 1988-08-31 | 1995-06-13 | The University Of Florida | Ethanol production by recombinant hosts |
| WO1991016427A1 (en) | 1990-04-24 | 1991-10-31 | Stratagene | Methods for phenotype creation from multiple gene populations |
| US5602030A (en) | 1994-03-28 | 1997-02-11 | University Of Florida Research Foundation | Recombinant glucose uptake system |
| US6428767B1 (en) | 1995-05-12 | 2002-08-06 | E. I. Du Pont De Nemours And Company | Method for identifying the source of carbon in 1,3-propanediol |
| US5965408A (en) | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
| US5939250A (en) | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
| US7056714B2 (en) * | 2003-03-11 | 2006-06-06 | University Of Iowa Research Foundation, Inc. | Carboxylic acid reductase polypeptide, nucleotide sequence encoding same and methods of use |
| DE102004052115A1 (de) | 2004-10-26 | 2006-04-27 | Westfälische Wilhelms-Universität Münster | Mikroorganismen zur Herstellung von Fettsäureestern, Verfahren zu deren Herstellung und deren Verwendung |
| EP2024491B1 (en) | 2006-05-19 | 2014-11-19 | LS9, Inc. | Production of fatty acids and derivatives thereof |
| AU2008230735A1 (en) | 2007-03-28 | 2008-10-02 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| CN101809146B (zh) | 2007-05-22 | 2013-12-11 | Ls9公司 | 产烃基因及其使用方法 |
| TWI351779B (en) | 2007-12-03 | 2011-11-01 | Advance Smart Ind Ltd | Apparatus and method for correcting residual capac |
| WO2009085278A1 (en) | 2007-12-21 | 2009-07-09 | Ls9, Inc. | Methods and compositions for producing olefins |
| JP2012504963A (ja) | 2008-10-07 | 2012-03-01 | エルエス９・インコーポレイテッド | 脂肪アルデヒドを生産するための方法および組成物 |
| CA3041892C (en) | 2008-10-28 | 2022-03-15 | REG Life Sciences, LLC | Methods for producing a fatty alcohol in a host cell |
| AP2011005777A0 (en) | 2008-12-23 | 2011-08-31 | Ls9 Inc | Methods and compositions related to thioesterase enzymes. |
| WO2010127318A2 (en) | 2009-05-01 | 2010-11-04 | The Regents Of The University Of California | Product of fatty acid esters from biomass polymers |
| US20100298612A1 (en) | 2009-05-22 | 2010-11-25 | Codexis, Inc. | Engineered biosynthesis of fatty alcohols |
| JP2013507145A (ja) * | 2009-10-13 | 2013-03-04 | ゲノマチカ， インク． | １，４−ブタンジオール、４−ヒドロキシブタナール、４−ヒドロキシブチリル−ＣｏＡ、プトレシン及び関連化合物の生成のための微生物体並びに関連する方法 |
| US8859259B2 (en) | 2010-02-14 | 2014-10-14 | Ls9, Inc. | Surfactant and cleaning compositions comprising microbially produced branched fatty alcohols |
| US20110250663A1 (en) | 2010-04-08 | 2011-10-13 | Ls9, Inc. | Methods and compositions related to fatty alcohol biosynthetic enzymes |
| US9133487B2 (en) * | 2011-04-01 | 2015-09-15 | Genomatica, Inc. | Microorganisms for producing methacrylic acid and methacrylate esters and methods related thereto |
| ES2808287T3 (es) * | 2011-04-01 | 2021-02-26 | Genomatica Inc | Métodos y composiciones para la producción mejorada de ácidos grasos y derivados de los mismos |
| US8617862B2 (en) * | 2011-06-22 | 2013-12-31 | Genomatica, Inc. | Microorganisms for producing propylene and methods related thereto |
| EP3674399B1 (en) * | 2012-04-02 | 2021-09-22 | Genomatica, Inc. | Car enzymes and improved production of fatty alcohols |
-
2013
- 2013-04-02 EP EP19212944.3A patent/EP3674399B1/en active Active
- 2013-04-02 KR KR1020217023277A patent/KR20210095226A/ko not_active Application Discontinuation
- 2013-04-02 AU AU2013243602A patent/AU2013243602B2/en not_active Ceased
- 2013-04-02 US US14/390,350 patent/US9340801B2/en active Active
- 2013-04-02 KR KR1020177026945A patent/KR20170113710A/ko active Search and Examination
- 2013-04-02 MY MYPI2014002838A patent/MY170889A/en unknown
- 2013-04-02 SI SI201331706T patent/SI3385374T1/sl unknown
- 2013-04-02 KR KR1020197017717A patent/KR102185762B1/ko active IP Right Grant
- 2013-04-02 KR KR1020147030704A patent/KR101831331B1/ko active IP Right Grant
- 2013-04-02 ES ES13766728.3T patent/ES2613553T3/es active Active
- 2013-04-02 JP JP2015504688A patent/JP6230594B2/ja active Active
- 2013-04-02 WO PCT/US2013/035040 patent/WO2013152052A2/en active Application Filing
- 2013-04-02 BR BR112014024674-2A patent/BR112014024674B1/pt active Search and Examination
- 2013-04-02 CA CA2883064A patent/CA2883064A1/en active Pending
- 2013-04-02 MX MX2014011903A patent/MX343296B/es active IP Right Grant
- 2013-04-02 EP EP18160746.6A patent/EP3385374B1/en active Active
- 2013-04-02 KR KR1020197005741A patent/KR102114841B1/ko active IP Right Grant
- 2013-04-02 MX MX2016013852A patent/MX358177B/es unknown
- 2013-04-02 KR KR1020207009760A patent/KR102282677B1/ko active IP Right Grant
- 2013-04-02 EP EP21191034.4A patent/EP3985108A1/en not_active Withdrawn
- 2013-04-02 CN CN201380026546.8A patent/CN104704113B/zh active Active
- 2013-04-02 ES ES16198810.0T patent/ES2666157T3/es active Active
- 2013-04-02 EP EP13766728.3A patent/EP2834350B1/en active Active
- 2013-04-02 ES ES18160746T patent/ES2786633T3/es active Active
- 2013-04-02 EP EP16198810.0A patent/EP3153579B1/en active Active
- 2013-04-02 EP EP22202380.6A patent/EP4186974A1/en active Pending
- 2013-04-02 BR BR122019026987-4A patent/BR122019026987B1/pt active IP Right Grant
-
2014
- 2014-10-29 CO CO14240039A patent/CO7170148A2/es unknown
-
2016
- 2016-05-13 US US15/154,636 patent/US9758769B2/en active Active
- 2016-09-20 AU AU2016231497A patent/AU2016231497B2/en not_active Ceased
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2017
- 2017-09-05 US US15/695,205 patent/US10301603B2/en active Active
-
2019
- 2019-05-16 US US16/414,550 patent/US11034937B2/en active Active
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