JP2018537952A5 - - Google Patents
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- JP2018537952A5 JP2018537952A5 JP2018517191A JP2018517191A JP2018537952A5 JP 2018537952 A5 JP2018537952 A5 JP 2018537952A5 JP 2018517191 A JP2018517191 A JP 2018517191A JP 2018517191 A JP2018517191 A JP 2018517191A JP 2018537952 A5 JP2018537952 A5 JP 2018537952A5
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- JP
- Japan
- Prior art keywords
- composition
- oligonucleotides
- oligonucleotide
- pattern
- base sequence
- Prior art date
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- 108091034117 Oligonucleotide Proteins 0.000 claims 33
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 13
- 238000012986 modification Methods 0.000 claims 8
- 230000004048 modification Effects 0.000 claims 8
- 108010069091 Dystrophin Proteins 0.000 claims 7
- 238000000034 method Methods 0.000 claims 5
- 102000001039 Dystrophin Human genes 0.000 claims 3
- 238000004132 cross linking Methods 0.000 claims 3
- 108020004999 messenger RNA Proteins 0.000 claims 3
- 108700024394 Exon Proteins 0.000 claims 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- 239000011574 phosphorus Substances 0.000 claims 2
- 238000013518 transcription Methods 0.000 claims 2
- 230000035897 transcription Effects 0.000 claims 2
- YIMATHOGWXZHFX-WCTZXXKLSA-N (2r,3r,4r,5r)-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolane-2,4-diol Chemical compound COCCO[C@H]1[C@H](O)O[C@H](CO)[C@H]1O YIMATHOGWXZHFX-WCTZXXKLSA-N 0.000 claims 1
- 108020004705 Codon Proteins 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000037433 frameshift Effects 0.000 claims 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- 201000006938 muscular dystrophy Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022052547A JP7696310B2 (ja) | 2015-10-09 | 2022-03-28 | オリゴヌクレオチド組成物およびその方法 |
| JP2024207586A JP2025029016A (ja) | 2015-10-09 | 2024-11-28 | オリゴヌクレオチド組成物およびその方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562239839P | 2015-10-09 | 2015-10-09 | |
| US62/239,839 | 2015-10-09 | ||
| US201662331966P | 2016-05-04 | 2016-05-04 | |
| US201662331961P | 2016-05-04 | 2016-05-04 | |
| US62/331,961 | 2016-05-04 | ||
| US62/331,966 | 2016-05-04 | ||
| PCT/US2016/056123 WO2017062862A2 (en) | 2015-10-09 | 2016-10-07 | Oligonucleotide compositions and methods thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022052547A Division JP7696310B2 (ja) | 2015-10-09 | 2022-03-28 | オリゴヌクレオチド組成物およびその方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537952A JP2018537952A (ja) | 2018-12-27 |
| JP2018537952A5 true JP2018537952A5 (https=) | 2019-11-14 |
| JP7511326B2 JP7511326B2 (ja) | 2024-07-05 |
Family
ID=58488684
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018517191A Active JP7511326B2 (ja) | 2015-10-09 | 2016-10-07 | オリゴヌクレオチド組成物およびその方法 |
| JP2019518395A Pending JP2019530698A (ja) | 2015-10-09 | 2017-10-06 | オリゴヌクレオチド組成物およびその方法 |
| JP2022052547A Active JP7696310B2 (ja) | 2015-10-09 | 2022-03-28 | オリゴヌクレオチド組成物およびその方法 |
| JP2024207586A Pending JP2025029016A (ja) | 2015-10-09 | 2024-11-28 | オリゴヌクレオチド組成物およびその方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019518395A Pending JP2019530698A (ja) | 2015-10-09 | 2017-10-06 | オリゴヌクレオチド組成物およびその方法 |
| JP2022052547A Active JP7696310B2 (ja) | 2015-10-09 | 2022-03-28 | オリゴヌクレオチド組成物およびその方法 |
| JP2024207586A Pending JP2025029016A (ja) | 2015-10-09 | 2024-11-28 | オリゴヌクレオチド組成物およびその方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US20190127733A1 (https=) |
| EP (2) | EP3359523A4 (https=) |
| JP (4) | JP7511326B2 (https=) |
| KR (1) | KR102933365B1 (https=) |
| CN (3) | CN108137492B (https=) |
| AU (4) | AU2016334232B2 (https=) |
| BR (1) | BR112018006636B1 (https=) |
| CA (2) | CA2999772A1 (https=) |
| CL (1) | CL2018000818A1 (https=) |
| CO (1) | CO2018004758A2 (https=) |
| CR (1) | CR20180233A (https=) |
| EC (1) | ECSP18032914A (https=) |
| IL (2) | IL295755A (https=) |
| MA (2) | MA46427A (https=) |
| MX (2) | MX2018003992A (https=) |
| NI (1) | NI201800045A (https=) |
| PE (1) | PE20181353A1 (https=) |
| PH (1) | PH12018500719A1 (https=) |
| SG (1) | SG10201912902TA (https=) |
| SV (1) | SV2018005661A (https=) |
| TW (1) | TW201722439A (https=) |
| WO (2) | WO2017062862A2 (https=) |
Families Citing this family (134)
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| RU2740501C2 (ru) | 2017-02-21 | 2021-01-14 | Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) | МОДИФИЦИРОВАННЫЕ ОЛИГОНУКЛЕОТИДЫ, АКТИВИРУЮЩИЕ РНКазу Н |
| US11603532B2 (en) | 2017-06-02 | 2023-03-14 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| US11597927B2 (en) | 2017-06-02 | 2023-03-07 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| JP2020522265A (ja) | 2017-06-02 | 2020-07-30 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | オリゴヌクレオチド組成物及びその使用方法 |
| US11718638B2 (en) | 2017-06-21 | 2023-08-08 | Wave Life Sciences Ltd. | Compounds, compositions and methods for synthesis |
| WO2019002237A1 (en) | 2017-06-28 | 2019-01-03 | Roche Innovation Center Copenhagen A/S | METHOD OF MULTIPLE COUPLING AND OXIDATION |
| TW201920672A (zh) | 2017-08-08 | 2019-06-01 | 新加坡商波濤生命科學有限公司 | 寡核苷酸組合物及其使用方法 |
| CN111108096A (zh) | 2017-09-18 | 2020-05-05 | 波涛生命科学有限公司 | 寡核苷酸制备技术 |
| EP3694530A4 (en) | 2017-10-12 | 2021-06-30 | Wave Life Sciences Ltd. | COMPOSITIONS OF OLIGONUCLEOTIDES AND RELATED PROCESSES |
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