JP2018534265A - β−ニコチンアミドモノヌクレオチドの結晶形態 - Google Patents

β−ニコチンアミドモノヌクレオチドの結晶形態 Download PDF

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JP2018534265A
JP2018534265A JP2018516685A JP2018516685A JP2018534265A JP 2018534265 A JP2018534265 A JP 2018534265A JP 2018516685 A JP2018516685 A JP 2018516685A JP 2018516685 A JP2018516685 A JP 2018516685A JP 2018534265 A JP2018534265 A JP 2018534265A
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Prior art keywords
compound
nmn
crystalline compound
nad
certain embodiments
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Japanese (ja)
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カール，アンドリュー
フェルナンデス，フィリップ
リビングストン，デーヴィッド，ジェイ．
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メトロ インターナショナル バイオテック，エルエルシー
メトロ インターナショナル バイオテック，エルエルシー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP2018516685A 2015-10-02 2016-09-30 β−ニコチンアミドモノヌクレオチドの結晶形態 Pending JP2018534265A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562236657P 2015-10-02 2015-10-02
US62/236,657 2015-10-02
PCT/US2016/054776 WO2017059249A1 (en) 2015-10-02 2016-09-30 Crystal forms of beta-nicotinamide mononucleotide

Related Child Applications (1)

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JP2020205773A Division JP2021063081A (ja) 2015-10-02 2020-12-11 β−ニコチンアミドモノヌクレオチドの結晶形態

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JP2018534265A true JP2018534265A (ja) 2018-11-22

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JP2018516685A Pending JP2018534265A (ja) 2015-10-02 2016-09-30 β−ニコチンアミドモノヌクレオチドの結晶形態
JP2020205773A Pending JP2021063081A (ja) 2015-10-02 2020-12-11 β−ニコチンアミドモノヌクレオチドの結晶形態
JP2022131443A Pending JP2022176979A (ja) 2015-10-02 2022-08-22 β－ニコチンアミドモノヌクレオチドの結晶形態
JP2024111468A Pending JP2024161353A (ja) 2015-10-02 2024-07-11 β－ニコチンアミドモノヌクレオチドの結晶形態

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JP2020205773A Pending JP2021063081A (ja) 2015-10-02 2020-12-11 β−ニコチンアミドモノヌクレオチドの結晶形態
JP2022131443A Pending JP2022176979A (ja) 2015-10-02 2022-08-22 β－ニコチンアミドモノヌクレオチドの結晶形態
JP2024111468A Pending JP2024161353A (ja) 2015-10-02 2024-07-11 β－ニコチンアミドモノヌクレオチドの結晶形態

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US (6) US10392415B2 (https=)
EP (2) EP4272746A3 (https=)
JP (4) JP2018534265A (https=)
KR (1) KR102779733B1 (https=)
CN (1) CN108697722B (https=)
AU (1) AU2016331918B2 (https=)
BR (1) BR112018006243A2 (https=)
CA (1) CA3000744C (https=)
EA (1) EA037104B1 (https=)
GB (1) GB2542881B (https=)
IL (1) IL258276B (https=)
MX (1) MX390064B (https=)
WO (1) WO2017059249A1 (https=)
ZA (1) ZA201802657B (https=)

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JPWO2021192683A1 (https=) * 2020-03-27 2021-09-30
JPWO2021200545A1 (https=) * 2020-03-30 2021-10-07
JP2023001065A (ja) * 2021-06-18 2023-01-04 邦泰生物工程（深▲セン▼）有限公司 ニコチンアミドモノヌクレオチド－イソニコチノイド共結晶およびその組成物
JP2023001064A (ja) * 2021-06-18 2023-01-04 邦泰生物工程（深▲セン▼）有限公司 ニコチンアミドモノヌクレオチド共結晶を調製する方法
WO2025004768A1 (ja) * 2023-06-29 2025-01-02 株式会社カネカ 結晶性複合体、及びその製造方法、並びに組成物

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WO2016188091A1 (zh) * 2015-12-11 2016-12-01 邦泰生物工程(深圳)有限公司 烟酰胺单核苷酸在制备防治动脉硬化、心脑血管疾病的药物中的应用及其药物
WO2018047715A1 (ja) * 2016-09-06 2018-03-15 協和発酵バイオ株式会社 β－ニコチンアミドモノヌクレオチドの結晶及びその製造方法
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CN112694505A (zh) * 2020-12-30 2021-04-23 音芙医药科技(上海)有限公司 一种高密度的nmn的制备方法
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CN113912653B (zh) * 2021-06-04 2024-04-23 天津大学 一种提高β-烟酰胺单核苷酸结晶粉末松堆密度的方法
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