JP2018534265A - β−ニコチンアミドモノヌクレオチドの結晶形態 - Google Patents

β−ニコチンアミドモノヌクレオチドの結晶形態 Download PDF

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Publication number
JP2018534265A
JP2018534265A JP2018516685A JP2018516685A JP2018534265A JP 2018534265 A JP2018534265 A JP 2018534265A JP 2018516685 A JP2018516685 A JP 2018516685A JP 2018516685 A JP2018516685 A JP 2018516685A JP 2018534265 A JP2018534265 A JP 2018534265A
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Prior art keywords
compound
nmn
crystalline compound
nad
certain embodiments
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Japanese (ja)
Inventor
カール，アンドリュー
フェルナンデス，フィリップ
リビングストン，デーヴィッド，ジェイ．
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メトロ インターナショナル バイオテック，エルエルシー
メトロ インターナショナル バイオテック，エルエルシー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP2018516685A 2015-10-02 2016-09-30 β−ニコチンアミドモノヌクレオチドの結晶形態 Pending JP2018534265A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562236657P 2015-10-02 2015-10-02
US62/236,657 2015-10-02
PCT/US2016/054776 WO2017059249A1 (en) 2015-10-02 2016-09-30 Crystal forms of beta-nicotinamide mononucleotide

Related Child Applications (1)

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JP2020205773A Division JP2021063081A (ja) 2015-10-02 2020-12-11 β−ニコチンアミドモノヌクレオチドの結晶形態

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JP2018534265A true JP2018534265A (ja) 2018-11-22

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JP2018516685A Pending JP2018534265A (ja) 2015-10-02 2016-09-30 β−ニコチンアミドモノヌクレオチドの結晶形態
JP2020205773A Pending JP2021063081A (ja) 2015-10-02 2020-12-11 β−ニコチンアミドモノヌクレオチドの結晶形態
JP2022131443A Pending JP2022176979A (ja) 2015-10-02 2022-08-22 β－ニコチンアミドモノヌクレオチドの結晶形態
JP2024111468A Pending JP2024161353A (ja) 2015-10-02 2024-07-11 β－ニコチンアミドモノヌクレオチドの結晶形態

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JP2020205773A Pending JP2021063081A (ja) 2015-10-02 2020-12-11 β−ニコチンアミドモノヌクレオチドの結晶形態
JP2022131443A Pending JP2022176979A (ja) 2015-10-02 2022-08-22 β－ニコチンアミドモノヌクレオチドの結晶形態
JP2024111468A Pending JP2024161353A (ja) 2015-10-02 2024-07-11 β－ニコチンアミドモノヌクレオチドの結晶形態

Country Status (14)

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US (6) US10392415B2 (https=)
EP (2) EP4272746A3 (https=)
JP (4) JP2018534265A (https=)
KR (1) KR102779733B1 (https=)
CN (1) CN108697722B (https=)
AU (1) AU2016331918B2 (https=)
BR (1) BR112018006243A2 (https=)
CA (1) CA3000744C (https=)
EA (1) EA037104B1 (https=)
GB (1) GB2542881B (https=)
IL (1) IL258276B (https=)
MX (1) MX390064B (https=)
WO (1) WO2017059249A1 (https=)
ZA (1) ZA201802657B (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2021192683A1 (https=) * 2020-03-27 2021-09-30
JPWO2021200545A1 (https=) * 2020-03-30 2021-10-07
JP2023001064A (ja) * 2021-06-18 2023-01-04 邦泰生物工程（深▲セン▼）有限公司 ニコチンアミドモノヌクレオチド共結晶を調製する方法
JP2023001065A (ja) * 2021-06-18 2023-01-04 邦泰生物工程（深▲セン▼）有限公司 ニコチンアミドモノヌクレオチド－イソニコチノイド共結晶およびその組成物
WO2025004768A1 (ja) * 2023-06-29 2025-01-02 株式会社カネカ 結晶性複合体、及びその製造方法、並びに組成物

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6949002B6 (ja) 2015-08-05 2021-11-17 メトロ インターナショナル バイオテック，エルエルシー ニコチンアミドモノヌクレオチド誘導体及びそれらの使用
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
WO2016188092A1 (zh) * 2015-12-11 2016-12-01 邦泰生物工程(深圳)有限公司 烟酰胺单核苷酸在制备防治动脉硬化、心脑血管疾病的保健品中的应用及其保健品
CN106659729A (zh) * 2015-12-11 2017-05-10 邦泰生物工程(深圳)有限公司 烟酰胺单核苷酸在制备防治动脉硬化、心脑血管疾病的药物中的应用及其药物
WO2018047715A1 (ja) * 2016-09-06 2018-03-15 協和発酵バイオ株式会社 β－ニコチンアミドモノヌクレオチドの結晶及びその製造方法
CA3045876A1 (en) 2016-11-11 2018-05-17 The Queen's University Of Belfast Scalable syntheses of nicotinoyl ribosides and reduced nic otinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof
MX2019006278A (es) 2016-11-29 2019-08-21 Univ Iowa Res Found Uso de precursores de nad para mejorar la salud materna y/o salud de la descendencia.
US11071747B2 (en) 2016-11-29 2021-07-27 University Of Iowa Research Foundation Use of NAD precursors for breast enhancement
US20200085849A1 (en) * 2017-05-18 2020-03-19 Elysium Health, Inc. Methods and compositions for improving sleep
US11180521B2 (en) 2018-01-30 2021-11-23 Metro International Biotech, Llc Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof
US10654883B2 (en) 2018-05-15 2020-05-19 Jumpstart Fertility Pty Ltd Inorganic salts of nicotinic acid mononucleotide as anti-aging agents
CN109674808A (zh) * 2019-01-30 2019-04-26 四川大学 β-烟酰胺单核苷酸或其前体在制备延缓肺衰老药物中的用途
CN109939120B (zh) * 2019-03-01 2020-01-31 北京慧宝源生物技术股份有限公司 含烟酰胺单核苷酸和罗汉果苷的组合物及其应用
US11939348B2 (en) 2019-03-22 2024-03-26 Metro International Biotech, Llc Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide
US10618927B1 (en) 2019-03-22 2020-04-14 Metro International Biotech, Llc Compositions and methods for modulation of nicotinamide adenine dinucleotide
CN110658224B (zh) * 2019-10-15 2022-11-22 中国中医科学院中药研究所 一种氢核磁定量分析技术测定nmn绝对含量的方法
CN112823778B (zh) * 2019-11-21 2024-06-14 百瑞全球有限公司 毛发护理组合物及其制备方法
CN113121628A (zh) * 2019-12-30 2021-07-16 尚科生物医药（上海）有限公司 一种无定型烟酰胺单核苷酸的制备方法
FR3110836B1 (fr) * 2020-05-29 2023-06-16 Nuvamid Utilisation de NMN pour réduire l’immunodépression et l’immunosénescence
CN111588729A (zh) * 2020-06-16 2020-08-28 无锡脑镁素生物医药科技有限公司 β-烟酰胺单核苷酸在预防脱发或促进毛发生长产品中的应用
CN112538101B (zh) * 2020-08-13 2026-02-03 常州博海威医药科技股份有限公司 一种β烟酰胺单核苷酸的新晶型及其制备方法和用途
CN112076204A (zh) * 2020-09-29 2020-12-15 深圳雾件科技有限公司 一种烟酰胺单核苷酸在运动神经元修复的应用
CN114349809A (zh) * 2020-10-13 2022-04-15 华东理工大学 β-烟酰胺单核苷酸的晶型A及其制备方法
EP4253396A4 (en) * 2020-11-27 2024-09-11 Mirailab Bioscience Inc. HIGH PURITY BETA-NICOTINAMIDE MONONUCLEOTIDE (NMN) AND PROCESS FOR ITS PRODUCTION
CN112694505A (zh) * 2020-12-30 2021-04-23 音芙医药科技(上海)有限公司 一种高密度的nmn的制备方法
EP4322932A4 (en) * 2021-04-13 2025-01-15 Animal Biosciences, Inc. Formulations of nicotinic acid derivatives and flavonoid polyphenols and uses thereof
WO2022251491A1 (en) 2021-05-27 2022-12-01 Metro International Biotech, Llc Crystalline solids of nicotinic acid mononucleotide and esters thereof and methods of making and use
CN113912653B (zh) * 2021-06-04 2024-04-23 天津大学 一种提高β-烟酰胺单核苷酸结晶粉末松堆密度的方法
WO2023077503A1 (zh) * 2021-11-08 2023-05-11 邦泰生物工程(深圳)有限公司 一种提高烟酰胺单核苷酸晶体的堆密度的方法及其晶体
CN114129509B (zh) * 2021-12-03 2023-12-01 药酚享科技(北京)有限公司 一种保湿性nmn亲水凝胶剂及其制备方法
CN114214270B (zh) * 2021-12-17 2023-11-24 中国农业科学院北京畜牧兽医研究所 一种调控冷冻牛卵母细胞的发育能力的方法及其应用
CN114213486A (zh) * 2021-12-31 2022-03-22 浙江拓普药业股份有限公司 一种西兰花中烟酰胺单核苷酸的提取纯化方法
CN114540283B (zh) * 2022-01-27 2023-10-20 中国农业科学院北京畜牧兽医研究所 用于牛体外胚胎生产的高效玻璃化冷冻方法
WO2024251966A1 (en) 2023-06-07 2024-12-12 Bohan & Co As. Crystalline reduced nicotinamide mononucleotide (nmnh) and process thereof
CN117126213A (zh) * 2023-08-07 2023-11-28 青岛瑞思德生物科技有限公司 一种关于nmn制备的重结晶方法

Family Cites Families (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3201389A (en) 1962-09-24 1965-08-17 Kyowa Hakko Kogyo Kk Method for preparing ribonucleoside-5'-phosphates or their salts from ribonucleosides
US3451997A (en) 1965-11-30 1969-06-24 Kyowa Hakko Kogyo Kk Monothio-phosphate ester catalysis for preparation of ribonucleoside derivatives
US4172896A (en) 1978-06-05 1979-10-30 Dainippon Pharmaceutical Co., Ltd. Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
US4411995A (en) 1981-09-28 1983-10-25 Massachusetts Institute Of Technology Synthesis of nicotinamide cofactors
GB9217295D0 (en) 1992-08-14 1992-09-30 Wellcome Found Controlled released tablets
GB9315856D0 (en) 1993-07-30 1993-09-15 Wellcome Found Stabilized pharmaceutical
US5541231A (en) 1993-07-30 1996-07-30 Glaxo Wellcome Inc. Stabilized Pharmaceutical
US5358970A (en) 1993-08-12 1994-10-25 Burroughs Wellcome Co. Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
DE69839355T2 (de) 1997-07-29 2009-06-04 Alcon Laboratories, Inc., Fort Worth Ophthalmische Zusammensetzungen enthaltend Galaktomannanpolymere und Borat
AU2483599A (en) 1998-01-29 1999-08-16 Sepracor, Inc. Pharmaceutical uses of optically pure (-)-bupropion
US8889112B2 (en) 1999-09-16 2014-11-18 Ocularis Pharma, Llc Ophthalmic formulations including selective alpha 1 antagonists
JP4880190B2 (ja) 2001-04-30 2012-02-22 トロムスドルフ ゲーエムベーハー ウント コンパニー カーゲー アルツナイミッテル 医薬として活性なウリジンエステル
US7977049B2 (en) 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
US20040224039A1 (en) 2003-02-12 2004-11-11 Donald Brucker Compositions and methods for the treatment of diseases and disorder associated with oxidative damage
US6887855B2 (en) * 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US6933289B2 (en) 2003-07-01 2005-08-23 Allergan, Inc. Inhibition of irritating side effects associated with use of a topical ophthalmic medication
EP1654002B2 (en) 2003-08-07 2014-01-29 Allergan, Inc. Compositions for delivery of therapeutics into the eyes
US20050059744A1 (en) 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
US20090035275A1 (en) 2003-10-31 2009-02-05 John Geoffrey Pickering Methods and formulations for protecting cells, and for treating diseases and conditions by optimizing the intracellular concentration of NAD
CN1964627B (zh) 2004-06-04 2011-10-19 华盛顿大学 治疗神经病变的方法和组合物
WO2006094235A1 (en) 2005-03-03 2006-09-08 Sirtris Pharmaceuticals, Inc. Fused heterocyclic compounds and their use as sirtuin modulators
US20070149466A1 (en) 2005-07-07 2007-06-28 Michael Milburn Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders
US7855289B2 (en) 2005-08-04 2010-12-21 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
JP5063878B2 (ja) 2005-08-30 2012-10-31 扶桑薬品工業株式会社 硫化水素塩を含有する消化器系疾患の予防／治療用組成物
US20080020413A1 (en) * 2006-03-29 2008-01-24 Columbia University Crystalline visfatin and methods therefor
CA2646674A1 (en) 2006-04-20 2007-11-01 Fred Hutchinson Cancer Research Center Use of chalcogenides for treating shock and other adverse conditions
US20080318892A1 (en) 2006-04-28 2008-12-25 John Geoffrey Pickering Methods and formulations for protecting cells, and for treating diseases and conditions by optimizing the intracellular concentration of nad
WO2007136744A1 (en) * 2006-05-19 2007-11-29 The Johns Hopkins University Crystal structure of a substrate complex of nampt/pbef/visfatin
US20100047177A1 (en) * 2007-01-26 2010-02-25 Washington University Methods and compositions for treating neuropathies
CN101497638B (zh) 2008-01-30 2012-09-26 中国科学院大连化学物理研究所 一种nad+类似物及其合成和应用
US11219696B2 (en) 2008-12-19 2022-01-11 Nationwide Children's Hospital Delivery of polynucleotides using recombinant AAV9
CN101601679B (zh) 2009-03-17 2011-08-10 中国人民解放军第二军医大学 一种烟酰胺单核苷酸的应用
US20100297079A1 (en) 2009-05-20 2010-11-25 Chimerix, Inc. Compounds, compositions and methods for treating viral infection
KR20110061909A (ko) * 2009-12-02 2011-06-10 삼성전자주식회사 도펀트로 도핑된 그라펜 및 이를 이용한 소자
CN102985553B (zh) 2010-04-15 2015-11-25 西特里斯药业公司 沉默调节蛋白活化剂和活化测定
US8481711B2 (en) 2010-07-06 2013-07-09 Hidenori Kamanishi Neurite outgrowth agent
AR082886A1 (es) 2010-09-03 2013-01-16 Forma Therapeutics Inc Compuestos y composiciones farmaceuticas que los contienen
CN103270023B (zh) 2010-09-03 2016-11-02 福马Tm有限责任公司 作为用于治疗疾病诸如癌症的nampt 抑制剂的4-{[(吡啶-3-基-甲基)氨基羰基]氨基}苯-砜衍生物
EP2611804A1 (en) 2010-09-03 2013-07-10 Forma TM, LLC. Novel compounds and compositions for the inhibition of nampt
WO2012094343A1 (en) 2011-01-05 2012-07-12 Trilink Biotechnologies Chemically substituted thermosensitive probes and cofactors for hot start ligation
WO2012114204A2 (en) 2011-02-15 2012-08-30 Ecole Polytechnique Federale De Lausanne (Epfl) Epfl-Tto Methods of treating mitochondrial dysfunction
US20120107888A1 (en) 2011-02-17 2012-05-03 Qteros, Inc. Modulation of fermentation products through vitamin supplementation
RU2616612C2 (ru) 2011-05-04 2017-04-18 ФОРМА ТиЭм, ЭлЭлСИ Новые соединения и композиции для ингибирования nampt
US20120328526A1 (en) 2011-06-27 2012-12-27 University Of Maryland, Baltimore Modulation of Nad+ Activity in Neuropathophysiological Conditions and Uses Thereof
CA2840516A1 (en) 2011-06-29 2013-01-03 President And Fellows Of Harvard College Small molecule cd38 inhibitors and methods of using same
WO2013130943A1 (en) 2012-03-02 2013-09-06 Genentech, Inc. Alkyl-and di-substituted amido-benzyl sulfonamide derivatives
WO2013127268A1 (en) 2012-03-02 2013-09-06 Genentech,Inc. Amido-benzyl sulfone and sulfonamide derivatives
JP2015508785A (ja) 2012-03-02 2015-03-23 ジェネンテック， インコーポレイテッド ピリジニル及びピリミジニルスルホキシド及びスルホン誘導体
US9822129B2 (en) 2012-03-02 2017-11-21 Genentech, Inc. Amido spirocyclic amide and sulfonamide derivatives
SG11201405054PA (en) 2012-03-02 2014-09-26 Genentech Inc Amido-benzyl sulfone and sulfoxide derivatives
EP2872128B1 (en) 2012-07-16 2020-02-19 Cornell University Nicotinamide riboside to treat hearing loss
US9877981B2 (en) * 2012-10-09 2018-01-30 President And Fellows Of Harvard College NAD biosynthesis and precursors for the treatment and prevention of cancer and proliferation
CN102876759A (zh) * 2012-10-29 2013-01-16 尚科生物医药（上海）有限公司 尼克酰胺腺嘌呤二核苷酸的制备方法
WO2014074715A1 (en) 2012-11-07 2014-05-15 Genentech, Inc. Cyclopropyl amide derivatives
WO2014111906A1 (en) 2013-01-21 2014-07-24 Ecole Polytechnique Federale De Lausanne (Epfl) Bioluminescence imaging of small biomolecules
EP2968306B1 (en) 2013-03-15 2023-06-07 Washington University Administration of nicotinamide mononucleotide in the treatment of dry eye
US20140271355A1 (en) 2013-03-15 2014-09-18 Sabre Intellectual Property Holdings Llc Apparatus and process for focused gas phase application of biocide
GB201313465D0 (en) 2013-07-29 2013-09-11 Queens University Of The Belfast Methods of preparing nicotinamide riboside and derivatives thereof
WO2015069860A1 (en) 2013-11-06 2015-05-14 President And Fellows Of Harvard College Biological production of nad precursors and analogs
MX373132B (es) 2013-11-12 2020-05-25 Ortho Nutra Llc Suplemento a base de teacrina y método de uso del mismo.
US10398701B2 (en) 2013-11-12 2019-09-03 Ortho-Nutra, Llc Theacrine-based supplement and method of use thereof in a synergistic combination with caffeine
WO2015070280A1 (en) 2013-11-14 2015-05-21 Newsouth Innovations Pty Limited Senescence and senescence associated secretory phenotype
CN104367587B (zh) 2013-12-06 2018-06-29 中国人民解放军第二军医大学 烟酰胺单核苷酸在制备促脑缺血后神经再生药物中的应用
US20150258052A1 (en) 2014-03-13 2015-09-17 Salk Institute For Biological Studies Methods of using fexaramine and agents that increase sympathetic nervous system activity to promote browning of white adipose tissue
AU2015229055B2 (en) 2014-03-13 2019-09-12 Salk Institute For Biological Studies Analogs of fexaramine and methods of making and using
US10301268B2 (en) 2014-03-13 2019-05-28 The Salk Institute For Biological Studies Analogs of fexaramine and methods of making and using
KR20170012449A (ko) 2014-06-02 2017-02-02 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 결정질 베타-d-니코틴아미드 리보시드의 제조 및 용도
US20170087180A1 (en) 2014-06-03 2017-03-30 Sulfagenix, Inc. Methods and compositions for treating nitric oxide deficiency disorders and related conditions
CA2951287A1 (en) 2014-06-06 2015-12-10 Glaxosmithkline Intellectual Property (No. 2) Limited Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof
CN106715454B (zh) 2014-07-24 2020-06-16 格雷斯公司 烟酰胺核苷的结晶形式
US10653782B2 (en) 2014-11-25 2020-05-19 Nortwestern University Retroviral particles expressing Sirt1 embedded within PPCN
US20170326100A1 (en) 2014-12-09 2017-11-16 Amorepacific Corporation Composition for activating longevity gene
KR102629310B1 (ko) 2015-03-09 2024-01-24 더블유.알. 그레이스 앤드 캄파니-콘. 니코틴아미드 리보사이드의 결정 형태
CN104817604B (zh) 2015-03-16 2017-08-04 邦泰生物工程(深圳)有限公司 一种β‑烟酰胺单核苷酸的纯化方法
WO2016149672A1 (en) 2015-03-18 2016-09-22 The Regents Of The University Of California Methods of preventing and reversing stem cell aging
US20160355539A1 (en) 2015-06-04 2016-12-08 Chromadex, Inc. Selective solvent free phosphorylation
US20180177703A1 (en) 2015-06-25 2018-06-28 N.V. Perricone Llc Niacinamide Mononucleotide Formulations For Skin Aging
JP6949002B6 (ja) 2015-08-05 2021-11-17 メトロ インターナショナル バイオテック，エルエルシー ニコチンアミドモノヌクレオチド誘導体及びそれらの使用
TW201713774A (zh) 2015-08-06 2017-04-16 Kohjin Life Sciences Co Ltd 含有β-菸鹼醯胺單核苷酸的酵母萃取物及其製造方法
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
SG11201802933YA (en) 2015-10-07 2018-05-30 Joel Huizenga Resetting biological pathways for defending against and repairing deterioration from human aging
US10611790B2 (en) 2015-11-02 2020-04-07 Mitobridge, Inc. Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases
JP6803854B2 (ja) 2015-12-21 2020-12-23 昭和電工株式会社 ニコチンアミドモノヌクレオチド誘導体、その塩、その製造方法、皮膚外用剤、化粧料、食品添加剤
EP3187180A1 (en) 2015-12-28 2017-07-05 Ludwig-Maximilians-Universität München Adenosylhomocysteinase binding substances for medical use
US11248018B2 (en) 2016-02-23 2022-02-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Process for preparation of nicotinamide riboside (NR) and cosmetic composition comprising (NR and a phosphate-binding agent
CA3017254C (en) 2016-03-16 2023-08-22 ChromaDex Inc. B-vitamin and amino acid conjugates of nicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof
US10183036B2 (en) 2016-04-20 2019-01-22 ChromaDex Inc. Use of nicotinic acid riboside or nicotinamide riboside derivatives, and reduced derivatives thereof, as NAD+ increasing precursors
WO2017218580A1 (en) 2016-06-14 2017-12-21 Rejuvenation Therapeutics Corporation Synthetic methods for the preparation of nicotinamide riboside and related compounds
CN107889505B (zh) 2016-07-30 2021-05-25 邦泰生物工程(深圳)有限公司 一种制备烟酰胺单核苷酸的方法
WO2018023205A1 (zh) 2016-07-30 2018-02-08 邦泰生物工程(深圳)有限公司 一种烟酰胺单核苷酸的纯化方法
CN107922952B (zh) 2016-07-30 2021-04-27 邦泰生物工程(深圳)有限公司 一种制备烟酰胺单核苷酸的方法
CN108026535B (zh) 2016-07-30 2021-04-27 邦泰生物工程(深圳)有限公司 一种制备烟酰胺单核苷酸的方法
CN107889504B (zh) 2016-07-30 2021-07-27 邦泰生物工程(深圳)有限公司 一种制备烟酰胺单核苷酸的方法
WO2017185549A1 (zh) 2016-07-30 2017-11-02 邦泰生物工程(深圳)有限公司 一种制备烟酰胺单核苷酸的方法2
WO2018047715A1 (ja) * 2016-09-06 2018-03-15 協和発酵バイオ株式会社 β－ニコチンアミドモノヌクレオチドの結晶及びその製造方法
EP3512158B1 (en) 2016-09-09 2021-08-18 Nec Corporation Transmitting device, receiving device, quantum key distribution method, and quantum key distribution program for quantum key distribution system
WO2018052019A1 (ja) 2016-09-13 2018-03-22 めぐみ 田中 視覚機能改善剤及び視覚機能の改善方法
US20200009170A1 (en) 2016-09-13 2020-01-09 Megumi Tanaka Sleep display agent property and method for improving sleep disorders
CA3045876A1 (en) 2016-11-11 2018-05-17 The Queen's University Of Belfast Scalable syntheses of nicotinoyl ribosides and reduced nic otinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof
CN110325190A (zh) 2016-12-21 2019-10-11 新南创新私人有限公司 增加血管密度的方法
CN106755209B (zh) 2016-12-29 2021-07-23 苏州汉酶生物技术有限公司 一种酶法制备β-烟酰胺单核苷酸的方法
WO2018132833A1 (en) 2017-01-13 2018-07-19 The Regents Of The University Of Colorado, A Body Corporate Methods for treating hypertension and arterial stiffness
US11634690B2 (en) 2017-01-31 2023-04-25 Oriental Yeast Co., Ltd. Agent for accelerating growth of pluripotent stem cells
JP6920071B2 (ja) 2017-02-16 2021-08-18 ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ アディポネクチン分泌向上剤
AU2018250242B2 (en) 2017-04-05 2021-07-15 Cornell University Beta-nicotinate ester nucleotides and processes for preparing same
WO2019023748A1 (en) 2017-07-31 2019-02-07 Newsouth Innovations Pty Limited METHODS FOR INCREASING FERTILITY
US11180521B2 (en) 2018-01-30 2021-11-23 Metro International Biotech, Llc Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof
US20210388018A1 (en) 2018-10-01 2021-12-16 Cornell University Methyl and ethyl nicotinate-riboside-5-phosphates, preparation thereof and methods of use thereof
JP2022512126A (ja) 2018-12-10 2022-02-02 クロマデックス，インコーポレイテッド ニコチノイルリボシド及びその誘導体の結晶形態、並びにその調製方法
US10618927B1 (en) 2019-03-22 2020-04-14 Metro International Biotech, Llc Compositions and methods for modulation of nicotinamide adenine dinucleotide
US11939348B2 (en) 2019-03-22 2024-03-26 Metro International Biotech, Llc Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide
EP3941481B1 (en) 2019-03-22 2024-09-18 Metro International Biotech, LLC Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide
WO2021234009A1 (fr) 2020-05-20 2021-11-25 Nuvamid Sa Compositions cosmetiques anti-age comprenant du nmn
WO2022251491A1 (en) 2021-05-27 2022-12-01 Metro International Biotech, Llc Crystalline solids of nicotinic acid mononucleotide and esters thereof and methods of making and use

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
PRODUCT INFORMATION, Β-NICOTINAMIDE MONONUCLEOTIDE, ITEM NO.16411, [ONLINE], JPN7019003088, 11 March 2014 (2014-03-11), ISSN: 0004432462 *
SYNTHESIS, vol. 1981, no. 5, JPN6017038721, 1981, pages 388 - 389, ISSN: 0004432463 *
仲井由宣 花野学編, 新製剤学, vol. 第１版第２刷, JPN6016032041, 25 April 1984 (1984-04-25), pages 102 - 104, ISSN: 0004432464 *
塩路雄作, 固形製剤の製造技術, vol. 普及版第１刷, JPN6016031894, 27 January 2003 (2003-01-27), pages 9 - 14, ISSN: 0004432465 *
平山令明編著, 有機化合物結晶作製ハンドブック−原理とノウハウ−, JPN6016031902, 25 July 2008 (2008-07-25), pages 37 - 84, ISSN: 0004432466 *
社団法人日本化学会編, 第４版 実験化学講座１ 基本操作Ｉ, vol. 第２刷, JPN6016031896, 5 April 1996 (1996-04-05), pages 184 - 186, ISSN: 0004432467 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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WO2021192683A1 (ja) * 2020-03-27 2021-09-30 オリエンタル酵母工業株式会社 β－ニコチンアミドモノヌクレオチド又はその薬理学的に許容される塩からなる化合物、並びにその品質評価方法および酵素反応性の判定方法
JP7648026B2 (ja) 2020-03-27 2025-03-18 オリエンタル酵母工業株式会社 β－ニコチンアミドモノヌクレオチド又はその薬理学的に許容される塩からなる化合物を含む組成物、並びにその品質評価方法および酵素反応性の判定方法
JPWO2021200545A1 (https=) * 2020-03-30 2021-10-07
JP7677949B2 (ja) 2020-03-30 2025-05-15 オリエンタル酵母工業株式会社 幹細胞の染色体安定化剤
JP2023001064A (ja) * 2021-06-18 2023-01-04 邦泰生物工程（深▲セン▼）有限公司 ニコチンアミドモノヌクレオチド共結晶を調製する方法
JP2023001065A (ja) * 2021-06-18 2023-01-04 邦泰生物工程（深▲セン▼）有限公司 ニコチンアミドモノヌクレオチド－イソニコチノイド共結晶およびその組成物
JP7394410B2 (ja) 2021-06-18 2023-12-08 邦泰生物工程（深▲セン▼）有限公司 ニコチンアミドモノヌクレオチド共結晶を調製する方法
JP7438512B2 (ja) 2021-06-18 2024-02-27 邦泰生物工程（深▲セン▼）有限公司 ニコチンアミドモノヌクレオチド－イソニコチノイド共結晶およびその組成物
WO2025004768A1 (ja) * 2023-06-29 2025-01-02 株式会社カネカ 結晶性複合体、及びその製造方法、並びに組成物

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