JP2018512847A5 - - Google Patents

Download PDF

Info

Publication number
JP2018512847A5
JP2018512847A5 JP2017550609A JP2017550609A JP2018512847A5 JP 2018512847 A5 JP2018512847 A5 JP 2018512847A5 JP 2017550609 A JP2017550609 A JP 2017550609A JP 2017550609 A JP2017550609 A JP 2017550609A JP 2018512847 A5 JP2018512847 A5 JP 2018512847A5
Authority
JP
Japan
Prior art keywords
nucleic acid
signal
acid molecule
target nucleic
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017550609A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018512847A (ja
JP7123560B2 (ja
Filing date
Publication date
Priority claimed from US14/665,904 external-priority patent/US9708647B2/en
Application filed filed Critical
Publication of JP2018512847A publication Critical patent/JP2018512847A/ja
Publication of JP2018512847A5 publication Critical patent/JP2018512847A5/ja
Application granted granted Critical
Publication of JP7123560B2 publication Critical patent/JP7123560B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017550609A 2015-03-23 2016-03-22 集積型アレイを使用する核酸ハイブリダイゼーション熱力学の多重分析 Active JP7123560B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/665,904 2015-03-23
US14/665,904 US9708647B2 (en) 2015-03-23 2015-03-23 Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
PCT/US2016/023634 WO2016154227A1 (en) 2015-03-23 2016-03-22 Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020190152A Division JP2021036890A (ja) 2015-03-23 2020-11-16 集積型アレイを使用する核酸ハイブリダイゼーション熱力学の多重分析

Publications (3)

Publication Number Publication Date
JP2018512847A JP2018512847A (ja) 2018-05-24
JP2018512847A5 true JP2018512847A5 (enExample) 2019-05-09
JP7123560B2 JP7123560B2 (ja) 2022-08-23

Family

ID=56976446

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2017550609A Active JP7123560B2 (ja) 2015-03-23 2016-03-22 集積型アレイを使用する核酸ハイブリダイゼーション熱力学の多重分析
JP2020190152A Withdrawn JP2021036890A (ja) 2015-03-23 2020-11-16 集積型アレイを使用する核酸ハイブリダイゼーション熱力学の多重分析
JP2022113860A Pending JP2022137243A (ja) 2015-03-23 2022-07-15 集積型アレイを使用する核酸ハイブリダイゼーション熱力学の多重分析

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2020190152A Withdrawn JP2021036890A (ja) 2015-03-23 2020-11-16 集積型アレイを使用する核酸ハイブリダイゼーション熱力学の多重分析
JP2022113860A Pending JP2022137243A (ja) 2015-03-23 2022-07-15 集積型アレイを使用する核酸ハイブリダイゼーション熱力学の多重分析

Country Status (6)

Country Link
US (3) US9708647B2 (enExample)
EP (2) EP3274094B1 (enExample)
JP (3) JP7123560B2 (enExample)
CN (1) CN107614108B (enExample)
GB (1) GB2555950A (enExample)
WO (1) WO2016154227A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US8048626B2 (en) 2006-07-28 2011-11-01 California Institute Of Technology Multiplex Q-PCR arrays
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
JP6778194B2 (ja) 2014-12-31 2020-10-28 ビスビュー メディカル,インコーポレイテッド 分子診断試験のためのデバイス及び方法
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
US10718758B2 (en) 2016-06-03 2020-07-21 International Business Machines Corporation Biosensor for optical detection of nucleotide sequence
US10373704B2 (en) * 2016-06-03 2019-08-06 International Business Machines Corporation Reduction of surface nucleotide hybridization by optimizing a biosensor sensing surface area
US10712308B2 (en) 2016-06-03 2020-07-14 International Business Machines Corporation Biosensor for electrical detection of a nucleotide sequence
GB201708338D0 (en) 2017-05-24 2017-07-05 Univ Court Univ Of Glasgow Metabolite detection apparatus and method of detecting metabolites
WO2018222800A2 (en) 2017-05-31 2018-12-06 Centrillion Technologies, Inc. Oligonucleotide probe array with electronic detection system
US11162130B2 (en) 2017-11-09 2021-11-02 Visby Medical, Inc. Portable molecular diagnostic device and methods for the detection of target viruses
JP2019093377A (ja) 2017-11-22 2019-06-20 株式会社エンプラス 流体チップ、流体デバイスおよびそれらの製造方法
KR20210081335A (ko) 2018-09-03 2021-07-01 비스비 메디컬, 인코포레이티드 항생제 감수성 시험을 위한 장치 및 방법
WO2020186252A1 (en) 2019-03-14 2020-09-17 Insilixa, Inc. Methods and systems for time-gated fluorescent-based detection
CN119510370A (zh) 2019-03-14 2025-02-25 因斯利克萨公司 基于时间门控的荧光检测的方法和系统
KR20220005009A (ko) 2019-04-28 2022-01-12 비스비 메디컬, 인코포레이티드 디지털 검출 능력 및 무선 연결성을 갖는 분자 진단 디바이스
US11352675B2 (en) 2020-01-03 2022-06-07 Visby Medical, Inc. Devices and methods for antibiotic susceptability testing
WO2023028618A1 (en) * 2021-08-27 2023-03-02 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods to determine nucleic acid conformations and uses thereof
WO2023049349A1 (en) * 2021-09-23 2023-03-30 N6 Tec, Inc. Methods and systems for sample analysis
US20250297303A1 (en) 2024-03-21 2025-09-25 Cepheid Compositions and methods for selective extraction of oligonucleotides from complex matrices

Family Cites Families (215)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4027971A (en) 1973-01-08 1977-06-07 Philip Kolman Method of simultaneously counting blood cells
US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
GB8314523D0 (en) 1983-05-25 1983-06-29 Lowe C R Diagnostic device
US4539295A (en) 1983-06-30 1985-09-03 Beckman Instruments, Inc. Binary kinetic assay method and apparatus
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5333675C1 (en) 1986-02-25 2001-05-01 Perkin Elmer Corp Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5656493A (en) 1985-03-28 1997-08-12 The Perkin-Elmer Corporation System for automated performance of the polymerase chain reaction
CA1339653C (en) 1986-02-25 1998-02-03 Larry J. Johnson Appartus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US5082830A (en) 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe
US6054270A (en) 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5871928A (en) 1989-06-07 1999-02-16 Fodor; Stephen P. A. Methods for nucleic acid analysis
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
EP0731175A3 (en) 1989-07-11 2004-05-26 Gen-Probe Incorporated Oligonucleotide probes for HIV nucleic acid
EP0468531B2 (en) * 1990-07-27 1997-11-12 Fuji Photo Film Co., Ltd. 2-Diazo-1,2-quinone compounds and image forming materials prepared using the compounds
US5386023A (en) 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
US5602240A (en) 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
KR100236506B1 (ko) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
US6048690A (en) 1991-11-07 2000-04-11 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5270184A (en) 1991-11-19 1993-12-14 Becton, Dickinson And Company Nucleic acid target generation
DE69233087T2 (de) 1991-11-22 2003-12-24 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Verfahren zur Herstellung von Polymerarrays
US5644048A (en) 1992-01-10 1997-07-01 Isis Pharmaceuticals, Inc. Process for preparing phosphorothioate oligonucleotides
EP0566751B1 (en) 1992-03-23 1996-01-10 F. Hoffmann-La Roche Ag DNA detection method
US5323115A (en) 1992-05-05 1994-06-21 Xerox Corporation Electrostatic voltmeter producing a low voltage output
US5674698A (en) 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5837501A (en) 1993-07-09 1998-11-17 Akzo Nobel N.V. Nucleic acid quantitation by co-amplification of target with multiple internal controls
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5637684A (en) 1994-02-23 1997-06-10 Isis Pharmaceuticals, Inc. Phosphoramidate and phosphorothioamidate oligomeric compounds
US5455705A (en) 1994-03-14 1995-10-03 Analog Devices, Inc. Transimpedance amplifier for optical receiver
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US6379897B1 (en) 2000-11-09 2002-04-30 Nanogen, Inc. Methods for gene expression monitoring on electronic microarrays
US5491063A (en) 1994-09-01 1996-02-13 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
US5599668A (en) 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US6600996B2 (en) 1994-10-21 2003-07-29 Affymetrix, Inc. Computer-aided techniques for analyzing biological sequences
US5571673A (en) 1994-11-23 1996-11-05 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
WO1997032212A1 (en) 1996-03-01 1997-09-04 Beckman Instruments, Inc. System for simultaneously conducting multiple ligand binding assays
US6114122A (en) 1996-03-26 2000-09-05 Affymetrix, Inc. Fluidics station with a mounting system and method of using
US5627054A (en) 1996-04-05 1997-05-06 The United States Of America As Represented By The Secretary Of The Army Competitor primer asymmetric polymerase chain reaction
US5925519A (en) 1996-06-03 1999-07-20 The Regents Of The University Of California Genetic alterations associated with prostate cancer
US6174670B1 (en) 1996-06-04 2001-01-16 University Of Utah Research Foundation Monitoring amplification of DNA during PCR
AU3477397A (en) 1996-06-04 1998-01-05 Paul J. Werbos 3-brain architecture for an intelligent decision and control system
US6984491B2 (en) 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
CA2389358C (en) 1996-12-31 2008-07-15 Genometrix Incorporated Multiplexed molecular analysis apparatus and method
ATE340869T1 (de) * 1997-01-15 2006-10-15 Xzillion Gmbh & Co Kg Massenmarkierte hybridisierungssonden
US5846726A (en) 1997-05-13 1998-12-08 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
JP2001514859A (ja) 1997-09-04 2001-09-18 バイエル コーポレイション クエンチ可能な蛍光標識を有するオリゴヌクレオチドプローブおよびその使用方法
US20010046673A1 (en) 1999-03-16 2001-11-29 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
CA2325886C (en) 1998-04-09 2009-07-21 California Institute Of Technology Electronic techniques for analyte detection
US6330092B1 (en) 1998-05-08 2001-12-11 Agilent Technologies, Inc. Polarization based differential receiver for reduction of background in free-space optical links
US6319958B1 (en) 1998-06-22 2001-11-20 Wisconsin Alumni Research Foundation Method of sensitizing microbial cells to antimicrobial compound
DE1020534T1 (de) 1998-11-09 2001-03-01 Eiken Kagaku K.K., Tokio/Tokyo Verfahren zur synthetisieren von nukleinsäure
AU2965500A (en) 1999-01-15 2000-08-01 Gene Logic, Inc. Immobilized nucleic acid hybridization reagent and method
US6743581B1 (en) 1999-01-25 2004-06-01 Ut-Battelle, Lc Multifunctional and multispectral biosensor devices and methods of use
US7107253B1 (en) 1999-04-05 2006-09-12 American Board Of Family Practice, Inc. Computer architecture and process of patient generation, evolution and simulation for computer based testing system using bayesian networks as a scripting language
US7423750B2 (en) 2001-11-29 2008-09-09 Applera Corporation Configurations, systems, and methods for optical scanning with at least one first relative angular motion and at least one second angular motion or at least one linear motion
US6277607B1 (en) 1999-05-24 2001-08-21 Sanjay Tyagi High specificity primers, amplification methods and kits
US6516276B1 (en) 1999-06-18 2003-02-04 Eos Biotechnology, Inc. Method and apparatus for analysis of data from biomolecular arrays
WO2000079009A2 (en) 1999-06-22 2000-12-28 Invitrogen Corporation Improved primers and methods for the detection and discrimination of nucleic acids
US6251639B1 (en) 1999-09-13 2001-06-26 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences, using a RNA-DNA composite primer
AU7708500A (en) 1999-09-22 2001-04-24 Ge Healthcare Bio-Sciences Ab Three-dimensional microarray system for parallel genotyping of single nucleotide polymorphisms
US6673536B1 (en) 1999-09-29 2004-01-06 Rosetta Inpharmatics Llc. Methods of ranking oligonucleotides for specificity using wash dissociation histories
US6784982B1 (en) 1999-11-04 2004-08-31 Regents Of The University Of Minnesota Direct mapping of DNA chips to detector arrays
DE10002566A1 (de) 2000-01-21 2001-08-02 Fraunhofer Ges Forschung Verfahren und Einrichtung zur Bestimmung des Schmelzpunktes und/oder der Bindungskonstante von Substanzen, wie z. B. DNA-Sequenzen, in einer Probe
US7033763B2 (en) 2000-02-23 2006-04-25 City Of Hope Pyrophosphorolysis activated polymerization (PAP)
US6579680B2 (en) 2000-02-28 2003-06-17 Corning Incorporated Method for label-free detection of hybridized DNA targets
DE60143974D1 (de) 2000-03-29 2011-03-10 Lgc Ltd Hybridisierungsprobe und Methode zum schnellen Nachweis und zur schnellen Unterscheidung von Sequenzen
US7998673B2 (en) 2000-03-29 2011-08-16 Lgc Limited Hybridisation beacon and method of rapid sequence detection and discrimination
US7019129B1 (en) 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
WO2002008414A1 (en) 2000-06-27 2002-01-31 National Institute Of Advanced Industrial Science And Technology Novel nucleic acid probes and method of assaying nucleic acid by using the same
US6472887B1 (en) 2000-06-28 2002-10-29 Hewlett-Packard Company Capacitive sensor for sensing the amount of material in a container
DE10036457A1 (de) 2000-07-26 2002-02-14 Giesing Michael Verwendung eines bildgebenden photoelektrischen Flächensensors zur Auswertung von Biochips und Bildgebungsverfahren hierfür
US20050089924A1 (en) 2000-08-14 2005-04-28 Chih-Ming Ho Biosensors and methods for their use
US6724324B1 (en) 2000-08-21 2004-04-20 Delphi Technologies, Inc. Capacitive proximity sensor
US6469524B1 (en) 2000-08-25 2002-10-22 Delphi Technologies, Inc. System and method for interrogating a capacitive sensor
CN1348096A (zh) 2000-10-10 2002-05-08 栾国彦 一种均相特异性检测核酸的探针及应用方法
DE60125312T2 (de) 2000-10-26 2007-06-06 Agilent Technologies, Inc. (n.d. Ges. d. Staates Delaware), Santa Clara Mikroarray
US6818427B1 (en) 2000-10-27 2004-11-16 Millennium Pharmaceuticals, Inc. MEKK1 molecules and uses thereof
US8900811B2 (en) * 2000-11-16 2014-12-02 Caliper Life Sciences, Inc. Method and apparatus for generating thermal melting curves in a microfluidic device
US20050202470A1 (en) 2000-11-16 2005-09-15 Caliper Life Sciences, Inc. Binding assays using molecular melt curves
US6432695B1 (en) 2001-02-16 2002-08-13 Institute Of Microelectronics Miniaturized thermal cycler
CA2439307A1 (en) 2001-02-23 2002-09-06 Genicon Sciences Corporation Methods for providing extended dynamic range in analyte assays
US6946251B2 (en) 2001-03-09 2005-09-20 Nugen Technologies, Inc. Methods and compositions for amplification of RNA sequences using RNA-DNA composite primers
US20020146745A1 (en) 2001-04-03 2002-10-10 Surromed, Inc. Methods and reagents for multiplexed analyte capture, surface array self-assembly, and analysis of complex biological samples
WO2002086162A1 (en) * 2001-04-23 2002-10-31 Samsung Electronics Co., Ltd. Molecular detection chip including mosfet, molecular detection device employing the chip, and molecular detection method using the device
GB0111459D0 (en) 2001-05-10 2001-07-04 Isis Innovation Universal fluorescent sensors
AU2002339853A1 (en) 2001-05-24 2002-12-03 Genospectra, Inc. Pairs of nucleic acid probes with interactive signaling moieties and nucleic acid probes with enhanced hybridization efficiency and specificity
US20020187477A1 (en) 2001-06-06 2002-12-12 Hong Xue Method for detecting single nucleotide polymorphisms (SNPs) and point mutations
CA2452693A1 (en) 2001-06-06 2002-12-12 Digital Optical Imaging Corporation Light modulated microarray reader and methods relating thereto
US20030040000A1 (en) 2001-08-08 2003-02-27 Connolly Dennis M. Methods for attaching nucleic acid molecules to electrically conductive surfaces
US7173032B2 (en) 2001-09-21 2007-02-06 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
US6593091B2 (en) 2001-09-24 2003-07-15 Beckman Coulter, Inc. Oligonucleotide probes for detecting nucleic acids through changes in flourescence resonance energy transfer
US6744502B2 (en) 2001-09-28 2004-06-01 Pe Corporation (Ny) Shaped illumination geometry and intensity using a diffractive optical element
US20070010664A1 (en) 2001-10-01 2007-01-11 Thomas Elizabeth A Gene expression in the central nervous system regulated by neuroleptic agents
KR20040068122A (ko) 2001-10-15 2004-07-30 바이오어레이 솔루션스 리미티드 공동 검색과 효소-매개된 탐지에 의한 다형성 좌위의 다중분석
US20030071843A1 (en) 2001-10-17 2003-04-17 Bruce Hoff System and method for specifying and applying microarray data preparation
WO2003043402A2 (en) 2001-10-19 2003-05-30 Proligo Llc Nucleic acid probes and methods to detect and/or quantify nucleic acid analytes
US7198897B2 (en) 2001-12-19 2007-04-03 Brandeis University Late-PCR
AU2003210571A1 (en) 2002-01-18 2003-09-02 University Of Utah Research Foundation Detection of single nucleotide polymorphisms using planar waveguides
WO2003065244A1 (en) 2002-01-30 2003-08-07 Board Of Regents, The University Of Texas System Probabilistic boolean networks
AU2003231058A1 (en) 2002-04-22 2003-11-03 Wisconsin Alumni Research Foundation Single nucleotide polymorphism analysis using surface invasive cleavage reactions
US7785776B2 (en) 2002-05-13 2010-08-31 Idaho Technology, Inc. Genotyping by amplicon melting curve analysis
US6750963B2 (en) 2002-05-21 2004-06-15 Agilent Technologies, Inc. Imaging systems for signals on a surface
JP3904111B2 (ja) 2002-06-04 2007-04-11 ソニー株式会社 固体撮像装置及びその信号処理方法
WO2004011144A2 (en) 2002-07-29 2004-02-05 Dumas David P Transparent polymer support for electrophoresis and electrochromatography and related methods
US7267751B2 (en) 2002-08-20 2007-09-11 Nanogen, Inc. Programmable multiplexed active biologic array
EP1539979B1 (en) 2002-09-20 2008-11-19 New England Biolabs, Inc. Helicase dependent amplification of nucleic acids
ATE290016T1 (de) 2002-10-21 2005-03-15 Axxam S R L Photoprotein mit verbesserter biolumineszenz
US20040086864A1 (en) 2002-10-22 2004-05-06 The Chinese University Of Hong Kong Novel classification methods for pleural effusions
WO2004038042A1 (en) 2002-10-24 2004-05-06 Ben Gao A 4-dimensional method and equipment of detecting nucleic acid hybrid pair on the gene chip
US20040147045A1 (en) 2002-10-29 2004-07-29 Gentel Biosurfaces, Inc. Signal molecule arrays
DE60325541D1 (de) 2002-10-31 2009-02-12 Hoffmann La Roche Verfahren/Präparat zur Erkennung von Pankreaskrebs
US7390457B2 (en) 2002-10-31 2008-06-24 Agilent Technologies, Inc. Integrated microfluidic array device
US20040121337A1 (en) 2002-12-19 2004-06-24 Nomadics, Inc. Luminescent polymers and methods of use thereof
US20060014151A1 (en) 2002-12-25 2006-01-19 Jun Ogura Optical dna sensor, dna reading apparatus, identification method of dna and manufacturing method of optical dna sensor
DE10315074A1 (de) 2003-04-02 2004-10-14 Clondiag Chip Technologies Gmbh Vorrichtung zur Vervielfältigung und zum Nachweis von Nukleinsäuren
WO2004087950A2 (en) 2003-04-04 2004-10-14 Roche Diagnostics Gmbh Improved system for multi color real time pcr
WO2004097371A2 (en) 2003-04-25 2004-11-11 Board Of Regents, The University Of Texas System System and method for the detection of analytes
US7554007B2 (en) 2003-05-22 2009-06-30 Evogene Ltd. Methods of increasing abiotic stress tolerance and/or biomass in plants
US7125945B2 (en) 2003-09-19 2006-10-24 Varian, Inc. Functionalized polymer for oligonucleotide purification
US20050112585A1 (en) 2003-11-21 2005-05-26 Dominic Zichi Method for adjusting the quantification range of individual analytes in a multiplexed assay
US7330369B2 (en) 2004-04-06 2008-02-12 Bao Tran NANO-electronic memory array
US7995679B2 (en) 2004-04-27 2011-08-09 Broadcom Corporation Method and system for charge sensing with variable gain, offset compensation, and demodulation
WO2005118870A2 (en) 2004-05-28 2005-12-15 Nanogen, Inc. Nanoscale electronic detection system and methods for their manufacture
US7479557B2 (en) 2004-06-10 2009-01-20 Agency For Science, Technology +Research DNA threading intercalators
WO2006014351A2 (en) 2004-07-02 2006-02-09 Blueshift Biotechnologies, Inc. Exploring fluorophore microenvironments
US8517329B2 (en) 2004-07-26 2013-08-27 3M Innovative Properties Company Easel stand mountable display board
JP2006047153A (ja) * 2004-08-05 2006-02-16 Sony Corp Dnaチップの製造方法と製造システム、ハイブリダイゼーション検出方法と検出システム、並びに基板処理装置と基板処理方法
CN1280422C (zh) 2004-08-26 2006-10-18 北京博奥生物芯片有限责任公司 一种不对称pcr扩增方法及其应用
US20070212681A1 (en) 2004-08-30 2007-09-13 Benjamin Shapiro Cell canaries for biochemical pathogen detection
US20080085839A1 (en) * 2004-09-01 2008-04-10 Holger Klapproth Method For The Analysis Of Point Mutations
US20120094298A1 (en) 2005-09-02 2012-04-19 Bioarray Solutions Limited Nucleic acid amplification with integrated multiplex detection
WO2006037527A1 (en) 2004-09-30 2006-04-13 Pamgene Bv Masked solid porous supports allowing fast and easy reagent exchange to accelerate electrode-based microarrays
US7585664B2 (en) * 2004-10-14 2009-09-08 The Hong Kong University Of Science And Technology Integrated circuit optical detector for biological detection
US20060088844A1 (en) 2004-10-22 2006-04-27 Honeywell International Inc. Real-time PCR microarray based on evanescent wave biosensor
EP1659183A1 (en) 2004-11-18 2006-05-24 Eppendorf Array Technologies Real-time quantification of multiple targets on a micro-array
ATE549420T1 (de) 2004-11-18 2012-03-15 Eppendorf Array Tech Sa Echtzeit-pcr von nukleinsäuren auf einem mikroarray
JP2006162457A (ja) 2004-12-08 2006-06-22 Canon Inc 電位測定装置および画像形成装置
US7824890B2 (en) 2005-02-19 2010-11-02 Avacta Group Plc Isothermal amplification of nucleic acids
US7507565B2 (en) 2005-03-11 2009-03-24 Stanford University Bioluminescence resonance energy transfer (BRET) systems and methods of use thereof
US9223929B2 (en) 2005-03-14 2015-12-29 The California Institute Of Technology Method and apparatus for detection, identification and quantification of single-and multi-analytes in affinity-based sensor arrays
FR2892196B1 (fr) 2005-10-18 2008-06-20 Genewave Soc Par Actions Simpl Procede de fabrication d'un biocapteur a detection integree
US7463353B2 (en) 2006-05-31 2008-12-09 Uchicago Argonne, Llc Modular, micro-scale, optical array and biodetection system
US8637436B2 (en) * 2006-08-24 2014-01-28 California Institute Of Technology Integrated semiconductor bioarray
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
WO2007143669A2 (en) 2006-06-05 2007-12-13 California Institute Of Technology Real time micro arrays
BRPI0712655A2 (pt) * 2006-06-08 2012-11-20 Koninkl Philips Electronics Nv dispositivo de sensor microeletrânico, mÉtodo para investigaÇço de pelo menos uma substÂncia alvo biolàgica, e, uso do dispositivo de sensor microeletrânico
WO2008012728A1 (en) * 2006-07-27 2008-01-31 Koninklijke Philips Electronics N.V. Device for molecular diagnosis
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US8048626B2 (en) * 2006-07-28 2011-11-01 California Institute Of Technology Multiplex Q-PCR arrays
WO2008082713A2 (en) 2006-08-24 2008-07-10 California Institute Of Technology Integrated semiconductor bioarray
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
CN101583724A (zh) * 2006-11-29 2009-11-18 佳能美国生命科学公司 用于数字多重pcr测定的装置和方法
US9114398B2 (en) 2006-11-29 2015-08-25 Canon U.S. Life Sciences, Inc. Device and method for digital multiplex PCR assays
KR101433208B1 (ko) * 2006-12-13 2014-08-22 루미넥스 코포레이션 실시간으로 pcr의 다중 분석을 위한 시스템과 방법
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
EP2639578B1 (en) 2006-12-14 2016-09-14 Life Technologies Corporation Apparatus for measuring analytes using large scale fet arrays
EP2126766A2 (en) 2007-01-26 2009-12-02 Illumina Inc. Image data efficient genetic sequencing method and system
EP1956097A1 (en) 2007-02-06 2008-08-13 bioMerieux B.V. Method for discriminating single nucleotide polymorphisms (SNPs)
EP1995327A1 (en) 2007-05-21 2008-11-26 Humboldt Universität zu Berlin Probe for detecting a particular nucleic acid sequence
EP2952588A1 (en) 2007-08-06 2015-12-09 Orion Genomics, LLC Single nucleotide polymorphism in igf2 for determining the allele-specific expression of the igf2 gene
DE102007044664B4 (de) * 2007-09-18 2012-01-05 Friz Biochem Gesellschaft Für Bioanalytik Mbh Verdrängungsassay zur Detektion von Nukleinsäureoligomer-Hybridisierungsereignissen
WO2009061783A2 (en) 2007-11-05 2009-05-14 University Of Rochester Dna microarray having hairpin probes tethered to nanostructured metal surface
WO2009082706A1 (en) 2007-12-21 2009-07-02 The Trustees Of Columbia University In The City Of New York Active cmos sensor array for electrochemical biomolecular detection
EP2240613B1 (en) * 2008-02-06 2013-09-11 Ludwig-Maximilians-Universität München Thermo-optical characterisation of nucleic acid molecules
EP2307545A4 (en) 2008-06-18 2011-11-30 Ge Healthcare Bio Sciences METHOD FOR SEPARATING DOUBLE-STRAND AND SINGLE-STRAND NUCLEIC ACIDS FROM THE SAME SAMPLE
US9393566B2 (en) 2008-06-23 2016-07-19 Canon U.S. Life Sciences, Inc. System and method for temperature referencing for melt curve data collection
EP2138587A1 (en) 2008-06-23 2009-12-30 Koninklijke Philips Electronics N.V. Amplification of nucleic acids using temperature zones
US9103785B2 (en) 2008-06-25 2015-08-11 Emergence Genomics, Llc Method and apparatus for melting curve analysis of nucleic acids in microarray format
US8058005B2 (en) * 2008-10-23 2011-11-15 Honeywell International Inc. Method for single nucleotide polymorphism and mutation detection using real time polymerase chain reaction microarray
US20100122904A1 (en) * 2008-11-17 2010-05-20 Board Of Regents, The University Of Texas System Incorporating cmos integrated circuits in the design of affinity-based biosensor systems
CN102224257A (zh) 2008-11-21 2011-10-19 皇家飞利浦电子股份有限公司 使用双链核酸特异性染料在固体表面上的实时多重pcr检测
EP2391883B1 (en) * 2009-01-30 2018-03-07 Micronics, Inc. Portable high gain fluorescence detection system
WO2011066186A1 (en) 2009-11-25 2011-06-03 Gen9, Inc. Methods and apparatuses for chip-based dna error reduction
US20110308313A1 (en) 2010-06-17 2011-12-22 Geneasys Pty Ltd Humidity sensor
WO2012030995A2 (en) * 2010-08-31 2012-03-08 Canon U.S. Life Sciences, Inc. Optical system for high resolution thermal melt detection
KR20120042100A (ko) 2010-10-22 2012-05-03 주식회사 씨젠 이중표지 고정화 프로브를 이용한 고상에서의 타겟 핵산서열 검출
CA2965074A1 (en) 2010-12-27 2012-07-05 Abbott Molecular Inc. Quantitating high titer samples by digital pcr
US20120295805A1 (en) 2011-05-18 2012-11-22 Polytechnic Institute Of New York University Solid phase methods for thermodynamic and kinetic quantification of interactions between nucleic acids and small molecules
CN102433376B (zh) 2011-10-19 2013-07-31 上海千友生物科技有限公司 基于荧光淬灭的基因变异检测方法及探针
US9433943B2 (en) * 2011-11-15 2016-09-06 The Board Of Trustees Of The University Of Illinois Thermal control of droplets by nanoscale field effect transistors
CA2854790A1 (en) 2011-11-29 2013-06-06 Agrigenetics, Inc. High throughput single nucleotide polymorphism assay
CA2858119A1 (en) 2011-12-09 2013-06-13 Sietzema SIETZE Method for detection of bacteria in milk
CN104379760B (zh) 2012-04-05 2018-03-16 Bd公司 用于流式细胞术的样品制备
WO2013158280A1 (en) * 2012-04-20 2013-10-24 The Trustees Of Columbia University In The City Of New York Systems and methods for single-molecule nucleic-acid assay platforms
US9341589B2 (en) 2012-06-20 2016-05-17 Board Of Regents, The University Of Texas System Active-electrode integrated biosensor array and methods for use thereof
US8969781B2 (en) 2012-06-28 2015-03-03 Board Of Regents, The University Of Texas System Integrated optical biosensor array including charge injection circuit and quantizer circuit
US20140162266A1 (en) 2012-12-05 2014-06-12 Bio-Rad Laboratories, Inc. Methods for polymerase chain reaction copy number variation assays
US9718056B2 (en) 2013-03-15 2017-08-01 Syracuse University Microfluidics polymerase chain reaction and high resolution melt detection
US9983163B2 (en) 2013-04-30 2018-05-29 Board Of Regents, The University Of Texas System Integrated electro-analytical biosensor array
TWI527905B (zh) * 2013-11-06 2016-04-01 國立台灣大學 透過利用基因檢測技術與微珠微流道結合進行單核苷酸多態性檢測之方法
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
CN108351349B (zh) 2015-09-10 2020-09-29 因斯利克萨公司 用于多路定量核酸扩增的方法和系统
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension

Similar Documents

Publication Publication Date Title
JP2018512847A5 (enExample)
US20260022414A1 (en) Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
US9080202B2 (en) Method of SNP detection by using gene detection technique in bead-based microfluidics
US20210310056A1 (en) Real-time multiplexed hydrolysis probe assay using spectrally identifiable microspheres
EP2180066B1 (en) Single nucleotide polymorphism genotyping detection via the real-time invader assay microarray platform
HK1201568A1 (en) Hydrolysis probes
Wei et al. A highly sensitive SPRi biosensing strategy for simultaneous detection of multiplex miRNAs based on strand displacement amplification and AuNP signal enhancement
JP2014533502A5 (enExample)
US20240352508A1 (en) Methods, systems and compositions for detection of multiple analytes
US20170175177A1 (en) Method for detecting nucleic acid, capture probe, detection probe set, microarray, nucleic acid detection kit, nucleic-acid-immobilized solid phase, and fluid device
WO2024211816A2 (en) Methods and devices for detecting biological analytes using time-resolved optical reporters
US20230068047A1 (en) Digital amplification assay analysis method
US7838236B2 (en) Analytical method and kit
JPWO2020236992A5 (enExample)
JP2012239424A (ja) 核酸塩基配列解析方法および核酸塩基配列解析のためのマイクロチップと混合試薬
JP2019532632A (ja) 単一ヌクレオチド検出方法および関連プローブ
Bardea et al. Sensitive detection and identification of DNA and RNA using a patterned capillary tube
KR100809679B1 (ko) 혼성화된 핵산의 검출 및 신호 증폭 방법
JPWO2020225564A5 (enExample)
HK1255931A1 (en) Hydrolysis probe