JP2018505651A5 - - Google Patents

Info

Publication number

JP2018505651A5

JP2018505651A5 JP2017526502A JP2017526502A JP2018505651A5 JP 2018505651 A5 JP2018505651 A5 JP 2018505651A5 JP 2017526502 A JP2017526502 A JP 2017526502A JP 2017526502 A JP2017526502 A JP 2017526502A JP 2018505651 A5 JP2018505651 A5 JP 2018505651A5

Authority

JP

Japan

Prior art keywords

antibody

disease

seq

hvr

bace1

Prior art date

2015-11-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 102100021257 Beta-secretase 1 Human genes 0.000 claims 19
• 101000894895 Homo sapiens Beta-secretase 1 Proteins 0.000 claims 19
• 239000003814 drug Substances 0.000 claims 11
• 208000011580 syndromic disease Diseases 0.000 claims 10
• 229920001184 polypeptide Polymers 0.000 claims 8
• 102000004196 processed proteins & peptides Human genes 0.000 claims 8
• 108090000765 processed proteins & peptides Proteins 0.000 claims 8
• 208000012902 Nervous system disease Diseases 0.000 claims 7
• 230000000694 effects Effects 0.000 claims 7
• 208000024827 Alzheimer disease Diseases 0.000 claims 6
• 208000030886 Traumatic Brain injury Diseases 0.000 claims 6
• 230000009529 traumatic brain injury Effects 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
• 208000006011 Stroke Diseases 0.000 claims 4
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 4
• 239000012472 biological sample Substances 0.000 claims 4
• ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 201000006417 multiple sclerosis Diseases 0.000 claims 4
• 201000006938 muscular dystrophy Diseases 0.000 claims 4
• 210000001519 tissue Anatomy 0.000 claims 4
• 210000004027 cell Anatomy 0.000 claims 3
• 230000007850 degeneration Effects 0.000 claims 3
• 201000010099 disease Diseases 0.000 claims 3
• 230000001537 neural effect Effects 0.000 claims 3
• 208000011403 Alexander disease Diseases 0.000 claims 2
• 208000037259 Amyloid Plaque Diseases 0.000 claims 2
• 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 2
• 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 2
• 101710137189 Amyloid-beta A4 protein Proteins 0.000 claims 2
• 101710151993 Amyloid-beta precursor protein Proteins 0.000 claims 2
• 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims 2
• 208000009575 Angelman syndrome Diseases 0.000 claims 2
• 102000014461 Ataxins Human genes 0.000 claims 2
• 108010078286 Ataxins Proteins 0.000 claims 2
• 208000022526 Canavan disease Diseases 0.000 claims 2
• 206010008025 Cerebellar ataxia Diseases 0.000 claims 2
• 206010008027 Cerebellar atrophy Diseases 0.000 claims 2
• 201000003883 Cystic fibrosis Diseases 0.000 claims 2
• 206010012289 Dementia Diseases 0.000 claims 2
• 201000011240 Frontotemporal dementia Diseases 0.000 claims 2
• 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 2
• 208000010412 Glaucoma Diseases 0.000 claims 2
• 208000023105 Huntington disease Diseases 0.000 claims 2
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
• 208000005870 Lafora disease Diseases 0.000 claims 2
• 208000014161 Lafora myoclonic epilepsy Diseases 0.000 claims 2
• 208000009625 Lesch-Nyhan syndrome Diseases 0.000 claims 2
• 208000009829 Lewy Body Disease Diseases 0.000 claims 2
• 201000002832 Lewy body dementia Diseases 0.000 claims 2
• 241001465754 Metazoa Species 0.000 claims 2
• 208000026072 Motor neurone disease Diseases 0.000 claims 2
• 208000001089 Multiple system atrophy Diseases 0.000 claims 2
• 208000010191 Osteitis Deformans Diseases 0.000 claims 2
• 208000027868 Paget disease Diseases 0.000 claims 2
• 208000018737 Parkinson disease Diseases 0.000 claims 2
• 208000000609 Pick Disease of the Brain Diseases 0.000 claims 2
• 208000000474 Poliomyelitis Diseases 0.000 claims 2
• 201000004035 RIDDLE syndrome Diseases 0.000 claims 2
• 208000006289 Rett Syndrome Diseases 0.000 claims 2
• 208000009415 Spinocerebellar Ataxias Diseases 0.000 claims 2
• 206010048327 Supranuclear palsy Diseases 0.000 claims 2
• 208000035317 Total hypoxanthine-guanine phosphoribosyl transferase deficiency Diseases 0.000 claims 2
• 208000000323 Tourette Syndrome Diseases 0.000 claims 2
• 208000016620 Tourette disease Diseases 0.000 claims 2
• 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 claims 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 2
• DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical group C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims 2
• 201000004562 autosomal dominant cerebellar ataxia Diseases 0.000 claims 2
• 208000005881 bovine spongiform encephalopathy Diseases 0.000 claims 2
• 210000005013 brain tissue Anatomy 0.000 claims 2
• 208000017580 chronic wasting disease Diseases 0.000 claims 2
• 229960003920 cocaine Drugs 0.000 claims 2
• 230000003111 delayed effect Effects 0.000 claims 2
• 208000035475 disorder Diseases 0.000 claims 2
• 238000002868 homogeneous time resolved fluorescence Methods 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 206010023497 kuru Diseases 0.000 claims 2
• 208000027202 mammary Paget disease Diseases 0.000 claims 2
• 208000005264 motor neuron disease Diseases 0.000 claims 2
• 201000000585 muscular atrophy Diseases 0.000 claims 2
• 210000000653 nervous system Anatomy 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 208000008864 scrapie Diseases 0.000 claims 2
• 239000000758 substrate Substances 0.000 claims 2
• 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 2
• 201000006397 traumatic glaucoma Diseases 0.000 claims 2
• 201000004384 Alopecia Diseases 0.000 claims 1
• 102100034452 Alternative prion protein Human genes 0.000 claims 1
• 206010003694 Atrophy Diseases 0.000 claims 1
• 206010006542 Bulbar palsy Diseases 0.000 claims 1
• 241000282693 Cercopithecidae Species 0.000 claims 1
• 208000003351 Melanosis Diseases 0.000 claims 1
• 241000699666 Mus <mouse, genus> Species 0.000 claims 1
• 206010028289 Muscle atrophy Diseases 0.000 claims 1
• 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
• 206010033799 Paralysis Diseases 0.000 claims 1
• 241000009328 Perro Species 0.000 claims 1
• 208000024571 Pick disease Diseases 0.000 claims 1
• 108091000054 Prion Proteins 0.000 claims 1
• 241000700159 Rattus Species 0.000 claims 1
• 208000009106 Shy-Drager Syndrome Diseases 0.000 claims 1
• 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
• 229940125528 allosteric inhibitor Drugs 0.000 claims 1
• 238000003556 assay Methods 0.000 claims 1
• 230000037444 atrophy Effects 0.000 claims 1
• 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
• 230000001054 cortical effect Effects 0.000 claims 1
• 238000007821 culture assay Methods 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 239000002254 cytotoxic agent Substances 0.000 claims 1
• 231100000599 cytotoxic agent Toxicity 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 201000006061 fatal familial insomnia Diseases 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 230000002496 gastric effect Effects 0.000 claims 1
• 208000024963 hair loss Diseases 0.000 claims 1
• 230000003676 hair loss Effects 0.000 claims 1
• 210000005003 heart tissue Anatomy 0.000 claims 1
• 230000002440 hepatic effect Effects 0.000 claims 1
• 229940127121 immunoconjugate Drugs 0.000 claims 1
• 230000005764 inhibitory process Effects 0.000 claims 1
• 206010022437 insomnia Diseases 0.000 claims 1
• 231100000518 lethal Toxicity 0.000 claims 1
• 230000001665 lethal effect Effects 0.000 claims 1
• 210000004185 liver Anatomy 0.000 claims 1
• 210000002751 lymph Anatomy 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 210000003097 mucus Anatomy 0.000 claims 1
• 230000020763 muscle atrophy Effects 0.000 claims 1
• 210000001577 neostriatum Anatomy 0.000 claims 1
• 210000002569 neuron Anatomy 0.000 claims 1
• 239000000825 pharmaceutical preparation Substances 0.000 claims 1
• 230000007505 plaque formation Effects 0.000 claims 1
• 210000002381 plasma Anatomy 0.000 claims 1
• 201000002241 progressive bulbar palsy Diseases 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 210000003296 saliva Anatomy 0.000 claims 1
• 230000028327 secretion Effects 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1
• 230000014616 translation Effects 0.000 claims 1
• 230000002792 vascular Effects 0.000 claims 1