JP2017536102A5 - - Google Patents

Info

Publication number

JP2017536102A5

JP2017536102A5 JP2017520354A JP2017520354A JP2017536102A5 JP 2017536102 A5 JP2017536102 A5 JP 2017536102A5 JP 2017520354 A JP2017520354 A JP 2017520354A JP 2017520354 A JP2017520354 A JP 2017520354A JP 2017536102 A5 JP2017536102 A5 JP 2017536102A5

Authority

JP

Japan

Prior art keywords

antibody

hvr

disease

synuclein

amino acid

Prior art date

2015-10-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 125000003275 alpha amino acid group Chemical group 0.000 claims 32
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 20
• 208000009829 Lewy Body Disease Diseases 0.000 claims 20
• 201000002832 Lewy body dementia Diseases 0.000 claims 20
• 208000018737 Parkinson disease Diseases 0.000 claims 20
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 20
• 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 claims 12
• 206010003591 Ataxia Diseases 0.000 claims 10
• 206010012289 Dementia Diseases 0.000 claims 10
• 208000001089 Multiple system atrophy Diseases 0.000 claims 10
• 206010033799 Paralysis Diseases 0.000 claims 10
• 102000019355 Synuclein Human genes 0.000 claims 10
• 108050006783 Synuclein Proteins 0.000 claims 10
• 230000002567 autonomic effect Effects 0.000 claims 10
• 210000004556 brain Anatomy 0.000 claims 10
• 230000008021 deposition Effects 0.000 claims 10
• 201000010099 disease Diseases 0.000 claims 10
• 208000035475 disorder Diseases 0.000 claims 10
• 229910052742 iron Inorganic materials 0.000 claims 10
• 210000005036 nerve Anatomy 0.000 claims 10
• 208000021090 palsy Diseases 0.000 claims 10
• 208000002593 pantothenate kinase-associated neurodegeneration Diseases 0.000 claims 10
• 230000009885 systemic effect Effects 0.000 claims 10
• 102000003802 alpha-Synuclein Human genes 0.000 claims 9
• 108090000185 alpha-Synuclein Proteins 0.000 claims 9
• 239000003814 drug Substances 0.000 claims 8
• 230000004770 neurodegeneration Effects 0.000 claims 6
• 125000000539 amino acid group Chemical group 0.000 claims 4
• 208000015122 neurodegenerative disease Diseases 0.000 claims 4
• 230000000626 neurodegenerative effect Effects 0.000 claims 4
• 238000000034 method Methods 0.000 claims 3
• 150000007523 nucleic acids Chemical class 0.000 claims 3
• 102000039446 nucleic acids Human genes 0.000 claims 3
• 108020004707 nucleic acids Proteins 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000000825 pharmaceutical preparation Substances 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 1