JP2015510510A5 - - Google Patents

Info

Publication number

JP2015510510A5

JP2015510510A5 JP2014555859A JP2014555859A JP2015510510A5 JP 2015510510 A5 JP2015510510 A5 JP 2015510510A5 JP 2014555859 A JP2014555859 A JP 2014555859A JP 2014555859 A JP2014555859 A JP 2014555859A JP 2015510510 A5 JP2015510510 A5 JP 2015510510A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

antibody

human

acid sequence

Prior art date

2013-02-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 125000003275 alpha amino acid group Chemical group 0.000 claims 63
• 125000000539 amino acid group Chemical group 0.000 claims 42
• 101000998132 Homo sapiens Interleukin-34 Proteins 0.000 claims 34
• 102000002580 human interleukin-34 Human genes 0.000 claims 34
• 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 claims 27
• 239000003814 drug Substances 0.000 claims 14
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 11
• 101000916628 Homo sapiens Macrophage colony-stimulating factor 1 Proteins 0.000 claims 11
• 102000053925 human CSF1 Human genes 0.000 claims 11
• 208000026278 immune system disease Diseases 0.000 claims 8
• 101710181549 Interleukin-34 Proteins 0.000 claims 4
• 150000001413 amino acids Chemical class 0.000 claims 4
• 239000000539 dimer Substances 0.000 claims 4
• 230000000694 effects Effects 0.000 claims 4
• 238000004519 manufacturing process Methods 0.000 claims 4
• 210000004027 cell Anatomy 0.000 claims 3
• 239000012634 fragment Substances 0.000 claims 3
• 150000007523 nucleic acids Chemical class 0.000 claims 3
• 102000039446 nucleic acids Human genes 0.000 claims 3
• 108020004707 nucleic acids Proteins 0.000 claims 3
• 208000032672 Histiocytosis haematophagic Diseases 0.000 claims 2
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 2
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 2
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
• 208000004987 Macrophage activation syndrome Diseases 0.000 claims 2
• 102000002067 Protein Subunits Human genes 0.000 claims 2
• 108010001267 Protein Subunits Proteins 0.000 claims 2
• 210000001185 bone marrow Anatomy 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 201000006417 multiple sclerosis Diseases 0.000 claims 2
• 230000001717 pathogenic effect Effects 0.000 claims 2
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
• 238000002560 therapeutic procedure Methods 0.000 claims 2
• GJLXVWOMRRWCIB-MERZOTPQSA-N (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanamide Chemical compound C([C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)C1=CC=C(O)C=C1 GJLXVWOMRRWCIB-MERZOTPQSA-N 0.000 claims 1
• 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
• 101710150918 Macrophage colony-stimulating factor 1 receptor Proteins 0.000 claims 1
• 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 claims 1
• 206010047115 Vasculitis Diseases 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims 1
• 208000024908 graft versus host disease Diseases 0.000 claims 1
• 102000052833 human CSF1R Human genes 0.000 claims 1
• 206010025135 lupus erythematosus Diseases 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 229960004641 rituximab Drugs 0.000 claims 1
• 201000000306 sarcoidosis Diseases 0.000 claims 1