JP2015533795A5 - - Google Patents
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- Publication number
- JP2015533795A5 JP2015533795A5 JP2015531286A JP2015531286A JP2015533795A5 JP 2015533795 A5 JP2015533795 A5 JP 2015533795A5 JP 2015531286 A JP2015531286 A JP 2015531286A JP 2015531286 A JP2015531286 A JP 2015531286A JP 2015533795 A5 JP2015533795 A5 JP 2015533795A5
- Authority
- JP
- Japan
- Prior art keywords
- hvr
- seq
- amino acid
- acid sequence
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 55
- 239000000427 antigen Substances 0.000 claims 25
- 102000036639 antigens Human genes 0.000 claims 25
- 108091007433 antigens Proteins 0.000 claims 25
- 239000012634 fragment Substances 0.000 claims 25
- 101000623903 Homo sapiens Cell surface glycoprotein MUC18 Proteins 0.000 claims 6
- 102100023126 Cell surface glycoprotein MUC18 Human genes 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- PJOHVEQSYPOERL-SHEAVXILSA-N (e)-n-[(4r,4as,7ar,12br)-3-(cyclopropylmethyl)-9-hydroxy-7-oxo-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-4a-yl]-3-(4-methylphenyl)prop-2-enamide Chemical compound C1=CC(C)=CC=C1\C=C\C(=O)N[C@]1(CCC(=O)[C@@H]2O3)[C@H]4CC5=CC=C(O)C3=C5[C@]12CCN4CC1CC1 PJOHVEQSYPOERL-SHEAVXILSA-N 0.000 claims 3
- 210000003169 central nervous system Anatomy 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 2
- 102000051110 human MCAM Human genes 0.000 claims 2
- 230000008595 infiltration Effects 0.000 claims 2
- 238000001764 infiltration Methods 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 208000002029 allergic contact dermatitis Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261698916P | 2012-09-10 | 2012-09-10 | |
| US61/698,916 | 2012-09-10 | ||
| US201261797179P | 2012-11-30 | 2012-11-30 | |
| US61/797,179 | 2012-11-30 | ||
| US201261797356P | 2012-12-05 | 2012-12-05 | |
| US61/797,356 | 2012-12-05 | ||
| PCT/US2013/058773 WO2014039975A2 (en) | 2012-09-10 | 2013-09-09 | Anti-mcam antibodies and associated methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015533795A JP2015533795A (ja) | 2015-11-26 |
| JP2015533795A5 true JP2015533795A5 (enExample) | 2016-11-04 |
| JP6339574B2 JP6339574B2 (ja) | 2018-06-06 |
Family
ID=50237783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531286A Expired - Fee Related JP6339574B2 (ja) | 2012-09-10 | 2013-09-09 | 抗ｍｃａｍ抗体及び関連する使用方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (6) | US20150239980A1 (enExample) |
| EP (2) | EP2892562B1 (enExample) |
| JP (1) | JP6339574B2 (enExample) |
| KR (1) | KR102194568B1 (enExample) |
| CN (2) | CN107266571A (enExample) |
| AR (1) | AR092488A1 (enExample) |
| AU (2) | AU2013312203B2 (enExample) |
| CA (1) | CA2884463A1 (enExample) |
| CL (1) | CL2015000582A1 (enExample) |
| CO (1) | CO7400878A2 (enExample) |
| CU (1) | CU20150023A7 (enExample) |
| DK (1) | DK2892562T3 (enExample) |
| EA (1) | EA201590528A1 (enExample) |
| ES (1) | ES2718208T3 (enExample) |
| IL (1) | IL237625A0 (enExample) |
| MX (1) | MX2015002918A (enExample) |
| MY (1) | MY182427A (enExample) |
| PE (1) | PE20151286A1 (enExample) |
| PH (1) | PH12015500514A1 (enExample) |
| SG (2) | SG10201708127UA (enExample) |
| TW (3) | TW201922795A (enExample) |
| WO (1) | WO2014039975A2 (enExample) |
| ZA (1) | ZA201501858B (enExample) |
Families Citing this family (41)
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| IN2014DN10515A (enExample) | 2006-03-31 | 2015-08-21 | Chugai Pharmaceutical Co Ltd | |
| MX369784B (es) | 2007-09-26 | 2019-11-21 | Chugai Pharmaceutical Co Ltd | Metodo de modificacion del punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr). |
| PT2708559T (pt) | 2008-04-11 | 2018-05-16 | Chugai Pharmaceutical Co Ltd | Molécula de ligação ao antigénio capaz de se ligar repetidamente a duas ou mais moléculas de antigénio |
| TWI654204B (zh) | 2010-11-30 | 2019-03-21 | 中外製藥股份有限公司 | 具有鈣依存性的抗原結合能力之抗體 |
| JP6774164B2 (ja) | 2012-08-24 | 2020-10-21 | 中外製薬株式会社 | マウスＦｃγＲＩＩ特異的Ｆｃ抗体 |
| MX371442B (es) | 2012-08-24 | 2020-01-30 | Chugai Pharmaceutical Co Ltd | VARIANTE DE LA REGION FC ESPECIFICA PARA FCyRIIB. |
| TW201922795A (zh) | 2012-09-10 | 2019-06-16 | 愛爾蘭商尼歐托普生物科學公司 | 抗ｍｃａｍ抗體及相關使用方法 |
| CA2908350C (en) | 2013-04-02 | 2023-08-08 | Futa Mimoto | Fc region variant |
| CA2938933A1 (en) | 2014-03-12 | 2015-09-17 | Prothena Biosciences Limited | Anti-laminin4 antibodies specific for lg4-5 |
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| DK3116911T3 (da) * | 2014-03-12 | 2019-09-30 | Prothena Biosciences Ltd | Anti-mcam-antistoffer og tilhørende fremgangsmåder til anvendelse |
| JP2017510627A (ja) * | 2014-03-13 | 2017-04-13 | プロセナ バイオサイエンシーズ リミテッド | 多発性硬化症の併用治療 |
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| AR103161A1 (es) | 2014-12-19 | 2017-04-19 | Chugai Pharmaceutical Co Ltd | Anticuerpos antimiostatina y regiones fc variantes así como métodos de uso |
| EP3816179A3 (en) | 2015-02-05 | 2021-08-04 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant comprising a modified fcrn-binding domain |
| CN104710513A (zh) * | 2015-04-06 | 2015-06-17 | 苏州普罗达生物科技有限公司 | 黑色素瘤细胞粘附分子拮抗剂多肽及其应用 |
| CN104725483A (zh) * | 2015-04-06 | 2015-06-24 | 苏州普罗达生物科技有限公司 | 一种黑色素瘤细胞粘附分子拮抗剂多肽及其应用 |
| WO2017046774A2 (en) * | 2015-09-16 | 2017-03-23 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica or takayasu's arteritis |
| CA2998716A1 (en) * | 2015-09-16 | 2017-03-23 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica or takayasu's arteritis |
| CN109154611B (zh) | 2015-12-09 | 2022-04-08 | 科尔沃斯制药股份有限公司 | 人源化抗cd73抗体 |
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| WO2017208210A1 (en) | 2016-06-03 | 2017-12-07 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
| CN116251182A (zh) | 2016-08-05 | 2023-06-13 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| WO2018223140A1 (en) * | 2017-06-02 | 2018-12-06 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
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| CN113423830B (zh) * | 2018-12-21 | 2023-08-22 | 普众发现医药科技(上海)有限公司 | 对muc18特异性的抗体 |
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| EP4263600A1 (en) | 2020-12-18 | 2023-10-25 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| EP4463135A2 (en) | 2022-01-10 | 2024-11-20 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
| WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| EP4602174A1 (en) | 2022-10-13 | 2025-08-20 | Sana Biotechnology, Inc. | Viral particles targeting hematopoietic stem cells |
| WO2024119157A1 (en) | 2022-12-02 | 2024-06-06 | Sana Biotechnology, Inc. | Lipid particles with cofusogens and methods of producing and using the same |
| AU2024274792A1 (en) | 2023-05-23 | 2025-10-23 | Sana Biotechnology, Inc. | Tandem fusogens and related lipid particles |
| US12311033B2 (en) | 2023-05-31 | 2025-05-27 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025076127A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| WO2025184529A1 (en) | 2024-03-01 | 2025-09-04 | Sana Biotechnology, Inc. | Viral particles with fusogen display and related compositions and methods |
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| JP2017510627A (ja) | 2014-03-13 | 2017-04-13 | プロセナ バイオサイエンシーズ リミテッド | 多発性硬化症の併用治療 |
| CA2998716A1 (en) | 2015-09-16 | 2017-03-23 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica or takayasu's arteritis |
| WO2017046774A2 (en) | 2015-09-16 | 2017-03-23 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica or takayasu's arteritis |
| WO2017149513A1 (en) | 2016-03-03 | 2017-09-08 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
| WO2017208210A1 (en) | 2016-06-03 | 2017-12-07 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
| WO2018223140A1 (en) | 2017-06-02 | 2018-12-06 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
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2013
- 2013-09-06 TW TW108108483A patent/TW201922795A/zh unknown
- 2013-09-06 TW TW102132203A patent/TWI595007B/zh not_active IP Right Cessation
- 2013-09-06 TW TW106116728A patent/TWI660972B/zh not_active IP Right Cessation
- 2013-09-09 ES ES13836030T patent/ES2718208T3/es active Active
- 2013-09-09 WO PCT/US2013/058773 patent/WO2014039975A2/en not_active Ceased
- 2013-09-09 MY MYPI2015700717A patent/MY182427A/en unknown
- 2013-09-09 US US14/427,290 patent/US20150239980A1/en not_active Abandoned
- 2013-09-09 MX MX2015002918A patent/MX2015002918A/es unknown
- 2013-09-09 AU AU2013312203A patent/AU2013312203B2/en not_active Ceased
- 2013-09-09 CN CN201710411450.3A patent/CN107266571A/zh active Pending
- 2013-09-09 PE PE2015000328A patent/PE20151286A1/es not_active Application Discontinuation
- 2013-09-09 CA CA2884463A patent/CA2884463A1/en not_active Abandoned
- 2013-09-09 AR ARP130103202A patent/AR092488A1/es unknown
- 2013-09-09 JP JP2015531286A patent/JP6339574B2/ja not_active Expired - Fee Related
- 2013-09-09 CN CN201380047188.9A patent/CN105120895A/zh active Pending
- 2013-09-09 DK DK13836030.0T patent/DK2892562T3/en active
- 2013-09-09 EP EP13836030.0A patent/EP2892562B1/en active Active
- 2013-09-09 EA EA201590528A patent/EA201590528A1/ru unknown
- 2013-09-09 US US14/021,777 patent/US9447190B2/en not_active Expired - Fee Related
- 2013-09-09 SG SG10201708127UA patent/SG10201708127UA/en unknown
- 2013-09-09 SG SG11201501773RA patent/SG11201501773RA/en unknown
- 2013-09-09 EP EP19155167.0A patent/EP3530287A1/en not_active Withdrawn
- 2013-09-09 KR KR1020157008706A patent/KR102194568B1/ko not_active Expired - Fee Related
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2015
- 2015-03-09 IL IL237625A patent/IL237625A0/en unknown
- 2015-03-09 CL CL2015000582A patent/CL2015000582A1/es unknown
- 2015-03-10 CU CUP2015000023A patent/CU20150023A7/es unknown
- 2015-03-10 PH PH12015500514A patent/PH12015500514A1/en unknown
- 2015-03-18 ZA ZA2015/01858A patent/ZA201501858B/en unknown
- 2015-04-08 CO CO15077895A patent/CO7400878A2/es unknown
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2016
- 2016-07-28 US US15/222,849 patent/US10414825B2/en not_active Expired - Fee Related
- 2016-07-28 US US15/222,848 patent/US10407507B2/en not_active Expired - Fee Related
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2017
- 2017-10-05 US US15/726,170 patent/US10584177B2/en not_active Expired - Fee Related
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2018
- 2018-10-04 AU AU2018241135A patent/AU2018241135B2/en not_active Ceased
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2020
- 2020-01-16 US US16/745,178 patent/US20200216560A1/en not_active Abandoned
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