JP2015533795A5 - - Google Patents
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- JP2015533795A5 JP2015533795A5 JP2015531286A JP2015531286A JP2015533795A5 JP 2015533795 A5 JP2015533795 A5 JP 2015533795A5 JP 2015531286 A JP2015531286 A JP 2015531286A JP 2015531286 A JP2015531286 A JP 2015531286A JP 2015533795 A5 JP2015533795 A5 JP 2015533795A5
- Authority
- JP
- Japan
- Prior art keywords
- hvr
- seq
- amino acid
- acid sequence
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 55
- 239000000427 antigen Substances 0.000 claims 25
- 102000036639 antigens Human genes 0.000 claims 25
- 108091007433 antigens Proteins 0.000 claims 25
- 239000012634 fragment Substances 0.000 claims 25
- 101000623903 Homo sapiens Cell surface glycoprotein MUC18 Proteins 0.000 claims 6
- 102100023126 Cell surface glycoprotein MUC18 Human genes 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- PJOHVEQSYPOERL-SHEAVXILSA-N (e)-n-[(4r,4as,7ar,12br)-3-(cyclopropylmethyl)-9-hydroxy-7-oxo-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-4a-yl]-3-(4-methylphenyl)prop-2-enamide Chemical compound C1=CC(C)=CC=C1\C=C\C(=O)N[C@]1(CCC(=O)[C@@H]2O3)[C@H]4CC5=CC=C(O)C3=C5[C@]12CCN4CC1CC1 PJOHVEQSYPOERL-SHEAVXILSA-N 0.000 claims 3
- 210000003169 central nervous system Anatomy 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 2
- 102000051110 human MCAM Human genes 0.000 claims 2
- 230000008595 infiltration Effects 0.000 claims 2
- 238000001764 infiltration Methods 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 208000002029 allergic contact dermatitis Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261698916P | 2012-09-10 | 2012-09-10 | |
| US61/698,916 | 2012-09-10 | ||
| US201261797179P | 2012-11-30 | 2012-11-30 | |
| US61/797,179 | 2012-11-30 | ||
| US201261797356P | 2012-12-05 | 2012-12-05 | |
| US61/797,356 | 2012-12-05 | ||
| PCT/US2013/058773 WO2014039975A2 (en) | 2012-09-10 | 2013-09-09 | Anti-mcam antibodies and associated methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015533795A JP2015533795A (ja) | 2015-11-26 |
| JP2015533795A5 true JP2015533795A5 (enExample) | 2016-11-04 |
| JP6339574B2 JP6339574B2 (ja) | 2018-06-06 |
Family
ID=50237783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531286A Expired - Fee Related JP6339574B2 (ja) | 2012-09-10 | 2013-09-09 | 抗ｍｃａｍ抗体及び関連する使用方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (6) | US20150239980A1 (enExample) |
| EP (2) | EP2892562B1 (enExample) |
| JP (1) | JP6339574B2 (enExample) |
| KR (1) | KR102194568B1 (enExample) |
| CN (2) | CN105120895A (enExample) |
| AR (1) | AR092488A1 (enExample) |
| AU (2) | AU2013312203B2 (enExample) |
| CA (1) | CA2884463A1 (enExample) |
| CL (1) | CL2015000582A1 (enExample) |
| CO (1) | CO7400878A2 (enExample) |
| CU (1) | CU20150023A7 (enExample) |
| DK (1) | DK2892562T3 (enExample) |
| EA (1) | EA201590528A1 (enExample) |
| ES (1) | ES2718208T3 (enExample) |
| IL (1) | IL237625A0 (enExample) |
| MX (1) | MX2015002918A (enExample) |
| MY (1) | MY182427A (enExample) |
| PE (1) | PE20151286A1 (enExample) |
| PH (1) | PH12015500514A1 (enExample) |
| SG (2) | SG10201708127UA (enExample) |
| TW (3) | TWI595007B (enExample) |
| WO (1) | WO2014039975A2 (enExample) |
| ZA (1) | ZA201501858B (enExample) |
Families Citing this family (41)
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| ES2568436T3 (es) | 2006-03-31 | 2016-04-29 | Chugai Seiyaku Kabushiki Kaisha | Procedimiento para controlar la farmacocinética en sangre de anticuerpos |
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| EP3056513A1 (en) | 2008-04-11 | 2016-08-17 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| KR102568454B1 (ko) | 2010-11-30 | 2023-08-18 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복해서 결합하는 항원 결합 분자 |
| EP2889376A4 (en) | 2012-08-24 | 2016-11-02 | Chugai Pharmaceutical Co Ltd | MOUSE FC RII SPECIFIC FC ANTIBODY |
| TW202237660A (zh) | 2012-08-24 | 2022-10-01 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
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| WO2014163101A1 (ja) | 2013-04-02 | 2014-10-09 | 中外製薬株式会社 | Ｆｃ領域改変体 |
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| PT3116911T (pt) | 2014-03-12 | 2019-09-04 | Prothena Biosciences Ltd | Anticorpos anti-mcam e métodos de utilização associados |
| EP3116910A1 (en) * | 2014-03-13 | 2017-01-18 | Prothena Biosciences Limited | Combination treatment for multiple sclerosis |
| US20170216409A1 (en) * | 2014-08-05 | 2017-08-03 | The University Of Chicago | Modulation of laminin alpha-4 in the prevention, treatment, and management of metabolic syndromes |
| EP4600372A3 (en) | 2014-12-19 | 2025-11-19 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
| KR102605798B1 (ko) | 2015-02-05 | 2023-11-23 | 추가이 세이야쿠 가부시키가이샤 | 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용 |
| CN104725483A (zh) * | 2015-04-06 | 2015-06-24 | 苏州普罗达生物科技有限公司 | 一种黑色素瘤细胞粘附分子拮抗剂多肽及其应用 |
| CN104710513A (zh) * | 2015-04-06 | 2015-06-17 | 苏州普罗达生物科技有限公司 | 黑色素瘤细胞粘附分子拮抗剂多肽及其应用 |
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| WO2017208210A1 (en) | 2016-06-03 | 2017-12-07 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
| US11053308B2 (en) | 2016-08-05 | 2021-07-06 | Chugai Seiyaku Kabushiki Kaisha | Method for treating IL-8-related diseases |
| WO2018223140A1 (en) * | 2017-06-02 | 2018-12-06 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
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| AU2019401657B2 (en) * | 2018-12-21 | 2025-10-09 | Multitude Therapeutics Inc. | Antibodies specific to MUC18 |
| JP2024500847A (ja) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス，インコーポレイテッド | 適合可能な受容体特異性を有するキメラ抗原受容体システム |
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| WO2024081820A1 (en) | 2022-10-13 | 2024-04-18 | Sana Biotechnology, Inc. | Viral particles targeting hematopoietic stem cells |
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| CN121443743A (zh) | 2023-05-23 | 2026-01-30 | 赛纳生物技术公司 | 串联融合剂和相关脂质颗粒 |
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| US20170129954A1 (en) | 2014-03-12 | 2017-05-11 | Prothena Biosciences Limited | Use of Anti-MCAM Antibodies for Treatment or Prophylaxis of Giant Cell Arteritis, Polymyalgia Rheumatica or Takayasus Arteritis |
| US20170101470A1 (en) | 2014-03-12 | 2017-04-13 | Prothena Biosciences Limited | Use of Anti-MCAM Antibodies for Treatment or Prophylaxis of Giant Cell Arteritis, Polymyalgia Rheumatica or Takayasus Arteritis |
| EP3116910A1 (en) | 2014-03-13 | 2017-01-18 | Prothena Biosciences Limited | Combination treatment for multiple sclerosis |
| CA2998716A1 (en) | 2015-09-16 | 2017-03-23 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica or takayasu's arteritis |
| WO2017046774A2 (en) | 2015-09-16 | 2017-03-23 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica or takayasu's arteritis |
| WO2017149513A1 (en) | 2016-03-03 | 2017-09-08 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
| WO2017208210A1 (en) | 2016-06-03 | 2017-12-07 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
| WO2018223140A1 (en) | 2017-06-02 | 2018-12-06 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
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2013
- 2013-09-06 TW TW102132203A patent/TWI595007B/zh not_active IP Right Cessation
- 2013-09-06 TW TW106116728A patent/TWI660972B/zh not_active IP Right Cessation
- 2013-09-06 TW TW108108483A patent/TW201922795A/zh unknown
- 2013-09-09 EA EA201590528A patent/EA201590528A1/ru unknown
- 2013-09-09 SG SG10201708127UA patent/SG10201708127UA/en unknown
- 2013-09-09 US US14/427,290 patent/US20150239980A1/en not_active Abandoned
- 2013-09-09 AU AU2013312203A patent/AU2013312203B2/en not_active Ceased
- 2013-09-09 DK DK13836030.0T patent/DK2892562T3/en active
- 2013-09-09 EP EP13836030.0A patent/EP2892562B1/en active Active
- 2013-09-09 US US14/021,777 patent/US9447190B2/en not_active Expired - Fee Related
- 2013-09-09 CN CN201380047188.9A patent/CN105120895A/zh active Pending
- 2013-09-09 MY MYPI2015700717A patent/MY182427A/en unknown
- 2013-09-09 MX MX2015002918A patent/MX2015002918A/es unknown
- 2013-09-09 EP EP19155167.0A patent/EP3530287A1/en not_active Withdrawn
- 2013-09-09 WO PCT/US2013/058773 patent/WO2014039975A2/en not_active Ceased
- 2013-09-09 CA CA2884463A patent/CA2884463A1/en not_active Abandoned
- 2013-09-09 PE PE2015000328A patent/PE20151286A1/es not_active Application Discontinuation
- 2013-09-09 ES ES13836030T patent/ES2718208T3/es active Active
- 2013-09-09 JP JP2015531286A patent/JP6339574B2/ja not_active Expired - Fee Related
- 2013-09-09 KR KR1020157008706A patent/KR102194568B1/ko not_active Expired - Fee Related
- 2013-09-09 SG SG11201501773RA patent/SG11201501773RA/en unknown
- 2013-09-09 CN CN201710411450.3A patent/CN107266571A/zh active Pending
- 2013-09-09 AR ARP130103202A patent/AR092488A1/es unknown
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2015
- 2015-03-09 IL IL237625A patent/IL237625A0/en unknown
- 2015-03-09 CL CL2015000582A patent/CL2015000582A1/es unknown
- 2015-03-10 CU CUP2015000023A patent/CU20150023A7/es unknown
- 2015-03-10 PH PH12015500514A patent/PH12015500514A1/en unknown
- 2015-03-18 ZA ZA2015/01858A patent/ZA201501858B/en unknown
- 2015-04-08 CO CO15077895A patent/CO7400878A2/es unknown
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2016
- 2016-07-28 US US15/222,848 patent/US10407507B2/en not_active Expired - Fee Related
- 2016-07-28 US US15/222,849 patent/US10414825B2/en not_active Expired - Fee Related
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2017
- 2017-10-05 US US15/726,170 patent/US10584177B2/en not_active Expired - Fee Related
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2018
- 2018-10-04 AU AU2018241135A patent/AU2018241135B2/en not_active Ceased
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2020
- 2020-01-16 US US16/745,178 patent/US20200216560A1/en not_active Abandoned
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