JP2014502150A5 - - Google Patents

Info

Publication number

JP2014502150A5

JP2014502150A5 JP2013538846A JP2013538846A JP2014502150A5 JP 2014502150 A5 JP2014502150 A5 JP 2014502150A5 JP 2013538846 A JP2013538846 A JP 2013538846A JP 2013538846 A JP2013538846 A JP 2013538846A JP 2014502150 A5 JP2014502150 A5 JP 2014502150A5

Authority

JP

Japan

Prior art keywords

seq

antibody

hvr

disease

amino acid

Prior art date

2011-11-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 125000003275 alpha amino acid group Chemical group 0.000 claims 38
• 102100021257 Beta-secretase 1 Human genes 0.000 claims 20
• 101000894895 Homo sapiens Beta-secretase 1 Proteins 0.000 claims 20
• 208000012902 Nervous system disease Diseases 0.000 claims 20
• 239000003814 drug Substances 0.000 claims 12
• 208000025966 Neurological disease Diseases 0.000 claims 11
• 150000001413 amino acids Chemical class 0.000 claims 10
• 229910052698 phosphorus Inorganic materials 0.000 claims 10
• 208000024827 Alzheimer disease Diseases 0.000 claims 8
• 208000030886 Traumatic Brain injury Diseases 0.000 claims 8
• 230000009529 traumatic brain injury Effects 0.000 claims 8
• 239000012634 fragment Substances 0.000 claims 7
• 201000006938 muscular dystrophy Diseases 0.000 claims 7
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 6
• 239000012472 biological sample Substances 0.000 claims 6
• 201000010099 disease Diseases 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 201000006417 multiple sclerosis Diseases 0.000 claims 6
• 208000011580 syndromic disease Diseases 0.000 claims 6
• 208000001089 Multiple system atrophy Diseases 0.000 claims 5
• 208000006011 Stroke Diseases 0.000 claims 5
• 229920001184 polypeptide Polymers 0.000 claims 5
• 108090000765 processed proteins & peptides Proteins 0.000 claims 5
• 102000004196 processed proteins & peptides Human genes 0.000 claims 5
• 230000007850 degeneration Effects 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 208000011403 Alexander disease Diseases 0.000 claims 3
• 208000009575 Angelman syndrome Diseases 0.000 claims 3
• 206010006542 Bulbar palsy Diseases 0.000 claims 3
• 208000022526 Canavan disease Diseases 0.000 claims 3
• 206010008027 Cerebellar atrophy Diseases 0.000 claims 3
• 206010012289 Dementia Diseases 0.000 claims 3
• 201000011240 Frontotemporal dementia Diseases 0.000 claims 3
• 208000010412 Glaucoma Diseases 0.000 claims 3
• 208000023105 Huntington disease Diseases 0.000 claims 3
• 208000005870 Lafora disease Diseases 0.000 claims 3
• 208000014161 Lafora myoclonic epilepsy Diseases 0.000 claims 3
• 208000009625 Lesch-Nyhan syndrome Diseases 0.000 claims 3
• 208000009829 Lewy Body Disease Diseases 0.000 claims 3
• 201000002832 Lewy body dementia Diseases 0.000 claims 3
• 208000026072 Motor neurone disease Diseases 0.000 claims 3
• 208000002537 Neuronal Ceroid-Lipofuscinoses Diseases 0.000 claims 3
• 208000010191 Osteitis Deformans Diseases 0.000 claims 3
• 208000027868 Paget disease Diseases 0.000 claims 3
• 208000018737 Parkinson disease Diseases 0.000 claims 3
• 208000000609 Pick Disease of the Brain Diseases 0.000 claims 3
• 208000010366 Postpoliomyelitis syndrome Diseases 0.000 claims 3
• 201000004035 RIDDLE syndrome Diseases 0.000 claims 3
• 208000006289 Rett Syndrome Diseases 0.000 claims 3
• 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 3
• 208000035317 Total hypoxanthine-guanine phosphoribosyl transferase deficiency Diseases 0.000 claims 3
• 208000000323 Tourette Syndrome Diseases 0.000 claims 3
• 208000016620 Tourette disease Diseases 0.000 claims 3
• 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 claims 3
• 208000005881 bovine spongiform encephalopathy Diseases 0.000 claims 3
• 208000017580 chronic wasting disease Diseases 0.000 claims 3
• 206010022437 insomnia Diseases 0.000 claims 3
• 206010023497 kuru Diseases 0.000 claims 3
• 231100000518 lethal Toxicity 0.000 claims 3
• 230000001665 lethal effect Effects 0.000 claims 3
• 208000027202 mammary Paget disease Diseases 0.000 claims 3
• 208000005264 motor neuron disease Diseases 0.000 claims 3
• 201000008051 neuronal ceroid lipofuscinosis Diseases 0.000 claims 3
• 201000002241 progressive bulbar palsy Diseases 0.000 claims 3
• 208000008864 scrapie Diseases 0.000 claims 3
• 210000001519 tissue Anatomy 0.000 claims 3
• 208000037259 Amyloid Plaque Diseases 0.000 claims 2
• 102000014461 Ataxins Human genes 0.000 claims 2
• 108010078286 Ataxins Proteins 0.000 claims 2
• 206010008025 Cerebellar ataxia Diseases 0.000 claims 2
• 201000003883 Cystic fibrosis Diseases 0.000 claims 2
• 208000002972 Hepatolenticular Degeneration Diseases 0.000 claims 2
• 208000008948 Menkes Kinky Hair Syndrome Diseases 0.000 claims 2
• 208000012583 Menkes disease Diseases 0.000 claims 2
• 206010027294 Menkes' syndrome Diseases 0.000 claims 2
• 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 2
• 240000007817 Olea europaea Species 0.000 claims 2
• 208000009106 Shy-Drager Syndrome Diseases 0.000 claims 2
• 208000009415 Spinocerebellar Ataxias Diseases 0.000 claims 2
• 206010048327 Supranuclear palsy Diseases 0.000 claims 2
• 208000006657 Unverricht-Lundborg syndrome Diseases 0.000 claims 2
• 208000018839 Wilson disease Diseases 0.000 claims 2
• 201000004562 autosomal dominant cerebellar ataxia Diseases 0.000 claims 2
• 210000005013 brain tissue Anatomy 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 210000001175 cerebrospinal fluid Anatomy 0.000 claims 2
• ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 230000002496 gastric effect Effects 0.000 claims 2
• 210000005003 heart tissue Anatomy 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 210000002751 lymph Anatomy 0.000 claims 2
• 210000003097 mucus Anatomy 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 210000002381 plasma Anatomy 0.000 claims 2
• 210000003296 saliva Anatomy 0.000 claims 2
• 230000028327 secretion Effects 0.000 claims 2
• 210000002966 serum Anatomy 0.000 claims 2
• 230000014616 translation Effects 0.000 claims 2
• 201000006397 traumatic glaucoma Diseases 0.000 claims 2
• 230000002792 vascular Effects 0.000 claims 2
• IEPMBYOIQGCVHO-UHFFFAOYSA-N 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid;hydron;chloride Chemical compound Cl.C1CNC(C)CN1C(C(=C1C)F)=CC2=C1C(=O)C(C(O)=O)=CN2C1CC1 IEPMBYOIQGCVHO-UHFFFAOYSA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical group C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 1
• 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 1
• 208000010200 Cockayne syndrome Diseases 0.000 claims 1
• 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims 1
• 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 206010033799 Paralysis Diseases 0.000 claims 1
• 125000000539 amino acid group Chemical group 0.000 claims 1
• 229960003920 cocaine Drugs 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 231100000433 cytotoxic Toxicity 0.000 claims 1
• 230000001472 cytotoxic effect Effects 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000000835 fiber Substances 0.000 claims 1
• 230000002440 hepatic effect Effects 0.000 claims 1
• 229940127121 immunoconjugate Drugs 0.000 claims 1
• 230000005764 inhibitory process Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 210000000944 nerve tissue Anatomy 0.000 claims 1
• 230000001537 neural effect Effects 0.000 claims 1
• 229910052757 nitrogen Inorganic materials 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 230000007505 plaque formation Effects 0.000 claims 1
• 208000016658 polyneuropathy-intellectual disability-acromicria-premature menopause syndrome Diseases 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 208000020219 spinocerebellar ataxia 48 Diseases 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 210000003523 substantia nigra Anatomy 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1