JP6859259B2 - ＢＡＣＥｌに対する抗体及び神経疾患免疫療法のためのその使用 - Google Patents

ＢＡＣＥｌに対する抗体及び神経疾患免疫療法のためのその使用 Download PDF

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JP6859259B2
JP6859259B2 JP2017526502A JP2017526502A JP6859259B2 JP 6859259 B2 JP6859259 B2 JP 6859259B2 JP 2017526502 A JP2017526502 A JP 2017526502A JP 2017526502 A JP2017526502 A JP 2017526502A JP 6859259 B2 JP6859259 B2 JP 6859259B2
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antibody
bace1
disease
hvr
seq
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JP2018505651A (ja
JP2018505651A5 (enExample
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イーチン リウ，
イーチン リウ，
ジャスビンダル アトウォル，
ジャスビンダル アトウォル，
セシリア プイ チー チウ，
セシリア プイ チー チウ，
ライアン ジェー． ワッツ，
ライアン ジェー． ワッツ，
ヤン ウー，
ヤン ウー，
エリック クラウランド，
エリック クラウランド，
マイケル フェルトハウス，
マイケル フェルトハウス，
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Genentech Inc
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6871—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
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JP2017526502A 2014-11-19 2015-11-18 ＢＡＣＥｌに対する抗体及び神経疾患免疫療法のためのその使用 Active JP6859259B2 (ja)

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US201462081966P 2014-11-19 2014-11-19
US62/081,966 2014-11-19
PCT/US2015/061401 WO2016081639A1 (en) 2014-11-19 2015-11-18 Antibodies against bace1 and use thereof for neural disease immunotherapy

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JP2018505651A JP2018505651A (ja) 2018-03-01
JP2018505651A5 JP2018505651A5 (enExample) 2018-12-27
JP6859259B2 true JP6859259B2 (ja) 2021-04-14

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US (2) US10882920B2 (enExample)
EP (2) EP3845565A3 (enExample)
JP (1) JP6859259B2 (enExample)
CN (1) CN107108745B (enExample)
WO (1) WO2016081639A1 (enExample)

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EP3221361B1 (en) 2014-11-19 2021-04-21 Genentech, Inc. Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use
KR102725051B1 (ko) 2015-09-23 2024-11-04 제넨테크, 인크. 항-vegf 항체의 최적화된 변이체들
US11525002B2 (en) 2017-10-11 2022-12-13 Board Of Regents, The University Of Texas System Human PD-L1 antibodies and methods of use therefor
WO2019094608A1 (en) 2017-11-08 2019-05-16 Denali Therapeutics Inc. Anti-bace1 antibodies and methods of use thereof
CN119101158A (zh) 2018-03-23 2024-12-10 得克萨斯州大学系统董事会 人pd-l2抗体及其使用方法
CN117586412A (zh) 2018-03-23 2024-02-23 得克萨斯州大学系统董事会 针对人pd-l1和pd-l2的双重特异性抗体及其使用方法
EP4501355A3 (en) 2018-03-23 2025-04-30 Board Of Regents, The University Of Texas System Dual specificity antibodies to pd-l1 and pd-l2 and methods of use therefor
CN108760661B (zh) * 2018-09-08 2023-06-09 重庆科技学院 一种石油废水重金属离子多通道检测芯片
JP2022514290A (ja) 2018-12-20 2022-02-10 ジェネンテック， インコーポレイテッド 改変抗体ｆｃおよび使用方法
TW202045545A (zh) 2019-02-22 2020-12-16 美商安維塔生物科學股份有限公司 白蛋白結合抗體及其用途
TW202128961A (zh) 2019-11-20 2021-08-01 美商安維塔生物科學股份有限公司 細胞激素融合蛋白及其醫藥組合物及治療應用
TWI896628B (zh) 2020-03-26 2025-09-11 美國凡德貝爾大學 針對嚴重急性呼吸症候群冠狀病毒２(SARS-CoV-2)之人單株抗體
WO2021195326A1 (en) * 2020-03-26 2021-09-30 Vanderbilt University Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (sars-cov-2)
CA3177029A1 (en) 2020-04-27 2021-11-04 Aaron Sato Variant nucleic acid libraries for coronavirus

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