JP6859259B2 - ＢＡＣＥｌに対する抗体及び神経疾患免疫療法のためのその使用 - Google Patents

ＢＡＣＥｌに対する抗体及び神経疾患免疫療法のためのその使用 Download PDF

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JP6859259B2
JP6859259B2 JP2017526502A JP2017526502A JP6859259B2 JP 6859259 B2 JP6859259 B2 JP 6859259B2 JP 2017526502 A JP2017526502 A JP 2017526502A JP 2017526502 A JP2017526502 A JP 2017526502A JP 6859259 B2 JP6859259 B2 JP 6859259B2
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antibody
bace1
disease
hvr
seq
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JP2018505651A5 (enExample
JP2018505651A (ja
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イーチン リウ，
イーチン リウ，
ジャスビンダル アトウォル，
ジャスビンダル アトウォル，
セシリア プイ チー チウ，
セシリア プイ チー チウ，
ライアン ジェー． ワッツ，
ライアン ジェー． ワッツ，
ヤン ウー，
ヤン ウー，
エリック クラウランド，
エリック クラウランド，
マイケル フェルトハウス，
マイケル フェルトハウス，
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Genentech Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6871—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
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JP2017526502A 2014-11-19 2015-11-18 ＢＡＣＥｌに対する抗体及び神経疾患免疫療法のためのその使用 Active JP6859259B2 (ja)

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US201462081966P 2014-11-19 2014-11-19
US62/081,966 2014-11-19
PCT/US2015/061401 WO2016081639A1 (en) 2014-11-19 2015-11-18 Antibodies against bace1 and use thereof for neural disease immunotherapy

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JP2018505651A JP2018505651A (ja) 2018-03-01
JP2018505651A5 JP2018505651A5 (enExample) 2018-12-27
JP6859259B2 true JP6859259B2 (ja) 2021-04-14

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US (2) US10882920B2 (enExample)
EP (2) EP3845565A3 (enExample)
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WO2016081640A1 (en) 2014-11-19 2016-05-26 Genentech, Inc. Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use
JP6959912B2 (ja) 2015-09-23 2021-11-05 ジェネンテック， インコーポレイテッド 抗ｖｅｇｆ抗体の最適化変異体
EP3694545A4 (en) * 2017-10-11 2021-12-01 Board Of Regents, The University Of Texas System HUMAN PD-L1 ANTIBODIES AND METHOD OF USING THEM
WO2019094608A1 (en) 2017-11-08 2019-05-16 Denali Therapeutics Inc. Anti-bace1 antibodies and methods of use thereof
US12187799B2 (en) 2018-03-23 2025-01-07 Board Of Regents, The University Of Texas System Dual specificity antibodies to PD-L1 and PD-L2 and methods of use therefor
CA3092695A1 (en) 2018-03-23 2019-09-26 Board Of Regents, The University Of Texas System Human pd-l2 antibodies and methods of use therefor
WO2019182867A1 (en) 2018-03-23 2019-09-26 Board Of Regents, The University Of Texas System Dual specificity antibodies to human pd-l1 and pd-l2 and methods of use therefor
CN108760661B (zh) * 2018-09-08 2023-06-09 重庆科技学院 一种石油废水重金属离子多通道检测芯片
CN113227131B (zh) * 2018-12-20 2025-03-04 豪夫迈·罗氏有限公司 经修饰的抗体Fc及其使用方法
US12479909B2 (en) 2019-02-22 2025-11-25 Anwita Biosciences, Inc. Albumin binding antibodies and use thereof
WO2021102063A1 (en) 2019-11-20 2021-05-27 Anwita Biosciences, Inc. Cytokine fusion proteins, and their pharmaceutical compositions and therapeutic applications
WO2021195326A1 (en) * 2020-03-26 2021-09-30 Vanderbilt University Human monoclonal antibodies to severe acute respiratory syndrome coronavirus 2 (sars-cov-2)
MX2022011892A (es) 2020-03-26 2022-10-18 Univ Vanderbilt Anticuerpos monoclonales humanos dirigidos contra el coronavirus 2 del sindrome respiratorio agudo grave (sars-cov-2).
WO2021222316A2 (en) 2020-04-27 2021-11-04 Twist Bioscience Corporation Variant nucleic acid libraries for coronavirus

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