|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4737456A
(en)
|
1985-05-09 |
1988-04-12 |
Syntex (U.S.A.) Inc. |
Reducing interference in ligand-receptor binding assays
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
|
JPS633262A
(ja)
|
1986-06-24 |
1988-01-08 |
Toshiba Corp |
網状赤血球の分析方法及び装置
|
|
US5567610A
(en)
|
1986-09-04 |
1996-10-22 |
Bioinvent International Ab |
Method of producing human monoclonal antibodies and kit therefor
|
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
|
AU600575B2
(en)
|
1987-03-18 |
1990-08-16 |
Sb2, Inc. |
Altered antibodies
|
|
US5770701A
(en)
|
1987-10-30 |
1998-06-23 |
American Cyanamid Company |
Process for preparing targeted forms of methyltrithio antitumor agents
|
|
US5606040A
(en)
|
1987-10-30 |
1997-02-25 |
American Cyanamid Company |
Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
WO1990005144A1
(en)
|
1988-11-11 |
1990-05-17 |
Medical Research Council |
Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
|
|
US5175384A
(en)
|
1988-12-05 |
1992-12-29 |
Genpharm International |
Transgenic mice depleted in mature t-cells and methods for making transgenic mice
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
US5672683A
(en)
|
1989-09-07 |
1997-09-30 |
Alkermes, Inc. |
Transferrin neuropharmaceutical agent fusion protein
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
CA2026147C
(en)
|
1989-10-25 |
2006-02-07 |
Ravi J. Chari |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
US5959177A
(en)
|
1989-10-27 |
1999-09-28 |
The Scripps Research Institute |
Transgenic plants expressing assembled secretory antibodies
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5229275A
(en)
|
1990-04-26 |
1993-07-20 |
Akzo N.V. |
In-vitro method for producing antigen-specific human monoclonal antibodies
|
|
EP0546084A4
(en)
|
1990-08-17 |
1994-10-19 |
Univ Boston |
Proteases causing abnormal degradation of amyloid -g(b)-protein precursor
|
|
US5200339A
(en)
|
1990-08-17 |
1993-04-06 |
Abraham Carmela R |
Proteases causing abnormal degradation of amyloid β-protein precursor
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
WO1992009690A2
(en)
|
1990-12-03 |
1992-06-11 |
Genentech, Inc. |
Enrichment method for variant proteins with altered binding properties
|
|
US5571894A
(en)
|
1991-02-05 |
1996-11-05 |
Ciba-Geigy Corporation |
Recombinant antibodies specific for a growth factor receptor
|
|
EP0590058B1
(en)
|
1991-06-14 |
2003-11-26 |
Genentech, Inc. |
HUMANIZED Heregulin ANTIBODy
|
|
GB9114948D0
(en)
|
1991-07-11 |
1991-08-28 |
Pfizer Ltd |
Process for preparing sertraline intermediates
|
|
MX9204374A
(es)
|
1991-07-25 |
1993-03-01 |
Idec Pharma Corp |
Anticuerpo recombinante y metodo para su produccion.
|
|
WO1993006217A1
(en)
|
1991-09-19 |
1993-04-01 |
Genentech, Inc. |
EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab')2 ANTIBODIES
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
FI941572L
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
|
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
|
JPH07509444A
(ja)
|
1991-11-26 |
1995-10-19 |
アルカーメス・インコーポレーテツド |
トランスフェリンセレプター特異的抗体−神経薬又は診断薬複合体の製造法
|
|
ATE419355T1
(de)
|
1992-02-06 |
2009-01-15 |
Novartis Vaccines & Diagnostic |
Marker für krebs und biosynthetisches bindeprotein dafür
|
|
EP0626012B1
(en)
|
1992-02-11 |
2003-07-09 |
Cell Genesys, Inc. |
Homogenotization of gene-targeting events
|
|
US5573905A
(en)
|
1992-03-30 |
1996-11-12 |
The Scripps Research Institute |
Encoded combinatorial chemical libraries
|
|
ATE191853T1
(de)
|
1992-07-27 |
2000-05-15 |
Us Health |
Zielgerichte liposome zur blut-hirne schranke
|
|
ES2091684T3
(es)
|
1992-11-13 |
1996-11-01 |
Idec Pharma Corp |
Aplicacion terapeutica de anticuerpos quimericos y radiomarcados contra el antigeno de diferenciacion restringida de los linfocitos b humanos para el tratamiento del linfoma de las celulas b.
|
|
US5635483A
(en)
|
1992-12-03 |
1997-06-03 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
|
|
US5780588A
(en)
|
1993-01-26 |
1998-07-14 |
Arizona Board Of Regents |
Elucidation and synthesis of selected pentapeptides
|
|
WO1994029351A2
(en)
|
1993-06-16 |
1994-12-22 |
Celltech Limited |
Antibodies
|
|
US5773001A
(en)
|
1994-06-03 |
1998-06-30 |
American Cyanamid Company |
Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
|
|
US5789199A
(en)
|
1994-11-03 |
1998-08-04 |
Genentech, Inc. |
Process for bacterial production of polypeptides
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US5840523A
(en)
|
1995-03-01 |
1998-11-24 |
Genetech, Inc. |
Methods and compositions for secretion of heterologous polypeptides
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US6015555A
(en)
|
1995-05-19 |
2000-01-18 |
Alkermes, Inc. |
Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates
|
|
US5714586A
(en)
|
1995-06-07 |
1998-02-03 |
American Cyanamid Company |
Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
|
|
EP0871720A2
(en)
|
1995-06-07 |
1998-10-21 |
Athena Neurosciences, Inc. |
Beta-secretase, antibodies to beta-secretase, and assays for detecting beta-secretase inhibition
|
|
US6329163B1
(en)
|
1995-06-07 |
2001-12-11 |
Elan Pharmaceuticals, Inc. |
Assays for detecting β-secretase inhibition
|
|
US6221645B1
(en)
|
1995-06-07 |
2001-04-24 |
Elan Pharmaceuticals, Inc. |
β-secretase antibody
|
|
US5744346A
(en)
|
1995-06-07 |
1998-04-28 |
Athena Neurosciences, Inc. |
β-secretase
|
|
US5712374A
(en)
|
1995-06-07 |
1998-01-27 |
American Cyanamid Company |
Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
|
|
US6267958B1
(en)
|
1995-07-27 |
2001-07-31 |
Genentech, Inc. |
Protein formulation
|
|
GB9603256D0
(en)
|
1996-02-16 |
1996-04-17 |
Wellcome Found |
Antibodies
|
|
WO1998026059A1
(en)
|
1996-12-11 |
1998-06-18 |
Athena Neurosciences, Inc. |
Beta-secretase isolated from human 293 cells
|
|
GB9701684D0
(en)
|
1997-01-28 |
1997-03-19 |
Smithkline Beecham Plc |
Novel compounds
|
|
EP0979281B1
(en)
|
1997-05-02 |
2005-07-20 |
Genentech, Inc. |
A method for making multispecific antibodies having heteromultimeric and common components
|
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
US6171586B1
(en)
|
1997-06-13 |
2001-01-09 |
Genentech, Inc. |
Antibody formulation
|
|
EP0994903B1
(en)
|
1997-06-24 |
2005-05-25 |
Genentech, Inc. |
Methods and compositions for galactosylated glycoproteins
|
|
US6040498A
(en)
|
1998-08-11 |
2000-03-21 |
North Caroline State University |
Genetically engineered duckweed
|
|
AU759779B2
(en)
|
1997-10-31 |
2003-05-01 |
Genentech Inc. |
Methods and compositions comprising glycoprotein glycoforms
|
|
US6610833B1
(en)
|
1997-11-24 |
2003-08-26 |
The Institute For Human Genetics And Biochemistry |
Monoclonal human natural antibodies
|
|
JP4460155B2
(ja)
|
1997-12-05 |
2010-05-12 |
ザ・スクリプス・リサーチ・インステイチユート |
マウス抗体のヒト化
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
DE69937291T2
(de)
|
1998-04-02 |
2008-07-10 |
Genentech, Inc., South San Francisco |
Antikörpervarianten und fragmente davon
|
|
JP4334141B2
(ja)
|
1998-04-20 |
2009-09-30 |
グリカート バイオテクノロジー アクチェンゲゼルシャフト |
抗体依存性細胞傷害性を改善するための抗体のグリコシル化操作
|
|
US6699671B1
(en)
|
1998-09-24 |
2004-03-02 |
Pharmacia & Upjohn Company |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor
|
|
US7115410B1
(en)
|
1999-02-10 |
2006-10-03 |
Elan Pharmaceuticals, Inc. |
β-secretase enzyme compositions and methods
|
|
US7456007B1
(en)
|
1998-12-31 |
2008-11-25 |
Elan Pharmaceuticals, Inc. |
β-secretase enzyme compositions and methods
|
|
BR0008758A
(pt)
|
1999-01-15 |
2001-12-04 |
Genentech Inc |
Variantes de polipeptìdeos parentais com funçãoefetora alterada, polipeptìdeos, composição ácidonucleico isolado, vetor, célula hospedeira,método para produzir uma variante depolipeptìdeo, método para o tratamento de umadesordem em mamìferos e método para produziruma região fc variante
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
NZ534876A
(en)
|
1999-02-10 |
2006-02-24 |
Elan Pharm Inc |
Human beta-secretase enzyme, inhibitors and their compositions and uses
|
|
AU3770800A
(en)
|
1999-03-26 |
2000-10-16 |
Amgen, Inc. |
Beta secretase genes and polypeptides
|
|
CA2369292C
(en)
|
1999-04-09 |
2010-09-21 |
Kyowa Hakko Kogyo Co. Ltd. |
Method of modulating the activity of functional immune molecules
|
|
AU5773500A
(en)
|
1999-06-28 |
2001-01-31 |
Board Of Trustees Of The University Of Illinois, The |
Inhibitors of memapsin 2 and use thereof
|
|
US7125978B1
(en)
|
1999-10-04 |
2006-10-24 |
Medicago Inc. |
Promoter for regulating expression of foreign genes
|
|
JP2003512821A
(ja)
|
1999-10-04 |
2003-04-08 |
メディカゴ インコーポレイテッド |
外来性遺伝子の転写調節方法
|
|
WO2001029246A1
(fr)
|
1999-10-19 |
2001-04-26 |
Kyowa Hakko Kogyo Co., Ltd. |
Procede de production d'un polypeptide
|
|
GB9924957D0
(en)
|
1999-10-21 |
1999-12-22 |
Smithkline Beecham Plc |
Novel treatment
|
|
US7514408B1
(en)
|
1999-12-02 |
2009-04-07 |
Elan Pharmaceuticals, Inc. |
β-secretase enzyme compositions and methods
|
|
US20030180714A1
(en)
|
1999-12-15 |
2003-09-25 |
Genentech, Inc. |
Shotgun scanning
|
|
CA2395660A1
(en)
|
1999-12-29 |
2001-07-12 |
Immunogen, Inc. |
Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
|
|
KR100767146B1
(ko)
|
2000-02-24 |
2007-10-15 |
워싱톤 유니버시티 |
Aβ 펩티드를 격리시키는 인간화 항체
|
|
DK1272647T3
(en)
|
2000-04-11 |
2014-12-15 |
Genentech Inc |
Multivalent antibodies and uses thereof
|
|
AU2001268005A1
(en)
|
2000-07-07 |
2002-01-21 |
Lars Lannfelt |
Prevention and treatment of alzheimer's disease
|
|
TW200628612A
(en)
|
2000-07-19 |
2006-08-16 |
Pharmacia & Up John Company |
Substrates and assays for β-secretase activity
|
|
WO2002025276A1
(en)
|
2000-09-22 |
2002-03-28 |
Wyeth |
Crystal structure of bace and uses thereof
|
|
US7064191B2
(en)
|
2000-10-06 |
2006-06-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Process for purifying antibody
|
|
EA013563B1
(ru)
|
2000-10-06 |
2010-06-30 |
Киова Хакко Кирин Ко., Лтд. |
Трансгенное животное, продуцирующее антитела с измененными углеводными цепями, способ получения антител и содержащее антитела лекарственное средство
|
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
|
US20020157122A1
(en)
|
2000-10-27 |
2002-10-24 |
Wong Philip C. |
Beta-secretase transgenic organisms, anti-beta-secretase antibodies, and methods of use thereof
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
DK1354034T3
(da)
|
2000-11-30 |
2008-03-25 |
Medarex Inc |
Transgene transchromosomale gnavere til fremstilling af humane antistoffer
|
|
PE20020574A1
(es)
|
2000-12-06 |
2002-07-02 |
Wyeth Corp |
Anticuerpos humanizados que reconocen el peptido amiloideo beta
|
|
PT1355919E
(pt)
|
2000-12-12 |
2011-03-02 |
Medimmune Llc |
Moléculas com semivida longa, composições que as contêm e suas utilizações
|
|
US7217556B1
(en)
|
2000-12-23 |
2007-05-15 |
Pfizer Inc |
Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in Alzheimer's disease
|
|
US7601528B1
(en)
|
2000-12-23 |
2009-10-13 |
Elan Pharmaceuticals, Inc. |
Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease
|
|
AU2002239727C1
(en)
|
2000-12-28 |
2005-12-22 |
Oklahoma Medical Research Foundation |
Inhibitors of memapsin 2 and use thereof
|
|
US7384773B1
(en)
|
2001-05-10 |
2008-06-10 |
Pfizer Inc |
Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof
|
|
EP1990057A1
(en)
|
2001-05-22 |
2008-11-12 |
Merck & Co., Inc. |
Beta-secretase substrates and uses thereof
|
|
CA2455365C
(en)
|
2001-08-03 |
2014-07-29 |
Glycart Biotechnology Ag |
Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
|
|
US20040192898A1
(en)
|
2001-08-17 |
2004-09-30 |
Jia Audrey Yunhua |
Anti-abeta antibodies
|
|
WO2003016467A2
(en)
|
2001-08-17 |
2003-02-27 |
Eli Lilly And Company |
Use of antibodies having high affinity for soluble ass to treat conditions and diseases related to ass
|
|
JP4547152B2
(ja)
|
2001-10-23 |
2010-09-22 |
オクラホマ メディカル リサーチ ファウンデーション |
β−セクレターゼ阻害剤および使用方法
|
|
ATE430580T1
(de)
|
2001-10-25 |
2009-05-15 |
Genentech Inc |
Glycoprotein-zusammensetzungen
|
|
US20040093621A1
(en)
|
2001-12-25 |
2004-05-13 |
Kyowa Hakko Kogyo Co., Ltd |
Antibody composition which specifically binds to CD20
|
|
MY139983A
(en)
|
2002-03-12 |
2009-11-30 |
Janssen Alzheimer Immunotherap |
Humanized antibodies that recognize beta amyloid peptide
|
|
US20030224512A1
(en)
|
2002-05-31 |
2003-12-04 |
Isis Pharmaceuticals Inc. |
Antisense modulation of beta-site APP-cleaving enzyme expression
|
|
ES2362419T3
(es)
|
2002-04-09 |
2011-07-05 |
Kyowa Hakko Kirin Co., Ltd. |
Células con depresión o deleción de la actividad de la proteína que participa en el transporte de gdp-fucosa.
|
|
CN1930288B
(zh)
|
2002-04-09 |
2012-08-08 |
协和发酵麒麟株式会社 |
基因组被修饰的细胞
|
|
CA2481920A1
(en)
|
2002-04-09 |
2003-10-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Antibody composition-containing medicament
|
|
WO2003084570A1
(en)
|
2002-04-09 |
2003-10-16 |
Kyowa Hakko Kogyo Co., Ltd. |
DRUG CONTAINING ANTIBODY COMPOSITION APPROPRIATE FOR PATIENT SUFFERING FROM FcϜRIIIa POLYMORPHISM
|
|
WO2003085119A1
(en)
|
2002-04-09 |
2003-10-16 |
Kyowa Hakko Kogyo Co., Ltd. |
METHOD OF ENHANCING ACTIVITY OF ANTIBODY COMPOSITION OF BINDING TO FcϜ RECEPTOR IIIa
|
|
JPWO2003085118A1
(ja)
|
2002-04-09 |
2005-08-11 |
協和醗酵工業株式会社 |
抗体組成物の製造方法
|
|
US7166454B1
(en)
|
2002-05-24 |
2007-01-23 |
Schering Corporation |
Codon-optimized β-secretase and methods of refolding and processing
|
|
CA2488441C
(en)
|
2002-06-03 |
2015-01-27 |
Genentech, Inc. |
Synthetic antibody phage libraries
|
|
EP2305710A3
(en)
|
2002-06-03 |
2013-05-29 |
Genentech, Inc. |
Synthetic antibody phage libraries
|
|
WO2004029629A1
(en)
|
2002-09-27 |
2004-04-08 |
Janssen Pharmaceutica N.V. |
N-11 truncated amyloid-beta nomoclonal antibodies, compositions, methods and uses
|
|
MXPA05003621A
(es)
|
2002-10-09 |
2005-10-19 |
Rinat Neuroscience Corp |
Metodos de tratamiento de la enfermedad de alzheimer usando anticuerpos dirigidos contra el peptido beta amiloide y composiciones de los mismos.
|
|
AU2003285892A1
(en)
|
2002-10-15 |
2004-05-04 |
Bristol-Myers Squibb Company |
Bace binding peptides and uses thereof
|
|
US7361740B2
(en)
|
2002-10-15 |
2008-04-22 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
US20050142141A1
(en)
|
2002-11-27 |
2005-06-30 |
Pardridge William M. |
Delivery of enzymes to the brain
|
|
PT1572744E
(pt)
|
2002-12-16 |
2010-09-07 |
Genentech Inc |
Variantes de imunoglobulina e utilizações destas
|
|
US20050079574A1
(en)
|
2003-01-16 |
2005-04-14 |
Genentech, Inc. |
Synthetic antibody phage libraries
|
|
US7871607B2
(en)
|
2003-03-05 |
2011-01-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
|
|
US20060104968A1
(en)
|
2003-03-05 |
2006-05-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
|
|
KR20060054174A
(ko)
|
2003-03-28 |
2006-05-22 |
센토코 인코포레이티드 |
항-아밀로이드 항체, 조성물, 방법 및 용도
|
|
US7482136B2
(en)
|
2003-05-02 |
2009-01-27 |
Elan Pharmaceuticals, Inc. |
Glycosylation variants of BACE
|
|
PE20050627A1
(es)
|
2003-05-30 |
2005-08-10 |
Wyeth Corp |
Anticuerpos humanizados que reconocen el peptido beta amiloideo
|
|
US8597911B2
(en)
|
2003-06-11 |
2013-12-03 |
Chugai Seiyaku Kabushiki Kaisha |
Process for producing antibodies
|
|
CA2531684C
(en)
|
2003-07-22 |
2014-03-11 |
Crucell Holland B.V. |
Binding molecules against sars-coronavirus and uses thereof
|
|
US20050106667A1
(en)
|
2003-08-01 |
2005-05-19 |
Genentech, Inc |
Binding polypeptides with restricted diversity sequences
|
|
US7758859B2
(en)
|
2003-08-01 |
2010-07-20 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
US20070185042A1
(en)
|
2003-08-08 |
2007-08-09 |
The Brigham And Women's Hospital, Inc. President And Fellows Of Harvard College |
Sirna based methods for treating alzheimer's disease
|
|
AU2004279742A1
(en)
|
2003-10-08 |
2005-04-21 |
Kyowa Hakko Kirin Co., Ltd. |
Fused protein composition
|
|
EP1705251A4
(en)
|
2003-10-09 |
2009-10-28 |
Kyowa Hakko Kirin Co Ltd |
PROCESS FOR PRODUCING ANTIBODY COMPOSITION BY RNA INHIBITION OF FUNCTION OF $ G (A) 1,6-FUCOSYLTRANSFERASE
|
|
US20070149763A1
(en)
|
2003-10-15 |
2007-06-28 |
Bristol-Myers Squibb Company |
Beta secretase exosite binding peptides and methods for identifying beta secretase modulators
|
|
ME01775B
(me)
|
2003-11-05 |
2011-02-28 |
Glycart Biotechnology Ag |
Cd20 antitijela sa povećanim afinitetom vezivanja za fc receptor i efektornom funkcijom
|
|
NZ583292A
(en)
|
2003-11-06 |
2012-03-30 |
Seattle Genetics Inc |
Monomethylvaline compounds capable of conjugation to ligands
|
|
EA200600918A1
(ru)
|
2003-11-06 |
2006-10-27 |
Игзонхит Терапьютикс Са |
Васе455, вариант альтернативного сплайсинга бета-секретазы человека
|
|
EP1699485A4
(en)
|
2003-11-14 |
2007-12-19 |
Massachusetts Inst Technology |
ANTI-HYDROLYSATE ANTIBODIES AND ITS USES
|
|
JPWO2005053742A1
(ja)
|
2003-12-04 |
2007-06-28 |
協和醗酵工業株式会社 |
抗体組成物を含有する医薬
|
|
CA2561686C
(en)
|
2004-03-31 |
2014-12-02 |
Genentech, Inc. |
Humanized anti-tgf-beta antibodies
|
|
US7785903B2
(en)
|
2004-04-09 |
2010-08-31 |
Genentech, Inc. |
Variable domain library and uses
|
|
BR122019012028B1
(pt)
|
2004-04-13 |
2023-09-26 |
F. Hoffmann-La Roche Ag |
Anticorpos anti-p-selectina, molécula de ácido nucléico, vetor, e composição
|
|
EP1740616B1
(en)
|
2004-04-30 |
2011-12-14 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Anti-tfr antibody.
|
|
MX2007000998A
(es)
|
2004-07-30 |
2007-07-11 |
Rinat Neuroscience Corp |
Anticuerpos dirigidos peptido beta-amiloide y procedimientos que usan los mismos.
|
|
TWI380996B
(zh)
|
2004-09-17 |
2013-01-01 |
Hoffmann La Roche |
抗ox40l抗體
|
|
ES2579805T3
(es)
|
2004-09-23 |
2016-08-16 |
Genentech, Inc. |
Anticuerpos y conjugados modificados por ingeniería genética con cisteína
|
|
EP1799260A4
(en)
|
2004-09-29 |
2011-09-28 |
Centocor Inc |
ANTI-AMYLOID ANTIBODIES, COMPOSITIONS, TECHNIQUES AND USES
|
|
WO2006038684A1
(ja)
|
2004-10-01 |
2006-04-13 |
Takeda Pharmaceutical Company Limited |
膜貫通型酵素阻害物質のスクリーニング方法
|
|
AU2005294146B2
(en)
|
2004-10-04 |
2011-09-15 |
Genentech, Inc. |
Modulators of hepatocyte growth factor activator
|
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
|
US8802820B2
(en)
|
2004-11-12 |
2014-08-12 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
EP1838854B1
(en)
|
2004-12-15 |
2012-10-31 |
Janssen Alzheimer Immunotherapy |
Antibodies that recognize Beta Amyloid Peptide
|
|
AR052051A1
(es)
|
2004-12-15 |
2007-02-28 |
Neuralab Ltd |
Anticuerpos ab humanizados usados en mejorar la cognicion
|
|
WO2006066171A1
(en)
|
2004-12-15 |
2006-06-22 |
Neuralab Limited |
Amyloid βετα antibodies for use in improving cognition
|
|
ES2259270B1
(es)
|
2005-03-09 |
2007-11-01 |
Consejo Superior De Investigaciones Cientificas |
Metodo de diagnostico in vitro de la enfermedad de alzheimer mediante un anticuerpo monoclonal.
|
|
AU2006279896A1
(en)
|
2005-08-10 |
2007-02-22 |
Oklahoma Medical Research Foundation |
Truncated memapsin 2 for use for treating Alzheimer's disease
|
|
US8142781B2
(en)
|
2005-10-07 |
2012-03-27 |
Armagen Technologies, Inc. |
Fusion proteins for blood-brain barrier delivery
|
|
EP2465870A1
(en)
|
2005-11-07 |
2012-06-20 |
Genentech, Inc. |
Binding polypeptides with diversified and consensus VH/VL hypervariable sequences
|
|
UA96139C2
(uk)
|
2005-11-08 |
2011-10-10 |
Дженентек, Інк. |
Антитіло до нейропіліну-1 (nrp1)
|
|
US20070237764A1
(en)
|
2005-12-02 |
2007-10-11 |
Genentech, Inc. |
Binding polypeptides with restricted diversity sequences
|
|
WO2007130697A2
(en)
|
2006-01-05 |
2007-11-15 |
Genentech, Inc. |
Anti-ephb4 antibodies and methods using same
|
|
ZA200806187B
(en)
|
2006-01-20 |
2009-10-28 |
Genentech Inc |
Anti-EphrinB2 antibodies and methods using same
|
|
WO2007134050A2
(en)
|
2006-05-09 |
2007-11-22 |
Genentech, Inc. |
Binding polypeptides with optimized scaffolds
|
|
HRP20140172T1
(hr)
|
2006-05-30 |
2014-03-28 |
Genentech, Inc. |
Protutijela i imunokonjugati kao i njihove uporabe
|
|
WO2007147901A1
(en)
|
2006-06-22 |
2007-12-27 |
Novo Nordisk A/S |
Production of bispecific antibodies
|
|
ES2399075T3
(es)
|
2006-08-30 |
2013-03-25 |
Genentech, Inc. |
Anticuerpos multiespecíficos
|
|
MX2009003938A
(es)
|
2006-10-27 |
2009-04-24 |
Genentech Inc |
Anticuerpos e inmunoconjugados y sus usos.
|
|
US20100047232A1
(en)
|
2006-11-14 |
2010-02-25 |
Jasvinder Atwal |
Modulators of neuronal regeneration
|
|
US20080226635A1
(en)
|
2006-12-22 |
2008-09-18 |
Hans Koll |
Antibodies against insulin-like growth factor I receptor and uses thereof
|
|
JP2010518115A
(ja)
|
2007-02-09 |
2010-05-27 |
ジェネンテック, インコーポレイテッド |
抗Robo4抗体およびそれらのための使用
|
|
EP2139496A2
(en)
|
2007-04-19 |
2010-01-06 |
Vib Vzw |
Oligonucleotide compositions for the treatment of alzheimer's disease
|
|
CN100592373C
(zh)
|
2007-05-25 |
2010-02-24 |
群康科技(深圳)有限公司 |
液晶显示面板驱动装置及其驱动方法
|
|
US9370531B2
(en)
|
2007-08-31 |
2016-06-21 |
New York University |
Method of providing patient specific immune response in amyloidoses and protein aggregation disorders
|
|
CA2697193C
(en)
|
2007-09-14 |
2017-06-06 |
Adimab, Inc. |
Rationally designed, synthetic antibody libraries and uses therefor
|
|
US8877688B2
(en)
|
2007-09-14 |
2014-11-04 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
|
PT2235064E
(pt)
|
2008-01-07 |
2016-03-01 |
Amgen Inc |
Método de preparação de moléculas heterodiméricas de fc de anticorpos utilizando efeitos de indução eletrostática
|
|
WO2009121948A2
(en)
|
2008-04-03 |
2009-10-08 |
Vib Vzw |
Single domain antibodies capable of modulating bace activity
|
|
WO2009155609A1
(en)
|
2008-06-20 |
2009-12-23 |
Oklahoma Medical Research Foundation |
IMMUNOGENIC MEMAPSIN 2 β-SECRETASE PEPTIDES AND METHODS OF USE
|
|
TW201019959A
(en)
|
2008-08-19 |
2010-06-01 |
Regeneron Pharma |
Human antibodies to human RANKL
|
|
US8790642B2
(en)
|
2008-08-29 |
2014-07-29 |
Genentech, Inc. |
Cross-reactive and bispecific anti-IL-17A/F antibodies
|
|
US20100233156A1
(en)
|
2009-03-09 |
2010-09-16 |
Georgetown University |
Treating Central Nervous System Injury with Beta and Gamma Secretase Inhibitors
|
|
JP5944822B2
(ja)
|
2009-06-15 |
2016-07-05 |
フエー・イー・ベー・フエー・ゼツト・ウエー |
Bace1抑制性抗体
|
|
DK2560683T4
(da)
|
2010-04-23 |
2022-08-29 |
Hoffmann La Roche |
Fremstilling af heteromultimeriske proteiner
|
|
US20140286966A1
(en)
|
2010-07-06 |
2014-09-25 |
Youngman Oh |
Methods and compositions for the treatment of metabolic syndrome, obstructive respiratory disorders, cancer and related diseases
|
|
WO2012009568A2
(en)
|
2010-07-16 |
2012-01-19 |
Adimab, Llc |
Antibody libraries
|
|
AR083819A1
(es)
|
2010-11-10 |
2013-03-27 |
Genentech Inc |
UN ANTICUERPO QUE SE UNE A BACE1 (ENZIMA 1 DE DISOCIACION DE PROTEINA PRECURSORA DEL AMILOIDE DE SITIO b), METODOS Y COMPOSICIONES PARA INMUNOTERAPIA PARA ENFERMEDAD NEURAL
|
|
EA034333B1
(ru)
|
2010-11-30 |
2020-01-29 |
Дженентек, Инк. |
Варианты антитела для переноса соединения через гематоэнцефалический барьер
|
|
WO2012081713A1
(ja)
|
2010-12-13 |
2012-06-21 |
学校法人福岡大学 |
血液脳関門障害症候群治療薬
|
|
MX348071B
(es)
|
2011-03-16 |
2017-05-26 |
Amgen Inc |
Variantes de fc.
|
|
KR20160044598A
(ko)
|
2011-03-29 |
2016-04-25 |
로슈 글리카트 아게 |
항체 Fc 변이체
|
|
BR112013026306A2
(pt)
|
2011-04-20 |
2017-09-05 |
Roche Glycart Ag |
MÉTODO E CONSTRUTOS PARA A PASSAGEM DE PENDENTE DO pH DA BARREIRA SANGUE-CÉREBRO
|
|
CN103974709B
(zh)
|
2011-10-14 |
2016-12-14 |
霍夫曼-拉罗奇有限公司 |
Bace1的肽抑制剂
|
|
EA201491920A1
(ru)
|
2012-05-21 |
2016-03-31 |
Дженентек, Инк. |
Способы повышения безопасности транспорта через гематоэнцефалический барьер
|
|
EP3587448B1
(en)
|
2013-03-15 |
2021-05-19 |
Xencor, Inc. |
Heterodimeric proteins
|
|
EP4324480A3
(en)
|
2013-05-20 |
2024-05-08 |
F. Hoffmann-La Roche AG |
Anti-transferrin receptor antibodies and methods of use
|
|
CN103897033A
(zh)
|
2014-03-31 |
2014-07-02 |
中国药科大学 |
转铁蛋白受体TfR特异性结合肽及其应用
|
|
EP3221362B1
(en)
|
2014-11-19 |
2019-07-24 |
F.Hoffmann-La Roche Ag |
Anti-transferrin receptor antibodies and methods of use
|
|
JP6859259B2
(ja)
|
2014-11-19 |
2021-04-14 |
ジェネンテック, インコーポレイテッド |
BACElに対する抗体及び神経疾患免疫療法のためのその使用
|