JP2018503357A5 - - Google Patents
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- JP2018503357A5 JP2018503357A5 JP2017526547A JP2017526547A JP2018503357A5 JP 2018503357 A5 JP2018503357 A5 JP 2018503357A5 JP 2017526547 A JP2017526547 A JP 2017526547A JP 2017526547 A JP2017526547 A JP 2017526547A JP 2018503357 A5 JP2018503357 A5 JP 2018503357A5
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- 150000001875 compounds Chemical class 0.000 claims 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
- 230000004048 modification Effects 0.000 claims 15
- 238000012986 modification Methods 0.000 claims 15
- 102000007238 Transferrin Receptors Human genes 0.000 claims 13
- 108010033576 Transferrin Receptors Proteins 0.000 claims 12
- 239000003814 drug Substances 0.000 claims 12
- 239000012636 effector Substances 0.000 claims 8
- 150000001413 amino acids Chemical group 0.000 claims 7
- 210000003169 central nervous system Anatomy 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 230000024203 complement activation Effects 0.000 claims 5
- 230000013595 glycosylation Effects 0.000 claims 5
- 238000006206 glycosylation reaction Methods 0.000 claims 5
- 201000001119 neuropathy Diseases 0.000 claims 5
- 230000007823 neuropathy Effects 0.000 claims 5
- 208000033808 peripheral neuropathy Diseases 0.000 claims 5
- 210000001995 reticulocyte Anatomy 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 4
- 102100021257 Beta-secretase 1 Human genes 0.000 claims 3
- 101710150192 Beta-secretase 1 Proteins 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 3
- 208000015439 Lysosomal storage disease Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 208000012902 Nervous system disease Diseases 0.000 claims 3
- 230000001154 acute effect Effects 0.000 claims 3
- 206010002022 amyloidosis Diseases 0.000 claims 3
- 230000003542 behavioural effect Effects 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
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- 230000000813 microbial effect Effects 0.000 claims 3
- 230000004770 neurodegeneration Effects 0.000 claims 3
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- 208000024891 symptom Diseases 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 230000003612 virological effect Effects 0.000 claims 3
- 101710137189 Amyloid-beta A4 protein Proteins 0.000 claims 2
- 101710151993 Amyloid-beta precursor protein Proteins 0.000 claims 2
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims 2
- 102100029470 Apolipoprotein E Human genes 0.000 claims 2
- 101710095339 Apolipoprotein E Proteins 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 102000001301 EGF receptor Human genes 0.000 claims 2
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- 102000009109 Fc receptors Human genes 0.000 claims 2
- 108010087819 Fc receptors Proteins 0.000 claims 2
- 101000941879 Homo sapiens Leucine-rich repeat serine/threonine-protein kinase 2 Proteins 0.000 claims 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 102100032693 Leucine-rich repeat serine/threonine-protein kinase 2 Human genes 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 102000007339 Nerve Growth Factor Receptors Human genes 0.000 claims 2
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- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 210000003743 erythrocyte Anatomy 0.000 claims 2
- 229940105423 erythropoietin Drugs 0.000 claims 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
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- 102000039446 nucleic acids Human genes 0.000 claims 2
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- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 2
- 238000011287 therapeutic dose Methods 0.000 claims 2
- 102100026882 Alpha-synuclein Human genes 0.000 claims 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 claims 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 claims 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- 102000004018 Caspase 6 Human genes 0.000 claims 1
- 108090000425 Caspase 6 Proteins 0.000 claims 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 101000619542 Homo sapiens E3 ubiquitin-protein ligase parkin Proteins 0.000 claims 1
- 101000766306 Homo sapiens Serotransferrin Proteins 0.000 claims 1
- 101000835093 Homo sapiens Transferrin receptor protein 1 Proteins 0.000 claims 1
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 1
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 1
- 108010036933 Presenilin-1 Proteins 0.000 claims 1
- 102000012412 Presenilin-1 Human genes 0.000 claims 1
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- 102000004338 Transferrin Human genes 0.000 claims 1
- 108090000901 Transferrin Proteins 0.000 claims 1
- 229930003779 Vitamin B12 Natural products 0.000 claims 1
- 229930003268 Vitamin C Natural products 0.000 claims 1
- 108090000185 alpha-Synuclein Proteins 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
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- 125000000837 carbohydrate group Chemical group 0.000 claims 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims 1
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- 235000019152 folic acid Nutrition 0.000 claims 1
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- XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical compound NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 claims 1
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- 239000013589 supplement Substances 0.000 claims 1
- 102000013498 tau Proteins Human genes 0.000 claims 1
- 108010026424 tau Proteins Proteins 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 239000012581 transferrin Substances 0.000 claims 1
- 235000019163 vitamin B12 Nutrition 0.000 claims 1
- 239000011715 vitamin B12 Substances 0.000 claims 1
- 235000019154 vitamin C Nutrition 0.000 claims 1
- 239000011718 vitamin C Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462081827P | 2014-11-19 | 2014-11-19 | |
| US62/081,827 | 2014-11-19 | ||
| PCT/US2015/061405 WO2016081643A1 (en) | 2014-11-19 | 2015-11-18 | Anti-transferrin receptor antibodies and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020173079A Division JP2021035365A (ja) | 2014-11-19 | 2020-10-14 | 抗トランスフェリン受容体抗体及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018503357A JP2018503357A (ja) | 2018-02-08 |
| JP2018503357A5 true JP2018503357A5 (enExample) | 2018-12-27 |
| JP6779876B2 JP6779876B2 (ja) | 2020-11-04 |
Family
ID=54780465
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017526547A Active JP6779876B2 (ja) | 2014-11-19 | 2015-11-18 | 抗トランスフェリン受容体抗体及びその使用方法 |
| JP2020173079A Withdrawn JP2021035365A (ja) | 2014-11-19 | 2020-10-14 | 抗トランスフェリン受容体抗体及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020173079A Withdrawn JP2021035365A (ja) | 2014-11-19 | 2020-10-14 | 抗トランスフェリン受容体抗体及びその使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10508151B2 (enExample) |
| EP (1) | EP3221362B1 (enExample) |
| JP (2) | JP6779876B2 (enExample) |
| CN (1) | CN107001473B (enExample) |
| WO (1) | WO2016081643A1 (enExample) |
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| EP3325006A4 (en) | 2015-07-17 | 2019-03-06 | The Trustees of Columbia University in the City of New York | METHOD FOR TREATING CD166-EXPRESSIVE CANCER |
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| PT2235064E (pt) | 2008-01-07 | 2016-03-01 | Amgen Inc | Método de preparação de moléculas heterodiméricas de fc de anticorpos utilizando efeitos de indução eletrostática |
| EA034333B1 (ru) * | 2010-11-30 | 2020-01-29 | Дженентек, Инк. | Варианты антитела для переноса соединения через гематоэнцефалический барьер |
| KR20160044598A (ko) | 2011-03-29 | 2016-04-25 | 로슈 글리카트 아게 | 항체 Fc 변이체 |
| EA201491920A1 (ru) * | 2012-05-21 | 2016-03-31 | Дженентек, Инк. | Способы повышения безопасности транспорта через гематоэнцефалический барьер |
| EP4324480A3 (en) | 2013-05-20 | 2024-05-08 | F. Hoffmann-La Roche AG | Anti-transferrin receptor antibodies and methods of use |
-
2015
- 2015-11-18 EP EP15804652.4A patent/EP3221362B1/en active Active
- 2015-11-18 CN CN201580062928.5A patent/CN107001473B/zh active Active
- 2015-11-18 JP JP2017526547A patent/JP6779876B2/ja active Active
- 2015-11-18 US US15/525,832 patent/US10508151B2/en active Active
- 2015-11-18 WO PCT/US2015/061405 patent/WO2016081643A1/en not_active Ceased
-
2019
- 2019-10-31 US US16/670,104 patent/US11098129B2/en active Active
-
2020
- 2020-10-14 JP JP2020173079A patent/JP2021035365A/ja not_active Withdrawn
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