JP2013500940A5 - - Google Patents
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- JP2013500940A5 JP2013500940A5 JP2012505915A JP2012505915A JP2013500940A5 JP 2013500940 A5 JP2013500940 A5 JP 2013500940A5 JP 2012505915 A JP2012505915 A JP 2012505915A JP 2012505915 A JP2012505915 A JP 2012505915A JP 2013500940 A5 JP2013500940 A5 JP 2013500940A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- subject
- sample
- alzheimer
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 8
- 208000024827 Alzheimer disease Diseases 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000009825 accumulation Methods 0.000 claims 1
- 230000003941 amyloidogenesis Effects 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000007507 senile plaque formation Effects 0.000 claims 1
- 208000022288 senile plaque formation Diseases 0.000 claims 1
- 230000007633 synaptic toxicity Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23179709P | 2009-08-06 | 2009-08-06 | |
| US61/231,797 | 2009-08-06 | ||
| US28255010P | 2010-02-26 | 2010-02-26 | |
| US61/282,550 | 2010-02-26 | ||
| PCT/JP2010/004926 WO2011016239A1 (en) | 2009-08-06 | 2010-08-05 | Antibodies that specifically bind to a beta oligomers and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013500940A JP2013500940A (ja) | 2013-01-10 |
| JP2013500940A5 true JP2013500940A5 (enExample) | 2014-05-15 |
| JP5599454B2 JP5599454B2 (ja) | 2014-10-01 |
Family
ID=43544148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012505915A Expired - Fee Related JP5599454B2 (ja) | 2009-08-06 | 2010-08-05 | Ａβオリゴマーに特異的に結合する抗体およびその利用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8613924B2 (enExample) |
| EP (1) | EP2462162B1 (enExample) |
| JP (1) | JP5599454B2 (enExample) |
| CN (1) | CN102596997B (enExample) |
| DK (1) | DK2462162T3 (enExample) |
| ES (1) | ES2614949T3 (enExample) |
| WO (1) | WO2011016239A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2426143T3 (pl) * | 2007-01-05 | 2017-12-29 | University Of Zurich | Sposób zapewniania specyficznych wobec choroby cząsteczek wiążących i celów |
| HRP20140049T1 (hr) | 2007-01-05 | 2014-02-28 | University Of Zürich | Anti beta-amiloid antitijela i njihova upotreba |
| CN101965365A (zh) * | 2007-10-19 | 2011-02-02 | 伊缪纳斯制药株式会社 | 能够特异性结合Aβ寡聚体的抗体及其应用 |
| PL2246427T3 (pl) | 2008-02-08 | 2017-06-30 | Immunas Pharma, Inc. | Przeciwciała zdolne do wiązania się swoiście do oligomerów amyloidu beta i ich stosowanie |
| CA2730073A1 (en) * | 2008-07-09 | 2010-01-14 | University Of Zurich | Method of promoting neurogenesis |
| US9085614B2 (en) | 2008-08-01 | 2015-07-21 | Immunas Pharma, Inc. | Antibodies that specifically bind to Aβ oligomers and uses thereof |
| DK2370466T3 (en) | 2008-12-19 | 2015-08-03 | Univ Zuerich | Humane anti-alpha-synuclein-autoantistoffer |
| JP5812418B2 (ja) | 2009-04-17 | 2015-11-11 | イムナス・ファーマ株式会社 | Ａβオリゴマーに特異的に結合する抗体およびその利用 |
| EP2462161B1 (en) | 2009-08-06 | 2017-03-08 | Immunas Pharma, Inc. | Antibodies that specifically bind to a beta oligomers and use thereof |
| US9320793B2 (en) * | 2010-07-14 | 2016-04-26 | Acumen Pharmaceuticals, Inc. | Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42 |
| CA2839563C (en) | 2011-06-23 | 2019-10-29 | Biogen Idec International Neuroscience Gmbh | Anti-alpha synuclein binding molecules |
| US9588129B2 (en) * | 2013-03-15 | 2017-03-07 | Amira Medical Technologies Inc. | Methods for analyzing blood to detect diseases associated with abnormal protein aggregation |
| WO2016061389A2 (en) * | 2014-10-16 | 2016-04-21 | Genentech, Inc. | Anti-alpha-synuclein antibodies and methods of use |
| MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
| DK3672631T5 (da) | 2017-08-22 | 2024-08-26 | Biogen Ma Inc | Farmaceutiske sammensætninger indeholdende anti-beta-amyloid-antistoffer |
| CN108020673A (zh) * | 2017-11-15 | 2018-05-11 | 首都医科大学宣武医院 | Aβ试剂盒、检测方法及应用 |
| IL276830B2 (en) * | 2018-03-08 | 2025-08-01 | Phanes Therapeutics Inc | Anti-claudin 18.2 antibodies and uses thereof |
| AU2019244481A1 (en) * | 2018-03-28 | 2020-10-01 | Axon Neuroscience Se | Antibody-based methods of detecting and treating Alzheimer's disease |
| CN115028723B (zh) * | 2019-03-07 | 2023-08-29 | 瑞阳(苏州)生物科技有限公司 | 人IL-1β蛋白结合分子及其编码基因和应用 |
| JP2022547993A (ja) * | 2019-09-10 | 2022-11-16 | エイシー イミューン ソシエテ アノニム | 診断のための新規分子 |
| WO2021055670A1 (en) | 2019-09-20 | 2021-03-25 | Avx Corporation | Somatic cell-based electrical biosensor |
| WO2022040149A1 (en) * | 2020-08-18 | 2022-02-24 | Omeros Corporation | Monoclonal antibodies, compositions and methods for detecting complement factor d |
| CN114573694B (zh) * | 2020-12-01 | 2023-09-01 | 深圳华柏生物科技有限公司 | 一种抗IL13Rα2抗体及其制备方法和用途 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0239102A3 (en) | 1986-03-28 | 1989-07-12 | Tsuji, Kimiyoshi | Process for the formation of human-human hybridoma |
| DE69127627T2 (de) | 1990-08-29 | 1998-02-19 | Genpharm Int | Produktion und Nützung nicht-menschliche transgentiere zur Produktion heterologe Antikörper |
| NZ255101A (en) | 1992-07-24 | 1997-08-22 | Cell Genesys Inc | A yeast artificial chromosome (yac) vector containing an hprt minigene expressible in murine stem cells and genetically modified rodent therefor |
| AU6819494A (en) | 1993-04-26 | 1994-11-21 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| EP1978033A3 (en) | 1995-04-27 | 2008-12-24 | Amgen Fremont Inc. | Human antibodies derived from immunized xenomice |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6218506B1 (en) | 1997-02-05 | 2001-04-17 | Northwestern University | Amyloid β protein (globular assembly and uses thereof) |
| US20030068316A1 (en) * | 1997-02-05 | 2003-04-10 | Klein William L. | Anti-ADDL antibodies and uses thereof |
| AR022952A1 (es) | 1999-03-19 | 2002-09-04 | Smithkline Beecham Corp | ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL |
| AUPR617901A0 (en) | 2001-07-06 | 2001-08-02 | Pacmab Pty Ltd | Method for treating multiple myeloma |
| EP1420032B2 (en) | 2001-08-03 | 2015-12-16 | Medical & Biological Laboratories Co., Ltd. | Antibody recognizing gm1 ganglioside-bound amyloid beta-protein and dna encoding the antibody |
| WO2010012004A2 (en) | 2008-07-25 | 2010-01-28 | The Regents Of The University Of California | Monoclonal antibodies specific for pathological amyoid aggregates common to amyloids formed from proteins of differing sequence |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| US8394379B2 (en) | 2003-05-15 | 2013-03-12 | Iogenetics, Llc | Targeted cryptosporidium biocides |
| CA2572602A1 (en) * | 2004-07-02 | 2006-02-09 | Northwestern University | Monolocal antibodies that target pathological assemblies of amyloid .beta. (abeta) |
| US20080044356A1 (en) | 2004-10-22 | 2008-02-21 | Regents Of The University Of Minnesota | Assemblies of Oligomeric Amyloid Beta Protein and Uses Thereof |
| EP2465872A3 (en) | 2004-10-25 | 2012-12-19 | Merck Sharp & Dohme Corporation | Anti-ADDL antibodies and uses thereof |
| PL1830881T3 (pl) * | 2004-12-10 | 2010-11-30 | Novimmune Sa | Terapie skojarzone celowane na wiele receptorów Toll-podobnych i ich zastosowanie |
| AR051800A1 (es) | 2004-12-15 | 2007-02-07 | Wyeth Corp | Anticuerpos a beta usados en mejorar la cognicion |
| AU2006211625A1 (en) | 2005-01-14 | 2006-08-10 | The Regents Of The University Of California | Compositions and methods for inhibiting drusen formation and for diagnosing or treating drusen-related disorders |
| KR20080021585A (ko) * | 2005-03-05 | 2008-03-07 | 애보트 게엠베하 운트 콤파니 카게 | 스크리닝 방법, 비확산성 ａ-베타 올리고머의 정제 방법,당해 비확산성 ａ-베타 올리고머에 대한 선택적 항체 및당해 항체의 제조 방법 |
| US7741448B2 (en) | 2005-06-21 | 2010-06-22 | Medical & Biological Laboratories Co., Ltd. | Antibody having inhibitory effect on amyloid fibril formation |
| EP1749839A1 (en) | 2005-07-22 | 2007-02-07 | Novoplant GmbH | Antigen binding polypeptides against F4(K88) fimbriae |
| DE602007011415D1 (de) * | 2006-03-23 | 2011-02-03 | Bioartic Neuroscience Ab | Verbesserte protofibrilselektive antikörper und deren verwendung |
| US20090232801A1 (en) | 2007-05-30 | 2009-09-17 | Abbot Laboratories | Humanized Antibodies Which Bind To AB (1-42) Globulomer And Uses Thereof |
| US20100291071A1 (en) | 2008-08-01 | 2010-11-18 | Immunas Pharma, Inc. | Antibody Specific Binding to A-Beta Oligomer and the Use |
| CN101965365A (zh) | 2007-10-19 | 2011-02-02 | 伊缪纳斯制药株式会社 | 能够特异性结合Aβ寡聚体的抗体及其应用 |
| PL2246427T3 (pl) | 2008-02-08 | 2017-06-30 | Immunas Pharma, Inc. | Przeciwciała zdolne do wiązania się swoiście do oligomerów amyloidu beta i ich stosowanie |
| US9085614B2 (en) | 2008-08-01 | 2015-07-21 | Immunas Pharma, Inc. | Antibodies that specifically bind to Aβ oligomers and uses thereof |
| JP5812418B2 (ja) | 2009-04-17 | 2015-11-11 | イムナス・ファーマ株式会社 | Ａβオリゴマーに特異的に結合する抗体およびその利用 |
| EP2462161B1 (en) | 2009-08-06 | 2017-03-08 | Immunas Pharma, Inc. | Antibodies that specifically bind to a beta oligomers and use thereof |
-
2010
- 2010-08-05 CN CN201080034845.2A patent/CN102596997B/zh not_active Expired - Fee Related
- 2010-08-05 WO PCT/JP2010/004926 patent/WO2011016239A1/en not_active Ceased
- 2010-08-05 DK DK10806239.9T patent/DK2462162T3/en active
- 2010-08-05 US US13/389,228 patent/US8613924B2/en not_active Expired - Fee Related
- 2010-08-05 ES ES10806239.9T patent/ES2614949T3/es active Active
- 2010-08-05 EP EP10806239.9A patent/EP2462162B1/en not_active Not-in-force
- 2010-08-05 JP JP2012505915A patent/JP5599454B2/ja not_active Expired - Fee Related
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