JP2014530597A5 - - Google Patents
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- JP2014530597A5 JP2014530597A5 JP2014530333A JP2014530333A JP2014530597A5 JP 2014530597 A5 JP2014530597 A5 JP 2014530597A5 JP 2014530333 A JP2014530333 A JP 2014530333A JP 2014530333 A JP2014530333 A JP 2014530333A JP 2014530597 A5 JP2014530597 A5 JP 2014530597A5
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- tau
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161536339P | 2011-09-19 | 2011-09-19 | |
| US61/536,339 | 2011-09-19 | ||
| US201261653115P | 2012-05-30 | 2012-05-30 | |
| US61/653,115 | 2012-05-30 | ||
| PCT/IB2012/002246 WO2013041962A1 (en) | 2011-09-19 | 2012-09-14 | Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016230258A Division JP6360869B2 (ja) | 2011-09-19 | 2016-11-28 | アルツハイマー病におけるタウ媒介性病理のタンパク質ベースの治療および診断 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530597A JP2014530597A (ja) | 2014-11-20 |
| JP2014530597A5 true JP2014530597A5 (enExample) | 2015-11-05 |
| JP6253583B2 JP6253583B2 (ja) | 2017-12-27 |
Family
ID=47216372
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014530333A Active JP6253583B2 (ja) | 2011-09-19 | 2012-09-14 | アルツハイマー病におけるタウ媒介性病理のタンパク質ベースの治療および診断 |
| JP2016230258A Active JP6360869B2 (ja) | 2011-09-19 | 2016-11-28 | アルツハイマー病におけるタウ媒介性病理のタンパク質ベースの治療および診断 |
| JP2017033138A Active JP6286590B2 (ja) | 2011-09-19 | 2017-02-24 | アルツハイマー病におけるタウ媒介性病理のタンパク質ベースの治療および診断 |
| JP2018059946A Active JP6499345B2 (ja) | 2011-09-19 | 2018-03-27 | アルツハイマー病におけるタウ媒介性病理のタンパク質ベースの治療および診断 |
| JP2018132100A Active JP6637124B2 (ja) | 2011-09-19 | 2018-07-12 | アルツハイマー病におけるタウ媒介性病理のタンパク質ベースの治療および診断 |
| JP2019228943A Active JP6950981B2 (ja) | 2011-09-19 | 2019-12-19 | アルツハイマー病におけるタウ媒介性病理のタンパク質ベースの治療および診断 |
| JP2021150176A Active JP7182316B2 (ja) | 2011-09-19 | 2021-09-15 | アルツハイマー病におけるタウ媒介性病理のタンパク質ベースの治療および診断 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016230258A Active JP6360869B2 (ja) | 2011-09-19 | 2016-11-28 | アルツハイマー病におけるタウ媒介性病理のタンパク質ベースの治療および診断 |
| JP2017033138A Active JP6286590B2 (ja) | 2011-09-19 | 2017-02-24 | アルツハイマー病におけるタウ媒介性病理のタンパク質ベースの治療および診断 |
| JP2018059946A Active JP6499345B2 (ja) | 2011-09-19 | 2018-03-27 | アルツハイマー病におけるタウ媒介性病理のタンパク質ベースの治療および診断 |
| JP2018132100A Active JP6637124B2 (ja) | 2011-09-19 | 2018-07-12 | アルツハイマー病におけるタウ媒介性病理のタンパク質ベースの治療および診断 |
| JP2019228943A Active JP6950981B2 (ja) | 2011-09-19 | 2019-12-19 | アルツハイマー病におけるタウ媒介性病理のタンパク質ベースの治療および診断 |
| JP2021150176A Active JP7182316B2 (ja) | 2011-09-19 | 2021-09-15 | アルツハイマー病におけるタウ媒介性病理のタンパク質ベースの治療および診断 |
Country Status (30)
| Country | Link |
|---|---|
| US (5) | US9518101B2 (enExample) |
| EP (2) | EP2758433B1 (enExample) |
| JP (7) | JP6253583B2 (enExample) |
| KR (3) | KR20210099167A (enExample) |
| CN (3) | CN104185640B (enExample) |
| AU (3) | AU2012311234B2 (enExample) |
| BR (1) | BR112014006376B1 (enExample) |
| CA (1) | CA2848346A1 (enExample) |
| CL (3) | CL2014000679A1 (enExample) |
| CY (1) | CY1119792T1 (enExample) |
| DK (1) | DK2758433T3 (enExample) |
| ES (1) | ES2656442T3 (enExample) |
| HR (1) | HRP20180083T8 (enExample) |
| HU (1) | HUE036177T2 (enExample) |
| IL (4) | IL231201B (enExample) |
| LT (1) | LT2758433T (enExample) |
| ME (1) | ME03008B (enExample) |
| MX (2) | MX347505B (enExample) |
| MY (1) | MY183989A (enExample) |
| PL (1) | PL2758433T3 (enExample) |
| PT (1) | PT2758433T (enExample) |
| RS (1) | RS56852B1 (enExample) |
| RU (2) | RU2018102103A (enExample) |
| SG (4) | SG10201703771WA (enExample) |
| SI (1) | SI2758433T1 (enExample) |
| SM (1) | SMT201800109T1 (enExample) |
| TR (1) | TR201800669T4 (enExample) |
| UA (2) | UA123390C2 (enExample) |
| WO (1) | WO2013041962A1 (enExample) |
| ZA (1) | ZA201401333B (enExample) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012106363A2 (en) * | 2011-01-31 | 2012-08-09 | Intellect Neurosciences Inc. | Treatment of tauopathies |
| SMT201800109T1 (it) * | 2011-09-19 | 2018-05-02 | Axon Neuroscience Se | Terapia a base di proteine e diagnosi di una patologia mediata da tau nella malattia di alzheimer |
| WO2014008404A1 (en) | 2012-07-03 | 2014-01-09 | Washington University | Antibodies to tau |
| JP6290212B2 (ja) | 2012-08-16 | 2018-03-07 | アイピエリアン,インコーポレイティド | タウオパチーの処置方法 |
| US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
| JP6674888B2 (ja) | 2013-03-13 | 2020-04-01 | プロセナ バイオサイエンシーズ リミテッド | タウ免疫療法 |
| JP6629201B2 (ja) * | 2013-11-27 | 2020-01-15 | アイピエリアン,インコーポレイティド | タウオパチーの処置方法 |
| WO2015098963A1 (ja) * | 2013-12-26 | 2015-07-02 | 東亞合成株式会社 | カルレティキュリンの発現促進方法および該方法に用いられる合成ペプチド |
| NZ630610A (en) | 2014-02-14 | 2019-05-31 | Ipierian Inc | Tau peptides, anti-tau antibodies, and methods of use thereof |
| ZA201608812B (en) | 2014-06-26 | 2019-08-28 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| CA2952745A1 (en) * | 2014-06-26 | 2015-12-30 | Janssen Vaccines & Prevention B.V. | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| TW202136296A (zh) | 2014-06-27 | 2021-10-01 | 美商C2N醫療診斷有限責任公司 | 人類化抗-tau抗體 |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| BR112017006419A2 (pt) | 2014-09-30 | 2017-12-19 | Univ Washington | medições cinéticas de tau |
| KR102584655B1 (ko) | 2014-11-14 | 2023-10-06 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
| PT3221349T (pt) | 2014-11-19 | 2021-01-21 | Axon Neuroscience Se | Anticorpos tau humanizados na doença de alzheimer |
| TWI669314B (zh) | 2015-02-26 | 2019-08-21 | 美國禮來大藥廠 | 針對tau之抗體及其用途 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| EP3303386B1 (en) | 2015-06-05 | 2024-08-28 | Genentech, Inc. | Anti-tau antibodies and methods of use |
| CN107849105B (zh) | 2015-07-06 | 2021-09-17 | Ucb生物制药有限责任公司 | Tau结合抗体 |
| CA2991451A1 (en) | 2015-07-06 | 2017-01-12 | Ucb Biopharma Sprl | Tau-binding antibodies |
| JO3711B1 (ar) * | 2015-07-13 | 2021-01-31 | H Lundbeck As | أجسام مضادة محددة لبروتين تاو وطرق استعمالها |
| GB201518675D0 (en) * | 2015-10-21 | 2015-12-02 | Cellcap Technologies Ltd | Detection of structural forms of proteins |
| US11326182B2 (en) | 2016-04-29 | 2022-05-10 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| WO2017189964A2 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| EP3452509A1 (en) | 2016-05-02 | 2019-03-13 | Prothena Biosciences Limited | Antibodies recognizing tau |
| CN109219615B (zh) * | 2016-05-02 | 2022-12-09 | 普罗塞纳生物科学有限公司 | 识别tau的抗体 |
| PL3452507T3 (pl) | 2016-05-02 | 2023-01-09 | Prothena Biosciences Limited | Immunoterapia tau |
| RU2758488C2 (ru) | 2016-05-18 | 2021-10-28 | Вояджер Терапьютикс, Инк. | Модулирующие полинуклеотиды |
| KR101997319B1 (ko) * | 2016-06-21 | 2019-07-08 | 전남대학교산학협력단 | 이형태체 항원인식 항체 생산을 유도하는 플라젤린 백신보조제 기반의 백신의 제조 및 그 응용 |
| US10988529B2 (en) | 2016-08-09 | 2021-04-27 | Eli Lilly And Company | Combination therapy |
| FR3058143B1 (fr) * | 2016-10-27 | 2021-03-12 | Univ Grenoble Alpes | Nanocorps anti-tau |
| AU2017373889B2 (en) | 2016-12-07 | 2025-01-02 | Ac Immune Sa | Anti-Tau antibodies and methods of use |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| CN110248959B (zh) | 2016-12-07 | 2023-06-30 | 基因泰克公司 | 抗tau抗体和使用方法 |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11001615B2 (en) | 2016-12-21 | 2021-05-11 | Adel Inc. | Mutated tau protein fragment and use thereof |
| KR20190134997A (ko) | 2017-02-17 | 2019-12-05 | 데날리 테라퓨틱스 인크. | 항-tau 항체 및 이의 사용 방법 |
| CN110418804A (zh) * | 2017-03-28 | 2019-11-05 | 扬森疫苗与预防公司 | 与tau特异性地结合的结合分子 |
| US20210147481A1 (en) * | 2017-04-21 | 2021-05-20 | Ohio University | Peptide-based inhibitors of mark family proteins |
| CN110881274B (zh) * | 2017-05-02 | 2024-11-15 | 普罗塞纳生物科学有限公司 | 识别tau的抗体 |
| AU2018308088B2 (en) | 2017-07-25 | 2025-05-29 | Truebinding, Inc. | Treating cancer by blocking the interaction of TIM-3 and its ligand |
| JP7029718B2 (ja) * | 2017-07-31 | 2022-03-04 | 国立研究開発法人量子科学技術研究開発機構 | リン酸化タウタンパク質の測定方法 |
| JP7160929B2 (ja) | 2017-10-02 | 2022-10-25 | ブラックソーン セラピューティクス インコーポレイテッド | 神経画像処理及び遺伝子発現マッピングデータのコンピュータ生成型予測応用のための方法及びシステム |
| TWI750419B (zh) * | 2017-10-16 | 2021-12-21 | 日商衛材R&D企管股份有限公司 | 抗tau抗體及其用途 |
| KR102710762B1 (ko) | 2017-10-25 | 2024-09-25 | 얀센 파마슈티칼즈, 인코포레이티드 | 인산화 타우 펩티드의 조성물 및 이의 용도 |
| EP3700558A4 (en) * | 2017-10-27 | 2022-03-09 | United Neuroscience | TAU PEPTIDE IMMUNOGENIC CONSTRUCTIONS |
| WO2019120527A1 (en) * | 2017-12-20 | 2019-06-27 | Michael Heneka | Novel means and methods for treating neurodegenerative diseases |
| WO2019175735A1 (en) | 2018-03-11 | 2019-09-19 | Koorosh Shahpasand | Conformation-independent antibodies against neurotoxic tau proteins |
| MX2020009991A (es) * | 2018-03-28 | 2020-10-14 | Axon Neuroscience Se | Metodos basados en anticuerpos para detectar y tratar la enfermedad de alzheimer. |
| RU2679080C1 (ru) * | 2018-04-17 | 2019-02-05 | Александр Олегович Морозов | Пептид и способ лечения болезни альцгеймера |
| RU2679059C1 (ru) * | 2018-04-17 | 2019-02-05 | Александр Олегович Морозов | Пептид и способ лечения болезни альцгеймера |
| AU2019262220B2 (en) * | 2018-05-03 | 2025-10-16 | Washington University | Methods of diagnosing and treating based on site-specific tau phosphorylation |
| US11085935B2 (en) | 2018-05-03 | 2021-08-10 | Washington University | Methods of treating based on site-specific tau phosphorylation |
| MY206038A (en) * | 2018-07-03 | 2024-11-26 | Hoffmann La Roche | Oligonucleotides for modulating tau expression |
| CA3107788A1 (en) | 2018-07-31 | 2020-02-06 | Eli Lilly And Company | Combination of anti-tau antibody and oga inhibitor for treatment of diseases characterized by aberrant tau aggregation |
| WO2020097561A1 (en) * | 2018-11-08 | 2020-05-14 | Prothena Biosciences Limited | Antibodies recognizing tau |
| WO2020106598A1 (en) * | 2018-11-19 | 2020-05-28 | The Board Of Regents Of The University Of Texas System | Tau peptide antigens and antibodies binding thereto for the treatment of tauopathies |
| WO2020120644A1 (en) * | 2018-12-13 | 2020-06-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New anti tau svqivykpv epitope single domain antibody |
| KR20210125048A (ko) | 2019-02-08 | 2021-10-15 | 에이씨 이뮨 에스.에이. | 인산화 타우 펩티드 백신의 안전한 투여 방법 |
| JP7681316B2 (ja) * | 2019-02-08 | 2025-05-22 | プロセナ バイオサイエンシーズ リミテッド | タウを認識する抗体 |
| AU2020231366A1 (en) | 2019-03-03 | 2021-08-12 | Prothena Biosciences Limited | Antibodies recognizing tau |
| EP3947446A1 (en) * | 2019-03-25 | 2022-02-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Treatment of taupathy disorders by targeting new tau species |
| CN114173812A (zh) * | 2019-04-24 | 2022-03-11 | 杨森制药公司 | Tau疫苗的异源给予 |
| EA202192888A1 (ru) * | 2019-05-31 | 2022-03-23 | Эли Лилли Энд Компани | Соединения и способы нацеливания на тау человека |
| GB201909393D0 (en) | 2019-06-28 | 2019-08-14 | Gen2 Neuroscience Ltd | Tau epitope and binding molecules |
| KR102509648B1 (ko) * | 2019-08-06 | 2023-03-15 | 아프리노이아 테라퓨틱스 리미티드 | 병리학적 타우 종에 결합하는 항체 및 이의 용도 |
| WO2021030615A1 (en) * | 2019-08-13 | 2021-02-18 | Washington University | Methods to detect mtbr tau isoforms and use thereof |
| US20220275038A1 (en) * | 2019-08-15 | 2022-09-01 | Tokyo Medical University | Clsp derivative incapable of being affected by clsp inhibiting substance, and clsp activity enhancing/protecting agent |
| US20220402979A1 (en) * | 2019-09-09 | 2022-12-22 | Axon Neuroscience Se | Biomarkers and treatments of alzheimer's disease and mild cognitive impairment |
| US12493043B2 (en) | 2019-09-10 | 2025-12-09 | Washington University | Blood-based assay for diagnosing and treating based on site-specific tau phosphorylation |
| JP2022553329A (ja) * | 2019-10-22 | 2022-12-22 | バイオジェン・エムエイ・インコーポレイテッド | アルツハイマー病を治療するための抗ベータ-アミロイド抗体 |
| IL270800A (en) * | 2019-11-20 | 2021-05-31 | Yeda Res & Dev | A method for treating Alzheimer's disease |
| CN110841059A (zh) * | 2019-12-03 | 2020-02-28 | 南通大学 | 老年性痴呆小鼠模型的制备方法 |
| TWI853145B (zh) * | 2020-02-05 | 2024-08-21 | 日商住友製藥股份有限公司 | Tau蛋白病變及失智症相關疾病之判定藥及判定方法 |
| BR112022023366A2 (pt) * | 2020-05-19 | 2023-05-02 | Othair Prothena Ltd | Vacina com múltiplos epítopos para o tratamento de mal de alzheimer |
| US12281166B2 (en) | 2020-05-26 | 2025-04-22 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking Galectin-3 |
| AR122129A1 (es) * | 2020-08-07 | 2022-08-17 | Prothena Biosciences Ltd | Vacuna de tau para el tratamiento de la enfermedad de alzheimer |
| KR20230080397A (ko) * | 2020-08-07 | 2023-06-07 | 오타이르 프로테나 리미티드 | 알츠하이머 질환을 치료하기 위한 멀티에피토프 백신 |
| US20240003918A1 (en) | 2020-11-30 | 2024-01-04 | Enigma Biointelligence, Inc. | Non-invasive assessment of alzheimer's disease |
| EP4262754A1 (en) * | 2020-12-18 | 2023-10-25 | Sangamo Therapeutics, Inc. | Improved pharmaceutical compositions containing adeno-associated viral vector |
| TW202246320A (zh) * | 2021-02-14 | 2022-12-01 | 愛爾蘭商普羅帝納生物科學公司 | 使用識別tau之抗體之方法 |
| BR112023014151A2 (pt) * | 2021-02-19 | 2023-10-10 | Eisai R&D Man Co Ltd | Anticorpo tau anti-pt217 |
| US12144815B2 (en) | 2021-02-23 | 2024-11-19 | Hoth Therapeutics, Inc. | Use of aprepitant for treating Alzheimer's disease |
| CL2021001380A1 (es) | 2021-05-26 | 2022-01-14 | Corporacion Centro Int De Biomedicina Icc | Generación de un nuevo anticuerpo monoclonal sitio específico para la proteína tau y su uso como herramienta en biomarcadores específicos para la detección temprana de enfermedades neurodegenerativas y patologías involucradas con la proteína tau como alzheimer y otras demencias. |
| CN113430230A (zh) * | 2021-06-24 | 2021-09-24 | 南通大学 | tau截断体蛋白在诱导tau病理聚集中的应用 |
| EP4413366A4 (en) * | 2021-10-08 | 2025-09-10 | Tiberias Tech Hk Limited | TIBTECH METHODS AND COMPOSITIONS FOR THE DETECTION OF CDH17 |
| CN113861441A (zh) * | 2021-10-28 | 2021-12-31 | 南开大学 | 一种tau蛋白特异的纳米分子伴侣的制备方法及其在抑制tau聚集中的应用 |
| US20250034559A1 (en) | 2021-11-17 | 2025-01-30 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of tau-related disorders |
| CN116554342A (zh) * | 2022-01-29 | 2023-08-08 | 元本(珠海横琴)生物科技有限公司 | 一种融合表达Tau-4R蛋白的大肠杆菌工程菌株 |
| EP4486387A1 (en) | 2022-02-28 | 2025-01-08 | Tridem Bioscience GmbH & Co KG | A conjugate consisting of or comprising at least a ss-glucan or a mannan |
| KR20250069606A (ko) | 2022-09-15 | 2025-05-19 | 보이저 테라퓨틱스, 인크. | 타우 결합 화합물 |
| WO2025019332A1 (en) * | 2023-07-14 | 2025-01-23 | Alzpath, Inc. | Methods for remote blood collection, extraction and analysis of neuro biomarkers |
| WO2025109524A1 (en) | 2023-11-22 | 2025-05-30 | Ac Immune Sa | Assays and methods for assessing vaccine preparations |
| CN117624354B (zh) * | 2023-11-30 | 2024-07-12 | 无锡傲锐东源生物科技有限公司 | 一种抗人乙酰化tau281兔单克隆抗体及其应用 |
| WO2025122634A1 (en) | 2023-12-05 | 2025-06-12 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of tau-related disorders |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4360019A (en) | 1979-02-28 | 1982-11-23 | Andros Incorporated | Implantable infusion device |
| US4424200A (en) | 1979-05-14 | 1984-01-03 | Nuc Med Inc. | Method for radiolabeling proteins with technetium-99m |
| US4692147A (en) | 1980-04-02 | 1987-09-08 | Medtronic, Inc. | Drug administration device |
| US4479930A (en) | 1982-07-26 | 1984-10-30 | Trustees Of The University Of Massachusetts | Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| US5208036A (en) | 1985-01-07 | 1993-05-04 | Syntex (U.S.A.) Inc. | N-(ω, (ω-1)-dialkyloxy)- and N-(ω, (ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4725852A (en) | 1985-05-09 | 1988-02-16 | Burlington Industries, Inc. | Random artificially perturbed liquid apparatus and method |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| US5811310A (en) * | 1986-09-30 | 1998-09-22 | Albert Einstein College Of Medicine Of Yeshiva Univ. | The Alz-50 monoclonal antibody and diagnostic assay for alzheimer's disease |
| DE3853515T3 (de) | 1987-05-21 | 2005-08-25 | Micromet Ag | Multifunktionelle proteine mit vorbestimmter zielsetzung. |
| US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| EP0362371A4 (en) | 1988-04-15 | 1990-10-24 | Protein Design Labs, Inc. | Il-2 receptor-specific chimeric antibodies |
| WO1990005144A1 (en) | 1988-11-11 | 1990-05-17 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| CA2067194C (en) | 1989-10-05 | 2003-03-18 | Glenn Kawasaki | Cell-free synthesis and isolation of novel genes and polypeptides |
| US5279833A (en) | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| GB9020282D0 (en) | 1990-09-17 | 1990-10-31 | Gorman Scott D | Altered antibodies and their preparation |
| US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| US5283185A (en) | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
| WO1993011231A1 (en) * | 1991-12-06 | 1993-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Tools for the diagnosis and treatment of alzheimer's disease |
| WO1994012629A1 (en) | 1992-12-02 | 1994-06-09 | Baylor College Of Medicine | Episomal vectors for gene therapy |
| JPH09501936A (ja) | 1993-08-26 | 1997-02-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 生物活性ペプチドをコードする裸のポリヌクレオチドを投与するための方法、組成物および装置 |
| US5505947A (en) | 1994-05-27 | 1996-04-09 | The University Of North Carolina At Chapel Hill | Attenuating mutations in Venezuelan Equine Encephalitis virus |
| KR100275591B1 (ko) * | 1994-10-28 | 2001-02-01 | 크리스타 헤르 조크 | 단백질 키나아제 npk-110 |
| GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| US5643207A (en) | 1995-04-28 | 1997-07-01 | Medtronic, Inc. | Implantable techniques for infusing a therapeutic agent with endogenous bodily fluid |
| US7153510B1 (en) | 1995-05-04 | 2006-12-26 | Yale University | Recombinant vesiculoviruses and their uses |
| EP1281718A3 (en) | 1995-11-10 | 2005-01-19 | ELAN CORPORATION, Plc | Peptides which enhance transport across tissues |
| US5820589A (en) | 1996-04-30 | 1998-10-13 | Medtronic, Inc. | Implantable non-invasive rate-adjustable pump |
| AUPP221098A0 (en) | 1998-03-06 | 1998-04-02 | Diatech Pty Ltd | V-like domain binding molecules |
| WO2000030680A1 (en) | 1998-11-23 | 2000-06-02 | Idec Pharmaceuticals Corporation | Tumor antigen-specific antibody-gp39 chimeric protein constructs |
| US6198966B1 (en) | 1999-02-26 | 2001-03-06 | Medtronic, Inc. | Recirculating implantable drug delivery system |
| JP3383618B2 (ja) | 1999-08-18 | 2003-03-04 | 松下電器産業株式会社 | 移動体通信端末装置及び受信強度検出方法 |
| ATE326700T1 (de) | 1999-09-09 | 2006-06-15 | Max Planck Gesellschaft | SCREENING NACH INHIBITOREN VON ßGEPAARTEN HELIKALEN FILAMENTENß |
| CA2384146A1 (en) * | 1999-09-09 | 2001-03-15 | Guy Rouleau | Diagnosis, prognosis and treatment of trinucleotide repeat-associated diseases and intranuclear inclusions-associated diseases |
| US6589746B1 (en) | 1999-10-21 | 2003-07-08 | University Of Cincinnati | Method of detecting axonally-derived protein tau in patients with traumatic CNS injury |
| AT500379B8 (de) | 2001-02-02 | 2009-08-15 | Axon Neuroscience | Tau-proteine |
| DE50111493D1 (de) | 2001-09-03 | 2007-01-04 | Bio Life Science Forschungs & Entwicklungsgesellschaft Mbh | Antigen-Mimotope und Vakzine gegen Krebserkrankungen |
| TWI226905B (en) | 2001-10-19 | 2005-01-21 | Bioware Technology Co Ltd | Low pressure-accelerated particle gene gun |
| JP4414332B2 (ja) * | 2002-07-12 | 2010-02-10 | アクソン・ニューロサイエンス・フォルシュングス−ウント・エントヴィックルングス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | アルツハイマーtauタンパク質を発現するトランスジェニック動物 |
| CA2487528A1 (en) * | 2002-07-24 | 2004-02-12 | Innogenetics N.V. | Prevention, treatment and diagnosis of diseases associated with beta-amyloid formation and/or aggregation |
| US7521230B2 (en) * | 2002-10-16 | 2009-04-21 | Board Of Regents Of The University Of Nebraska | Nucleic acid encoding a Brain Derived Tau Kinase polypeptide and methods of use thereof |
| EP1516930A1 (en) | 2003-09-16 | 2005-03-23 | Georg-August Universität Göttingen | Cellular model of tauopathies for lead identification and drug discovery |
| MXPA06003886A (es) | 2003-10-08 | 2006-08-11 | Ebioscience | Reactivos de enlace de inmunoglobulina naturales y metodos de fabricacion y uso de los mismos. |
| CN1721437A (zh) * | 2004-07-13 | 2006-01-18 | 中南大学 | 一种与Tau蛋白相关的多肽抗原及抗体 |
| US8012936B2 (en) * | 2006-03-29 | 2011-09-06 | New York University | Tau fragments for immunotherapy |
| US20070280935A1 (en) * | 2006-04-07 | 2007-12-06 | Bernd Bohrmann | Antibody that recognizes phosphorylated peptides |
| GB0624500D0 (en) * | 2006-12-07 | 2007-01-17 | Istituto Superiore Di Sanito | A novel passive vaccine for candida infections |
| ATE524487T1 (de) * | 2007-01-11 | 2011-09-15 | Univ Ramot | Tau peptidmimetikum zur behandlung von neurodegenerativen erkrankungen |
| TR201802286T4 (tr) * | 2007-04-20 | 2018-03-21 | The Chemo Sero Therapeutic Res Institute | Peptidle bağışıklık yanıtının arttırılması için yöntem. |
| WO2009000520A1 (en) * | 2007-06-25 | 2008-12-31 | Universität Duisburg-Essen | Screening-method for polymorphic markers in htra1 gene in neurodegenerative disorders |
| UA107571C2 (xx) * | 2009-04-03 | 2015-01-26 | Фармацевтична композиція | |
| EP4218794A3 (en) | 2009-06-10 | 2023-09-13 | New York University | Immunological targeting of pathological tau proteins |
| US8609097B2 (en) | 2009-06-10 | 2013-12-17 | Hoffmann-La Roche Inc. | Use of an anti-Tau pS422 antibody for the treatment of brain diseases |
| WO2011026031A1 (en) * | 2009-08-28 | 2011-03-03 | The Board Of Regents Of The University Of Texas System | Antibodies that bind tau oligomers |
| WO2011053565A2 (en) | 2009-10-29 | 2011-05-05 | Biomedical Sciences Research Centre "Alexander Fleming" | Compositions and methods for detecting a tauopathy |
| DK2496594T3 (en) | 2009-11-06 | 2018-03-05 | The J David Gladstone Inst | METHODS AND COMPOSITIONS FOR MODULATING TAU LEVELS |
| DK2501716T3 (en) * | 2009-11-19 | 2015-04-07 | Solis Biodyne Oü | Formations to increase polypeptidstabilitet and activity and related practices |
| CL2010000019A1 (es) | 2010-01-11 | 2010-06-11 | Univ Chile | Anticuerpo monoclonal contra el tnf humano y sus fragmentos, secuencias nucleotidicas que lo codifican, vector de expresion y celulas que las contienen, composiciones y kit que comprenden el anticuerpo, uso de los mismos y metodo para su obtencion. |
| SMT201800109T1 (it) * | 2011-09-19 | 2018-05-02 | Axon Neuroscience Se | Terapia a base di proteine e diagnosi di una patologia mediata da tau nella malattia di alzheimer |
| CA2874083C (en) * | 2014-12-05 | 2024-01-02 | Universite Laval | Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases |
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