MX2023008317A - Anticuerpo anti tau fosforilada en la treonina 217 (pt217). - Google Patents

Anticuerpo anti tau fosforilada en la treonina 217 (pt217).

Info

Publication number
MX2023008317A
MX2023008317A MX2023008317A MX2023008317A MX2023008317A MX 2023008317 A MX2023008317 A MX 2023008317A MX 2023008317 A MX2023008317 A MX 2023008317A MX 2023008317 A MX2023008317 A MX 2023008317A MX 2023008317 A MX2023008317 A MX 2023008317A
Authority
MX
Mexico
Prior art keywords
tau antibody
tau
antibody
disclosed
binding fragment
Prior art date
Application number
MX2023008317A
Other languages
English (en)
Inventor
Malcolm Ian Roberts
James Martin Staddon
Sonia CIEZAREK
Takashi Obara
Yohei Mukai
Lal Kishan AGARWALA
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of MX2023008317A publication Critical patent/MX2023008317A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4709Amyloid plaque core protein
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Se da a conocer en el presente documento un anticuerpo anti-pT217 Tau o un fragmento de unión a pT217 Tau del mismo.
MX2023008317A 2021-02-19 2022-02-17 Anticuerpo anti tau fosforilada en la treonina 217 (pt217). MX2023008317A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163151254P 2021-02-19 2021-02-19
PCT/JP2022/006458 WO2022176959A1 (en) 2021-02-19 2022-02-17 Anti-pt217 tau antibody

Publications (1)

Publication Number Publication Date
MX2023008317A true MX2023008317A (es) 2023-07-24

Family

ID=82930689

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023008317A MX2023008317A (es) 2021-02-19 2022-02-17 Anticuerpo anti tau fosforilada en la treonina 217 (pt217).

Country Status (12)

Country Link
US (1) US20240076361A1 (es)
EP (1) EP4259801A1 (es)
JP (1) JP2024509683A (es)
KR (1) KR20230147034A (es)
CN (1) CN116635414A (es)
AU (1) AU2022222134A1 (es)
BR (1) BR112023014151A2 (es)
CA (1) CA3203800A1 (es)
IL (1) IL304154A (es)
MX (1) MX2023008317A (es)
TW (1) TW202246321A (es)
WO (1) WO2022176959A1 (es)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY183989A (en) * 2011-09-19 2021-03-17 Axon Neuroscience Se Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease
JOP20180021A1 (ar) * 2017-03-16 2019-01-30 Janssen Biotech Inc الأجسام المضادة لتكتلات خيوط بروتين تاو (tau) الحلزونية المزدوجة واستخداماتها
EA202092087A1 (ru) * 2018-03-05 2020-11-17 Янссен Фармацевтика Нв Анализы для выявления нейродегенеративных заболеваний
AU2019244481A1 (en) * 2018-03-28 2020-10-01 Axon Neuroscience Se Antibody-based methods of detecting and treating Alzheimer's disease

Also Published As

Publication number Publication date
CN116635414A (zh) 2023-08-22
EP4259801A1 (en) 2023-10-18
WO2022176959A1 (en) 2022-08-25
JP2024509683A (ja) 2024-03-05
BR112023014151A2 (pt) 2023-10-10
IL304154A (en) 2023-09-01
US20240076361A1 (en) 2024-03-07
CA3203800A1 (en) 2022-08-25
TW202246321A (zh) 2022-12-01
AU2022222134A1 (en) 2023-07-13
KR20230147034A (ko) 2023-10-20

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