JP2015522562A5 - - Google Patents

Info

Publication number

JP2015522562A5

JP2015522562A5 JP2015516391A JP2015516391A JP2015522562A5 JP 2015522562 A5 JP2015522562 A5 JP 2015522562A5 JP 2015516391 A JP2015516391 A JP 2015516391A JP 2015516391 A JP2015516391 A JP 2015516391A JP 2015522562 A5 JP2015522562 A5 JP 2015522562A5

Authority

JP

Japan

Prior art keywords

antibody

pharmaceutical composition

fragment

composition according

seq

Prior art date

2013-06-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 claims 14
• 102100034452 Alternative prion protein Human genes 0.000 claims 9
• 239000012634 fragment Substances 0.000 claims 9
• 108091000054 Prion Proteins 0.000 claims 7
• 206010028980 Neoplasm Diseases 0.000 claims 5
• 201000011510 cancer Diseases 0.000 claims 5
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 3
• 101000573901 Homo sapiens Major prion protein Proteins 0.000 claims 3
• 201000010099 disease Diseases 0.000 claims 3
• 206010033128 Ovarian cancer Diseases 0.000 claims 2
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 230000001747 exhibiting effect Effects 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 238000009007 Diagnostic Kit Methods 0.000 claims 1
• 229930012538 Paclitaxel Natural products 0.000 claims 1
• 208000024777 Prion disease Diseases 0.000 claims 1
• 108010046334 Urease Proteins 0.000 claims 1
• 238000004220 aggregation Methods 0.000 claims 1
• 230000002776 aggregation Effects 0.000 claims 1
• 125000003275 alpha amino acid group Chemical group 0.000 claims 1
• 239000012472 biological sample Substances 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 238000001514 detection method Methods 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 208000010544 human prion disease Diseases 0.000 claims 1
• 208000032839 leukemia Diseases 0.000 claims 1
• 230000001404 mediated effect Effects 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 229960001592 paclitaxel Drugs 0.000 claims 1
• 239000000523 sample Substances 0.000 claims 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
• 239000003053 toxin Substances 0.000 claims 1
• 231100000765 toxin Toxicity 0.000 claims 1