EP2984170A4 - Use of antibody-urease conjugates for diagnostic and therapeutic purposes - Google Patents
Use of antibody-urease conjugates for diagnostic and therapeutic purposesInfo
- Publication number
- EP2984170A4 EP2984170A4 EP14782795.0A EP14782795A EP2984170A4 EP 2984170 A4 EP2984170 A4 EP 2984170A4 EP 14782795 A EP14782795 A EP 14782795A EP 2984170 A4 EP2984170 A4 EP 2984170A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- diagnostic
- antibody
- therapeutic purposes
- urease conjugates
- urease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6815—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
- C12Y305/01005—Urease (3.5.1.5)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361809842P | 2013-04-08 | 2013-04-08 | |
PCT/CA2014/050334 WO2014165985A1 (en) | 2013-04-08 | 2014-04-03 | Use of antibody-urease conjugates for diagnostic and therapeutic purposes |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2984170A1 EP2984170A1 (en) | 2016-02-17 |
EP2984170A4 true EP2984170A4 (en) | 2016-11-30 |
Family
ID=51688787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP14782795.0A Pending EP2984170A4 (en) | 2013-04-08 | 2014-04-03 | Use of antibody-urease conjugates for diagnostic and therapeutic purposes |
Country Status (8)
Country | Link |
---|---|
US (1) | US10316311B2 (en) |
EP (1) | EP2984170A4 (en) |
JP (1) | JP2016524459A (en) |
CN (2) | CN105247047A (en) |
AU (1) | AU2014252666B2 (en) |
CA (1) | CA2908475C (en) |
HK (1) | HK1216903A1 (en) |
WO (1) | WO2014165985A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3261678B8 (en) * | 2015-01-23 | 2021-03-17 | Helix Biopharma Corp. | Antibody-urease conjugates for therapeutic purposes |
EP3515473A4 (en) | 2016-09-24 | 2020-04-15 | Helix Biopharma Corp. | Restoring function of tumour acidified t cells |
CN110382551A (en) * | 2017-01-05 | 2019-10-25 | 赫利克斯生物药品公司 | Anti-VEGFR-2 urase conjugate |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5587458A (en) * | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
US7211250B2 (en) * | 2002-07-18 | 2007-05-01 | Helix Biopharma Corporation | Method and composition for inhibiting cancer cell growth |
WO2013185215A1 (en) * | 2012-06-12 | 2013-12-19 | Amorfix Life Sciences Ltd. | Antibodies and conjugates that target misfolded prion protein |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4218539A (en) * | 1978-03-24 | 1980-08-19 | Weltman Joel K | Enzyme conjugates and method of preparation and use |
US4360592A (en) * | 1979-11-13 | 1982-11-23 | Weltman Joel K | Process for the detection of antibodies |
US4657853A (en) * | 1984-09-14 | 1987-04-14 | E. I. Du Pont De Nemours And Company | Immunoassays utilizing covalent conjugates of polymerized enzyme and antibody |
US7723099B2 (en) * | 2003-09-10 | 2010-05-25 | Abbott Point Of Care Inc. | Immunoassay device with immuno-reference electrode |
-
2014
- 2014-04-03 CN CN201480025121.XA patent/CN105247047A/en active Pending
- 2014-04-03 JP JP2016505666A patent/JP2016524459A/en active Pending
- 2014-04-03 US US14/783,153 patent/US10316311B2/en active Active
- 2014-04-03 CN CN201811072550.9A patent/CN109248311A/en active Pending
- 2014-04-03 CA CA2908475A patent/CA2908475C/en active Active
- 2014-04-03 WO PCT/CA2014/050334 patent/WO2014165985A1/en active Application Filing
- 2014-04-03 EP EP14782795.0A patent/EP2984170A4/en active Pending
- 2014-04-03 AU AU2014252666A patent/AU2014252666B2/en not_active Ceased
-
2016
- 2016-04-22 HK HK16104650.5A patent/HK1216903A1/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5587458A (en) * | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
US7211250B2 (en) * | 2002-07-18 | 2007-05-01 | Helix Biopharma Corporation | Method and composition for inhibiting cancer cell growth |
WO2013185215A1 (en) * | 2012-06-12 | 2013-12-19 | Amorfix Life Sciences Ltd. | Antibodies and conjugates that target misfolded prion protein |
Non-Patent Citations (7)
Title |
---|
ANONYMOUS: "ANTI-MOUSE IgG (WHOLE MOLECUKE) UREASE CONJUGATE - Product No. U1004", XP002763195, Retrieved from the Internet <URL:http://www.sigmaaldrich.com/content/dam/sigma-aldrich/docs/Sigma/Datasheet/8/u1004dat.pdf> [retrieved on 20161020] * |
BAOMIN TIAN ET AL: "Production and Characterization of a Camelid Single Domain Antibody-Urease Enzyme Conjugate for the Treatment of Cancer", BIOCONJUGATE CHEMISTRY., vol. 26, no. 6, 17 June 2015 (2015-06-17), US, pages 1144 - 1155, XP055271801, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.5b00237 * |
CHAO H: "DOS47 - Killing cancer by altering the tumor microenvironment", DRUG DELIVERY TECHNOLOGY 2011 DRUG DELIVERY TECHNOLOGY USA, vol. 11, no. 1, January 2011 (2011-01-01), pages 68 - 72, XP002763192, ISSN: 1537-2898 * |
HEMAN CHAO ET AL: "Development of an alkalizing antibody-enzyme conjugate for NSCLC treatment that is in Phase I clinical testing Preclinical Studies Abstract Background Starting Dose Derivations Acknowledgement", L-DOS47 PRESENTATION AT AACR 2013 ANNUAL MEETING, 5 April 2013 (2013-04-05), XP055285609, Retrieved from the Internet <URL:http://www.helixbiopharma.com/wp-content/uploads/2014/02/Helix-BioPharma-AACR.pdf> [retrieved on 20160704] * |
KUMAR RAMESH K.: "Preparation of anti-human IgG-hrp conjugate and its use in ELISA and western blotting experiments", J. ANAL. BIOANAL. TECHNIQUES, vol. 3, no. 7, 2012, pages 85, XP002763194, ISSN: 2155-9872, DOI: 10.4172/2155-9872.S1.010 * |
See also references of WO2014165985A1 * |
WINSTON S E ET AL: "Chapter 11 - UNIT 11.1: Conjugation of Enzymes to AntibodiesConjugation of enzymes to antibodies.", CURRENT PROTOCOLS IN MOLECULAR BIOLOGY (FREDERICK M. AUSUBEL ET AL), no. Supplement 50, 1 May 2001 (2001-05-01), pages 11.1.1 - 11.1.7, XP002763193, ISSN: 1934-3647, DOI: 10.1002/0471142727.mb1101s50 * |
Also Published As
Publication number | Publication date |
---|---|
AU2014252666A1 (en) | 2015-11-12 |
WO2014165985A1 (en) | 2014-10-16 |
US20160138002A1 (en) | 2016-05-19 |
CA2908475A1 (en) | 2014-10-16 |
CN109248311A (en) | 2019-01-22 |
HK1216903A1 (en) | 2016-12-09 |
CN105247047A (en) | 2016-01-13 |
JP2016524459A (en) | 2016-08-18 |
AU2014252666B2 (en) | 2017-02-02 |
EP2984170A1 (en) | 2016-02-17 |
US10316311B2 (en) | 2019-06-11 |
CA2908475C (en) | 2020-09-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20151029 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20161103 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 35/00 20060101ALI20161026BHEP Ipc: C07K 16/28 20060101ALN20161026BHEP Ipc: C07K 16/00 20060101ALN20161026BHEP Ipc: A61K 47/48 20060101AFI20161026BHEP Ipc: C12N 9/96 20060101ALN20161026BHEP Ipc: C12N 9/80 20060101ALN20161026BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |
|
17Q | First examination report despatched |
Effective date: 20180710 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: EXAMINATION IS IN PROGRESS |