JP2015530971A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015530971A5 JP2015530971A5 JP2015520685A JP2015520685A JP2015530971A5 JP 2015530971 A5 JP2015530971 A5 JP 2015530971A5 JP 2015520685 A JP2015520685 A JP 2015520685A JP 2015520685 A JP2015520685 A JP 2015520685A JP 2015530971 A5 JP2015530971 A5 JP 2015530971A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- tau
- amino acid
- antibody
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261667515P | 2012-07-03 | 2012-07-03 | |
| US61/667,515 | 2012-07-03 | ||
| US201261694989P | 2012-08-30 | 2012-08-30 | |
| US61/694,989 | 2012-08-30 | ||
| PCT/US2013/049333 WO2014008404A1 (en) | 2012-07-03 | 2013-07-03 | Antibodies to tau |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018098889A Division JP2018184398A (ja) | 2012-07-03 | 2018-05-23 | タウに対する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015530971A JP2015530971A (ja) | 2015-10-29 |
| JP2015530971A5 true JP2015530971A5 (enExample) | 2016-08-18 |
| JP6345655B2 JP6345655B2 (ja) | 2018-06-20 |
Family
ID=49882495
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015520685A Expired - Fee Related JP6345655B2 (ja) | 2012-07-03 | 2013-07-03 | タウに対する抗体 |
| JP2018098889A Pending JP2018184398A (ja) | 2012-07-03 | 2018-05-23 | タウに対する抗体 |
| JP2020070416A Pending JP2020125310A (ja) | 2012-07-03 | 2020-04-09 | タウに対する抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018098889A Pending JP2018184398A (ja) | 2012-07-03 | 2018-05-23 | タウに対する抗体 |
| JP2020070416A Pending JP2020125310A (ja) | 2012-07-03 | 2020-04-09 | タウに対する抗体 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9834596B2 (enExample) |
| EP (2) | EP2870176A4 (enExample) |
| JP (3) | JP6345655B2 (enExample) |
| KR (3) | KR102494798B1 (enExample) |
| CN (2) | CN104781278B (enExample) |
| AU (3) | AU2013286680B2 (enExample) |
| BR (1) | BR112014033116B1 (enExample) |
| CA (1) | CA2877397A1 (enExample) |
| HK (1) | HK1209768A1 (enExample) |
| IL (3) | IL236409B (enExample) |
| IN (1) | IN2015KN00007A (enExample) |
| MX (2) | MX359555B (enExample) |
| MY (1) | MY171473A (enExample) |
| NZ (2) | NZ739622A (enExample) |
| RU (2) | RU2668159C2 (enExample) |
| SG (3) | SG11201408626YA (enExample) |
| WO (1) | WO2014008404A1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6345655B2 (ja) | 2012-07-03 | 2018-06-20 | ワシントン・ユニバーシティWashington University | タウに対する抗体 |
| DK2885010T3 (da) | 2012-08-16 | 2020-02-03 | Ipierian Inc | Fremgangsmåder til behandling med tauopati |
| US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
| MX375354B (es) | 2013-03-13 | 2025-03-06 | Prothena Biosciences Ltd | Anticuerpos que se unen a tau y usos de los mismos. |
| JP2017512751A (ja) | 2014-02-14 | 2017-05-25 | アイピエリアン,インコーポレイティド | タウペプチド、抗タウ抗体、およびそれらの使用方法 |
| WO2015165961A1 (en) | 2014-04-29 | 2015-11-05 | Affiris Ag | Treatment and prevention of alzheimer's disease (ad) |
| ZA201608812B (en) | 2014-06-26 | 2019-08-28 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| NZ727020A (en) * | 2014-06-26 | 2022-02-25 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| TW202136296A (zh) * | 2014-06-27 | 2021-10-01 | 美商C2N醫療診斷有限責任公司 | 人類化抗-tau抗體 |
| US10830775B2 (en) | 2014-09-30 | 2020-11-10 | Washington University | Tau kinetic measurements |
| MA41451A (fr) * | 2015-02-04 | 2017-12-12 | Univ Washington | Constructions anti-tau |
| JO3576B1 (ar) | 2015-02-26 | 2020-07-05 | Lilly Co Eli | أجسام مضادة لـ tau واستخداماتها |
| UA126272C2 (uk) | 2015-06-05 | 2022-09-14 | Дженентек, Інк. | Антитіло проти тау-білка та спосіб його застосування |
| EA037092B1 (ru) * | 2015-07-06 | 2021-02-04 | Юсб Биофарма Срл | Тау-связывающие антитела |
| MX2017015908A (es) | 2015-07-06 | 2018-03-15 | Ucb Biopharma Sprl | Anticuerpos de union a tau. |
| GB201512203D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
| JO3711B1 (ar) | 2015-07-13 | 2021-01-31 | H Lundbeck As | أجسام مضادة محددة لبروتين تاو وطرق استعمالها |
| CN108137679B (zh) * | 2015-08-13 | 2022-07-19 | 纽约大学 | 对Tau的{p}Ser404表位有选择性的基于抗体的分子和它们在诊断和治疗Tau疾病中的用途 |
| CN109580954B (zh) * | 2015-09-16 | 2022-03-22 | 北京九强生物技术股份有限公司 | 一种人肌钙蛋白i的超敏定量测定试剂盒及其检测方法 |
| CA3022673A1 (en) | 2016-05-02 | 2017-11-09 | Prothena Biosciences Limited | Tau immunotherapy |
| EA201892412A1 (ru) | 2016-05-02 | 2019-05-31 | Протена Биосайенсис Лимитед | Антитела, распознающие тау |
| CA3022515A1 (en) | 2016-05-02 | 2017-11-09 | Prothena Biosciences Limited | Antibodies recognizing tau |
| KR102551971B1 (ko) | 2016-07-12 | 2023-07-07 | 하. 룬드벡 아크티에셀스카브 | 과인산화된 타우에 특이적인 항체 및 이의 사용 방법 |
| EP3496750A2 (en) | 2016-08-09 | 2019-06-19 | Eli Lilly and Company | Combination therapy |
| MA46836A (fr) | 2016-11-15 | 2019-09-25 | H Lundbeck As | Agents, utilisations et procédés pour le traitement d'une synucléinopathie |
| KR20240035636A (ko) | 2016-12-07 | 2024-03-15 | 제넨테크, 인크. | 항-타우 항체 및 이의 이용 방법 |
| AR110321A1 (es) | 2016-12-07 | 2019-03-20 | Genentech Inc | Anticuerpos antitau y métodos de uso |
| CN106749658B (zh) * | 2016-12-15 | 2019-11-12 | 北京师范大学 | 抑制Tau蛋白聚集的抗体型分子伴侣 |
| EP3555127B1 (en) | 2016-12-16 | 2024-12-18 | H. Lundbeck A/S | Agents, uses and methods |
| US10364286B2 (en) | 2016-12-22 | 2019-07-30 | H. Lundbeck A/S | Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation |
| SG11201907422RA (en) * | 2017-02-17 | 2019-09-27 | Denali Therapeutics Inc | Anti-tau antibodies and methods of use thereof |
| CA3055957A1 (en) * | 2017-03-09 | 2018-09-13 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of pediatric brain tumors with targeting of cd47 pathway |
| KR102784294B1 (ko) | 2017-05-02 | 2025-03-19 | 프로테나 바이오사이언시즈 리미티드 | 타우 인식 항체 |
| NZ762251A (en) | 2017-10-16 | 2025-12-19 | Eisai R&D Man Co Ltd | Anti-tau antibodies and uses thereof |
| TW202003036A (zh) * | 2018-03-23 | 2020-01-16 | 德商艾伯維德國有限及兩合公司 | 穩定水性抗-tau抗體調配物 |
| US11629175B2 (en) | 2018-04-27 | 2023-04-18 | Ecole Polytechnique Federale De Lausanne (Epfl) | Method for preparing PHFS-like Tau aggregates |
| CN112543648A (zh) | 2018-07-31 | 2021-03-23 | 伊莱利利公司 | 组合疗法 |
| CN109613242A (zh) * | 2018-11-01 | 2019-04-12 | 深圳天辰医疗科技有限公司 | 一种肌酸激酶同工酶检测试剂盒及其制备方法 |
| CN119371527A (zh) | 2019-03-03 | 2025-01-28 | 普罗塞纳生物科学有限公司 | 识别tau的抗体 |
| US11845931B2 (en) * | 2019-03-18 | 2023-12-19 | Regeneron Pharmaceuticals, Inc. | CRISPR/Cas screening platform to identify genetic modifiers of tau seeding or aggregation |
| CA3127814C (en) * | 2019-03-18 | 2024-05-14 | Regeneron Pharmaceuticals, Inc. | Crispr/cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation |
| CN110055280A (zh) * | 2019-03-19 | 2019-07-26 | 深圳大学 | 一种稳定表达mCherry-tau的细胞系及其构建方法与应用 |
| GB2600599B (en) * | 2019-07-15 | 2025-05-21 | Adel Inc | Anti-Tau antibody and use thereof |
| MX2022001817A (es) * | 2019-08-13 | 2022-03-11 | Washington University St Louis | Metodos para detectar isoformas de la region de union a microtubulos (mtbr) tau y uso de las mismas. |
| MX2022004107A (es) | 2019-10-09 | 2022-08-10 | Bluerock Therapeutics Lp | Celulas con expresion transgenica sostenida. |
| US20250340623A1 (en) * | 2019-12-04 | 2025-11-06 | Ac Immune Sa | Novel Molecules for Therapy and Diagnosis |
| WO2022099314A1 (en) * | 2020-11-09 | 2022-05-12 | Meso Scale Technologies, Llc. | Methods and kits for detecting tau |
| WO2022144406A1 (en) | 2020-12-29 | 2022-07-07 | Neurimmune Ag | Human anti-tau antibodies |
| IL307168A (en) | 2021-03-26 | 2023-11-01 | Janssen Biotech Inc | Humanized antibodies against paired helical strands of TAU protein and their uses |
| EP4314048A1 (en) | 2021-03-26 | 2024-02-07 | Janssen Biotech, Inc. | Anti-tau antibodies and uses thereof |
| CL2021001380A1 (es) | 2021-05-26 | 2022-01-14 | Corporacion Centro Int De Biomedicina Icc | Generación de un nuevo anticuerpo monoclonal sitio específico para la proteína tau y su uso como herramienta en biomarcadores específicos para la detección temprana de enfermedades neurodegenerativas y patologías involucradas con la proteína tau como alzheimer y otras demencias. |
| JP2025530718A (ja) * | 2022-08-23 | 2025-09-17 | ワシントン・ユニバーシティ | 抗タウmtbr抗体、ならびにタウの切断された断片の検出方法およびその用途 |
| CN121773336A (zh) * | 2023-07-20 | 2026-03-31 | 拉亚·蒙托柳加亚 | P-tau免疫测定 |
| WO2025216325A1 (ja) * | 2024-04-11 | 2025-10-16 | 国立大学法人東京大学 | 生体から脳間質液中のタウシードを回収する方法 |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO884368L (no) | 1987-10-02 | 1989-04-03 | Du Pont | Immunanalyse ved anvendelse av igg-innfangelsesantistoff og multippel, monoklonalt antistoffpaavisningssystem. |
| AU2414092A (en) | 1991-08-01 | 1993-03-02 | Paul H. Voorheis | Diagnostic method for alzheimer's disease |
| US5733734A (en) | 1991-08-14 | 1998-03-31 | The Trustees Of The University Of Pennsylvania | Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments |
| DK0610330T3 (da) | 1991-10-25 | 1998-01-26 | Innogenetics Nv | Monoklonale antistoffer mod microtubulus-associeret protein tau |
| US7408027B1 (en) | 1991-12-06 | 2008-08-05 | Max-Planck-Gesellschaft Zur Forderung Der Wissenchaften | Tools for the diagnosis and treatment of Alzheimer's disease |
| WO1993011231A1 (en) | 1991-12-06 | 1993-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Tools for the diagnosis and treatment of alzheimer's disease |
| JPH06239899A (ja) | 1993-02-12 | 1994-08-30 | Teijin Ltd | ヒトタウ蛋白に対する抗体、並びに該抗体を利用する体液中のヒトタウ蛋白の測定方法 |
| US6121003A (en) | 1994-07-29 | 2000-09-19 | Innogentics N.V. | Monoclonal antibodies specific for an epitope of phosphorylated tau, and their use |
| US20020086009A1 (en) | 1996-03-13 | 2002-07-04 | Koichi Ishiguro | Anti-phosphorylated tau protein antibodies and methods for detecting alzheimer`s disease with the use of the same |
| WO1998022120A1 (en) | 1996-11-19 | 1998-05-28 | The Wistar Institute Of Anatomy & Biology | Diagnostic and therapeutic reagents for alzheimer's disease |
| US6797478B1 (en) | 1998-03-05 | 2004-09-28 | University Of Cincinnati | Method of detecting axonal damage, from associated disease states using tau monoclonal antibodies |
| RU2238947C2 (ru) * | 1998-07-14 | 2004-10-27 | Янссен Фармацевтика Н.В. | Нейротрофический фактор роста человека (эновин), кодирующая его выделенная молекула нуклеиновой кислоты, вектор (варианты), фармацевтическая композиция (варианты), антитело, способ обнаружения фактора роста, набор, способ идентификации агониста или антагониста (варианты) |
| CN1325491A (zh) | 1998-09-08 | 2001-12-05 | 基因创新有限公司 | 作为早期CNS损伤标记物的τ |
| US6495376B1 (en) * | 1999-02-18 | 2002-12-17 | Beth Israel Deaconess Medical Center | Methods and compositions for regulating protein-protein interactions |
| US6589746B1 (en) | 1999-10-21 | 2003-07-08 | University Of Cincinnati | Method of detecting axonally-derived protein tau in patients with traumatic CNS injury |
| US20020182660A1 (en) | 2000-02-18 | 2002-12-05 | Fong Kei-Lai L. | N- and C-terminus specific immunoassays for full length beta-amyloid peptide-Abeta(1-40), Abeta(1-39), Abeta(1-40), Abeta(1-42) , and Abeta(1-43) |
| AT500379B8 (de) | 2001-02-02 | 2009-08-15 | Axon Neuroscience | Tau-proteine |
| AR035119A1 (es) | 2001-08-16 | 2004-04-14 | Lilly Co Eli | Anticuerpos humanos antagonistas anti-htnfsf13b |
| WO2003057881A1 (en) | 2001-12-28 | 2003-07-17 | Chugai Seiyaku Kabushiki Kaisha | Method of stabilizing protein |
| SG187991A1 (en) | 2002-05-02 | 2013-03-28 | Wyeth Corp | Calicheamicin derivative-carrier conjugates |
| GB0210121D0 (en) | 2002-05-02 | 2002-06-12 | Celltech R&D Ltd | Biological products |
| JP4414332B2 (ja) | 2002-07-12 | 2010-02-10 | アクソン・ニューロサイエンス・フォルシュングス−ウント・エントヴィックルングス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | アルツハイマーtauタンパク質を発現するトランスジェニック動物 |
| ES2352668T3 (es) | 2002-08-14 | 2011-02-22 | Mitsubishi Chemical Medience Corporation | Anticuerpo específico para una proteína tau del sistema nervioso central. |
| FI20030652A0 (fi) | 2003-04-30 | 2003-04-30 | Susann Eriksson | Parannettu immunomääritys |
| CN1871259A (zh) | 2003-08-22 | 2006-11-29 | 比奥根艾迪克Ma公司 | 具有改变的效应物功能的经改进的抗体和制备它的方法 |
| WO2005080986A1 (en) | 2004-02-18 | 2005-09-01 | University Of Iowa Research Foundation | Antibodies to phosphorylated tau, methods of making and methods of use |
| CA2598321A1 (en) | 2005-02-19 | 2006-08-24 | Peoplebio, Inc. | Method for differentially detecting multimeric form from monomeric form of multimer-forming polypeptides |
| JP2009506302A (ja) | 2005-08-04 | 2009-02-12 | イェシバ・ユニバーシティ | Ablによるタウのリン酸化 |
| ES2321996B1 (es) | 2006-01-26 | 2010-03-05 | Consejo Superior Investig. Cientificas | Uso de compuestos que se unen al dominio de union a microtubulos de tau en la elaboracion de composiciones farmaceuticas, dichas composiciones farmaceuticas y su aplicacion en el tratamiento de tauopatias. |
| US8012936B2 (en) | 2006-03-29 | 2011-09-06 | New York University | Tau fragments for immunotherapy |
| US20080220449A1 (en) | 2007-02-08 | 2008-09-11 | Oligomerix, Inc. | Biomarkers and assays for Alzheimer's disease |
| NZ588555A (en) | 2008-04-24 | 2012-06-29 | Bristol Myers Squibb Co | Use of epothilone d in treating tau-associated diseases including alzheimer's disease |
| CN101307108B (zh) | 2008-06-25 | 2012-04-04 | 南京川博生物技术有限公司 | 抗磷酸化Tau蛋白抗体及其在AD症异常磷酸化Tau蛋白水平测定上的用途 |
| PT2365802T (pt) * | 2008-11-11 | 2017-11-14 | Univ Texas | Microcápsulas de rapamicina e utilização para o tratamento de cancro |
| US9605054B2 (en) | 2009-02-23 | 2017-03-28 | The Board Of Trustees Of The University Of Illinois | Composition and method for treating a tauopathy |
| WO2010096751A1 (en) | 2009-02-23 | 2010-08-26 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for treating a disease mediated by soluble oligomeric amyloid beta |
| UA107571C2 (xx) | 2009-04-03 | 2015-01-26 | Фармацевтична композиція | |
| WO2010129674A2 (en) | 2009-05-05 | 2010-11-11 | New York University | Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins |
| CA3239368A1 (en) * | 2009-06-10 | 2010-12-16 | New York University | Immunological targeting of pathological tau proteins |
| CA2768346A1 (en) * | 2009-07-30 | 2011-02-03 | Pfizer Vaccines Llc | Antigenic tau peptides and uses thereof |
| AU2010286501B2 (en) | 2009-08-28 | 2015-06-11 | The Board Of Regents Of The University Of Texas System | Antibodies that bind Tau oligomers |
| HUE040281T2 (hu) * | 2009-09-14 | 2019-03-28 | Banyan Biomarkers Inc | Autoantitest markerek traumás agysérülés diagnózisára |
| WO2011045166A1 (en) | 2009-09-24 | 2011-04-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fkbp52-tau interaction as a novel therapeutical target for treating the neurological disorders involving tau dysfunction |
| WO2011109112A2 (en) | 2010-03-05 | 2011-09-09 | Albert Einstein College Of Medicine Of Yeshiva University | Method of detecting tau protein and tau fragments in serum |
| PE20140218A1 (es) * | 2010-10-07 | 2014-03-01 | Ac Inmune S A | Composicion farmaceutica |
| AU2013205313B2 (en) | 2010-10-07 | 2016-05-19 | Ac Immune S.A. | Phosphospecific antibodies recognising tau |
| SG189174A1 (en) | 2010-10-11 | 2013-05-31 | Biogen Idec Internat Neuroscience Gmbh | Human anti-tau antibodies |
| US8703137B2 (en) | 2011-01-31 | 2014-04-22 | Intellect Neurosciences Inc. | Treatment of tauopathies |
| WO2012149365A2 (en) | 2011-04-27 | 2012-11-01 | Northwestern University | Antibodies selective for pathological tau dimers and prefibrillar pathological tau oligomers and their uses in treatment, diagnosis and monitoring of tauopathies |
| US20120321594A1 (en) | 2011-05-06 | 2012-12-20 | New York University | Methods of controlling axon or dendrite development of neuronal cells |
| EP2709728B1 (en) | 2011-05-20 | 2019-01-23 | Oligomerix, Inc. | Tau protease methods of use |
| GB201111361D0 (en) | 2011-07-04 | 2011-08-17 | Nordic Bioscience As | Biochemical markers for neurodegenerative conditions |
| GB201112056D0 (en) | 2011-07-14 | 2011-08-31 | Univ Leuven Kath | Antibodies |
| US9926353B2 (en) | 2011-07-19 | 2018-03-27 | New York University | Immunotherapeutic modulation of amyloidogenic disease using non-fibrillogenic, non-amyloidogenic polymerized proteins and peptides |
| US9518101B2 (en) | 2011-09-19 | 2016-12-13 | Axon Neuroscience Se | Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease |
| ES2600915T3 (es) | 2011-10-07 | 2017-02-13 | Ac Immune S.A. | Anticuerpos fosfoespecíficos que reconocen Tau |
| WO2013063086A1 (en) | 2011-10-24 | 2013-05-02 | Intellect Neurosciences, Inc. | Compositions and methods for treatment of proteinopathies |
| PT2794654T (pt) | 2011-12-20 | 2019-09-10 | Janssen Biotech Inc | Anticorpos anti-phf-tau e suas utilizações |
| EP2834270B1 (en) | 2012-04-05 | 2019-10-30 | AC Immune S.A. | Humanized tau antibody |
| WO2013177104A2 (en) | 2012-05-21 | 2013-11-28 | Felder Mitchell S | Treatment for tauopathies |
| BR112014029566A2 (pt) | 2012-05-31 | 2017-07-25 | Univ Osaka City | agente terapêutico ou agente profilático para desordens cognitivas, anticorpo monoclonal, anticorpo para proteína tau fosforilada, e, peptídeo |
| JP6345655B2 (ja) | 2012-07-03 | 2018-06-20 | ワシントン・ユニバーシティWashington University | タウに対する抗体 |
| DK2885010T3 (da) | 2012-08-16 | 2020-02-03 | Ipierian Inc | Fremgangsmåder til behandling med tauopati |
| US20140056901A1 (en) | 2012-08-21 | 2014-02-27 | The Institute For Molecular Medicine | Anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies |
| WO2014031697A2 (en) | 2012-08-21 | 2014-02-27 | The Institute Of Molecular Medicine | COMPOSITIONS AND METHODS RELATED TO DISEASES ASSOCIATED WITH DEPOSITS OF AMYLOID, TAU, AND α-SYNUCLEIN |
| EP4356927A3 (en) | 2012-10-12 | 2024-10-02 | Arizona Board of Regents on behalf of Arizona State University | Antibody based reagents that specifically recognize toxic oligomeric forms of tau |
| WO2014089104A1 (en) | 2012-12-03 | 2014-06-12 | Washington University | Method for detection of aggregates in biological samples |
| US8921150B2 (en) | 2012-12-06 | 2014-12-30 | Taiwan Semiconductor Manufacturing Co., Ltd. | Process to achieve contact protrusion for single damascene via |
| US9200068B2 (en) | 2012-12-18 | 2015-12-01 | Regents Of The University Of Minnesota | Compositions and methods related to tauopathy |
| HRP20201422T1 (hr) | 2012-12-21 | 2021-02-19 | Biogen Ma Inc. | Ljudska anti-tau antitijela |
| WO2014096321A1 (en) | 2012-12-21 | 2014-06-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antibodies specific to tau phosphorylated at serine 422 and uses for the treatment and diagnosis of tauopathies |
| US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
| MX375354B (es) | 2013-03-13 | 2025-03-06 | Prothena Biosciences Ltd | Anticuerpos que se unen a tau y usos de los mismos. |
| WO2014159244A2 (en) | 2013-03-14 | 2014-10-02 | Merck Patent Gmbh | O-GlcNAc TAU ANTIBODY AND USE THEREOF |
| CA2903091C (en) | 2013-03-15 | 2022-09-06 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the generation and use of conformation-specific antibodies |
| BR112015023262B8 (pt) | 2013-03-15 | 2024-02-06 | Ac Immune Sa | Anticorpo isolado, imunoconjugado, formulação farmacêutica e usos do anticorpo |
| TW202136296A (zh) | 2014-06-27 | 2021-10-01 | 美商C2N醫療診斷有限責任公司 | 人類化抗-tau抗體 |
-
2013
- 2013-07-03 JP JP2015520685A patent/JP6345655B2/ja not_active Expired - Fee Related
- 2013-07-03 BR BR112014033116-2A patent/BR112014033116B1/pt active IP Right Grant
- 2013-07-03 AU AU2013286680A patent/AU2013286680B2/en active Active
- 2013-07-03 CN CN201380045706.3A patent/CN104781278B/zh active Active
- 2013-07-03 KR KR1020207033554A patent/KR102494798B1/ko active Active
- 2013-07-03 MY MYPI2014704038A patent/MY171473A/en unknown
- 2013-07-03 MX MX2014016024A patent/MX359555B/es active IP Right Grant
- 2013-07-03 CN CN201810507442.3A patent/CN108623682A/zh active Pending
- 2013-07-03 US US14/412,309 patent/US9834596B2/en active Active
- 2013-07-03 SG SG11201408626YA patent/SG11201408626YA/en unknown
- 2013-07-03 RU RU2015103228A patent/RU2668159C2/ru active
- 2013-07-03 CA CA2877397A patent/CA2877397A1/en not_active Abandoned
- 2013-07-03 EP EP13813988.6A patent/EP2870176A4/en not_active Withdrawn
- 2013-07-03 SG SG10201708959WA patent/SG10201708959WA/en unknown
- 2013-07-03 KR KR20157002867A patent/KR20150036346A/ko not_active Abandoned
- 2013-07-03 KR KR1020207002242A patent/KR20200013072A/ko not_active Ceased
- 2013-07-03 NZ NZ739622A patent/NZ739622A/en not_active IP Right Cessation
- 2013-07-03 SG SG10201913370PA patent/SG10201913370PA/en unknown
- 2013-07-03 NZ NZ703423A patent/NZ703423A/en not_active IP Right Cessation
- 2013-07-03 WO PCT/US2013/049333 patent/WO2014008404A1/en not_active Ceased
- 2013-07-03 RU RU2018132044A patent/RU2018132044A/ru unknown
- 2013-07-03 HK HK15110657.6A patent/HK1209768A1/xx unknown
- 2013-07-03 IN IN7KON2015 patent/IN2015KN00007A/en unknown
- 2013-07-03 EP EP20199802.8A patent/EP3838921A3/en not_active Withdrawn
-
2014
- 2014-12-19 MX MX2022000026A patent/MX2022000026A/es unknown
- 2014-12-23 IL IL236409A patent/IL236409B/en active IP Right Grant
-
2017
- 2017-06-02 US US15/612,695 patent/US20180037641A1/en not_active Abandoned
-
2018
- 2018-05-23 JP JP2018098889A patent/JP2018184398A/ja active Pending
- 2018-09-17 AU AU2018229564A patent/AU2018229564A1/en not_active Abandoned
-
2020
- 2020-04-09 JP JP2020070416A patent/JP2020125310A/ja active Pending
- 2020-08-28 AU AU2020223765A patent/AU2020223765A1/en not_active Abandoned
- 2020-09-29 IL IL277643A patent/IL277643A/en unknown
-
2021
- 2021-12-21 IL IL289241A patent/IL289241A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2015103228A (ru) | Антитела против тау | |
| JP2014526898A5 (enExample) | ||
| RU2474588C2 (ru) | Перекрестно-реактивные антитела анти-il-17a/il-17f и способы их применения | |
| HRP20170568T1 (hr) | Protutijela anti-ox40 i postupci za njihovu uporabu | |
| RU2016100892A (ru) | Антитела против tweakr и их применение | |
| JP2013500940A5 (enExample) | ||
| JP2010526028A5 (enExample) | ||
| HRP20200390T1 (hr) | Monoklonska antitijela protiv humanog antigena starenja b stanica (bcma) | |
| FI3332006T3 (fi) | Uusia anti-PD-L1-vasta-aineita | |
| JP2021500916A5 (enExample) | ||
| JP2013538057A5 (enExample) | ||
| JP2017535257A5 (enExample) | ||
| JP2015535828A5 (enExample) | ||
| HRP20251181T1 (hr) | Protutijela na protein gprc5d, bispecifične molekule koje vezuju antigen i koje vezuju gprc5d i cd3 te njihove primjene | |
| JP2014511179A5 (enExample) | ||
| JP2013506428A5 (enExample) | ||
| HRP20230844T1 (hr) | Anti-cd3 antitijela, bispecifične molekule koje vežu antigen koji veže cd3 i cd20, i njihove upotrebe | |
| JP2018512138A5 (enExample) | ||
| RU2017145653A (ru) | Средства, пути применения и способы лечения синуклеопатии | |
| JP2018520668A5 (enExample) | ||
| FI3826667T3 (fi) | Claudin6 vasta-aineita ja menetelmiä syövän hoitamiseksi | |
| JP2016509585A5 (enExample) | ||
| JP2016501881A (ja) | 血液脳関門(bbb)を透過する二重特異性結合タンパク質 | |
| JP2015531768A5 (enExample) | ||
| JP2017512838A5 (enExample) |