|
DE3888224T2
(de)
|
1987-04-24 |
1994-07-21 |
Teijin Ltd |
Bestimmung vom Tumornekrosefaktor; monoklonaler Antikörper und Zusammensetzung.
|
|
EP1541682A3
(en)
|
1988-09-02 |
2005-07-06 |
Dyax Corp. |
Generation and selection of recombinant varied binding proteins
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US4908372A
(en)
|
1988-10-13 |
1990-03-13 |
Merrell Dow Pharmaceuticals Inc. |
Antihistaminic piperidinyl benzimidazoles
|
|
DE3843534A1
(de)
|
1988-12-23 |
1990-07-12 |
Basf Ag |
Neue tnf-polypeptide
|
|
US6448380B2
(en)
|
1989-08-07 |
2002-09-10 |
Peptech Limited |
Tumor necrosis factor antibodies
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
US5780225A
(en)
|
1990-01-12 |
1998-07-14 |
Stratagene |
Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
|
|
WO1991010737A1
(en)
|
1990-01-11 |
1991-07-25 |
Molecular Affinities Corporation |
Production of antibodies using gene libraries
|
|
ES2087997T3
(es)
|
1990-01-12 |
1996-08-01 |
Cell Genesys Inc |
Generacion de anticuerpos xenogenicos.
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
WO1992002551A1
(en)
|
1990-08-02 |
1992-02-20 |
B.R. Centre Limited |
Methods for the production of proteins with a desired function
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
ES2108048T3
(es)
|
1990-08-29 |
1997-12-16 |
Genpharm Int |
Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5698426A
(en)
|
1990-09-28 |
1997-12-16 |
Ixsys, Incorporated |
Surface expression libraries of heteromeric receptors
|
|
DE69129154T2
(de)
|
1990-12-03 |
1998-08-20 |
Genentech, Inc., South San Francisco, Calif. |
Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
|
|
GB9028123D0
(en)
|
1990-12-28 |
1991-02-13 |
Erba Carlo Spa |
Monoclonal antibodies against human tumor necrosis factor alpha
|
|
ATE414768T1
(de)
|
1991-04-10 |
2008-12-15 |
Scripps Research Inst |
Bibliotheken heterodimerer rezeptoren mittels phagemiden
|
|
GB9113120D0
(en)
|
1991-06-18 |
1991-08-07 |
Kodak Ltd |
Photographic processing apparatus
|
|
IT1249708B
(it)
|
1991-09-23 |
1995-03-09 |
Tecnogen Scpa |
Metodo per la determinazione del fattore di necrosi tumorale (tnf) in forma biologicamente attiva.
|
|
ATE463573T1
(de)
|
1991-12-02 |
2010-04-15 |
Medimmune Ltd |
Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
|
|
WO1993014083A1
(en)
|
1992-01-09 |
1993-07-22 |
Janssen Pharmaceutica N.V. |
Pharmaceutically active substituted benzimidazole derivatives
|
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
AU6001094A
(en)
|
1993-02-03 |
1994-08-29 |
N.V. Innogenetics S.A. |
Tnf-alpha muteins and a process for preparing them
|
|
CA2119089A1
(en)
|
1993-03-29 |
1994-09-30 |
David Banner |
Tumor necrosis factor muteins
|
|
WO1995015982A2
(en)
|
1993-12-08 |
1995-06-15 |
Genzyme Corporation |
Process for generating specific antibodies
|
|
DE69531148T2
(de)
|
1994-01-31 |
2004-04-29 |
Trustees Of Boston University, Boston |
Bibliotheken aus polyklonalen antikörpern
|
|
US5516637A
(en)
|
1994-06-10 |
1996-05-14 |
Dade International Inc. |
Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
|
|
DE4440613C1
(de)
|
1994-11-14 |
1996-07-25 |
Leica Ag |
Vorrichtung und Verfahren zur Detektion und Demodulation eines intensitätsmodulierten Strahlungsfeldes
|
|
TW453995B
(en)
|
1995-12-15 |
2001-09-11 |
Novartis Ag |
Certain alpha-substituted arylsulfonamido acetohydroxamic acids
|
|
JP2978435B2
(ja)
|
1996-01-24 |
1999-11-15 |
チッソ株式会社 |
アクリロキシプロピルシランの製造方法
|
|
CN1204230A
(zh)
|
1997-12-08 |
1999-01-06 |
李建安 |
一种手提电话机用防护罩及其制做方法
|
|
US20040009535A1
(en)
|
1998-11-27 |
2004-01-15 |
Celltech R&D, Inc. |
Compositions and methods for increasing bone mineralization
|
|
GB9828628D0
(en)
*
|
1998-12-23 |
1999-02-17 |
Glaxo Group Ltd |
Novel ligand
|
|
US7101974B2
(en)
*
|
2000-03-02 |
2006-09-05 |
Xencor |
TNF-αvariants
|
|
WO2002018540A2
(en)
|
2000-09-01 |
2002-03-07 |
Biogen, Inc. |
Pyridine derivatives useful as cd40:cd154 binding interruptor compounds and use thereof to treat immunological complications
|
|
DE60214392T2
(de)
|
2001-06-05 |
2008-01-17 |
Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield |
1,4-Disubstituierte Benzo-kondensierte Cycloalkyl-Harnstoffverbindungen
|
|
US6632810B2
(en)
|
2001-06-29 |
2003-10-14 |
Kowa Co., Ltd. |
Cyclic diamine compound with condensed-ring groups
|
|
JP2003040888A
(ja)
|
2001-07-30 |
2003-02-13 |
Sankyo Co Ltd |
イミダゾール誘導体
|
|
CA2494276A1
(en)
|
2002-08-01 |
2004-02-12 |
Wyeth |
Methods and reagents relating to inflammation and apoptosis
|
|
JP4603894B2
(ja)
|
2002-12-03 |
2010-12-22 |
ユセベ ファルマ ソシエテ アノニム |
抗体産生細胞を同定するためのアッセイ
|
|
AU2004235875A1
(en)
|
2003-05-09 |
2004-11-18 |
Pharmexa A/S |
Immunogenic human TNF alpha analogues with reduced cytotoxicity and methods of their preparation
|
|
GB0312481D0
(en)
|
2003-05-30 |
2003-07-09 |
Celltech R&D Ltd |
Antibodies
|
|
AU2004253738A1
(en)
|
2003-07-01 |
2005-01-13 |
Ucb Pharma S.A. |
Modified antibody Fab fragments
|
|
GB0315457D0
(en)
|
2003-07-01 |
2003-08-06 |
Celltech R&D Ltd |
Biological products
|
|
GB0315450D0
(en)
|
2003-07-01 |
2003-08-06 |
Celltech R&D Ltd |
Biological products
|
|
CN1849138B
(zh)
|
2003-07-15 |
2011-11-30 |
安姆根有限公司 |
作为选择性ngf途径抑制剂的人抗ngf中和抗体
|
|
US7268116B2
(en)
|
2003-10-02 |
2007-09-11 |
Genhunter Corp. |
Methods and compositions for producing secreted trimeric receptor analogs and biologically active fusion proteins
|
|
TW200526780A
(en)
|
2004-01-06 |
2005-08-16 |
Hayashibara Biochem Lab |
TNF antagonists and TNF inhibitors comprising the same as the active ingredient
|
|
GB0411186D0
(en)
|
2004-05-19 |
2004-06-23 |
Celltech R&D Ltd |
Biological products
|
|
RU2464276C2
(ru)
|
2005-05-18 |
2012-10-20 |
Аблинкс Н.В. |
Улучшенные нанотела против фактора некроза опухоли-альфа
|
|
DE102005023617A1
(de)
|
2005-05-21 |
2006-11-23 |
Aspre Ag |
Verfahren zum Mischen von Farben in einem Display
|
|
WO2007060411A1
(en)
|
2005-11-24 |
2007-05-31 |
Ucb Pharma S.A. |
Anti-tnf alpha antibodies which selectively inhibit tnf alpha signalling through the p55r
|
|
TW201531484A
(zh)
|
2007-05-21 |
2015-08-16 |
Alder Biopharmaceuticals Inc |
抗ＴＮＦ-α之抗體及其用途
|
|
KR20170036814A
(ko)
*
|
2007-05-21 |
2017-04-03 |
앨더바이오 홀딩스 엘엘씨 |
신규한 래빗 항체 인간화 방법 및 인간화된 래빗 항체
|
|
US20090035225A1
(en)
|
2007-08-03 |
2009-02-05 |
Alcon Research, Ltd. |
RNAi-RELATED INHIBITION OF TNFa SIGNALING PATHWAY FOR TREATMENT OF GLAUCOMA
|
|
JP5592792B2
(ja)
|
2007-09-26 |
2014-09-17 |
ユセベ ファルマ ソシエテ アノニム |
二重特異性抗体の融合体
|
|
US9365644B2
(en)
|
2008-04-23 |
2016-06-14 |
Epitomics, Inc. |
Anti-TNFα antibody
|
|
RU2653753C1
(ru)
|
2008-06-25 |
2018-05-14 |
ИЭсБиЭйТЕК, ЭН АЛЬКОН БАЙОМЕДИКАЛ РИСЕРЧ ЮНИТ ЭлЭлСи |
СТАБИЛЬНЫЕ И РАСТВОРИМЫЕ АНТИТЕЛА, ИНГИБИРУЮЩИЕ TNFα
|
|
RU2011151260A
(ru)
*
|
2008-11-20 |
2013-06-20 |
Панацеа Биотек Лтд. |
Пептиды, ингибирующие фактор некроза опухолей альфа, и их применения
|
|
JP2010172307A
(ja)
|
2009-01-30 |
2010-08-12 |
Saitama Medical Univ |
関節リウマチに対する可溶性ＴＮＦα／ＬＴαレセプター薬の薬効予測方法、及び薬効予測装置
|
|
US20120094935A1
(en)
|
2009-04-09 |
2012-04-19 |
West Anthony P |
Methods for creating or identifying compounds that bind tumor necrosis factor alpha
|
|
CA2758964A1
(en)
|
2009-04-16 |
2010-10-21 |
Abbott Biotherapeutics Corp. |
Anti-tnf-.alpha. antibodies and their uses
|
|
CN102958537B
(zh)
|
2010-04-07 |
2015-09-16 |
Abbvie公司 |
TNF-α结合蛋白
|
|
US8377441B2
(en)
|
2010-08-03 |
2013-02-19 |
National Cheng Kung University |
Treating breast cancer with anti-IL-19 antibody
|
|
CA2853974C
(en)
|
2010-10-30 |
2020-11-10 |
Kindex Therapeutics, Llc |
Cis 3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one derivatives, substantially enantiomerically pure compositions and methods
|
|
AR084210A1
(es)
|
2010-12-08 |
2013-05-02 |
Abbott Lab |
PROTEINAS DE UNION AL TNF-a
|
|
US20140112929A1
(en)
|
2011-06-17 |
2014-04-24 |
Glaxo Group Limited |
Tumour necrosis factor receptor 1 antagonists
|
|
EP2741760A2
(en)
|
2011-08-12 |
2014-06-18 |
B.S.R.C. "Alexander Fleming" |
Tnf superfamily trimerization inhibitors
|
|
US9550737B2
(en)
*
|
2012-06-11 |
2017-01-24 |
Ucb Biopharma Sprl |
TNF -α modulating benzimidazoles
|
|
WO2014001557A1
(en)
|
2012-06-28 |
2014-01-03 |
Ucb Pharma S.A. |
A method for identifying compounds of therapeutic interest
|
|
GB201212513D0
(en)
|
2012-07-13 |
2012-08-29 |
Ucb Pharma Sa |
Therapeutic agents
|
|
BR112015000675B1
(pt)
|
2012-07-13 |
2022-07-12 |
UCB Biopharma SRL |
Derivados de imidazopiridina como moduladores da atividade de tnf
|
|
WO2014040076A1
(en)
|
2012-09-10 |
2014-03-13 |
Xencor |
Methods of treating neurological diseases
|
|
AU2014215639B2
(en)
|
2013-01-25 |
2017-03-23 |
Thymon, Llc |
Compositions for selective reduction of circulating bioactive soluble TNF and methods for treating TNF-mediated disease
|
|
CN105307771B
(zh)
|
2013-03-12 |
2018-11-13 |
阿内洛技术股份有限公司 |
催化快速热解催化剂的再生
|
|
EP3022229A1
(en)
*
|
2013-07-15 |
2016-05-25 |
Novo Nordisk A/S |
Antibodies that bind urokinase plasminogen activator
|
|
GB201321730D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321736D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
CN105814022B
(zh)
|
2013-12-09 |
2018-09-28 |
Ucb生物制药私人有限公司 |
作为tnf活性调节剂的稠合的二环杂芳族衍生物
|
|
GB201321729D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321731D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321728D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321742D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321745D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321734D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic Agents
|
|
GB201321738D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic Agents
|
|
GB201321741D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321740D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321748D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321749D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321744D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321732D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321733D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321735D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic Agents
|
|
GB201321746D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321739D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321743D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
US9920052B2
(en)
|
2013-12-09 |
2018-03-20 |
Ucb Biopharma Sprl |
Imidazopyridine derivatives as modulators of TNF activity
|
|
GB201321737D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic Agents
|
|
CN107108672B
(zh)
|
2014-10-03 |
2019-11-08 |
Ucb生物制药私人有限公司 |
稠合的五环咪唑衍生物
|
|
TWI774028B
(zh)
|
2015-01-30 |
2022-08-11 |
學校法人埼玉醫科大學 |
抗ａｌｋ２抗體及其用途
|
|
EA201792054A1
(ru)
|
2015-03-18 |
2018-01-31 |
Бристол-Майерс Сквибб Компани |
Гетероциклические соединения, применимые в качестве ингибиторов tnf
|
|
KR102654709B1
(ko)
|
2015-03-18 |
2024-04-03 |
브리스톨-마이어스 스큅 컴퍼니 |
치환된 트리시클릭 헤테로시클릭 화합물
|
|
MX2017011433A
(es)
|
2015-03-18 |
2017-11-10 |
Bristol Myers Squibb Co |
Compuestos heterociclicos triciclicos utiles como inhibidores del factor de necrosis tumoral (tnf).
|
|
TW201706258A
(zh)
|
2015-04-17 |
2017-02-16 |
艾伯維有限公司 |
作為ｔｎｆ信號傳遞調節劑之吲唑酮
|
|
TW201710257A
(zh)
|
2015-04-17 |
2017-03-16 |
艾伯維有限公司 |
Ｔｎｆ信號傳遞之三環調節劑
|
|
WO2016168638A1
(en)
|
2015-04-17 |
2016-10-20 |
Abbvie Inc. |
Indazolones as modulators of tnf signaling
|
|
GB201509888D0
(en)
|
2015-06-08 |
2015-07-22 |
Ucb Biopharma Sprl |
Therapeutic agents
|
|
GB201509885D0
(en)
|
2015-06-08 |
2015-07-22 |
Ucb Biopharma Sprl |
Therapeutic agents
|
|
GB201509893D0
(en)
|
2015-06-08 |
2015-07-22 |
Ucb Biopharma Sprl |
Therapeutic agents
|
|
GB201510758D0
(en)
|
2015-06-18 |
2015-08-05 |
Ucb Biopharma Sprl |
Novel TNFa structure for use in therapy
|
|
KR102679517B1
(ko)
|
2015-08-03 |
2024-06-27 |
브리스톨-마이어스 스큅 컴퍼니 |
Tnf 알파의 조정제로서 유용한 시클릭 화합물
|
|
BR112018001960A2
(pt)
|
2015-08-03 |
2018-09-18 |
Bristol-Myers Squibb Company |
compostos heterocíclicos úteis como moduladores de tnf alfa
|
|
BR112018069936A2
(pt)
|
2016-04-01 |
2019-02-05 |
Sanofi Sa |
derivados de imidazol pentacíclicos fundidos como moduladores de atividade do tnf
|
|
US10654861B2
(en)
|
2016-04-01 |
2020-05-19 |
UCB Biopharma SRL |
Fused pentacyclic imidazole derivatives as modulators of TNF activity
|
|
CA3018907A1
(en)
|
2016-04-01 |
2017-10-05 |
Ucb Biopharma Sprl |
Fused pentacyclic imidazole derivatives as modulators of tnf activity
|
|
CA3018992A1
(en)
|
2016-04-01 |
2017-10-05 |
Ucb Biopharma Sprl |
Fused hexacyclic imidazole derivatives as modulators of tnf activity
|
|
GB201621907D0
(en)
|
2016-12-21 |
2017-02-01 |
Ucb Biopharma Sprl And Sanofi |
Antibody epitope
|