|
JP2647427B2
(ja)
|
1987-04-24 |
1997-08-27 |
帝人株式会社 |
被検者の病態の判定のための検出方法、モノクロ−ナル抗体および検出キット
|
|
EP1997891A1
(en)
|
1988-09-02 |
2008-12-03 |
Dyax Corporation |
Generation and selection of recombinant varied binding proteins
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US4908372A
(en)
|
1988-10-13 |
1990-03-13 |
Merrell Dow Pharmaceuticals Inc. |
Antihistaminic piperidinyl benzimidazoles
|
|
DE3843534A1
(de)
|
1988-12-23 |
1990-07-12 |
Basf Ag |
Neue tnf-polypeptide
|
|
US6448380B2
(en)
|
1989-08-07 |
2002-09-10 |
Peptech Limited |
Tumor necrosis factor antibodies
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
WO1991010737A1
(en)
|
1990-01-11 |
1991-07-25 |
Molecular Affinities Corporation |
Production of antibodies using gene libraries
|
|
US5780225A
(en)
|
1990-01-12 |
1998-07-14 |
Stratagene |
Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
|
|
DE69133566T2
(de)
|
1990-01-12 |
2007-12-06 |
Amgen Fremont Inc. |
Bildung von xenogenen Antikörpern
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
WO1992002551A1
(en)
|
1990-08-02 |
1992-02-20 |
B.R. Centre Limited |
Methods for the production of proteins with a desired function
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
KR100272077B1
(ko)
|
1990-08-29 |
2000-11-15 |
젠팜인터내셔날,인코포레이티드 |
이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5698426A
(en)
|
1990-09-28 |
1997-12-16 |
Ixsys, Incorporated |
Surface expression libraries of heteromeric receptors
|
|
WO1992009690A2
(en)
|
1990-12-03 |
1992-06-11 |
Genentech, Inc. |
Enrichment method for variant proteins with altered binding properties
|
|
GB9028123D0
(en)
|
1990-12-28 |
1991-02-13 |
Erba Carlo Spa |
Monoclonal antibodies against human tumor necrosis factor alpha
|
|
DE69233750D1
(de)
|
1991-04-10 |
2009-01-02 |
Scripps Research Inst |
Bibliotheken heterodimerer Rezeptoren mittels Phagemiden
|
|
GB9113120D0
(en)
|
1991-06-18 |
1991-08-07 |
Kodak Ltd |
Photographic processing apparatus
|
|
IT1249708B
(it)
|
1991-09-23 |
1995-03-09 |
Tecnogen Scpa |
Metodo per la determinazione del fattore di necrosi tumorale (tnf) in forma biologicamente attiva.
|
|
ATE408012T1
(de)
|
1991-12-02 |
2008-09-15 |
Medical Res Council |
Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
|
|
WO1993014083A1
(en)
|
1992-01-09 |
1993-07-22 |
Janssen Pharmaceutica N.V. |
Pharmaceutically active substituted benzimidazole derivatives
|
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
CA2155103A1
(en)
|
1993-02-03 |
1994-08-18 |
Rudolph Lucas |
Tnf-alpha muteins and a process for preparing them
|
|
CA2119089A1
(en)
|
1993-03-29 |
1994-09-30 |
David Banner |
Tumor necrosis factor muteins
|
|
WO1995015982A2
(en)
|
1993-12-08 |
1995-06-15 |
Genzyme Corporation |
Process for generating specific antibodies
|
|
DK1231268T3
(da)
|
1994-01-31 |
2005-11-21 |
Univ Boston |
Polyklonale antistofbiblioteker
|
|
US5516637A
(en)
|
1994-06-10 |
1996-05-14 |
Dade International Inc. |
Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
|
|
DE4440613C1
(de)
|
1994-11-14 |
1996-07-25 |
Leica Ag |
Vorrichtung und Verfahren zur Detektion und Demodulation eines intensitätsmodulierten Strahlungsfeldes
|
|
TW453995B
(en)
|
1995-12-15 |
2001-09-11 |
Novartis Ag |
Certain alpha-substituted arylsulfonamido acetohydroxamic acids
|
|
JP2978435B2
(ja)
|
1996-01-24 |
1999-11-15 |
チッソ株式会社 |
アクリロキシプロピルシランの製造方法
|
|
CN1204230A
(zh)
|
1997-12-08 |
1999-01-06 |
李建安 |
一种手提电话机用防护罩及其制做方法
|
|
US20040009535A1
(en)
|
1998-11-27 |
2004-01-15 |
Celltech R&D, Inc. |
Compositions and methods for increasing bone mineralization
|
|
GB9828628D0
(en)
*
|
1998-12-23 |
1999-02-17 |
Glaxo Group Ltd |
Novel ligand
|
|
US7101974B2
(en)
|
2000-03-02 |
2006-09-05 |
Xencor |
TNF-αvariants
|
|
AU2001287041B2
(en)
|
2000-09-01 |
2006-06-08 |
Biogen Idec Ma Inc. |
Pyridine derivatives useful as CD40:CD154 binding interruptor compounds and use thereof to treat immunological complications
|
|
WO2002098869A2
(en)
|
2001-06-05 |
2002-12-12 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
1,4-disubstituted benzo-fused cycloalkyl urea compounds
|
|
US6632810B2
(en)
|
2001-06-29 |
2003-10-14 |
Kowa Co., Ltd. |
Cyclic diamine compound with condensed-ring groups
|
|
JP2003040888A
(ja)
|
2001-07-30 |
2003-02-13 |
Sankyo Co Ltd |
イミダゾール誘導体
|
|
BR0313151A
(pt)
|
2002-08-01 |
2007-07-17 |
Wyeth Corp |
métodos e reagentes que se relacionam à inflamação e à apoptose
|
|
EP1570267B1
(en)
|
2002-12-03 |
2011-10-12 |
UCB Pharma, S.A. |
Assay for identifying antibody producing cells
|
|
NZ543976A
(en)
|
2003-05-09 |
2008-04-30 |
Pharmexa As |
Immunogenic human TNF alpha analogues with reduced cytotoxicity and methods of their preparation
|
|
GB0312481D0
(en)
|
2003-05-30 |
2003-07-09 |
Celltech R&D Ltd |
Antibodies
|
|
CA2527020A1
(en)
|
2003-07-01 |
2005-01-13 |
Celltech R & D Limited |
Modified antibody fab fragments
|
|
GB0315457D0
(en)
|
2003-07-01 |
2003-08-06 |
Celltech R&D Ltd |
Biological products
|
|
GB0315450D0
(en)
|
2003-07-01 |
2003-08-06 |
Celltech R&D Ltd |
Biological products
|
|
EA013614B1
(ru)
|
2003-07-15 |
2010-06-30 |
Амджен Инк. |
Изолированное антитело к фактору роста нервов (ngf) и способы его применения
|
|
US7268116B2
(en)
|
2003-10-02 |
2007-09-11 |
Genhunter Corp. |
Methods and compositions for producing secreted trimeric receptor analogs and biologically active fusion proteins
|
|
TW200526780A
(en)
|
2004-01-06 |
2005-08-16 |
Hayashibara Biochem Lab |
TNF antagonists and TNF inhibitors comprising the same as the active ingredient
|
|
GB0411186D0
(en)
|
2004-05-19 |
2004-06-23 |
Celltech R&D Ltd |
Biological products
|
|
CN103254309B
(zh)
|
2005-05-18 |
2017-09-26 |
埃博灵克斯股份有限公司 |
针对肿瘤坏死因子α的改进的纳米体TM
|
|
DE102005023617A1
(de)
|
2005-05-21 |
2006-11-23 |
Aspre Ag |
Verfahren zum Mischen von Farben in einem Display
|
|
WO2007060411A1
(en)
|
2005-11-24 |
2007-05-31 |
Ucb Pharma S.A. |
Anti-tnf alpha antibodies which selectively inhibit tnf alpha signalling through the p55r
|
|
MX343879B
(es)
*
|
2007-05-21 |
2016-11-25 |
Alderbio Holdings Llc |
Metodo de humanizacion de anticuerpo de conejo novedoso y anticuerpos de conejo humanizados.
|
|
TW201531484A
(zh)
|
2007-05-21 |
2015-08-16 |
Alder Biopharmaceuticals Inc |
抗TNF-α之抗體及其用途
|
|
WO2009020848A2
(en)
|
2007-08-03 |
2009-02-12 |
Alcon Research, Ltd. |
RNAI-RELATED INHIBITION OF TNFα SIGNALING PATHWAY FOR TREATMENT OF GLAUCOMA
|
|
ES2667729T3
(es)
|
2007-09-26 |
2018-05-14 |
Ucb Biopharma Sprl |
Fusiones de anticuerpos con doble especificidad
|
|
US9365644B2
(en)
|
2008-04-23 |
2016-06-14 |
Epitomics, Inc. |
Anti-TNFα antibody
|
|
MX345039B
(es)
|
2008-06-25 |
2017-01-16 |
Esbatech Alcon Biomed Res Unit |
Anticuerpos estables y solubles que inhiben el tnfa.
|
|
US20120010158A1
(en)
|
2008-11-20 |
2012-01-12 |
Panacea Biotec Ltd. |
Tumor necrosis factor inhibiting peptides and uses thereof
|
|
JP2010172307A
(ja)
|
2009-01-30 |
2010-08-12 |
Saitama Medical Univ |
関節リウマチに対する可溶性TNFα/LTαレセプター薬の薬効予測方法、及び薬効予測装置
|
|
WO2010118404A2
(en)
|
2009-04-09 |
2010-10-14 |
California Institute Of Technology |
Methods for creating or identifying compounds that bind tumor necrosis factor alpha
|
|
BRPI1012524A2
(pt)
|
2009-04-16 |
2020-09-29 |
Abbott Biotherapeutics Corp |
anticorpos anti-tnf-alfa e seus usos
|
|
BR112012025568A2
(pt)
|
2010-04-07 |
2017-03-28 |
Abbvie Inc |
proteínas de ligação ao tnf-<244>.
|
|
US8377441B2
(en)
|
2010-08-03 |
2013-02-19 |
National Cheng Kung University |
Treating breast cancer with anti-IL-19 antibody
|
|
ES2829388T3
(es)
|
2010-10-30 |
2021-05-31 |
Kindex Therapeutics Llc |
Derivados de cis 3,4-dihidroxi-2-(3-metilbutanoil)-5-(-3-metilbutil)-4-(4-metilpentanoil)cyclopent-2-en-1-ona, composiciones sustancialmente puras enantioméricamente y métodos
|
|
AR084210A1
(es)
|
2010-12-08 |
2013-05-02 |
Abbott Lab |
PROTEINAS DE UNION AL TNF-a
|
|
US20140112929A1
(en)
|
2011-06-17 |
2014-04-24 |
Glaxo Group Limited |
Tumour necrosis factor receptor 1 antagonists
|
|
CN103930126A
(zh)
|
2011-08-12 |
2014-07-16 |
Bsrc亚历山大.弗莱明 |
Tnf超家族三聚化的抑制剂
|
|
CN104428293B
(zh)
*
|
2012-06-11 |
2018-06-08 |
Ucb生物制药私人有限公司 |
调节TNFα的苯并咪唑类
|
|
EP2867674B1
(en)
*
|
2012-06-28 |
2018-10-10 |
UCB Biopharma SPRL |
A method for identifying compounds of therapeutic interest
|
|
GB201212513D0
(en)
|
2012-07-13 |
2012-08-29 |
Ucb Pharma Sa |
Therapeutic agents
|
|
BR112015000675B1
(pt)
*
|
2012-07-13 |
2022-07-12 |
UCB Biopharma SRL |
Derivados de imidazopiridina como moduladores da atividade de tnf
|
|
WO2014040076A1
(en)
|
2012-09-10 |
2014-03-13 |
Xencor |
Methods of treating neurological diseases
|
|
KR101759687B1
(ko)
|
2013-01-25 |
2017-07-19 |
타이몬, 엘엘씨 |
순환하는 생물활성 가용성 tnf의 선택적 감소를 위한 조성물 및 tnf-매개 질환의 치료 방법
|
|
BR112015022409A2
(pt)
|
2013-03-12 |
2017-07-18 |
Anellotech Inc |
regeneração do catalisador de pirólise catalítica rápida
|
|
CN105612183A
(zh)
*
|
2013-07-15 |
2016-05-25 |
诺和诺德股份有限公司 |
结合尿激酶纤溶酶原激活物的抗体
|
|
CN105814022B
(zh)
|
2013-12-09 |
2018-09-28 |
Ucb生物制药私人有限公司 |
作为tnf活性调节剂的稠合的二环杂芳族衍生物
|
|
GB201321729D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321733D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321743D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321734D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic Agents
|
|
GB201321739D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321745D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321735D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic Agents
|
|
GB201321737D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic Agents
|
|
GB201321742D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321730D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321728D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321740D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321738D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic Agents
|
|
GB201321732D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
JP6469692B2
(ja)
|
2013-12-09 |
2019-02-13 |
ユーシービー バイオファルマ エスピーアールエル |
Tnf活性のモジュレーターとしてのイミダゾピリジン誘導体
|
|
GB201321731D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321744D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321748D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321736D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321749D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321741D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321746D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
PE20170693A1
(es)
|
2014-10-03 |
2017-06-13 |
Ucb Biopharma Sprl |
Derivados de imidazol pentaciclicos fusionados
|
|
KR20170105558A
(ko)
*
|
2015-01-30 |
2017-09-19 |
각코우호우징 사이타마이카다이가쿠 |
항 alk2 항체
|
|
ES2803650T3
(es)
|
2015-03-18 |
2021-01-28 |
Bristol Myers Squibb Co |
Compuestos heterocíclicos útiles como inhibidores de TNF
|
|
SG11201707469WA
(en)
|
2015-03-18 |
2017-10-30 |
Bristol Myers Squibb Co |
Substituted tricyclic heterocyclic compounds
|
|
US10308652B2
(en)
|
2015-03-18 |
2019-06-04 |
Bristol-Myers Squibb Company |
Tricyclic heterocyclic compounds useful as inhibitors of TNF
|
|
AR104291A1
(es)
|
2015-04-17 |
2017-07-12 |
Abbvie Inc |
Moduladores tricíclicos de la señalización por tnf
|
|
TW201702247A
(zh)
|
2015-04-17 |
2017-01-16 |
艾伯維有限公司 |
作為tnf信號傳遞調節劑之吲唑酮
|
|
TW201706258A
(zh)
|
2015-04-17 |
2017-02-16 |
艾伯維有限公司 |
作為tnf信號傳遞調節劑之吲唑酮
|
|
GB201509885D0
(en)
|
2015-06-08 |
2015-07-22 |
Ucb Biopharma Sprl |
Therapeutic agents
|
|
GB201509888D0
(en)
|
2015-06-08 |
2015-07-22 |
Ucb Biopharma Sprl |
Therapeutic agents
|
|
GB201509893D0
(en)
|
2015-06-08 |
2015-07-22 |
Ucb Biopharma Sprl |
Therapeutic agents
|
|
GB201510758D0
(en)
|
2015-06-18 |
2015-08-05 |
Ucb Biopharma Sprl |
Novel TNFa structure for use in therapy
|
|
AU2016301215A1
(en)
|
2015-08-03 |
2018-03-22 |
Bristol-Myers Squibb Company |
Cyclic compounds useful as modulators of TNF alpha
|
|
MA43512A
(fr)
|
2015-08-03 |
2018-11-07 |
Bristol Myers Squibb Co |
Composés hétérocycliques utiles en tant que modulateurs du tnf alpha
|
|
EA201892153A1
(ru)
|
2016-04-01 |
2019-04-30 |
Юсб Байофарма Спрл |
Конденсированные пентациклические производные имидазола в качестве модуляторов активности tnf
|
|
CN109219608B
(zh)
|
2016-04-01 |
2021-12-21 |
Ucb生物制药私人有限公司 |
作为tnf活性调节剂的稠合五环咪唑衍生物
|
|
CN109195968B
(zh)
|
2016-04-01 |
2022-02-11 |
Ucb生物制药私人有限公司 |
作为tnf活性调节剂的稠合五环咪唑衍生物
|
|
WO2017167995A1
(en)
|
2016-04-01 |
2017-10-05 |
Ucb Biopharma Sprl |
Fused hexacyclic imidazole derivatives as modulators of tnf activity
|
|
GB201621907D0
(en)
|
2016-12-21 |
2017-02-01 |
Ucb Biopharma Sprl And Sanofi |
Antibody epitope
|