JP2018520668A5 - - Google Patents

Download PDF

Info

Publication number
JP2018520668A5
JP2018520668A5 JP2017565174A JP2017565174A JP2018520668A5 JP 2018520668 A5 JP2018520668 A5 JP 2018520668A5 JP 2017565174 A JP2017565174 A JP 2017565174A JP 2017565174 A JP2017565174 A JP 2017565174A JP 2018520668 A5 JP2018520668 A5 JP 2018520668A5
Authority
JP
Japan
Prior art keywords
compound
seq
tnf superfamily
antibody
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017565174A
Other languages
English (en)
Japanese (ja)
Other versions
JP6951256B2 (ja
JP2018520668A (ja
Filing date
Publication date
Priority claimed from GBGB1510758.4A external-priority patent/GB201510758D0/en
Application filed filed Critical
Publication of JP2018520668A publication Critical patent/JP2018520668A/ja
Publication of JP2018520668A5 publication Critical patent/JP2018520668A5/ja
Priority to JP2021155537A priority Critical patent/JP7159420B2/ja
Application granted granted Critical
Publication of JP6951256B2 publication Critical patent/JP6951256B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017565174A 2015-06-18 2015-10-22 抗体 Active JP6951256B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021155537A JP7159420B2 (ja) 2015-06-18 2021-09-24 抗体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1510758.4A GB201510758D0 (en) 2015-06-18 2015-06-18 Novel TNFa structure for use in therapy
GB1510758.4 2015-06-18
PCT/EP2015/074527 WO2016202414A1 (en) 2015-06-18 2015-10-22 Antibody

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021155537A Division JP7159420B2 (ja) 2015-06-18 2021-09-24 抗体

Publications (3)

Publication Number Publication Date
JP2018520668A JP2018520668A (ja) 2018-08-02
JP2018520668A5 true JP2018520668A5 (enExample) 2018-11-29
JP6951256B2 JP6951256B2 (ja) 2021-10-20

Family

ID=53784155

Family Applications (12)

Application Number Title Priority Date Filing Date
JP2017565173A Active JP6659030B2 (ja) 2015-06-18 2015-10-22 作用機構
JP2017565174A Active JP6951256B2 (ja) 2015-06-18 2015-10-22 抗体
JP2017565114A Active JP7336178B2 (ja) 2015-06-18 2015-10-22 治療における使用のための新規のTNFα構造
JP2017565189A Active JP6948954B2 (ja) 2015-06-18 2015-10-22 抗体エピトープ
JP2017565155A Active JP6781718B2 (ja) 2015-06-18 2015-10-22 モジュレータアッセイ
JP2019154528A Active JP6752344B2 (ja) 2015-06-18 2019-08-27 作用機構
JP2020174314A Pending JP2021038222A (ja) 2015-06-18 2020-10-16 モジュレータアッセイ
JP2021020352A Pending JP2021109880A (ja) 2015-06-18 2021-02-12 治療における使用のための新規のTNFα構造
JP2021095909A Abandoned JP2021153592A (ja) 2015-06-18 2021-06-08 抗体エピトープ
JP2021155537A Active JP7159420B2 (ja) 2015-06-18 2021-09-24 抗体
JP2023001089A Pending JP2023052250A (ja) 2015-06-18 2023-01-06 モジュレータアッセイ
JP2023046164A Pending JP2023100010A (ja) 2015-06-18 2023-03-23 治療における使用のための新規のTNFα構造

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2017565173A Active JP6659030B2 (ja) 2015-06-18 2015-10-22 作用機構

Family Applications After (10)

Application Number Title Priority Date Filing Date
JP2017565114A Active JP7336178B2 (ja) 2015-06-18 2015-10-22 治療における使用のための新規のTNFα構造
JP2017565189A Active JP6948954B2 (ja) 2015-06-18 2015-10-22 抗体エピトープ
JP2017565155A Active JP6781718B2 (ja) 2015-06-18 2015-10-22 モジュレータアッセイ
JP2019154528A Active JP6752344B2 (ja) 2015-06-18 2019-08-27 作用機構
JP2020174314A Pending JP2021038222A (ja) 2015-06-18 2020-10-16 モジュレータアッセイ
JP2021020352A Pending JP2021109880A (ja) 2015-06-18 2021-02-12 治療における使用のための新規のTNFα構造
JP2021095909A Abandoned JP2021153592A (ja) 2015-06-18 2021-06-08 抗体エピトープ
JP2021155537A Active JP7159420B2 (ja) 2015-06-18 2021-09-24 抗体
JP2023001089A Pending JP2023052250A (ja) 2015-06-18 2023-01-06 モジュレータアッセイ
JP2023046164A Pending JP2023100010A (ja) 2015-06-18 2023-03-23 治療における使用のための新規のTNFα構造

Country Status (16)

Country Link
US (12) US10969393B2 (enExample)
EP (8) EP3311169B1 (enExample)
JP (12) JP6659030B2 (enExample)
KR (2) KR102599907B1 (enExample)
CN (6) CN107771286B (enExample)
AU (2) AU2015398984B2 (enExample)
CA (5) CA2988516A1 (enExample)
CL (2) CL2017003189A1 (enExample)
EA (4) EA201890081A1 (enExample)
ES (5) ES2836769T3 (enExample)
GB (1) GB201510758D0 (enExample)
IL (2) IL256099B2 (enExample)
MX (2) MX2017015481A (enExample)
PL (4) PL3311169T3 (enExample)
PT (4) PT3311169T (enExample)
WO (5) WO2016202412A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1250040A1 (zh) 2015-03-31 2018-11-23 Sorriso Pharmaceuticals, Inc. 多肽
JP6895421B2 (ja) 2015-03-31 2021-06-30 ブイエイチスクエアード リミテッド ポリペプチド
CA2981098A1 (en) 2015-03-31 2016-10-06 Vhsquared Limited Peptide construct having a protease-cleavable linker
TW201706258A (zh) 2015-04-17 2017-02-16 艾伯維有限公司 作為tnf信號傳遞調節劑之吲唑酮
AR104291A1 (es) 2015-04-17 2017-07-12 Abbvie Inc Moduladores tricíclicos de la señalización por tnf
TW201702247A (zh) 2015-04-17 2017-01-16 艾伯維有限公司 作為tnf信號傳遞調節劑之吲唑酮
GB201510758D0 (en) 2015-06-18 2015-08-05 Ucb Biopharma Sprl Novel TNFa structure for use in therapy
GB201522394D0 (en) 2015-12-18 2016-02-03 Ucb Biopharma Sprl Antibodies
EP3519438A1 (en) 2016-09-30 2019-08-07 VHsquared Limited Compositions
GB201621907D0 (en) 2016-12-21 2017-02-01 Ucb Biopharma Sprl And Sanofi Antibody epitope
EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
CN110494136A (zh) * 2017-01-10 2019-11-22 瑞士苏黎世联邦理工学院 细胞保护性化合物及其用途
AU2020294980A1 (en) 2019-06-21 2022-02-17 Sorriso Pharmaceuticals, Inc. Polypeptides
EP3986931A1 (en) 2019-06-21 2022-04-27 Sorriso Pharmaceuticals, Inc. Polypeptides
JP7561364B2 (ja) * 2020-04-30 2024-10-04 国立大学法人東北大学 蛍光偏光免疫分析法

Family Cites Families (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2647427B2 (ja) 1987-04-24 1997-08-27 帝人株式会社 被検者の病態の判定のための検出方法、モノクロ−ナル抗体および検出キット
EP1997891A1 (en) 1988-09-02 2008-12-03 Dyax Corporation Generation and selection of recombinant varied binding proteins
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US4908372A (en) 1988-10-13 1990-03-13 Merrell Dow Pharmaceuticals Inc. Antihistaminic piperidinyl benzimidazoles
DE3843534A1 (de) 1988-12-23 1990-07-12 Basf Ag Neue tnf-polypeptide
US6448380B2 (en) 1989-08-07 2002-09-10 Peptech Limited Tumor necrosis factor antibodies
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
WO1991010737A1 (en) 1990-01-11 1991-07-25 Molecular Affinities Corporation Production of antibodies using gene libraries
US5780225A (en) 1990-01-12 1998-07-14 Stratagene Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
DE69133566T2 (de) 1990-01-12 2007-12-06 Amgen Fremont Inc. Bildung von xenogenen Antikörpern
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
WO1992002551A1 (en) 1990-08-02 1992-02-20 B.R. Centre Limited Methods for the production of proteins with a desired function
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
KR100272077B1 (ko) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5698426A (en) 1990-09-28 1997-12-16 Ixsys, Incorporated Surface expression libraries of heteromeric receptors
WO1992009690A2 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with altered binding properties
GB9028123D0 (en) 1990-12-28 1991-02-13 Erba Carlo Spa Monoclonal antibodies against human tumor necrosis factor alpha
DE69233750D1 (de) 1991-04-10 2009-01-02 Scripps Research Inst Bibliotheken heterodimerer Rezeptoren mittels Phagemiden
GB9113120D0 (en) 1991-06-18 1991-08-07 Kodak Ltd Photographic processing apparatus
IT1249708B (it) 1991-09-23 1995-03-09 Tecnogen Scpa Metodo per la determinazione del fattore di necrosi tumorale (tnf) in forma biologicamente attiva.
ATE408012T1 (de) 1991-12-02 2008-09-15 Medical Res Council Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
WO1993014083A1 (en) 1992-01-09 1993-07-22 Janssen Pharmaceutica N.V. Pharmaceutically active substituted benzimidazole derivatives
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
CA2155103A1 (en) 1993-02-03 1994-08-18 Rudolph Lucas Tnf-alpha muteins and a process for preparing them
CA2119089A1 (en) 1993-03-29 1994-09-30 David Banner Tumor necrosis factor muteins
WO1995015982A2 (en) 1993-12-08 1995-06-15 Genzyme Corporation Process for generating specific antibodies
DK1231268T3 (da) 1994-01-31 2005-11-21 Univ Boston Polyklonale antistofbiblioteker
US5516637A (en) 1994-06-10 1996-05-14 Dade International Inc. Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
DE4440613C1 (de) 1994-11-14 1996-07-25 Leica Ag Vorrichtung und Verfahren zur Detektion und Demodulation eines intensitätsmodulierten Strahlungsfeldes
TW453995B (en) 1995-12-15 2001-09-11 Novartis Ag Certain alpha-substituted arylsulfonamido acetohydroxamic acids
JP2978435B2 (ja) 1996-01-24 1999-11-15 チッソ株式会社 アクリロキシプロピルシランの製造方法
CN1204230A (zh) 1997-12-08 1999-01-06 李建安 一种手提电话机用防护罩及其制做方法
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
GB9828628D0 (en) * 1998-12-23 1999-02-17 Glaxo Group Ltd Novel ligand
US7101974B2 (en) 2000-03-02 2006-09-05 Xencor TNF-αvariants
AU2001287041B2 (en) 2000-09-01 2006-06-08 Biogen Idec Ma Inc. Pyridine derivatives useful as CD40:CD154 binding interruptor compounds and use thereof to treat immunological complications
WO2002098869A2 (en) 2001-06-05 2002-12-12 Boehringer Ingelheim Pharmaceuticals, Inc. 1,4-disubstituted benzo-fused cycloalkyl urea compounds
US6632810B2 (en) 2001-06-29 2003-10-14 Kowa Co., Ltd. Cyclic diamine compound with condensed-ring groups
JP2003040888A (ja) 2001-07-30 2003-02-13 Sankyo Co Ltd イミダゾール誘導体
BR0313151A (pt) 2002-08-01 2007-07-17 Wyeth Corp métodos e reagentes que se relacionam à inflamação e à apoptose
EP1570267B1 (en) 2002-12-03 2011-10-12 UCB Pharma, S.A. Assay for identifying antibody producing cells
NZ543976A (en) 2003-05-09 2008-04-30 Pharmexa As Immunogenic human TNF alpha analogues with reduced cytotoxicity and methods of their preparation
GB0312481D0 (en) 2003-05-30 2003-07-09 Celltech R&D Ltd Antibodies
CA2527020A1 (en) 2003-07-01 2005-01-13 Celltech R & D Limited Modified antibody fab fragments
GB0315457D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0315450D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
EA013614B1 (ru) 2003-07-15 2010-06-30 Амджен Инк. Изолированное антитело к фактору роста нервов (ngf) и способы его применения
US7268116B2 (en) 2003-10-02 2007-09-11 Genhunter Corp. Methods and compositions for producing secreted trimeric receptor analogs and biologically active fusion proteins
TW200526780A (en) 2004-01-06 2005-08-16 Hayashibara Biochem Lab TNF antagonists and TNF inhibitors comprising the same as the active ingredient
GB0411186D0 (en) 2004-05-19 2004-06-23 Celltech R&D Ltd Biological products
CN103254309B (zh) 2005-05-18 2017-09-26 埃博灵克斯股份有限公司 针对肿瘤坏死因子α的改进的纳米体TM
DE102005023617A1 (de) 2005-05-21 2006-11-23 Aspre Ag Verfahren zum Mischen von Farben in einem Display
WO2007060411A1 (en) 2005-11-24 2007-05-31 Ucb Pharma S.A. Anti-tnf alpha antibodies which selectively inhibit tnf alpha signalling through the p55r
MX343879B (es) * 2007-05-21 2016-11-25 Alderbio Holdings Llc Metodo de humanizacion de anticuerpo de conejo novedoso y anticuerpos de conejo humanizados.
TW201531484A (zh) 2007-05-21 2015-08-16 Alder Biopharmaceuticals Inc 抗TNF-α之抗體及其用途
WO2009020848A2 (en) 2007-08-03 2009-02-12 Alcon Research, Ltd. RNAI-RELATED INHIBITION OF TNFα SIGNALING PATHWAY FOR TREATMENT OF GLAUCOMA
ES2667729T3 (es) 2007-09-26 2018-05-14 Ucb Biopharma Sprl Fusiones de anticuerpos con doble especificidad
US9365644B2 (en) 2008-04-23 2016-06-14 Epitomics, Inc. Anti-TNFα antibody
MX345039B (es) 2008-06-25 2017-01-16 Esbatech Alcon Biomed Res Unit Anticuerpos estables y solubles que inhiben el tnfa.
US20120010158A1 (en) 2008-11-20 2012-01-12 Panacea Biotec Ltd. Tumor necrosis factor inhibiting peptides and uses thereof
JP2010172307A (ja) 2009-01-30 2010-08-12 Saitama Medical Univ 関節リウマチに対する可溶性TNFα/LTαレセプター薬の薬効予測方法、及び薬効予測装置
WO2010118404A2 (en) 2009-04-09 2010-10-14 California Institute Of Technology Methods for creating or identifying compounds that bind tumor necrosis factor alpha
BRPI1012524A2 (pt) 2009-04-16 2020-09-29 Abbott Biotherapeutics Corp anticorpos anti-tnf-alfa e seus usos
BR112012025568A2 (pt) 2010-04-07 2017-03-28 Abbvie Inc proteínas de ligação ao tnf-<244>.
US8377441B2 (en) 2010-08-03 2013-02-19 National Cheng Kung University Treating breast cancer with anti-IL-19 antibody
ES2829388T3 (es) 2010-10-30 2021-05-31 Kindex Therapeutics Llc Derivados de cis 3,4-dihidroxi-2-(3-metilbutanoil)-5-(-3-metilbutil)-4-(4-metilpentanoil)cyclopent-2-en-1-ona, composiciones sustancialmente puras enantioméricamente y métodos
AR084210A1 (es) 2010-12-08 2013-05-02 Abbott Lab PROTEINAS DE UNION AL TNF-a
US20140112929A1 (en) 2011-06-17 2014-04-24 Glaxo Group Limited Tumour necrosis factor receptor 1 antagonists
CN103930126A (zh) 2011-08-12 2014-07-16 Bsrc亚历山大.弗莱明 Tnf超家族三聚化的抑制剂
CN104428293B (zh) * 2012-06-11 2018-06-08 Ucb生物制药私人有限公司 调节TNFα的苯并咪唑类
EP2867674B1 (en) * 2012-06-28 2018-10-10 UCB Biopharma SPRL A method for identifying compounds of therapeutic interest
GB201212513D0 (en) 2012-07-13 2012-08-29 Ucb Pharma Sa Therapeutic agents
BR112015000675B1 (pt) * 2012-07-13 2022-07-12 UCB Biopharma SRL Derivados de imidazopiridina como moduladores da atividade de tnf
WO2014040076A1 (en) 2012-09-10 2014-03-13 Xencor Methods of treating neurological diseases
KR101759687B1 (ko) 2013-01-25 2017-07-19 타이몬, 엘엘씨 순환하는 생물활성 가용성 tnf의 선택적 감소를 위한 조성물 및 tnf-매개 질환의 치료 방법
BR112015022409A2 (pt) 2013-03-12 2017-07-18 Anellotech Inc regeneração do catalisador de pirólise catalítica rápida
CN105612183A (zh) * 2013-07-15 2016-05-25 诺和诺德股份有限公司 结合尿激酶纤溶酶原激活物的抗体
CN105814022B (zh) 2013-12-09 2018-09-28 Ucb生物制药私人有限公司 作为tnf活性调节剂的稠合的二环杂芳族衍生物
GB201321729D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321733D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321743D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321734D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
GB201321739D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321745D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321735D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
GB201321737D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
GB201321742D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321730D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321728D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321740D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321738D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
GB201321732D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
JP6469692B2 (ja) 2013-12-09 2019-02-13 ユーシービー バイオファルマ エスピーアールエル Tnf活性のモジュレーターとしてのイミダゾピリジン誘導体
GB201321731D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321744D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321748D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321736D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321749D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321741D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
GB201321746D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
PE20170693A1 (es) 2014-10-03 2017-06-13 Ucb Biopharma Sprl Derivados de imidazol pentaciclicos fusionados
KR20170105558A (ko) * 2015-01-30 2017-09-19 각코우호우징 사이타마이카다이가쿠 항 alk2 항체
ES2803650T3 (es) 2015-03-18 2021-01-28 Bristol Myers Squibb Co Compuestos heterocíclicos útiles como inhibidores de TNF
SG11201707469WA (en) 2015-03-18 2017-10-30 Bristol Myers Squibb Co Substituted tricyclic heterocyclic compounds
US10308652B2 (en) 2015-03-18 2019-06-04 Bristol-Myers Squibb Company Tricyclic heterocyclic compounds useful as inhibitors of TNF
AR104291A1 (es) 2015-04-17 2017-07-12 Abbvie Inc Moduladores tricíclicos de la señalización por tnf
TW201702247A (zh) 2015-04-17 2017-01-16 艾伯維有限公司 作為tnf信號傳遞調節劑之吲唑酮
TW201706258A (zh) 2015-04-17 2017-02-16 艾伯維有限公司 作為tnf信號傳遞調節劑之吲唑酮
GB201509885D0 (en) 2015-06-08 2015-07-22 Ucb Biopharma Sprl Therapeutic agents
GB201509888D0 (en) 2015-06-08 2015-07-22 Ucb Biopharma Sprl Therapeutic agents
GB201509893D0 (en) 2015-06-08 2015-07-22 Ucb Biopharma Sprl Therapeutic agents
GB201510758D0 (en) 2015-06-18 2015-08-05 Ucb Biopharma Sprl Novel TNFa structure for use in therapy
AU2016301215A1 (en) 2015-08-03 2018-03-22 Bristol-Myers Squibb Company Cyclic compounds useful as modulators of TNF alpha
MA43512A (fr) 2015-08-03 2018-11-07 Bristol Myers Squibb Co Composés hétérocycliques utiles en tant que modulateurs du tnf alpha
EA201892153A1 (ru) 2016-04-01 2019-04-30 Юсб Байофарма Спрл Конденсированные пентациклические производные имидазола в качестве модуляторов активности tnf
CN109219608B (zh) 2016-04-01 2021-12-21 Ucb生物制药私人有限公司 作为tnf活性调节剂的稠合五环咪唑衍生物
CN109195968B (zh) 2016-04-01 2022-02-11 Ucb生物制药私人有限公司 作为tnf活性调节剂的稠合五环咪唑衍生物
WO2017167995A1 (en) 2016-04-01 2017-10-05 Ucb Biopharma Sprl Fused hexacyclic imidazole derivatives as modulators of tnf activity
GB201621907D0 (en) 2016-12-21 2017-02-01 Ucb Biopharma Sprl And Sanofi Antibody epitope

Similar Documents

Publication Publication Date Title
JP2018520668A5 (enExample)
AU2021203783B2 (en) Novel CD47 Monoclonal Antibodies and Uses Thereof
JP2018532383A5 (enExample)
JP2017535257A5 (enExample)
JP2018520657A5 (enExample)
JP2017505125A5 (enExample)
RU2012107286A (ru) Высокоаффинные человеческие антитела к человеческому ангиопоэтину-2
JP2020522261A5 (enExample)
JP2021500916A5 (enExample)
IL261666B2 (en) Binding proteins and methods of use thereof
JP2018511319A5 (enExample)
JP2013506428A5 (enExample)
JP2018508462A5 (enExample)
JP2015535828A5 (enExample)
CN104903352A (zh) 多价结合蛋白组合物
HRP20151019T1 (hr) PROTUTIJELA PROTIV c-MET
JP2015503909A5 (enExample)
EP2928919A2 (en) Blood-brain barrier (bbb) penetrating dual specific binding proteins
RU2018134065A (ru) Антитела, специфические к рецептору полиовируса (pvr) человека
JP2013500941A5 (enExample)
JP2016519650A5 (enExample)
JP2020530272A5 (enExample)
RU2014118739A (ru) Способы ингибирования роста опухоли путем антагонизирования ил-6 рецептора
RU2016100892A (ru) Антитела против tweakr и их применение
JP2018525333A5 (enExample)