JP2018508462A5 - - Google Patents
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- JP2018508462A5 JP2018508462A5 JP2017529627A JP2017529627A JP2018508462A5 JP 2018508462 A5 JP2018508462 A5 JP 2018508462A5 JP 2017529627 A JP2017529627 A JP 2017529627A JP 2017529627 A JP2017529627 A JP 2017529627A JP 2018508462 A5 JP2018508462 A5 JP 2018508462A5
- Authority
- JP
- Japan
- Prior art keywords
- bcma
- antibody
- composition
- cells
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims description 57
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims description 57
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims description 55
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 42
- 210000004027 cell Anatomy 0.000 claims description 34
- 239000000523 sample Substances 0.000 claims description 33
- 239000000203 mixture Substances 0.000 claims description 31
- 210000001124 body fluid Anatomy 0.000 claims description 25
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims description 24
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims description 24
- 239000010839 body fluid Substances 0.000 claims description 24
- 210000004180 plasmocyte Anatomy 0.000 claims description 22
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims description 19
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims description 19
- 101000801255 Homo sapiens Tumor necrosis factor receptor superfamily member 17 Proteins 0.000 claims description 17
- 102000046935 human TNFRSF17 Human genes 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 15
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims description 12
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims description 12
- 208000034578 Multiple myelomas Diseases 0.000 claims description 10
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 10
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 9
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 6
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 6
- 238000000338 in vitro Methods 0.000 claims description 6
- 230000001404 mediated effect Effects 0.000 claims description 6
- 239000013610 patient sample Substances 0.000 claims description 5
- 230000003442 weekly effect Effects 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 4
- 230000003211 malignant effect Effects 0.000 claims description 4
- 230000001225 therapeutic effect Effects 0.000 claims description 4
- 230000004913 activation Effects 0.000 claims description 3
- 239000012636 effector Substances 0.000 claims description 3
- 230000034190 positive regulation of NF-kappaB transcription factor activity Effects 0.000 claims description 3
- 238000002965 ELISA Methods 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 2
- 238000009175 antibody therapy Methods 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 238000004904 shortening Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 description 6
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 238000004040 coloring Methods 0.000 description 4
- YRNWIFYIFSBPAU-UHFFFAOYSA-N 4-[4-(dimethylamino)phenyl]-n,n-dimethylaniline Chemical compound C1=CC(N(C)C)=CC=C1C1=CC=C(N(C)C)C=C1 YRNWIFYIFSBPAU-UHFFFAOYSA-N 0.000 description 2
- 238000008157 ELISA kit Methods 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 108010090804 Streptavidin Proteins 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000012089 stop solution Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021069083A JP2021120374A (ja) | 2014-12-03 | 2021-04-15 | 疾患の処置における使用のためのｃｄ３イプシロンおよびｂｃｍａに対する二重特異的抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14196168.0 | 2014-12-03 | ||
| EP14196168.0A EP3029068A1 (en) | 2014-12-03 | 2014-12-03 | Bispecific antibodies against CD3epsilon and BCMA for use in the treatment of diseases |
| PCT/EP2015/078388 WO2016087531A1 (en) | 2014-12-03 | 2015-12-02 | Bispecific antibodies against cd3epsilon and bcma for use in treatment of diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021069083A Division JP2021120374A (ja) | 2014-12-03 | 2021-04-15 | 疾患の処置における使用のためのｃｄ３イプシロンおよびｂｃｍａに対する二重特異的抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018508462A JP2018508462A (ja) | 2018-03-29 |
| JP2018508462A5 true JP2018508462A5 (enExample) | 2019-01-17 |
Family
ID=52002823
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017529627A Pending JP2018508462A (ja) | 2014-12-03 | 2015-12-02 | 疾患の処置における使用のためのｃｄ３イプシロンおよびｂｃｍａに対する二特異性抗体 |
| JP2021069083A Pending JP2021120374A (ja) | 2014-12-03 | 2021-04-15 | 疾患の処置における使用のためのｃｄ３イプシロンおよびｂｃｍａに対する二重特異的抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021069083A Pending JP2021120374A (ja) | 2014-12-03 | 2021-04-15 | 疾患の処置における使用のためのｃｄ３イプシロンおよびｂｃｍａに対する二重特異的抗体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20170327580A1 (enExample) |
| EP (3) | EP3029068A1 (enExample) |
| JP (2) | JP2018508462A (enExample) |
| KR (1) | KR20170109535A (enExample) |
| CN (1) | CN107406505A (enExample) |
| AU (2) | AU2015357122B2 (enExample) |
| CA (1) | CA2969560A1 (enExample) |
| ES (1) | ES2959635T3 (enExample) |
| SG (1) | SG11201704572UA (enExample) |
| WO (1) | WO2016087531A1 (enExample) |
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| BR112014004168A2 (pt) | 2011-08-23 | 2017-12-12 | Roche Glycart Ag | anticorpo biespecífico, composição farmacêutica, uso do anticorpo biespecífico, célula hospedeira procariótica ou eucariótica, método de produção de anticorpo e invenção |
| JP6444874B2 (ja) | 2012-10-08 | 2018-12-26 | ロシュ グリクアート アーゲー | ２つのＦａｂフラグメントを含むＦｃ不含抗体および使用方法 |
| PE20151410A1 (es) | 2013-02-26 | 2015-09-18 | Roche Glycart Ag | Moleculas biespecificas de union a antigeno activadoras de celulas t |
| ES2979976T3 (es) | 2014-08-04 | 2024-09-27 | Hoffmann La Roche | Moléculas de unión a antígeno activadoras de linfocitos T biespecíficas |
| EP3204415B1 (en) | 2014-10-09 | 2020-06-17 | EngMab Sàrl | Bispecific antibodies against cd3epsilon and ror1 |
| CA2966566C (en) | 2014-11-20 | 2024-03-19 | F. Hoffmann-La Roche Ag | Combination therapy of t cell activating bispecific antigen binding molecules cd3 and folate receptor 1 (folr1) and pd-1 axis binding antagonists |
| MA40972B1 (fr) | 2014-11-20 | 2020-11-30 | Hoffmann La Roche | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t ciblant folr1 et cd3 |
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| UA127308C2 (uk) | 2016-03-22 | 2023-07-19 | Ф. Хоффманн-Ля Рош Аг | Активована протеазою біспецифічна молекула, яка зв'язує т-клітини |
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| BR112014004168A2 (pt) * | 2011-08-23 | 2017-12-12 | Roche Glycart Ag | anticorpo biespecífico, composição farmacêutica, uso do anticorpo biespecífico, célula hospedeira procariótica ou eucariótica, método de produção de anticorpo e invenção |
| TWI679212B (zh) * | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對ｂｃｍａ之e3以及ｃｄ３的結合分子 |
| RU2650805C2 (ru) | 2012-04-11 | 2018-04-17 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | Химерные антигенные рецепторы, нацеленные на антиген созревания в-клеток |
| TW201425336A (zh) | 2012-12-07 | 2014-07-01 | Amgen Inc | Ｂｃｍａ抗原結合蛋白質 |
| JP2016507523A (ja) | 2013-02-05 | 2016-03-10 | エンクマフ アーゲー | ＣＤ３εおよびＢＣＭＡに対する二重特異的抗体 |
| PE20151410A1 (es) | 2013-02-26 | 2015-09-18 | Roche Glycart Ag | Moleculas biespecificas de union a antigeno activadoras de celulas t |
| AR095374A1 (es) | 2013-03-15 | 2015-10-14 | Amgen Res Munich Gmbh | Moléculas de unión para bcma y cd3 |
| EP2789630A1 (en) | 2013-04-09 | 2014-10-15 | EngMab AG | Bispecific antibodies against CD3e and ROR1 |
| EP2982692A1 (en) | 2014-08-04 | 2016-02-10 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
| ES2979976T3 (es) * | 2014-08-04 | 2024-09-27 | Hoffmann La Roche | Moléculas de unión a antígeno activadoras de linfocitos T biespecíficas |
-
2014
- 2014-12-03 EP EP14196168.0A patent/EP3029068A1/en not_active Ceased
-
2015
- 2015-12-02 EP EP15804458.6A patent/EP3227333B1/en not_active Revoked
- 2015-12-02 JP JP2017529627A patent/JP2018508462A/ja active Pending
- 2015-12-02 SG SG11201704572UA patent/SG11201704572UA/en unknown
- 2015-12-02 US US15/533,043 patent/US20170327580A1/en not_active Abandoned
- 2015-12-02 ES ES15804458T patent/ES2959635T3/es active Active
- 2015-12-02 WO PCT/EP2015/078388 patent/WO2016087531A1/en not_active Ceased
- 2015-12-02 AU AU2015357122A patent/AU2015357122B2/en not_active Ceased
- 2015-12-02 CA CA2969560A patent/CA2969560A1/en active Pending
- 2015-12-02 EP EP23183309.6A patent/EP4282484A3/en not_active Withdrawn
- 2015-12-02 CN CN201580075389.9A patent/CN107406505A/zh active Pending
- 2015-12-02 KR KR1020177017812A patent/KR20170109535A/ko not_active Withdrawn
-
2020
- 2020-08-19 US US16/997,565 patent/US20200385471A1/en not_active Abandoned
-
2021
- 2021-04-15 JP JP2021069083A patent/JP2021120374A/ja active Pending
- 2021-08-25 AU AU2021221695A patent/AU2021221695A1/en not_active Abandoned
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