SG11201704572UA - Bispecific antibodies against cd3epsilon and bcma for use in treatment of diseases - Google Patents

Bispecific antibodies against cd3epsilon and bcma for use in treatment of diseases

Info

Publication number
SG11201704572UA
SG11201704572UA SG11201704572UA SG11201704572UA SG11201704572UA SG 11201704572U A SG11201704572U A SG 11201704572UA SG 11201704572U A SG11201704572U A SG 11201704572UA SG 11201704572U A SG11201704572U A SG 11201704572UA SG 11201704572U A SG11201704572U A SG 11201704572UA
Authority
SG
Singapore
Prior art keywords
bcma
diseases
treatment
antibodies against
bispecific antibodies
Prior art date
Application number
SG11201704572UA
Inventor
Minh Diem Vu
Klaus Strein
Erich Hunziker
Original Assignee
Engmab Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Engmab Ag filed Critical Engmab Ag
Publication of SG11201704572UA publication Critical patent/SG11201704572UA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30 CD40 or CD95
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG11201704572UA 2014-12-03 2015-12-02 Bispecific antibodies against cd3epsilon and bcma for use in treatment of diseases SG11201704572UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14196168.0A EP3029068A1 (en) 2014-12-03 2014-12-03 Bispecific antibodies against CD3epsilon and BCMA for use in the treatment of diseases
PCT/EP2015/078388 WO2016087531A1 (en) 2014-12-03 2015-12-02 Bispecific antibodies against cd3epsilon and bcma for use in treatment of diseases

Publications (1)

Publication Number Publication Date
SG11201704572UA true SG11201704572UA (en) 2017-07-28

Family

ID=52002823

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201704572UA SG11201704572UA (en) 2014-12-03 2015-12-02 Bispecific antibodies against cd3epsilon and bcma for use in treatment of diseases

Country Status (10)

Country Link
US (2) US20170327580A1 (en)
EP (3) EP3029068A1 (en)
JP (2) JP2018508462A (en)
KR (1) KR20170109535A (en)
CN (1) CN107406505A (en)
AU (2) AU2015357122B2 (en)
CA (1) CA2969560A1 (en)
ES (1) ES2959635T3 (en)
SG (1) SG11201704572UA (en)
WO (1) WO2016087531A1 (en)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101681818B1 (en) 2011-08-23 2016-12-01 로슈 글리카트 아게 Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use
CA2879768A1 (en) 2012-10-08 2014-04-17 Roche Glycart Ag Fc-free antibodies comprising two fab-fragments and methods of use
EA201891502A1 (en) 2013-02-26 2018-12-28 Роше Гликарт Аг BISPECIFIC ANTIGENSIVE-BONDING MOLECULES ACTIVATING T-CELLS
DK3177643T3 (en) 2014-08-04 2019-07-15 Hoffmann La Roche Bispecific T cell activating antigen binding molecules
ES2850325T3 (en) 2014-10-09 2021-08-27 Engmab Sarl Bispecific antibodies against CD3epsilon and ROR1
ES2835823T3 (en) 2014-11-20 2021-06-23 Hoffmann La Roche Combination of T-cell activating bispecific antigen-binding molecules for CD3 and folate receptor 1 (FolR1) and PD-1 axis-binding antagonists
TWI700298B (en) 2015-04-13 2020-08-01 美商輝瑞股份有限公司 Chimeric antigen receptors targeting b-cell maturation antigen
KR102405099B1 (en) 2015-04-13 2022-06-07 화이자 인코포레이티드 Therapeutic antibodies and their uses
ES2819976T5 (en) 2015-05-18 2024-02-23 Tcr2 Therapeutics Inc Compositions and medical uses for TCR reprogramming with fusion proteins
AR106188A1 (en) 2015-10-01 2017-12-20 Hoffmann La Roche ANTI-CD19 HUMANIZED HUMAN ANTIBODIES AND METHODS OF USE
BR112018000835A2 (en) 2015-10-02 2018-09-11 Hoffmann La Roche molecule, one or more polynucleotides, one or more vectors, cell, molecule production method, composition, use of the molecule, method of treating a disease and method for inducing lysis of a target cell
MX2018005229A (en) 2015-12-09 2019-04-29 F Hoffmann­La Roche Ag Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies.
CA3006529A1 (en) 2016-01-08 2017-07-13 F. Hoffmann-La Roche Ag Methods of treating cea-positive cancers using pd-1 axis binding antagonists and anti-cea/anti-cd3 bispecific antibodies
JP7015244B2 (en) 2016-03-22 2022-02-02 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Protease-activated T cell bispecific molecule
IL263102B2 (en) 2016-05-20 2023-11-01 Harpoon Therapeutics Inc Single domain serum albumin binding protein
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
AU2017306432A1 (en) 2016-08-02 2019-03-21 TCR2 Therapeutics Inc. Compositions and methods for TCR reprogramming using fusion proteins
WO2018060301A1 (en) 2016-09-30 2018-04-05 F. Hoffmann-La Roche Ag Bispecific antibodies against cd3
EP3445787B1 (en) 2016-10-07 2020-12-02 TCR2 Therapeutics Inc. Compositions and methods for t-cell receptors reprogramming using fusion proteins
AU2017353427A1 (en) 2016-11-02 2019-05-16 Bristol-Myers Squibb Company Bispecific antibody against BCMA and CD3 and an immunological drug for combined use in treating multiple myeloma
WO2018098365A2 (en) 2016-11-22 2018-05-31 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
CN110582509A (en) 2017-01-31 2019-12-17 诺华股份有限公司 Treatment of cancer using chimeric T cell receptor proteins with multispecific properties
EP3589662A4 (en) 2017-02-28 2020-12-30 Harpoon Therapeutics, Inc. Inducible monovalent antigen binding protein
EP3615055A1 (en) 2017-04-28 2020-03-04 Novartis AG Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
US20200179511A1 (en) 2017-04-28 2020-06-11 Novartis Ag Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
CN110891974B (en) 2017-05-12 2021-08-06 哈普恩治疗公司 Mesothelin binding proteins
WO2019000223A1 (en) 2017-06-27 2019-01-03 Nanjing Legend Biotech Co., Ltd. Chimeric antibody immune effctor cell engagers and methods of use thereof
WO2019035938A1 (en) 2017-08-16 2019-02-21 Elstar Therapeutics, Inc. Multispecific molecules that bind to bcma and uses thereof
US11136403B2 (en) 2017-10-13 2021-10-05 Harpoon Therapeutics, Inc. Trispecific proteins and methods of use
US10927180B2 (en) 2017-10-13 2021-02-23 Harpoon Therapeutics, Inc. B cell maturation antigen binding proteins
TWI829655B (en) 2017-10-18 2024-01-21 瑞士商諾華公司 Compositions and methods for selective protein degradation
AU2018369883A1 (en) 2017-11-15 2020-05-28 Novartis Ag BCMA-targeting chimeric antigen receptor, CD19-targeting chimeric antigen receptor, and combination therapies
KR20200096253A (en) 2017-11-30 2020-08-11 노파르티스 아게 BCMA-targeting chimeric antigen receptor, and uses thereof
US20200368268A1 (en) 2018-01-08 2020-11-26 Novartis Ag Immune-enhancing rnas for combination with chimeric antigen receptor therapy
WO2019152660A1 (en) 2018-01-31 2019-08-08 Novartis Ag Combination therapy using a chimeric antigen receptor
US11866498B2 (en) 2018-02-08 2024-01-09 Genentech, Inc. Bispecific antigen-binding molecules and methods of use
WO2019160956A1 (en) 2018-02-13 2019-08-22 Novartis Ag Chimeric antigen receptor therapy in combination with il-15r and il15
EP3802611A2 (en) 2018-06-01 2021-04-14 Novartis AG Binding molecules against bcma and uses thereof
AU2019297451A1 (en) 2018-07-03 2021-01-28 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
MX2021000488A (en) 2018-07-19 2021-04-12 Regeneron Pharma BISPECIFIC ANTI-BCMA x ANTI-CD3 ANTIBODIES AND USES THEREOF.
MX2021002393A (en) 2018-08-31 2021-07-15 Novartis Ag Methods of making chimeric antigen receptor-expressing cells.
WO2020047449A2 (en) 2018-08-31 2020-03-05 Novartis Ag Methods of making chimeric antigen receptor-expressing cells
MX2021003554A (en) 2018-09-25 2021-05-27 Harpoon Therapeutics Inc Dll3 binding proteins and methods of use.
TW202028239A (en) * 2018-09-28 2020-08-01 美商安進公司 Antibodies against soluble bcma
JP2022509454A (en) * 2018-10-31 2022-01-20 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド Cancer treatment
CN109485734B (en) * 2018-12-30 2020-05-12 广州百暨基因科技有限公司 Bispecific chimeric antigen receptor targeting BCMA and CD19 and application thereof
CA3127645A1 (en) * 2019-01-30 2020-08-06 The Wistar Institute Of Anatomy And Biology Dna-encoded bispecific t-cell engagers targeting cancer antigens and methods of use in cancer theraputics
WO2020176397A1 (en) 2019-02-25 2020-09-03 Novartis Ag Mesoporous silica particles compositions for viral delivery
EP3942025A1 (en) 2019-03-21 2022-01-26 Novartis AG Car-t cell therapies with enhanced efficacy
WO2020210678A1 (en) 2019-04-12 2020-10-15 Novartis Ag Methods of making chimeric antigen receptor-expressing cells
WO2020219742A1 (en) 2019-04-24 2020-10-29 Novartis Ag Compositions and methods for selective protein degradation
CN110229232B (en) * 2019-06-19 2020-05-19 北京智仁美博生物科技有限公司 Bispecific antibodies and uses thereof
BR112022010206A2 (en) 2019-11-26 2022-11-29 Novartis Ag CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF
BR112022016633A2 (en) 2020-02-27 2022-12-13 Novartis Ag METHODS FOR PRODUCING CELLS THAT EXPRESS CHIMERIC ANTIGEN RECEPTOR
KR20220146530A (en) 2020-02-27 2022-11-01 노파르티스 아게 Methods of Making Chimeric Antigen Receptor-Expressing Cells
CN116096862A (en) 2020-06-11 2023-05-09 诺华股份有限公司 ZBTB32 inhibitors and uses thereof
TWI811703B (en) 2020-06-19 2023-08-11 瑞士商赫孚孟拉羅股份公司 Antibodies binding to cd3 and cd19
JP2023538118A (en) 2020-08-21 2023-09-06 ノバルティス アーゲー Compositions and methods for in vivo generation of CAR-expressing cells
CN112285366B (en) * 2020-12-25 2021-06-08 南京广祺医药科技有限公司 ELISA method for determining bispecific antibody BsAb in serum and application thereof
BR112023020832A2 (en) 2021-04-08 2023-12-19 Marengo Therapeutics Inc TCR-BINDED MULTIFUNCTIONAL MOLECULES AND THEIR USES
CN118056008A (en) 2021-04-27 2024-05-17 诺华股份有限公司 Virus vector production system
WO2023021477A1 (en) 2021-08-20 2023-02-23 Novartis Ag Methods of making chimeric antigen receptor–expressing cells
WO2024025967A1 (en) * 2022-07-28 2024-02-01 Springworks Therapeutics, Inc. Determination of bcma level on plasma cells by flow cytometry
WO2024089639A1 (en) 2022-10-26 2024-05-02 Novartis Ag Lentiviral formulations

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3883899T3 (en) 1987-03-18 1999-04-22 Sb2 Inc CHANGED ANTIBODIES.
US5202238A (en) 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US20020142000A1 (en) 1999-01-15 2002-10-03 Digan Mary Ellen Anti-CD3 immunotoxins and therapeutic uses therefor
UA74798C2 (en) 1999-10-06 2006-02-15 Байоджен Айдек Ма Інк. Method for treating cancer in mammals using polypeptide interfering with interaction between april and its receptors
AU6232899A (en) 1999-10-06 2001-05-10 Campina Melkunie B.V. Use of transforming growth factor beta and growth factors in the treatment and prevention of diseases of the intestinal mucosa
AU2002238052A1 (en) 2001-02-20 2002-09-04 Zymogenetics, Inc. Antibodies that bind both bcma and taci
WO2007117600A2 (en) 2006-04-07 2007-10-18 Macrogenics, Inc. Combination therapy for treating autoimmune diseases
US7960944B2 (en) 2007-09-05 2011-06-14 Eveready Battery Company, Inc. Power supply that supplies power to and communicates with an electrical appliance
AU2009239437B2 (en) 2008-04-25 2014-11-13 University Of Washington Levels of BCMA protein expression on B cells and use in diagnostic methods
AU2010224160A1 (en) 2009-03-10 2011-09-22 Biogen Idec Ma Inc. Anti-BCMA antibodies
WO2012066058A1 (en) 2010-11-16 2012-05-24 Boehringer Ingelheim International Gmbh Agents and methods for treating diseases that correlate with bcma expression
EP2691417B1 (en) 2011-03-29 2018-08-01 Roche Glycart AG Antibody fc variants
US20130101599A1 (en) 2011-04-21 2013-04-25 Boehringer Ingelheim International Gmbh Bcma-based stratification and therapy for multiple myeloma patients
EA201790330A1 (en) * 2011-05-27 2018-02-28 Глаксо Груп Лимитед PROTEINS CONNECTING WITH BCMA (CD269 / TNFRSF17)
KR101681818B1 (en) * 2011-08-23 2016-12-01 로슈 글리카트 아게 Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use
TWI679212B (en) * 2011-11-15 2019-12-11 美商安進股份有限公司 Binding molecules for e3 of bcma and cd3
EA033110B1 (en) 2012-04-11 2019-08-30 Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез Chimeric antigen receptor targeting b-cell maturation antigen, nucleic acid encoding same, corresponding expression vector, host cell, uses and methods
TW201425336A (en) 2012-12-07 2014-07-01 Amgen Inc BCMA antigen binding proteins
PL2953972T3 (en) 2013-02-05 2021-03-08 Engmab Sàrl Method for the selection of antibodies against bcma
AR095374A1 (en) 2013-03-15 2015-10-14 Amgen Res (Munich) Gmbh UNION MOLECULES FOR BCMA AND CD3
DK3177643T3 (en) * 2014-08-04 2019-07-15 Hoffmann La Roche Bispecific T cell activating antigen binding molecules

Also Published As

Publication number Publication date
AU2015357122B2 (en) 2021-05-27
AU2015357122A1 (en) 2017-06-29
EP3227333B1 (en) 2023-08-16
US20200385471A1 (en) 2020-12-10
CN107406505A (en) 2017-11-28
JP2018508462A (en) 2018-03-29
CA2969560A1 (en) 2016-06-09
ES2959635T3 (en) 2024-02-27
EP3029068A1 (en) 2016-06-08
WO2016087531A1 (en) 2016-06-09
AU2021221695A1 (en) 2021-09-23
JP2021120374A (en) 2021-08-19
KR20170109535A (en) 2017-09-29
EP4282484A3 (en) 2024-02-28
US20170327580A1 (en) 2017-11-16
EP3227333A1 (en) 2017-10-11
EP4282484A2 (en) 2023-11-29

Similar Documents

Publication Publication Date Title
SG11201704572UA (en) Bispecific antibodies against cd3epsilon and bcma for use in treatment of diseases
IL282962A (en) Anti-pd-1 antibodies and methods of use thereof
HK1244492A1 (en) Anti-pd-1 antibodies and methods of use thereof
HK1252857A1 (en) Anti-cd3 antibodies and methods of use
HK1243102A1 (en) Anti-cd79b antibodies and methods of use
HRP20181359T1 (en) Anti-jagged1 antibodies and methods of use
IL251868A0 (en) Anti-tim3 antibodies and methods of use
IL251128A0 (en) Bispecific antibodies and methods of use in ophthalmology
ZA201606630B (en) Anti-ox40 antibodies and methods of use
SG11201704577TA (en) Bispecific antibodies against cd3epsilon and bcma
SG11201700551TA (en) Bispecific antibodies against cd3epsilon and bcma
IL251165A0 (en) Anti-il-1beta antibodies and methods of use
IL251477A0 (en) Anti-ang2 antibodies and methods of use
IL251286A0 (en) Anti-pdgf-b antibodies and methods of use
IL250507B (en) Anti-ck8 antibodies for use in the treatment of cancers
GB201420533D0 (en) Use of Nanomaterials in treating cancer
GB201418640D0 (en) Agents and methods for treatment of cancer
ZA201403006B (en) Composition for use in treatment of cancer