IT1249708B - Metodo per la determinazione del fattore di necrosi tumorale (tnf) in forma biologicamente attiva. - Google Patents
Metodo per la determinazione del fattore di necrosi tumorale (tnf) in forma biologicamente attiva.Info
- Publication number
- IT1249708B IT1249708B ITRM910710A ITRM910710A IT1249708B IT 1249708 B IT1249708 B IT 1249708B IT RM910710 A ITRM910710 A IT RM910710A IT RM910710 A ITRM910710 A IT RM910710A IT 1249708 B IT1249708 B IT 1249708B
- Authority
- IT
- Italy
- Prior art keywords
- tnf
- biologically active
- determining
- necrosis factor
- active form
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000017074 necrotic cell death Effects 0.000 title 1
- 230000001173 tumoral effect Effects 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
E' descritto un metodo per la rivelazione del TNF biologicamente attivo oligomerico, che utilizza reagenti capaci di reagire solo con TNF in forma oligomerica ma non con TNF complessato al recettore, ne con TNF in forma monomerica. E' anche descritto un kit per la realizzazione.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM910710A IT1249708B (it) | 1991-09-23 | 1991-09-23 | Metodo per la determinazione del fattore di necrosi tumorale (tnf) in forma biologicamente attiva. |
EP92921308A EP0605635A1 (en) | 1991-09-23 | 1992-09-17 | Method to detect tumor necrosis factor (tnf) as bioactive form |
PCT/IT1992/000116 WO1993006489A1 (en) | 1991-09-23 | 1992-09-17 | Method to detect tumor necrosis factor (tnf) as bioactive form |
AU26905/92A AU2690592A (en) | 1991-09-23 | 1992-09-17 | Method to detect tumor necrosis factor (tnf) as bioactive form |
JP5505949A JPH07502113A (ja) | 1991-09-23 | 1992-09-17 | 生理活性型の腫瘍壊死因子(tnf)の検出方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM910710A IT1249708B (it) | 1991-09-23 | 1991-09-23 | Metodo per la determinazione del fattore di necrosi tumorale (tnf) in forma biologicamente attiva. |
Publications (3)
Publication Number | Publication Date |
---|---|
ITRM910710A0 ITRM910710A0 (it) | 1991-09-23 |
ITRM910710A1 ITRM910710A1 (it) | 1993-03-23 |
IT1249708B true IT1249708B (it) | 1995-03-09 |
Family
ID=11400369
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITRM910710A IT1249708B (it) | 1991-09-23 | 1991-09-23 | Metodo per la determinazione del fattore di necrosi tumorale (tnf) in forma biologicamente attiva. |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0605635A1 (it) |
JP (1) | JPH07502113A (it) |
AU (1) | AU2690592A (it) |
IT (1) | IT1249708B (it) |
WO (1) | WO1993006489A1 (it) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6649352B1 (en) * | 1999-01-29 | 2003-11-18 | Center For Molecular Medicine And Immunology | Method of evaluating myelosuppressive state |
US7112409B2 (en) | 1999-01-29 | 2006-09-26 | Center For Molecular Medicine And Immunology | Method of determining cytokine dosage for myelosuppressive state |
GB201510758D0 (en) | 2015-06-18 | 2015-08-05 | Ucb Biopharma Sprl | Novel TNFa structure for use in therapy |
GB201621907D0 (en) | 2016-12-21 | 2017-02-01 | Ucb Biopharma Sprl And Sanofi | Antibody epitope |
-
1991
- 1991-09-23 IT ITRM910710A patent/IT1249708B/it active IP Right Grant
-
1992
- 1992-09-17 WO PCT/IT1992/000116 patent/WO1993006489A1/en not_active Application Discontinuation
- 1992-09-17 EP EP92921308A patent/EP0605635A1/en not_active Withdrawn
- 1992-09-17 JP JP5505949A patent/JPH07502113A/ja active Pending
- 1992-09-17 AU AU26905/92A patent/AU2690592A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ITRM910710A1 (it) | 1993-03-23 |
AU2690592A (en) | 1993-04-27 |
WO1993006489A1 (en) | 1993-04-01 |
EP0605635A1 (en) | 1994-07-13 |
ITRM910710A0 (it) | 1991-09-23 |
JPH07502113A (ja) | 1995-03-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19960909 |