JP2014533357A5 - - Google Patents
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- Publication number
- JP2014533357A5 JP2014533357A5 JP2014540007A JP2014540007A JP2014533357A5 JP 2014533357 A5 JP2014533357 A5 JP 2014533357A5 JP 2014540007 A JP2014540007 A JP 2014540007A JP 2014540007 A JP2014540007 A JP 2014540007A JP 2014533357 A5 JP2014533357 A5 JP 2014533357A5
- Authority
- JP
- Japan
- Prior art keywords
- synuclein
- level
- subject
- antibody
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000003802 alpha-Synuclein Human genes 0.000 claims description 128
- 108090000185 alpha-Synuclein Proteins 0.000 claims description 128
- 239000012634 fragment Substances 0.000 claims description 72
- 238000000034 method Methods 0.000 claims description 71
- 239000000427 antigen Substances 0.000 claims description 50
- 102000036639 antigens Human genes 0.000 claims description 50
- 108091007433 antigens Proteins 0.000 claims description 50
- 210000004556 brain Anatomy 0.000 claims description 50
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 24
- 201000010099 disease Diseases 0.000 claims description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
- 102000019355 Synuclein Human genes 0.000 claims description 15
- 108050006783 Synuclein Proteins 0.000 claims description 15
- 230000002093 peripheral effect Effects 0.000 claims description 14
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 12
- 208000018737 Parkinson disease Diseases 0.000 claims description 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 6
- 208000024827 Alzheimer disease Diseases 0.000 claims description 6
- 201000002832 Lewy body dementia Diseases 0.000 claims description 6
- 239000008280 blood Substances 0.000 claims description 6
- 210000004369 blood Anatomy 0.000 claims description 6
- 208000001089 Multiple system atrophy Diseases 0.000 claims description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
- 206010003840 Autonomic nervous system imbalance Diseases 0.000 claims description 3
- 206010012289 Dementia Diseases 0.000 claims description 3
- 201000010374 Down Syndrome Diseases 0.000 claims description 3
- 201000011240 Frontotemporal dementia Diseases 0.000 claims description 3
- 208000009829 Lewy Body Disease Diseases 0.000 claims description 3
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims description 3
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 3
- 206010044688 Trisomy 21 Diseases 0.000 claims description 3
- 230000000366 juvenile effect Effects 0.000 claims description 3
- 210000004558 lewy body Anatomy 0.000 claims description 3
- 208000033510 neuroaxonal dystrophy Diseases 0.000 claims description 3
- 230000009885 systemic effect Effects 0.000 claims description 3
- 230000009529 traumatic brain injury Effects 0.000 claims description 3
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 2
- 206010028289 Muscle atrophy Diseases 0.000 claims description 2
- 238000010253 intravenous injection Methods 0.000 claims description 2
- 229910052742 iron Inorganic materials 0.000 claims description 2
- 201000010901 lateral sclerosis Diseases 0.000 claims description 2
- 208000005264 motor neuron disease Diseases 0.000 claims description 2
- 230000020763 muscle atrophy Effects 0.000 claims description 2
- 201000000585 muscular atrophy Diseases 0.000 claims description 2
- 230000004770 neurodegeneration Effects 0.000 claims description 2
- 230000001568 sexual effect Effects 0.000 claims description 2
- 201000007601 neurodegeneration with brain iron accumulation Diseases 0.000 claims 1
- 208000002593 pantothenate kinase-associated neurodegeneration Diseases 0.000 description 3
- 206010003694 Atrophy Diseases 0.000 description 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161554924P | 2011-11-02 | 2011-11-02 | |
| US61/554,924 | 2011-11-02 | ||
| PCT/US2012/062430 WO2013066818A1 (en) | 2011-11-02 | 2012-10-29 | USE OF AN ANTI-α-SYNUCLEIN ANTIBODY TO DIAGNOSE AN ELEVATED LEVEL OF α-SYNUCLEIN IN THE BRAIN |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014533357A JP2014533357A (ja) | 2014-12-11 |
| JP2014533357A5 true JP2014533357A5 (enExample) | 2015-10-15 |
| JP6263473B2 JP6263473B2 (ja) | 2018-01-31 |
Family
ID=48192661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014540007A Expired - Fee Related JP6263473B2 (ja) | 2011-11-02 | 2012-10-29 | 脳における高レベルのα−シヌクレインを診断するための抗α−シヌクレイン抗体の使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20140295465A1 (enExample) |
| EP (1) | EP2773957B1 (enExample) |
| JP (1) | JP6263473B2 (enExample) |
| KR (1) | KR102036938B1 (enExample) |
| CN (2) | CN104040342A (enExample) |
| AU (1) | AU2012332814B2 (enExample) |
| BR (1) | BR112014010664A2 (enExample) |
| CA (1) | CA2854131C (enExample) |
| EA (1) | EA034213B1 (enExample) |
| IL (1) | IL232373B (enExample) |
| MX (1) | MX356797B (enExample) |
| WO (1) | WO2013066818A1 (enExample) |
| ZA (1) | ZA201403879B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2949666B1 (en) | 2008-12-19 | 2018-12-19 | Biogen International Neuroscience GmbH | Human anti-alpha-synuclein antibodies |
| LT2723379T (lt) | 2011-06-23 | 2018-10-25 | Biogen International Neuroscience Gmbh | Anti-alfa sinukleiną rišančios molekulės |
| US9732148B2 (en) | 2014-10-16 | 2017-08-15 | Genentech, Inc. | Anti-α-synuclein antibodies and methods of use |
| JP6273338B1 (ja) * | 2016-12-05 | 2018-01-31 | 磁量生技股▲ふん▼有限公司 | パーキンソン病からパーキンソン病認知症を特定する方法 |
| CA3049110A1 (en) * | 2017-01-06 | 2018-07-12 | Abl Bio Inc. | Anti-.alpha.-syn antibody and use thereof |
| BR112019013953A2 (pt) * | 2017-01-06 | 2020-02-11 | Abl Bio Inc. | Anticorpo anti-a-syn e uso do mesmo |
| SG11201906947SA (en) | 2017-02-17 | 2019-08-27 | Bristol Myers Squibb Co | Antibodies to alpha-synuclein and uses thereof |
| BR112020011875A2 (pt) | 2017-12-14 | 2020-11-24 | Abl Bio Inc. | anticorpo biespecífico ao a-syn/igf1r e uso do mesmo |
| GB201803553D0 (en) | 2018-03-06 | 2018-04-18 | Univ Newcastle | Detection of pathological protein aggregation |
| WO2020009482A1 (ko) * | 2018-07-03 | 2020-01-09 | 에이비엘바이오 주식회사 | 항 알파-시누클레인 항체 및 그 용도 |
| EP3629021A1 (en) * | 2018-09-26 | 2020-04-01 | Euroimmun Medizinische Labordiagnostika AG | Diagnosis of a neuroautoimmune disease |
| KR102252879B1 (ko) * | 2019-11-15 | 2021-05-17 | 성균관대학교산학협력단 | 혈장 내 aimp2를 이용한 파킨슨 질환의 진단 방법, 이를 위한 조성물 및 이를 포함하는 키트 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
| FR2686087A1 (fr) | 1992-01-13 | 1993-07-16 | Inst Nat Sante Rech Med | Nouvel antigene lymphocytaire, anticorps correspondant et leurs applications. |
| WO1999050300A1 (en) * | 1998-03-30 | 1999-10-07 | The Trustees Of The University Of Pennsylvania | Method of identifying, diagnosing and treating synuclein positive neurodegenerative disorders |
| EP1299411A4 (en) * | 2000-07-07 | 2006-02-15 | Panacea Pharm Llc | METHOD FOR PREVENTING INJURY OF NEURAL TISSUE AND TREATING ALPHA SYNUCLEINE-RELATED DISEASES |
| GB0203446D0 (en) * | 2002-02-14 | 2002-04-03 | Univ Lancaster | Detection and/or monitoring of synuclein-related diseases |
| US20080300204A1 (en) * | 2005-07-19 | 2008-12-04 | University Of Rochester | Alpha-Synuclein Antibodies and Methods Related Thereto |
| ES2641897T3 (es) | 2007-01-05 | 2017-11-14 | University Of Zurich | Procedimiento para proporcionar moléculas de unión y diana específicas de una enfermedad |
| CN101308144A (zh) * | 2007-05-16 | 2008-11-19 | 首都医科大学宣武医院 | 检测受试者体液内疾病相关蛋白聚合能力的方法 |
| TR201901497T4 (tr) * | 2008-04-29 | 2019-02-21 | Bioarctic Ab | Alfa-sinüklein ile ilişkili bozukluklar için terapötik ve teşhis yöntemlerinde kullanıma yönelik antikorlar ve aşılar. |
| EP2949666B1 (en) * | 2008-12-19 | 2018-12-19 | Biogen International Neuroscience GmbH | Human anti-alpha-synuclein antibodies |
| CN101692092B (zh) * | 2009-09-24 | 2013-04-10 | 首都医科大学宣武医院 | 定量检测人血清中自体α-突触核蛋白抗体的方法 |
-
2012
- 2012-10-29 US US14/355,743 patent/US20140295465A1/en not_active Abandoned
- 2012-10-29 CN CN201280065165.6A patent/CN104040342A/zh active Pending
- 2012-10-29 EA EA201490883A patent/EA034213B1/ru unknown
- 2012-10-29 EP EP12846452.6A patent/EP2773957B1/en active Active
- 2012-10-29 BR BR112014010664A patent/BR112014010664A2/pt not_active Application Discontinuation
- 2012-10-29 CA CA2854131A patent/CA2854131C/en active Active
- 2012-10-29 MX MX2014005378A patent/MX356797B/es active IP Right Grant
- 2012-10-29 CN CN201710252366.1A patent/CN107091931A/zh active Pending
- 2012-10-29 AU AU2012332814A patent/AU2012332814B2/en not_active Ceased
- 2012-10-29 JP JP2014540007A patent/JP6263473B2/ja not_active Expired - Fee Related
- 2012-10-29 WO PCT/US2012/062430 patent/WO2013066818A1/en not_active Ceased
- 2012-10-29 KR KR1020147014713A patent/KR102036938B1/ko not_active Expired - Fee Related
-
2014
- 2014-04-30 IL IL232373A patent/IL232373B/en active IP Right Grant
- 2014-05-27 ZA ZA2014/03879A patent/ZA201403879B/en unknown
-
2017
- 2017-01-19 US US15/409,671 patent/US20180011112A1/en not_active Abandoned
-
2018
- 2018-05-16 US US15/981,691 patent/US20190094245A1/en not_active Abandoned