JP2020510845A5 - - Google Patents
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- JP2020510845A5 JP2020510845A5 JP2019566047A JP2019566047A JP2020510845A5 JP 2020510845 A5 JP2020510845 A5 JP 2020510845A5 JP 2019566047 A JP2019566047 A JP 2019566047A JP 2019566047 A JP2019566047 A JP 2019566047A JP 2020510845 A5 JP2020510845 A5 JP 2020510845A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- seq
- antagonist antibody
- sema4d
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108010056102 CD100 antigen Proteins 0.000 claims description 80
- 102100027744 Semaphorin-4D Human genes 0.000 claims description 80
- 239000005557 antagonist Substances 0.000 claims description 65
- 230000004190 glucose uptake Effects 0.000 claims description 48
- 239000012634 fragment Substances 0.000 claims description 47
- 208000023105 Huntington disease Diseases 0.000 claims description 27
- 208000036110 Neuroinflammatory disease Diseases 0.000 claims description 26
- 208000027418 Wounds and injury Diseases 0.000 claims description 26
- 230000006378 damage Effects 0.000 claims description 26
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 26
- 208000035475 disorder Diseases 0.000 claims description 26
- 208000014674 injury Diseases 0.000 claims description 26
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 26
- 230000000626 neurodegenerative effect Effects 0.000 claims description 26
- 210000004556 brain Anatomy 0.000 claims description 24
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 20
- 239000000427 antigen Substances 0.000 claims description 15
- 108091007433 antigens Proteins 0.000 claims description 15
- 102000036639 antigens Human genes 0.000 claims description 15
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 8
- 208000037048 Prodromal Symptoms Diseases 0.000 claims description 8
- 208000010877 cognitive disease Diseases 0.000 claims description 6
- 230000002068 genetic effect Effects 0.000 claims description 6
- 238000012360 testing method Methods 0.000 claims description 6
- ZCXUVYAZINUVJD-AHXZWLDOSA-N 2-deoxy-2-((18)F)fluoro-alpha-D-glucose Chemical compound OC[C@H]1O[C@H](O)[C@H]([18F])[C@@H](O)[C@@H]1O ZCXUVYAZINUVJD-AHXZWLDOSA-N 0.000 claims description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
- 201000011240 Frontotemporal dementia Diseases 0.000 claims description 4
- 102100034384 Plexin-B1 Human genes 0.000 claims description 4
- 101710100559 Plexin-B1 Proteins 0.000 claims description 4
- 208000027061 mild cognitive impairment Diseases 0.000 claims description 4
- 201000006417 multiple sclerosis Diseases 0.000 claims description 4
- 101150043003 Htt gene Proteins 0.000 claims description 3
- 238000010176 18-FDG-positron emission tomography Methods 0.000 claims description 2
- 208000024827 Alzheimer disease Diseases 0.000 claims description 2
- 206010003591 Ataxia Diseases 0.000 claims description 2
- 102100025218 B-cell differentiation antigen CD72 Human genes 0.000 claims description 2
- 206010048962 Brain oedema Diseases 0.000 claims description 2
- 208000028698 Cognitive impairment Diseases 0.000 claims description 2
- 201000010374 Down Syndrome Diseases 0.000 claims description 2
- 101000934359 Homo sapiens B-cell differentiation antigen CD72 Proteins 0.000 claims description 2
- 208000018737 Parkinson disease Diseases 0.000 claims description 2
- 102100034383 Plexin-B2 Human genes 0.000 claims description 2
- 101710100551 Plexin-B2 Proteins 0.000 claims description 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 2
- 206010044688 Trisomy 21 Diseases 0.000 claims description 2
- 208000006752 brain edema Diseases 0.000 claims description 2
- 208000011235 central nervous system lupus Diseases 0.000 claims description 2
- 206010015037 epilepsy Diseases 0.000 claims description 2
- 238000003384 imaging method Methods 0.000 claims description 2
- 230000003993 interaction Effects 0.000 claims description 2
- 201000010901 lateral sclerosis Diseases 0.000 claims description 2
- 230000031864 metaphase Effects 0.000 claims description 2
- 208000005264 motor neuron disease Diseases 0.000 claims description 2
- 210000003205 muscle Anatomy 0.000 claims description 2
- 238000002600 positron emission tomography Methods 0.000 claims description 2
- 208000020431 spinal cord injury Diseases 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- 230000009529 traumatic brain injury Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 28
- 239000000203 mixture Substances 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 32
- 238000011156 evaluation Methods 0.000 description 3
- 208000024806 Brain atrophy Diseases 0.000 description 2
- 206010061296 Motor dysfunction Diseases 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000001149 cognitive effect Effects 0.000 description 1
- 230000003920 cognitive function Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000007659 motor function Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762461945P | 2017-02-22 | 2017-02-22 | |
| US62/461,945 | 2017-02-22 | ||
| PCT/US2018/018794 WO2018156509A1 (en) | 2017-02-22 | 2018-02-20 | Early detection of glial cell activation in neurodegenerative or neuroinflammatory diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020510845A JP2020510845A (ja) | 2020-04-09 |
| JP2020510845A5 true JP2020510845A5 (enExample) | 2021-03-25 |
| JP7626416B2 JP7626416B2 (ja) | 2025-02-04 |
Family
ID=63253999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019566047A Active JP7626416B2 (ja) | 2017-02-22 | 2018-02-20 | 神経変性疾患または神経炎症性疾患におけるグリア細胞活性化の早期検出方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20190383836A1 (enExample) |
| EP (1) | EP3585435A4 (enExample) |
| JP (1) | JP7626416B2 (enExample) |
| KR (1) | KR102533921B1 (enExample) |
| CN (1) | CN110325213A (enExample) |
| AU (1) | AU2018225493B2 (enExample) |
| BR (1) | BR112019017367A2 (enExample) |
| CA (1) | CA3050328A1 (enExample) |
| IL (1) | IL267940B2 (enExample) |
| MX (1) | MX2019009986A (enExample) |
| RU (1) | RU2766341C2 (enExample) |
| SG (1) | SG11201906670PA (enExample) |
| WO (1) | WO2018156509A1 (enExample) |
| ZA (1) | ZA201904431B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO2427212T3 (enExample) | 2009-05-08 | 2018-01-20 | ||
| CN104168956A (zh) | 2011-10-11 | 2014-11-26 | 瓦西尼斯公司 | 臂板蛋白-4d结合分子用于调节血脑屏障渗透性的用途 |
| US9708601B2 (en) | 2012-04-26 | 2017-07-18 | Vaccinex, Inc. | Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus |
| US10494440B2 (en) * | 2012-05-11 | 2019-12-03 | Vaccinex, Inc. | Use of semaphorin-4D binding molecules to promote neurogenesis following stroke |
| BR112015032690B1 (pt) | 2013-06-25 | 2020-03-10 | Vaccinex, Inc. | Uso de moléculas inibidoras de semaforina-4d em combinação com uma terapia imunomoduladora para inibir o crescimento tumoral e metástase |
| NZ630892A (en) | 2013-10-21 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treating neurodegenerative disorders |
| BR112018071686A2 (pt) | 2016-04-22 | 2019-02-19 | Vaccinex, Inc. | exibição de proteínas integrais de membrana em vírions extracelulares envelopados de poxvírus |
| WO2018026715A1 (en) | 2016-08-02 | 2018-02-08 | Vaccinex, Inc. | Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells |
| CN117597360A (zh) * | 2020-06-25 | 2024-02-23 | 瓦西尼斯公司 | 脑信号蛋白-4d结合分子在rett综合征治疗中的应用 |
| CA3231551A1 (en) * | 2021-09-27 | 2023-03-30 | Maurice Zauderer | Predictive outcome profiling for use of an anti-semaphorin-4d binding molecule to treat neurodegenerative disorders |
| AU2024243083A1 (en) * | 2023-04-03 | 2025-11-20 | Sialbio Co., Ltd. | Pharmaceutical composition for preventing or treating sjogren's syndrome, containing recombinant anti-semaphorin 4d antibody as active ingredient |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0892047A3 (de) * | 1997-07-09 | 2000-03-08 | Hoechst Marion Roussel Deutschland GmbH | Humanes und murines Semaphorin L |
| KR101603917B1 (ko) * | 2008-05-09 | 2016-03-17 | 애브비 인코포레이티드 | 최종 당화 산물의 수용체(rage)에 대한 항체 및 이의 용도 |
| CN104168956A (zh) * | 2011-10-11 | 2014-11-26 | 瓦西尼斯公司 | 臂板蛋白-4d结合分子用于调节血脑屏障渗透性的用途 |
| US10494440B2 (en) * | 2012-05-11 | 2019-12-03 | Vaccinex, Inc. | Use of semaphorin-4D binding molecules to promote neurogenesis following stroke |
| NZ630881A (en) * | 2013-10-10 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treatment of atherosclerosis |
| NZ630892A (en) * | 2013-10-21 | 2016-03-31 | Vaccinex Inc | Use of semaphorin-4d binding molecules for treating neurodegenerative disorders |
| WO2017011746A1 (en) * | 2015-07-15 | 2017-01-19 | Adm Diagnostics, Llc | System and methods for determining a brain condition of a patient sybject to multiple disease states |
-
2018
- 2018-02-20 WO PCT/US2018/018794 patent/WO2018156509A1/en not_active Ceased
- 2018-02-20 EP EP18757318.3A patent/EP3585435A4/en active Pending
- 2018-02-20 RU RU2019122337A patent/RU2766341C2/ru active
- 2018-02-20 MX MX2019009986A patent/MX2019009986A/es unknown
- 2018-02-20 CN CN201880013208.3A patent/CN110325213A/zh active Pending
- 2018-02-20 KR KR1020197027287A patent/KR102533921B1/ko active Active
- 2018-02-20 US US16/488,123 patent/US20190383836A1/en not_active Abandoned
- 2018-02-20 BR BR112019017367A patent/BR112019017367A2/pt unknown
- 2018-02-20 SG SG11201906670PA patent/SG11201906670PA/en unknown
- 2018-02-20 IL IL267940A patent/IL267940B2/en unknown
- 2018-02-20 JP JP2019566047A patent/JP7626416B2/ja active Active
- 2018-02-20 AU AU2018225493A patent/AU2018225493B2/en active Active
- 2018-02-20 CA CA3050328A patent/CA3050328A1/en active Pending
-
2019
- 2019-07-05 ZA ZA2019/04431A patent/ZA201904431B/en unknown
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