JP2014528695A5 - - Google Patents

Info

Publication number

JP2014528695A5

JP2014528695A5 JP2014517198A JP2014517198A JP2014528695A5 JP 2014528695 A5 JP2014528695 A5 JP 2014528695A5 JP 2014517198 A JP2014517198 A JP 2014517198A JP 2014517198 A JP2014517198 A JP 2014517198A JP 2014528695 A5 JP2014528695 A5 JP 2014528695A5

Authority

JP

Japan

Prior art keywords

seq

antibody

fragment

synuclein

antigen

Prior art date

2012-06-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 239000000427 antigen Substances 0.000 claims description 64
• 102000036639 antigens Human genes 0.000 claims description 64
• 108091007433 antigens Proteins 0.000 claims description 64
• 102000040430 polynucleotide Human genes 0.000 claims description 57
• 108091033319 polynucleotide Proteins 0.000 claims description 57
• 239000002157 polynucleotide Substances 0.000 claims description 57
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 49
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 46
• 229920001184 polypeptide Polymers 0.000 claims description 45
• 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 claims description 38
• 239000000203 mixture Substances 0.000 claims description 20
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 18
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• 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims description 16
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• 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims description 16
• 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims description 16
• 238000006467 substitution reaction Methods 0.000 claims description 16
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• 108050006783 Synuclein Proteins 0.000 claims description 8
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• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
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