JP2015505665A5 - - Google Patents
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- JP2015505665A5 JP2015505665A5 JP2014537750A JP2014537750A JP2015505665A5 JP 2015505665 A5 JP2015505665 A5 JP 2015505665A5 JP 2014537750 A JP2014537750 A JP 2014537750A JP 2014537750 A JP2014537750 A JP 2014537750A JP 2015505665 A5 JP2015505665 A5 JP 2015505665A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- tdp
- antibody
- group
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161553113P | 2011-10-28 | 2011-10-28 | |
| US61/553,113 | 2011-10-28 | ||
| PCT/IB2012/002905 WO2013061163A2 (en) | 2011-10-28 | 2012-10-26 | Tdp-43 specific binding molecules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017126314A Division JP6417451B2 (ja) | 2011-10-28 | 2017-06-28 | Ｔｄｐ−４３に特異的な結合分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015505665A JP2015505665A (ja) | 2015-02-26 |
| JP2015505665A5 true JP2015505665A5 (enExample) | 2015-10-29 |
| JP6240611B2 JP6240611B2 (ja) | 2017-11-29 |
Family
ID=47720540
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014537750A Expired - Fee Related JP6240611B2 (ja) | 2011-10-28 | 2012-10-26 | Ｔｄｐ−４３に特異的な結合分子 |
| JP2017126314A Expired - Fee Related JP6417451B2 (ja) | 2011-10-28 | 2017-06-28 | Ｔｄｐ−４３に特異的な結合分子 |
| JP2018174683A Expired - Fee Related JP6652609B2 (ja) | 2011-10-28 | 2018-09-19 | Ｔｄｐ−４３に特異的な結合分子 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017126314A Expired - Fee Related JP6417451B2 (ja) | 2011-10-28 | 2017-06-28 | Ｔｄｐ−４３に特異的な結合分子 |
| JP2018174683A Expired - Fee Related JP6652609B2 (ja) | 2011-10-28 | 2018-09-19 | Ｔｄｐ−４３に特異的な結合分子 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US9587014B2 (enExample) |
| EP (2) | EP3964524A1 (enExample) |
| JP (3) | JP6240611B2 (enExample) |
| KR (2) | KR101961508B1 (enExample) |
| CN (1) | CN104159918B (enExample) |
| AU (1) | AU2012327211C9 (enExample) |
| BR (1) | BR112014010161B1 (enExample) |
| CA (2) | CA3112082A1 (enExample) |
| CL (1) | CL2014001074A1 (enExample) |
| EA (1) | EA032003B1 (enExample) |
| ES (1) | ES2883212T3 (enExample) |
| IL (2) | IL232219B (enExample) |
| MX (2) | MX357678B (enExample) |
| MY (1) | MY167795A (enExample) |
| PH (1) | PH12014500940A1 (enExample) |
| SG (1) | SG11201401735WA (enExample) |
| WO (1) | WO2013061163A2 (enExample) |
| ZA (1) | ZA201403680B (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20140049T1 (hr) | 2007-01-05 | 2014-02-28 | University Of Zürich | Anti beta-amiloid antitijela i njihova upotreba |
| EP3964524A1 (en) | 2011-10-28 | 2022-03-09 | Biogen International Neuroscience GmbH | Tdp-43 specific binding molecules |
| WO2014198528A2 (en) | 2013-06-11 | 2014-12-18 | Paul Scherrer Institut | Method for determining mutateable ligand-gpcr binding at single amino acid resolution and pairs of mutated ligand and gpcr |
| US10191068B2 (en) | 2014-01-31 | 2019-01-29 | Arizona Board Of Regents On Behalf Of Arizona State University | Antibody based reagents that specifically recognize neurodegenerative disease related forms of the protein TDP-43 |
| EA201790165A1 (ru) | 2014-07-29 | 2017-07-31 | Нейриммьюн Холдинг Аг | Происходящие от человека антитела к гентингтину (htt) и их применение |
| CN104497121A (zh) * | 2014-08-29 | 2015-04-08 | 苏州顺升桥生物科技有限公司 | 淀粉样蛋白tdp-43及其用途 |
| WO2016053610A1 (en) * | 2014-10-03 | 2016-04-07 | Academia Sinica | Antibodies against pathological forms of tdp-43 and uses thereof |
| US9796778B1 (en) | 2014-10-03 | 2017-10-24 | Academia Sinica | Antibodies against pathological forms of TDP-43 and uses thereof |
| TWI592423B (zh) * | 2014-10-03 | 2017-07-21 | 中央研究院 | 可辨識致病性ｔｄｐ－４３之抗體及其用途 |
| MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
| US10509045B2 (en) | 2015-05-29 | 2019-12-17 | University Of Florida Research Foundation, Incorporated | Methods for diagnosing Huntington's disease |
| WO2017111166A1 (ja) * | 2015-12-25 | 2017-06-29 | 国立大学法人東京農工大学 | Ｔｄｐ－４３細胞内存在量関連疾患治療剤 |
| EP4063858A1 (en) | 2016-03-14 | 2022-09-28 | Biogen International Neuroscience GmbH | Antibody-dependent cell-mediated phagocytosis assay for reliably measuring uptake of aggregated proteins |
| EP3440100A4 (en) | 2016-04-04 | 2020-01-22 | University of Florida Research Foundation, Incorporated | HANDLING EIF3 TO MODULATE A NON-ATG TRANSLATION ASSOCIATED WITH A REPETITION (RAN) |
| US20190330318A1 (en) | 2016-07-25 | 2019-10-31 | Biogen Ma Inc. | Anti-hspa5 (grp78) antibodies and uses thereof |
| US20200031895A1 (en) | 2016-12-16 | 2020-01-30 | Biogen Ma Inc. | Stabilized proteolytically activated growth differentiation factor 11 |
| CA3054067A1 (en) * | 2017-03-14 | 2018-09-20 | Five Prime Therapeutics, Inc. | Antibodies binding to vista at acidic ph |
| AU2018255293B2 (en) | 2017-04-17 | 2024-03-07 | University Of Florida Research Foundation, Incorporated | Regulation of RAN translation by PKR and eIF2a-P pathways |
| JP7761373B2 (ja) * | 2017-05-30 | 2025-10-28 | ザ ユニヴァーシティ オブ ブリティッシュ コロンビア | Ｔｄｐ－４３のｒｎａ認識モチーフ１（ｒｒｍ１）中のエピトープ、およびそれらに対するミスフォールディング選択的抗体 |
| EP4233901A3 (en) | 2017-08-22 | 2023-09-06 | Biogen MA Inc. | Pharmaceutical compositions containing anti-beta amyloid antibodies |
| US12504380B2 (en) | 2017-09-25 | 2025-12-23 | University Of Florida Research Foundation, Incorporated | Immunoassays for detection of ran proteins |
| EP3724232B1 (en) | 2017-12-14 | 2024-12-04 | The University of Ottawa | Exosome packaging and targeted autophagy |
| WO2019118527A1 (en) * | 2017-12-14 | 2019-06-20 | The Johns Hopkins University | Novel anti-fungal inhibitors |
| SG11202006348VA (en) * | 2018-01-05 | 2020-07-29 | Ac Immune Sa | Misfolded tdp-43 binding molecules |
| US12215142B2 (en) | 2018-03-16 | 2025-02-04 | National University Corporation Shiga University Of Medical Science | Antibody fragment degrading and removing abnormal TDP-43 |
| PE20210290A1 (es) | 2018-03-21 | 2021-02-11 | Five Prime Therapeutics Inc | ANTICUERPOS DE UNION A VISTA A pH ACIDO |
| TW202019398A (zh) * | 2018-06-28 | 2020-06-01 | 張翔毓 | 用於治療或預防構形疾病之方法及藥物篩選方法 |
| AU2019301120A1 (en) | 2018-07-11 | 2021-02-25 | Bristol-Myers Squibb Company | Antibodies binding to VISTA at acidic pH |
| KR20210111242A (ko) | 2018-10-29 | 2021-09-10 | 바이오젠 엠에이 인코포레이티드 | 혈액 뇌 장벽 수송을 향상시키기 위한 인간화 및 안정화된 fc5 변이체 |
| CA3123116A1 (en) * | 2018-12-14 | 2020-06-18 | The University Of British Columbia | Antibodies to misfolded tdp-43 and methods of use |
| US20220315648A1 (en) * | 2019-05-23 | 2022-10-06 | Ac Immune Sa | Anti-TDP-43 Binding Molecules and Uses Thereof |
| WO2021026601A1 (en) * | 2019-08-12 | 2021-02-18 | Macquarie University | Compositions and methods for treatment |
| AU2020348916B2 (en) * | 2019-09-20 | 2025-12-18 | University Of Florida Research Foundation, Incorporated | Detection of antibodies against RAN proteins from serum and tissue lysates |
| GB202004863D0 (en) * | 2020-04-02 | 2020-05-20 | Univ Oxford Innovation Ltd | Method |
| AU2021265088A1 (en) | 2020-04-28 | 2022-11-03 | Sola Biosciences Llc | Compositions and methods for the treatment of TDP-43 proteinopathies |
| JP2023523066A (ja) * | 2020-04-29 | 2023-06-01 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | ミスフォールドｔｄｐ－４３に対する単鎖抗体およびイントラボディならびに使用方法 |
| JP2023547580A (ja) * | 2020-07-06 | 2023-11-13 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティ オブ テキサス システム | Ｔｄｐ－４３バイオセンサー細胞株 |
| EP4196162A1 (en) * | 2020-08-14 | 2023-06-21 | AC Immune SA | Humanized anti-tdp-43 binding molecules and uses thereof |
| US20240003918A1 (en) | 2020-11-30 | 2024-01-04 | Enigma Biointelligence, Inc. | Non-invasive assessment of alzheimer's disease |
| KR102549520B1 (ko) | 2021-01-29 | 2023-07-03 | 일리미스테라퓨틱스 주식회사 | 비염증성 식세포작용 유도 활성을 갖는 융합분자 |
| CN112920264B (zh) * | 2021-02-08 | 2022-07-05 | 武汉大学 | Tdp-43蛋白的o-糖基化突变体及其应用 |
| JP6961278B1 (ja) * | 2021-03-10 | 2021-11-05 | 国立研究開発法人量子科学技術研究開発機構 | 生体試料中のｔｄｐ−４３を測定する方法及び装置 |
| US20240226230A1 (en) * | 2021-05-27 | 2024-07-11 | Mayo Foundation For Medical Education And Research | Methods and materials for treating proteinopathies |
| CA3231484A1 (en) * | 2021-10-01 | 2023-04-06 | Qinwen Mao | Pathologic tdp-43 as a biomarker for the diagnosis of tdp-43 proteinopathy |
| CA3239708A1 (en) | 2021-12-03 | 2023-06-08 | Aubin MICHALON | Novel potency assay for antibody-based drugs and useful means therefor |
| TW202342519A (zh) | 2022-02-16 | 2023-11-01 | 瑞士商Ａｃ 免疫有限公司 | 人源化抗ｔｄｐ－４３結合分子及其用途 |
| WO2023194565A1 (en) * | 2022-04-08 | 2023-10-12 | Ac Immune Sa | Anti-tdp-43 binding molecules |
| WO2023205579A1 (en) * | 2022-04-18 | 2023-10-26 | The Regents Of The University Of California | Compositions and methods for disrupting pathological aggregates |
| JPWO2023204313A1 (enExample) | 2022-04-22 | 2023-10-26 | ||
| WO2024184494A1 (en) | 2023-03-08 | 2024-09-12 | Ac Immune Sa | Anti-tdp-43 binding molecules and uses thereof |
| WO2024263701A1 (en) * | 2023-06-20 | 2024-12-26 | The Trustees Of Dartmouth College | Chimeric antigen receptors (cars) targeting tdp43, tregs expressing said cars, and use thereof for the treatment of als, ftd and ad |
| KR102859015B1 (ko) * | 2023-07-20 | 2025-09-12 | 충북대학교 산학협력단 | ｃＡｂｌ에 의한 ＴＤＰ４３의 특이적 인산화 분석을 통한 신경퇴행성 질환을 진단하는 방법 및 이를 이용한 신경퇴행성 질환의 치료제 스크리닝 방법 |
| CN116875738A (zh) * | 2023-07-24 | 2023-10-13 | 山东省农业科学院畜牧兽医研究所 | 一种鉴定牛tdp-43基因启动子活性区域的方法 |
| TW202530253A (zh) * | 2023-09-15 | 2025-08-01 | 愛爾蘭商普羅希那生物科學有限公司 | 抗ｔｄｐ－４３抗體及其用途 |
| WO2025186332A1 (en) | 2024-03-05 | 2025-09-12 | Ac Immune Sa | Vectorized anti-tdp-43 antibodies |
| WO2026013218A1 (en) | 2024-07-10 | 2026-01-15 | Ac Immune Sa | Anti-tdp-43 vectors, binding molecules and uses thereof |
| CN119331085B (zh) * | 2024-10-16 | 2025-03-14 | 中国科学院合肥物质科学研究院 | 沙贝冠状病毒广谱中和抗体及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5688511A (en) * | 1991-11-05 | 1997-11-18 | Board Of Regents, The University Of Texas System | Cellular protein TDP-43 and regulation of HIV-1 gene expression |
| CA2253633A1 (en) | 1997-12-03 | 1999-06-03 | Boehringer Mannheim Corporation | Complex specific antibodies, method of preparation and uses thereof |
| US8354236B2 (en) * | 2006-09-29 | 2013-01-15 | The Trustees Of The University Of Pennsylvania | Detection of neurodegenerative disease |
| EP2099826B1 (en) * | 2007-01-05 | 2013-10-16 | University Of Zurich | Anti-beta-amyloid antibody and uses thereof |
| WO2008151055A1 (en) | 2007-06-01 | 2008-12-11 | Mayo Foundation For Medical Education And Research | Diagnosing neurodegenerative diseases |
| JP5439176B2 (ja) * | 2007-07-06 | 2014-03-12 | 公益財団法人東京都医学総合研究所 | Ｔｄｐ−４３凝集物に特異的に結合する抗体 |
| JP5798322B2 (ja) | 2008-02-01 | 2015-10-21 | ワシントン ユニバーシティ イン セント ルイス | Ｔｄｐ−４３蛋白質症に関連した配列およびその使用法 |
| EP3521309A1 (en) | 2008-12-19 | 2019-08-07 | Biogen International Neuroscience GmbH | Human anti-alpha-synuclein antibodies |
| CN101634656A (zh) | 2009-08-21 | 2010-01-27 | 武汉三鹰生物技术有限公司 | 人tdp-43的单抗包被酶标板的制法及elisa检测试剂盒 |
| EP3964524A1 (en) | 2011-10-28 | 2022-03-09 | Biogen International Neuroscience GmbH | Tdp-43 specific binding molecules |
-
2012
- 2012-10-26 EP EP21173838.0A patent/EP3964524A1/en not_active Withdrawn
- 2012-10-26 ES ES12824769T patent/ES2883212T3/es active Active
- 2012-10-26 US US14/354,404 patent/US9587014B2/en not_active Expired - Fee Related
- 2012-10-26 MY MYPI2014001180A patent/MY167795A/en unknown
- 2012-10-26 CN CN201280064098.6A patent/CN104159918B/zh not_active Expired - Fee Related
- 2012-10-26 PH PH1/2014/500940A patent/PH12014500940A1/en unknown
- 2012-10-26 SG SG11201401735WA patent/SG11201401735WA/en unknown
- 2012-10-26 AU AU2012327211A patent/AU2012327211C9/en not_active Ceased
- 2012-10-26 EP EP12824769.9A patent/EP2771359B1/en active Active
- 2012-10-26 WO PCT/IB2012/002905 patent/WO2013061163A2/en not_active Ceased
- 2012-10-26 CA CA3112082A patent/CA3112082A1/en active Pending
- 2012-10-26 BR BR112014010161-2A patent/BR112014010161B1/pt not_active IP Right Cessation
- 2012-10-26 CA CA2853412A patent/CA2853412C/en active Active
- 2012-10-26 KR KR1020147014139A patent/KR101961508B1/ko not_active Expired - Fee Related
- 2012-10-26 EA EA201490825A patent/EA032003B1/ru unknown
- 2012-10-26 MX MX2014005048A patent/MX357678B/es active IP Right Grant
- 2012-10-26 KR KR1020187035073A patent/KR102032080B1/ko not_active Expired - Fee Related
- 2012-10-26 JP JP2014537750A patent/JP6240611B2/ja not_active Expired - Fee Related
-
2014
- 2014-04-24 IL IL23221914A patent/IL232219B/en active IP Right Grant
- 2014-04-25 CL CL2014001074A patent/CL2014001074A1/es unknown
- 2014-04-25 MX MX2018008680A patent/MX2018008680A/es unknown
- 2014-05-20 ZA ZA2014/03680A patent/ZA201403680B/en unknown
-
2016
- 2016-11-04 US US15/343,450 patent/US10259866B2/en active Active
-
2017
- 2017-06-28 JP JP2017126314A patent/JP6417451B2/ja not_active Expired - Fee Related
-
2018
- 2018-09-19 JP JP2018174683A patent/JP6652609B2/ja not_active Expired - Fee Related
-
2019
- 2019-02-25 US US16/284,602 patent/US11091540B2/en not_active Expired - Fee Related
- 2019-10-28 IL IL270223A patent/IL270223B/en active IP Right Grant
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