BR112014010664A2 - uso de um anticorpo anti-alfa-sinucleína para diagnosticar um nível elevado de alfa-sinucleína no cérebro - Google Patents
uso de um anticorpo anti-alfa-sinucleína para diagnosticar um nível elevado de alfa-sinucleína no cérebroInfo
- Publication number
- BR112014010664A2 BR112014010664A2 BR112014010664A BR112014010664A BR112014010664A2 BR 112014010664 A2 BR112014010664 A2 BR 112014010664A2 BR 112014010664 A BR112014010664 A BR 112014010664A BR 112014010664 A BR112014010664 A BR 112014010664A BR 112014010664 A2 BR112014010664 A2 BR 112014010664A2
- Authority
- BR
- Brazil
- Prior art keywords
- synuclein
- brain
- diagnose
- antibody
- high level
- Prior art date
Links
- 210000004556 brain Anatomy 0.000 title abstract 8
- 102000003802 alpha-Synuclein Human genes 0.000 title abstract 6
- 108090000185 alpha-Synuclein Proteins 0.000 title abstract 6
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 210000002381 plasma Anatomy 0.000 abstract 2
- 102000019355 Synuclein Human genes 0.000 abstract 1
- 108050006783 Synuclein Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/38—Pediatrics
- G01N2800/385—Congenital anomalies
- G01N2800/387—Down syndrome; Trisomy 18; Trisomy 13
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Neurology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Neurosurgery (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161554924P | 2011-11-02 | 2011-11-02 | |
| PCT/US2012/062430 WO2013066818A1 (en) | 2011-11-02 | 2012-10-29 | USE OF AN ANTI-α-SYNUCLEIN ANTIBODY TO DIAGNOSE AN ELEVATED LEVEL OF α-SYNUCLEIN IN THE BRAIN |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014010664A2 true BR112014010664A2 (pt) | 2017-04-25 |
Family
ID=48192661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014010664A BR112014010664A2 (pt) | 2011-11-02 | 2012-10-29 | uso de um anticorpo anti-alfa-sinucleína para diagnosticar um nível elevado de alfa-sinucleína no cérebro |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20140295465A1 (enExample) |
| EP (1) | EP2773957B1 (enExample) |
| JP (1) | JP6263473B2 (enExample) |
| KR (1) | KR102036938B1 (enExample) |
| CN (2) | CN107091931A (enExample) |
| AU (1) | AU2012332814B2 (enExample) |
| BR (1) | BR112014010664A2 (enExample) |
| CA (1) | CA2854131C (enExample) |
| EA (1) | EA034213B1 (enExample) |
| IL (1) | IL232373B (enExample) |
| MX (1) | MX356797B (enExample) |
| WO (1) | WO2013066818A1 (enExample) |
| ZA (1) | ZA201403879B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010069603A1 (en) | 2008-12-19 | 2010-06-24 | Neurimmune Therapeutics Ag | Human anti-alpha-synuclein autoantibodies |
| LT2723379T (lt) | 2011-06-23 | 2018-10-25 | Biogen International Neuroscience Gmbh | Anti-alfa sinukleiną rišančios molekulės |
| JP2017536102A (ja) | 2014-10-16 | 2017-12-07 | ジェネンテック， インコーポレイテッド | 抗アルファ−シヌクレイン抗体及び使用方法 |
| JP6273338B1 (ja) * | 2016-12-05 | 2018-01-31 | 磁量生技股▲ふん▼有限公司 | パーキンソン病からパーキンソン病認知症を特定する方法 |
| WO2018128454A1 (ko) * | 2017-01-06 | 2018-07-12 | 에이비엘바이오 주식회사 | 항 α-SYN 항체 및 그 용도 |
| MX2019008029A (es) | 2017-01-06 | 2019-12-11 | Abl Bio Inc | Anticuerpo anti-alfa-sinucleina y su uso. |
| KR102573778B1 (ko) | 2017-02-17 | 2023-08-31 | 브리스톨-마이어스 스큅 컴퍼니 | 알파-시뉴클레인에 대한 항체 및 그의 용도 |
| CN116731173A (zh) | 2017-12-14 | 2023-09-12 | Abl生物公司 | 抗a-syn/igf1r的双特异性抗体及其用途 |
| GB201803553D0 (en) | 2018-03-06 | 2018-04-18 | Univ Newcastle | Detection of pathological protein aggregation |
| WO2020009482A1 (ko) * | 2018-07-03 | 2020-01-09 | 에이비엘바이오 주식회사 | 항 알파-시누클레인 항체 및 그 용도 |
| EP3629021A1 (en) * | 2018-09-26 | 2020-04-01 | Euroimmun Medizinische Labordiagnostika AG | Diagnosis of a neuroautoimmune disease |
| KR102252879B1 (ko) * | 2019-11-15 | 2021-05-17 | 성균관대학교산학협력단 | 혈장 내 aimp2를 이용한 파킨슨 질환의 진단 방법, 이를 위한 조성물 및 이를 포함하는 키트 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
| FR2686087A1 (fr) | 1992-01-13 | 1993-07-16 | Inst Nat Sante Rech Med | Nouvel antigene lymphocytaire, anticorps correspondant et leurs applications. |
| WO1999050300A1 (en) * | 1998-03-30 | 1999-10-07 | The Trustees Of The University Of Pennsylvania | Method of identifying, diagnosing and treating synuclein positive neurodegenerative disorders |
| CN1440420A (zh) * | 2000-07-07 | 2003-09-03 | 万能药制药公司 | 预防神经组织损伤和治疗α－共核蛋白疾病的方法 |
| GB0203446D0 (en) * | 2002-02-14 | 2002-04-03 | Univ Lancaster | Detection and/or monitoring of synuclein-related diseases |
| US20080300204A1 (en) * | 2005-07-19 | 2008-12-04 | University Of Rochester | Alpha-Synuclein Antibodies and Methods Related Thereto |
| US8906367B2 (en) | 2007-01-05 | 2014-12-09 | University Of Zurich | Method of providing disease-specific binding molecules and targets |
| CN101308144A (zh) * | 2007-05-16 | 2008-11-19 | 首都医科大学宣武医院 | 检测受试者体液内疾病相关蛋白聚合能力的方法 |
| JP5747414B2 (ja) * | 2008-04-29 | 2015-07-15 | バイオアークティック ニューロサイエンス アーベー | α−シヌクレイン関連疾患についての治療および診断方法における使用のための抗体およびワクチン |
| WO2010069603A1 (en) * | 2008-12-19 | 2010-06-24 | Neurimmune Therapeutics Ag | Human anti-alpha-synuclein autoantibodies |
| CN101692092B (zh) * | 2009-09-24 | 2013-04-10 | 首都医科大学宣武医院 | 定量检测人血清中自体α-突触核蛋白抗体的方法 |
-
2012
- 2012-10-29 WO PCT/US2012/062430 patent/WO2013066818A1/en not_active Ceased
- 2012-10-29 EA EA201490883A patent/EA034213B1/ru unknown
- 2012-10-29 KR KR1020147014713A patent/KR102036938B1/ko not_active Expired - Fee Related
- 2012-10-29 EP EP12846452.6A patent/EP2773957B1/en active Active
- 2012-10-29 MX MX2014005378A patent/MX356797B/es active IP Right Grant
- 2012-10-29 BR BR112014010664A patent/BR112014010664A2/pt not_active Application Discontinuation
- 2012-10-29 AU AU2012332814A patent/AU2012332814B2/en not_active Ceased
- 2012-10-29 CN CN201710252366.1A patent/CN107091931A/zh active Pending
- 2012-10-29 JP JP2014540007A patent/JP6263473B2/ja not_active Expired - Fee Related
- 2012-10-29 US US14/355,743 patent/US20140295465A1/en not_active Abandoned
- 2012-10-29 CA CA2854131A patent/CA2854131C/en active Active
- 2012-10-29 CN CN201280065165.6A patent/CN104040342A/zh active Pending
-
2014
- 2014-04-30 IL IL232373A patent/IL232373B/en active IP Right Grant
- 2014-05-27 ZA ZA2014/03879A patent/ZA201403879B/en unknown
-
2017
- 2017-01-19 US US15/409,671 patent/US20180011112A1/en not_active Abandoned
-
2018
- 2018-05-16 US US15/981,691 patent/US20190094245A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2014005378A (es) | 2015-01-19 |
| AU2012332814A1 (en) | 2014-06-12 |
| US20180011112A1 (en) | 2018-01-11 |
| EP2773957B1 (en) | 2017-11-29 |
| CA2854131A1 (en) | 2013-05-10 |
| US20190094245A1 (en) | 2019-03-28 |
| CA2854131C (en) | 2020-07-07 |
| ZA201403879B (en) | 2018-11-28 |
| EP2773957A1 (en) | 2014-09-10 |
| AU2012332814B2 (en) | 2017-12-14 |
| CN107091931A (zh) | 2017-08-25 |
| EA201490883A1 (ru) | 2014-10-30 |
| KR102036938B1 (ko) | 2019-10-25 |
| HK1201585A1 (en) | 2015-09-04 |
| CN104040342A (zh) | 2014-09-10 |
| IL232373B (en) | 2018-08-30 |
| EA034213B1 (ru) | 2020-01-17 |
| JP2014533357A (ja) | 2014-12-11 |
| WO2013066818A1 (en) | 2013-05-10 |
| US20140295465A1 (en) | 2014-10-02 |
| JP6263473B2 (ja) | 2018-01-31 |
| MX356797B (es) | 2018-06-14 |
| EP2773957A4 (en) | 2015-06-24 |
| KR20140095074A (ko) | 2014-07-31 |
| NZ625217A (en) | 2016-07-29 |
| IL232373A0 (en) | 2014-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112014010664A2 (pt) | uso de um anticorpo anti-alfa-sinucleína para diagnosticar um nível elevado de alfa-sinucleína no cérebro | |
| BRPI1015088A2 (pt) | peptídeo antigênio ou um fragmento funcional deste, composição farmacêutica, métodos para o tratamento de uma doença ou distúrbio neurodegenerativos tal como tauopatia, para induzir uma resposta imune em um animal, para diagnosticar uma doença, distúrbio ou condição e uma predisposição a doença, distúrbio ou condição, para monitorar a doença residual mínima em um paciente e para prever a receptividade de um paciente, anticorpo, kit de teste, epítopo e linha celular. | |
| BR112013033258A2 (pt) | moléculas de ligação de anti-alfa sinucleína | |
| ECSP16060104A (es) | Anticuerpo pd-1, fragmento de unión al antígeno de este y uso médico de este | |
| BR112018074978A2 (pt) | anticorpos para alfa-sinucleína e usos dos mesmos | |
| BR112012007365A2 (pt) | proteínas de ligação à il-1 | |
| CY1116584T1 (el) | Ανθρωπινα αυτοαντισωματα αντι-αλφα-συνουκλεϊνης | |
| BR112014008382A2 (pt) | anticorpo especificamente ligando a epítope no domínio sema do c-met | |
| ECSP11011239A (es) | Proteínas ligadoras il-1 | |
| CL2007000478A1 (es) | Anticuerpo humano o humanizado o fragmento funcional del mismo especifico para linfopoyetina estromal timica, tslp; polinucleotido que lo codifica; celula huesped que lo comprende; composicion farmaceutica que comprende al anticuerpo; y metodo para t | |
| BRPI0916624A2 (pt) | anticorpos monoclonais seletivos anti-hepcidina-25, seus usos, bem como método e kit para quantificar a quantidade de proteína hepcidina-25 em uma amostra de tecido ou fluido biológico | |
| BRPI0914925A2 (pt) | peptídeo cíclico, uso de um peptídeo, métodos para produzir um peptídeo cíclico e para diagnosticar uma doença ou condição, e, anticorpo | |
| ECSP10010322A (es) | Anticuerpos contra el virus de la influenza y métodos de uso de los mismos | |
| WO2011142827A3 (en) | Diagnostic markers for neuropsychiatric disease | |
| UA115439C2 (uk) | Гуманізоване антитіло, яке розпізнає альфа-синуклеїн | |
| WO2012154944A3 (en) | Methods of treating autophagy-associated disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits | |
| BR112015017403A2 (pt) | biomarcadores de terapia de combinação de anti-tnf e anti-il17 para doença inflamatória | |
| BR112015013312A2 (pt) | método para reduzir placas amiloides do cérebro usando anticorpos anti-abeta | |
| BR112015012708A2 (pt) | anticorpos para bmp-6 | |
| CL2011002416A1 (es) | Uso de un anticuerpo anti-il 17a y/o il-17f o fragmento que une antígeno del mismo que sirve en la preparación de un medicamento para el tratamiento de un trastorno de resistencia a insulina en un mamifero; kit. | |
| BR112013003279A2 (pt) | “métodos para tratar uma doença, método para neutralizar ou bloquear a atividade de il-1ß e/ou il-18, anticorpo, usos de um anticorpo e usos de um anticorpo monoclonal” | |
| JP2014533357A5 (enExample) | ||
| BRPI0706575B8 (pt) | uso colágeno de tipo v ou um componente antigênico do mesmo, e, método para identificar um paciente em espera de transplante de pulmão para um risco aumentado de rejeição de tecido de órgão transplantado. | |
| WO2011100396A3 (en) | Serum clusterin levels in systemic amyloidosis featuring cardiomyopathy | |
| CO6602134A2 (es) | Proteinas de union a antigeno especificas para componente amiloide serico p |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B25D | Requested change of name of applicant approved |
Owner name: BIOGEN INTERNATIONAL NEUROSCIENCE GMBH (CH) |
|
| B25G | Requested change of headquarter approved |
Owner name: BIOGEN INTERNATIONAL NEUROSCIENCE GMBH (CH) |
|
| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI. |
|
| B25G | Requested change of headquarter approved |
Owner name: BIOGEN INTERNATIONAL NEUROSCIENCE GMBH (CH) |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |
|
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |