BRPI0706575B8 - uso colágeno de tipo v ou um componente antigênico do mesmo, e, método para identificar um paciente em espera de transplante de pulmão para um risco aumentado de rejeição de tecido de órgão transplantado. - Google Patents
uso colágeno de tipo v ou um componente antigênico do mesmo, e, método para identificar um paciente em espera de transplante de pulmão para um risco aumentado de rejeição de tecido de órgão transplantado.Info
- Publication number
- BRPI0706575B8 BRPI0706575B8 BRPI0706575A BRPI0706575A BRPI0706575B8 BR PI0706575 B8 BRPI0706575 B8 BR PI0706575B8 BR PI0706575 A BRPI0706575 A BR PI0706575A BR PI0706575 A BRPI0706575 A BR PI0706575A BR PI0706575 B8 BRPI0706575 B8 BR PI0706575B8
- Authority
- BR
- Brazil
- Prior art keywords
- collagen
- type
- autoimmune response
- sample
- lung
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/12—Pulmonary diseases
Abstract
métodos para avaliar doença pulmonar, e para identificar pacientes sob risco aumentado de rejeição de tecido de órgão transplantado e de desenvolvimento de síndrome de bronquiolite obliterante, uso de pelo menos um composto que suprime a resposta autoimune, kit para avaliar doença pulmonar, e, composto que suprime a resposta autoimune. várias modalidades incluem métodos para diagnosticar e tratar condições médicas que envolvem uma resposta autoimune ao tecido conjuntivo, tal como colágeno encontrado em órgãos, tal como pulmão. em um método, distúrbios e doença pulmonar, tal como fibrose pulmonar idiopática (ipf), são diagnosticados pela análise de amostras de fluido ou de tecido obtidas de um paciente para evidência de uma resposta autoimune a vários tipos de colágeno incluindo, por exemplo, tipo v. um tipo de ensaio para evidência de uma resposta autoimune ao colágeno de tipo v compreende as etapas de obter uma amostra de fluido ou de tecido de um paciente, contatar pelo menos uma porção da amostra com um antígeno para o anticorpo anti-colágeno de tipo v e monitorar a mistura de amostra e antígeno para mudanças indicativas da presença de anti-colágeno e tipo v na amostra. outra modalidade inclui tratar doenças pulmonares tal como ipf pela administração de uma dose terapeuticamente efetiva de epítopos de vários colágenos incluindo colágeno de tipo v.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75919506P | 2006-01-13 | 2006-01-13 | |
| US60/759195 | 2006-01-13 | ||
| PCT/US2007/060533 WO2007120947A1 (en) | 2006-01-13 | 2007-01-13 | Molecules for the treatment of lung disease involving an immune reaction to connective tissue found in the lung |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0706575A2 BRPI0706575A2 (pt) | 2011-04-05 |
| BRPI0706575B1 BRPI0706575B1 (pt) | 2018-12-11 |
| BRPI0706575B8 true BRPI0706575B8 (pt) | 2021-05-25 |
Family
ID=38609836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0706575A BRPI0706575B8 (pt) | 2006-01-13 | 2007-01-13 | uso colágeno de tipo v ou um componente antigênico do mesmo, e, método para identificar um paciente em espera de transplante de pulmão para um risco aumentado de rejeição de tecido de órgão transplantado. |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7759075B2 (pt) |
| EP (2) | EP1977234B1 (pt) |
| JP (2) | JP5030973B2 (pt) |
| CN (1) | CN101375157B (pt) |
| AU (1) | AU2007238533C1 (pt) |
| BR (1) | BRPI0706575B8 (pt) |
| CA (2) | CA2965211C (pt) |
| HK (1) | HK1126861A1 (pt) |
| WO (1) | WO2007120947A1 (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101375157B (zh) * | 2006-01-13 | 2015-06-17 | 印第安纳大学研究和科技公司 | 用于治疗涉及对肺中存在的结缔组织自身免疫反应的肺病的分子 |
| EP3536325A1 (en) * | 2006-11-28 | 2019-09-11 | University Of Southern California | Method for promoting wound healing |
| JP2012518001A (ja) * | 2009-02-13 | 2012-08-09 | インディアナ ユニバーシティ リサーチ アンド テクノロジー コーポレイション | Ｍｍｐ２およびｍｍｐ９を阻害する化合物および方法 |
| CA2759611C (en) * | 2009-04-22 | 2018-11-13 | Indiana University Research And Technology Corporation | Compositions and methods for the treatment of chronic obstructive pulmonary disease and asthma |
| PT2496720T (pt) | 2009-11-06 | 2020-10-12 | Univ Leland Stanford Junior | Diagnóstico não-invasivo de rejeição de enxertos em pacientes sujeitos a transplantes de órgãos |
| EP2715353B1 (en) * | 2011-05-31 | 2016-08-24 | IDEXX Laboratories, Inc. | DETECTION OF DEGRADATION PRODUCTS OF FELINE NT-proBNP |
| CN107099581B (zh) * | 2012-03-27 | 2021-07-13 | 弗·哈夫曼-拉罗切有限公司 | 预测、诊断和治疗特发性肺纤维化的方法 |
| JP6058354B2 (ja) * | 2012-11-02 | 2017-01-11 | 東芝メディカルシステムズ株式会社 | 画像処理装置及び画像処理方法 |
| JP6312054B2 (ja) * | 2013-11-06 | 2018-04-18 | 学校法人日本大学 | 間質性肺炎のバイオマーカー |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444879A (en) * | 1981-01-29 | 1984-04-24 | Science Research Center, Inc. | Immunoassay with article having support film and immunological counterpart of analyte |
| ATE142344T1 (de) * | 1990-11-20 | 1996-09-15 | Behringwerke Ag | Immunotest für cyclosporin |
| US6911220B1 (en) * | 1992-02-19 | 2005-06-28 | The General Hospital Corporation | Allogeneic and xenogeneic transplantation |
| JP2702354B2 (ja) * | 1992-05-11 | 1998-01-21 | 帝人株式会社 | 血中の肺組織障害マーカー |
| US5778875A (en) * | 1996-05-06 | 1998-07-14 | U.S. Divers Co., Inc. | First stage regulator and rotatable in-line valve |
| AUPO026596A0 (en) * | 1996-06-05 | 1996-06-27 | Biomolecular Research Institute Limited | Viral peptide |
| US5962025A (en) | 1996-07-16 | 1999-10-05 | The University Of Tennessee Research Corporation | Method for treatment of systemic sclerosis and related fibrotic diseases |
| US5990274A (en) * | 1997-11-25 | 1999-11-23 | Dade Behring Inc. | Cyclosporine derivatives and uses thereof |
| UA74141C2 (uk) * | 1998-12-09 | 2005-11-15 | Дж.Д. Сірл Енд Ко. | Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти) |
| CA2398467C (en) * | 2000-01-31 | 2010-06-29 | Asahi Kasei Kabushiki Kaisha | Antibody for detecting chlamydia pneumoniae |
| US7348005B2 (en) * | 2000-03-15 | 2008-03-25 | Advanced Research And Technology Institute | Oral tolerance induction by collagen to prevent allograft rejection |
| BR0109455A (pt) * | 2000-03-23 | 2003-06-03 | Akzo Nobel Nv | Uso de mia e/ou seus fragmentos, método para tratar mamìferos sofrendo de, ou susceptìvel a, uma doença inflamatória, peptìdeo, composição farmacêutica, e, uso dos peptìdeos |
| JP2002220343A (ja) * | 2001-01-26 | 2002-08-09 | Toray Ind Inc | びまん性肺疾患延命剤 |
| AU2005234006A1 (en) * | 2004-04-08 | 2005-10-27 | Janssen Pharmaceutica N.V. | Immunohistochemical detection method of collagen in a tissue sample |
| AU2006315428B2 (en) | 2005-11-16 | 2011-12-01 | The University Of Tennessee Research Foundation | Methods of treating fibrosing diseases by induction of immune tolerance |
| CN101375157B (zh) * | 2006-01-13 | 2015-06-17 | 印第安纳大学研究和科技公司 | 用于治疗涉及对肺中存在的结缔组织自身免疫反应的肺病的分子 |
-
2007
- 2007-01-13 CN CN200780003133.2A patent/CN101375157B/zh active Active
- 2007-01-13 EP EP07756361.7A patent/EP1977234B1/en active Active
- 2007-01-13 CA CA2965211A patent/CA2965211C/en active Active
- 2007-01-13 BR BRPI0706575A patent/BRPI0706575B8/pt active IP Right Grant
- 2007-01-13 WO PCT/US2007/060533 patent/WO2007120947A1/en active Search and Examination
- 2007-01-13 JP JP2008550549A patent/JP5030973B2/ja active Active
- 2007-01-13 CA CA2641318A patent/CA2641318C/en active Active
- 2007-01-13 AU AU2007238533A patent/AU2007238533C1/en active Active
- 2007-01-13 EP EP13175642.1A patent/EP2672266B1/en not_active Not-in-force
-
2008
- 2008-07-11 US US12/171,661 patent/US7759075B2/en active Active
-
2009
- 2009-07-03 HK HK09105954.4A patent/HK1126861A1/xx unknown
-
2010
- 2010-06-25 US US12/823,570 patent/US7939281B2/en active Active
-
2011
- 2011-04-07 US US13/082,203 patent/US8039225B2/en active Active
- 2011-12-27 JP JP2011285617A patent/JP5936349B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2965211A1 (en) | 2007-10-25 |
| JP5936349B2 (ja) | 2016-06-22 |
| US8039225B2 (en) | 2011-10-18 |
| AU2007238533B2 (en) | 2012-09-20 |
| EP2672266B1 (en) | 2018-08-01 |
| JP5030973B2 (ja) | 2012-09-19 |
| US20110020838A1 (en) | 2011-01-27 |
| JP2009524023A (ja) | 2009-06-25 |
| BRPI0706575A2 (pt) | 2011-04-05 |
| CA2641318A1 (en) | 2007-10-25 |
| AU2007238533C1 (en) | 2013-08-15 |
| US20110183356A1 (en) | 2011-07-28 |
| US7939281B2 (en) | 2011-05-10 |
| EP2672266A3 (en) | 2014-02-05 |
| CN101375157A (zh) | 2009-02-25 |
| CA2641318C (en) | 2017-06-20 |
| WO2007120947A1 (en) | 2007-10-25 |
| CA2965211C (en) | 2020-06-30 |
| CN101375157B (zh) | 2015-06-17 |
| US7759075B2 (en) | 2010-07-20 |
| BRPI0706575B1 (pt) | 2018-12-11 |
| JP2012108137A (ja) | 2012-06-07 |
| EP1977234A4 (en) | 2009-06-03 |
| EP1977234B1 (en) | 2015-11-04 |
| EP2672266A2 (en) | 2013-12-11 |
| AU2007238533A1 (en) | 2007-10-25 |
| HK1126861A1 (en) | 2009-09-11 |
| EP1977234A1 (en) | 2008-10-08 |
| US20090017013A1 (en) | 2009-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B25G | Requested change of headquarter approved |
Owner name: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORA |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 11/12/2018, OBSERVADAS AS CONDICOES LEGAIS. |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 13/01/2007 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B15V | Prolongation of time limit allowed |