JP2018109050A5 - - Google Patents
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- JP2018109050A5 JP2018109050A5 JP2018034436A JP2018034436A JP2018109050A5 JP 2018109050 A5 JP2018109050 A5 JP 2018109050A5 JP 2018034436 A JP2018034436 A JP 2018034436A JP 2018034436 A JP2018034436 A JP 2018034436A JP 2018109050 A5 JP2018109050 A5 JP 2018109050A5
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- FUXJMHXHGDAHPD-UHFFFAOYSA-N pyrimidine-2-carboxamide Chemical class NC(=O)C1=NC=CC=N1 FUXJMHXHGDAHPD-UHFFFAOYSA-N 0.000 claims 5
- 229910004673 OPr Inorganic materials 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 4
- 239000001226 triphosphate Substances 0.000 claims 4
- 125000002103 4,4'-dimethoxytriphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 3
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 235000011178 triphosphate Nutrition 0.000 claims 3
- UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 claims 3
- 150000001540 azides Chemical class 0.000 claims 1
Claims (5)
- 以下の構造を持つＣ−５修飾アミノカルボニルピリミジン：
Ｒ’は、−Ｈ、−Ａｃ、−Ｂｚ、−Ｃ（Ｏ）ＣＨ２ＯＣＨ３および−ＳｉＭｅ２ｔＢｕからなる群より選択され；
Ｒ”は、Ｈ、ＤＭＴ、及び三リン酸（−Ｐ（Ｏ）（ＯＨ）−Ｏ−Ｐ（Ｏ）（ＯＨ）−Ｏ−Ｐ（Ｏ）（ＯＨ）２）又はその塩からなる群より選択され；
Ｘは、−Ｈ、−ＯＨ、−ＯＭｅ、−Ｏ−アリル、−Ｆ、−ＯＥｔ、−ＯＰｒ、−ＯＣＨ２ＣＨ２ＯＣＨ３、及び−アジドからなる群より選択され；
Ｒは、−（ＣＨ２）ｎ−ＲＸ１からなる群より選択され；
ＲＸ１は：
＊は、ＲＸ１基の（ＣＨ２）ｎへの付加点を示し；
ＲＸ４は、分岐鎖又は直鎖の低級アルキル（Ｃ１−Ｃ２０）からなる群より選択され；そして、
ｎ＝０〜１０である。 - 以下の構造を持つＣ−５修飾アミノカルボニルピリミジン：
Ｒ’は、−Ｈ、−Ａｃ、−Ｂｚ、−Ｃ（Ｏ）ＣＨ ２ ＯＣＨ ３ および−ＳｉＭｅ ２ ｔＢｕからなる群より選択され；
Ｒ”は、Ｈ、ＤＭＴ、及び三リン酸（−Ｐ（Ｏ）（ＯＨ）−Ｏ−Ｐ（Ｏ）（ＯＨ）−Ｏ−Ｐ（Ｏ）（ＯＨ） ２ ）又はその塩からなる群より選択され；
Ｘは、−Ｈ、−ＯＨ、−ＯＭｅ、−Ｏ−アリル、−Ｆ、−ＯＥｔ、−ＯＰｒ、−ＯＣＨ ２ ＣＨ ２ ＯＣＨ ３ 、及び−アジドからなる群より選択され；
Ｒは、−（ＣＨ ２ ） ｎ −Ｒ Ｘ１ からなる群より選択され；
Ｒ Ｘ１ は：
＊は、Ｒ Ｘ１ 基の（ＣＨ ２ ） ｎ への付加点を示し；
Ｒ Ｘ４ は、分岐鎖又は直鎖の低級アルキル（Ｃ１−Ｃ２０）からなる群より選択され；そして、
ｎ＝０〜１０である。 - 以下の構造を持つＣ−５修飾アミノカルボニルピリミジンの３’−ホスホロアミダイト：
Ｒ”は、Ｈ、ＤＭＴ、及び三リン酸（−Ｐ（Ｏ）（ＯＨ）−Ｏ−Ｐ（Ｏ）（ＯＨ）−Ｏ−Ｐ（Ｏ）（ＯＨ）２）又はその塩からなる群より選択され；
Ｘは、−Ｈ、−ＯＨ、−ＯＭｅ、−Ｏ−アリル、−Ｆ、−ＯＥｔ、−ＯＰｒ、−ＯＣＨ２ＣＨ２ＯＣＨ３、及び−アジドからなる群より選択され；
Ｒは、−（ＣＨ２）ｎ−ＲＸ１からなる群より選択され；
ＲＸ１は：
＊は、ＲＸ１基の（ＣＨ２）ｎへの付加点を示し；
ＲＸ４は、分岐鎖又は直鎖の低級アルキル（Ｃ１−Ｃ２０）からなる群より選択され；そして、
ｎ＝０〜１０である。 - 以下の構造を持つＣ−５修飾アミノカルボニルピリミジンの５’−三リン酸：
Ｒ’は、−Ｈ、−Ａｃ、−Ｂｚ、−Ｃ（Ｏ）ＣＨ２ＯＣＨ３および−ＳｉＭｅ２ｔＢｕからなる群より選択され；
Ｘは、−Ｈ、−ＯＨ、−ＯＭｅ、−Ｏ−アリル、−Ｆ、−ＯＥｔ、−ＯＰｒ、−ＯＣＨ２ＣＨ２ＯＣＨ３、及び−アジドからなる群より選択され；
Ｒは、−（ＣＨ２）ｎ−ＲＸ１からなる群より選択され；
ＲＸ１は：
＊は、ＲＸ１基の（ＣＨ２）ｎへの付加点を示し；
ＲＸ４は、分岐鎖又は直鎖の低級アルキル（Ｃ１−Ｃ２０）からなる群より選択され；そして、
ｎ＝０〜１０である。 - ｎ＝０、１又は２である、請求項１から４のいずれかに記載されるＣ−５修飾アミノカルボニルピリミジン。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32314510P | 2010-04-12 | 2010-04-12 | |
| US61/323,145 | 2010-04-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016041782A Division JP6352324B2 (ja) | 2010-04-12 | 2016-03-04 | ５位修飾ピリミジンとその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018109050A JP2018109050A (ja) | 2018-07-12 |
| JP2018109050A5 true JP2018109050A5 (ja) | 2018-08-23 |
| JP7025818B2 JP7025818B2 (ja) | 2022-02-25 |
Family
ID=44798979
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013505029A Active JP6012591B2 (ja) | 2010-04-12 | 2011-04-12 | β−ＮＧＦに対するアプタマー及びβ−ＮＧＦ介在疾患及び障害の治療におけるその使用 |
| JP2013505056A Active JP5901610B2 (ja) | 2010-04-12 | 2011-04-12 | ５位修飾ピリミジンとその使用 |
| JP2016041782A Active JP6352324B2 (ja) | 2010-04-12 | 2016-03-04 | ５位修飾ピリミジンとその使用 |
| JP2018034436A Active JP7025818B2 (ja) | 2010-04-12 | 2018-02-28 | ５位修飾ピリミジンとその使用 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013505029A Active JP6012591B2 (ja) | 2010-04-12 | 2011-04-12 | β−ＮＧＦに対するアプタマー及びβ−ＮＧＦ介在疾患及び障害の治療におけるその使用 |
| JP2013505056A Active JP5901610B2 (ja) | 2010-04-12 | 2011-04-12 | ５位修飾ピリミジンとその使用 |
| JP2016041782A Active JP6352324B2 (ja) | 2010-04-12 | 2016-03-04 | ５位修飾ピリミジンとその使用 |
Country Status (23)
| Country | Link |
|---|---|
| US (7) | US20110275794A1 (ja) |
| EP (3) | EP2558478B1 (ja) |
| JP (4) | JP6012591B2 (ja) |
| KR (4) | KR20130043099A (ja) |
| CN (4) | CN107033204A (ja) |
| AR (1) | AR081452A1 (ja) |
| AU (2) | AU2011240774B2 (ja) |
| BR (2) | BR112012025872B8 (ja) |
| CA (3) | CA2793451A1 (ja) |
| CO (1) | CO6630139A2 (ja) |
| DK (1) | DK2558478T3 (ja) |
| EA (1) | EA022429B1 (ja) |
| ES (3) | ES2610159T3 (ja) |
| HK (2) | HK1201740A1 (ja) |
| IL (5) | IL222339A (ja) |
| MX (3) | MX2020003168A (ja) |
| MY (1) | MY160608A (ja) |
| NO (1) | NO2558478T3 (ja) |
| NZ (1) | NZ602618A (ja) |
| SG (3) | SG184089A1 (ja) |
| TW (6) | TWI505833B (ja) |
| UA (1) | UA105290C2 (ja) |
| WO (2) | WO2011130289A1 (ja) |
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