JP2018021037A5 - - Google Patents
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- Publication number
- JP2018021037A5 JP2018021037A5 JP2017148823A JP2017148823A JP2018021037A5 JP 2018021037 A5 JP2018021037 A5 JP 2018021037A5 JP 2017148823 A JP2017148823 A JP 2017148823A JP 2017148823 A JP2017148823 A JP 2017148823A JP 2018021037 A5 JP2018021037 A5 JP 2018021037A5
- Authority
- JP
- Japan
- Prior art keywords
- recombinant fsh
- pharmaceutical composition
- cell line
- sialylation
- sialyltransferase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 210000005260 human cell Anatomy 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 1
- 208000000509 infertility Diseases 0.000 claims 1
- 230000036512 infertility Effects 0.000 claims 1
- 231100000535 infertility Toxicity 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000009450 sialylation Effects 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019194476A JP7316905B2 (ja) | 2008-04-16 | 2019-10-25 | アルファ２，３－およびアルファ２，６－シアリル化を含む組換えｆｓｈ |
| JP2021175403A JP2022031652A (ja) | 2008-04-16 | 2021-10-27 | アルファ２，３－およびアルファ２，６－シアリル化を含む組換えｆｓｈ |
| JP2023215339A JP2024038000A (ja) | 2008-04-16 | 2023-12-21 | アルファ２，３－およびアルファ２，６－シアリル化を含む組換えｆｓｈ |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4542408P | 2008-04-16 | 2008-04-16 | |
| US61/045,424 | 2008-04-16 | ||
| EP08251528 | 2008-04-25 | ||
| EP08251528.9 | 2008-04-25 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016198588A Division JP6486310B2 (ja) | 2008-04-16 | 2016-10-07 | アルファ２，３−およびアルファ２，６−シアリル化を含む組換えｆｓｈ |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019194476A Division JP7316905B2 (ja) | 2008-04-16 | 2019-10-25 | アルファ２，３－およびアルファ２，６－シアリル化を含む組換えｆｓｈ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018021037A JP2018021037A (ja) | 2018-02-08 |
| JP2018021037A5 true JP2018021037A5 (cg-RX-API-DMAC7.html) | 2018-11-08 |
| JP6762916B2 JP6762916B2 (ja) | 2020-09-30 |
Family
ID=39717519
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011504527A Pending JP2011519359A (ja) | 2008-04-16 | 2009-04-16 | アルファ２，３−およびアルファ２，６−シアリル化を含む組換えｆｓｈ |
| JP2014262056A Pending JP2015120696A (ja) | 2008-04-16 | 2014-12-25 | アルファ２，３−およびアルファ２，６−シアリル化を含む組換えｆｓｈ |
| JP2016198588A Active JP6486310B2 (ja) | 2008-04-16 | 2016-10-07 | アルファ２，３−およびアルファ２，６−シアリル化を含む組換えｆｓｈ |
| JP2017148823A Active JP6762916B2 (ja) | 2008-04-16 | 2017-08-01 | アルファ２，３−およびアルファ２，６−シアリル化を含む組換えｆｓｈ |
| JP2019194476A Active JP7316905B2 (ja) | 2008-04-16 | 2019-10-25 | アルファ２，３－およびアルファ２，６－シアリル化を含む組換えｆｓｈ |
| JP2021175403A Pending JP2022031652A (ja) | 2008-04-16 | 2021-10-27 | アルファ２，３－およびアルファ２，６－シアリル化を含む組換えｆｓｈ |
| JP2023215339A Pending JP2024038000A (ja) | 2008-04-16 | 2023-12-21 | アルファ２，３－およびアルファ２，６－シアリル化を含む組換えｆｓｈ |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011504527A Pending JP2011519359A (ja) | 2008-04-16 | 2009-04-16 | アルファ２，３−およびアルファ２，６−シアリル化を含む組換えｆｓｈ |
| JP2014262056A Pending JP2015120696A (ja) | 2008-04-16 | 2014-12-25 | アルファ２，３−およびアルファ２，６−シアリル化を含む組換えｆｓｈ |
| JP2016198588A Active JP6486310B2 (ja) | 2008-04-16 | 2016-10-07 | アルファ２，３−およびアルファ２，６−シアリル化を含む組換えｆｓｈ |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019194476A Active JP7316905B2 (ja) | 2008-04-16 | 2019-10-25 | アルファ２，３－およびアルファ２，６－シアリル化を含む組換えｆｓｈ |
| JP2021175403A Pending JP2022031652A (ja) | 2008-04-16 | 2021-10-27 | アルファ２，３－およびアルファ２，６－シアリル化を含む組換えｆｓｈ |
| JP2023215339A Pending JP2024038000A (ja) | 2008-04-16 | 2023-12-21 | アルファ２，３－およびアルファ２，６－シアリル化を含む組換えｆｓｈ |
Country Status (29)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI488640B (zh) | 2008-04-16 | 2015-06-21 | Ferring Int Ct Sa | 藥學製劑 |
| TWI604850B (zh) | 2009-10-05 | 2017-11-11 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| EP2417982A1 (en) | 2010-07-30 | 2012-02-15 | Ferring B.V. | Stabilization of gonadotropins |
| WO2012016576A1 (en) * | 2010-08-04 | 2012-02-09 | Glycotope Gmbh | Improved recombinant human follicle-stimulating hormone |
| HRP20150968T4 (hr) | 2010-09-29 | 2023-11-10 | Ferring B.V. | Pripravak za uporabu za liječenje neplodnosti |
| KR101898302B1 (ko) | 2010-10-15 | 2018-09-13 | 제이씨알 파마 가부시키가이샤 | 당사슬의 비환원 말단이 만노오스 잔기인 당 단백질의 제조 방법 |
| CA2831486A1 (en) * | 2011-03-31 | 2012-10-04 | Ferring B.V. | Pharmaceutical preparation |
| AR090095A1 (es) | 2011-06-06 | 2014-10-22 | Ferring Bv | Preparacion farmaceutica que comprende hormona estimulante del foliculo recombinante |
| JO3092B1 (ar) | 2011-08-08 | 2017-03-15 | Ferring Bv | مركب لتحفيز مسيطر عليه للمبيض |
| AU2012340501A1 (en) * | 2011-12-19 | 2013-07-11 | Grifols, S.A. | Compositions, methods, and kits for preparing sialylated recombinant proteins |
| WO2013161958A1 (ja) * | 2012-04-27 | 2013-10-31 | 日本ケミカルリサーチ株式会社 | 新規な発現ベクター |
| EP2824176A1 (en) * | 2013-07-11 | 2015-01-14 | Siamed'xpress | Methods for producing sialylated therapeutic proteins |
| JP6652334B2 (ja) | 2014-05-31 | 2020-02-19 | Ｊｃｒファーマ株式会社 | ウリジンとｎ−アセチル−ｄ−マンノサミンとを含有する培地 |
| JP2018500934A (ja) * | 2014-12-22 | 2018-01-18 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｃｍｐ依存性シアリダーゼ活性 |
| ES2784625T3 (es) | 2015-04-17 | 2020-09-29 | Ferring Bv | FSH para el tratamiento de la infertilidad |
| EP3313859B1 (en) | 2015-06-26 | 2019-11-20 | Ferring BV | Methods of purification and/or viral inactivation |
| EP3205719A1 (en) * | 2016-02-15 | 2017-08-16 | CEVEC Pharmaceuticals GmbH | Cell lines for producing recombinant glycoproteins with di-antennary n-glycans, methods using the same, and recombinant glycoproteins |
| GB201603280D0 (en) | 2016-02-24 | 2016-04-13 | Ferring Bv | Stable liquid gonadotropin formulation |
| EP3382014A1 (en) * | 2017-03-29 | 2018-10-03 | CEVEC Pharmaceuticals GmbH | Recombinant glycoproteins with reduced antennary fucosylation |
| EP3441471A1 (en) | 2017-08-08 | 2019-02-13 | CEVEC Pharmaceuticals GmbH | Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines |
| AR112541A1 (es) | 2017-09-01 | 2019-11-06 | Ferring Bv | Composición para estimulación ovárica controlada con hef recombinante |
| EP3787667B1 (en) | 2018-04-30 | 2025-03-26 | Ferring B.V. | Composition for controlled ovarian stimulation |
| TWI846743B (zh) | 2018-10-17 | 2024-07-01 | 荷蘭商菲林公司 | 用於控制性卵巢刺激之組成物及方法 |
| US20220380785A1 (en) * | 2019-11-01 | 2022-12-01 | The University Of British Columbia | Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins |
| TW202237173A (zh) | 2020-12-09 | 2022-10-01 | 荷蘭商菲林公司 | 用於受控的卵巢刺激之組成物及方法 |
| US20250241993A1 (en) | 2022-04-01 | 2025-07-31 | Ferring B.V. | Mixed protocol for treatment of infertility |
| US20250333466A1 (en) | 2022-05-26 | 2025-10-30 | Ferring B.V. | Compositions and methods for treatment of infertility in males |
| AU2023302100A1 (en) | 2022-07-08 | 2025-01-02 | Ferring B.V. | Compositions and methods for intrauterine insemination (iui) |
| TW202504578A (zh) | 2023-07-20 | 2025-02-01 | 荷蘭商輝凌責任有限公司 | 緩釋載藥微粒 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1206302B (it) | 1987-06-26 | 1989-04-14 | Serono Cesare Ist Ricerca | Ormone follicolo-stimolante urinario |
| US5541083A (en) | 1989-10-24 | 1996-07-30 | The Regents Of The University Of California | Method for producing secretable glycosyltransferases and other golgi processing enzymes |
| EP1445322B2 (en) | 1995-06-15 | 2012-06-06 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| JP3559652B2 (ja) * | 1996-06-25 | 2004-09-02 | グローリー工業株式会社 | 売上精算システムの管理装置 |
| IL122732A0 (en) * | 1997-01-15 | 1998-08-16 | Akzo Nobel Nv | Liquid gonadotropin-containing formulation its preparation and a device containing same |
| JP2001507215A (ja) | 1997-01-16 | 2001-06-05 | サイテル コーポレイション | 組換え糖タンパク質のインビトロでの実用的なシアリル化 |
| JPH1111665A (ja) | 1997-06-28 | 1999-01-19 | Shibuya Kogyo Co Ltd | 無菌エア搬送コンベヤ装置 |
| TWI235158B (en) * | 1997-09-01 | 2005-07-01 | Kirin Brewery | Human thrombopoietin produced by human established cell lines, processes foe preparing the same, and pharmaceutical composition comprising the same |
| EP1176976B2 (en) | 1999-05-07 | 2015-10-21 | Laboratoires Serono SA | Use of lh administered in mid- or late-follicular phase for the treatment of anovulatory women |
| JP2002011665A (ja) | 2000-06-28 | 2002-01-15 | Sintokogio Ltd | ショットブラスト装置モニタシステム |
| IL140110A0 (en) | 2000-12-05 | 2002-02-10 | Applied Research Systems | Improvement of homogeneity and secretion of recombinant proteins in mammalian systems |
| EP1621549A3 (en) * | 2001-10-22 | 2006-03-01 | Applied Research Systems ARS Holding N.V. | Compositions of fsh with high sialylation degree and their use for the preparation of medicinaments |
| BR0213402A (pt) | 2001-10-29 | 2004-10-13 | Crucell Holland Bv | Métodos para identificar uma célula de mamìfero capaz de produzir uma molécula proteinácea, para selecionar uma célula de mamìfero capaz de produzir uma molécula proteinácea, para se obter uma célula de mamìfero a partir de uma população heterogênea de células, e para produzir uma molécula proteinácea, composição farmaceuticamente aceitável, eritropoietina recombinantemente produzida, usos de uma célula de mamìfero, da eritropoietina recombinantemente produzida, e de uma composição de moléculas semelhantes à eritropoietina, preparação farmacêutica, método para o tratamento preventivo e/ou terapêutico de um distúrbio, composição de moléculas semelhates à eritropoietina, métodos para produzir, em uma célula de mamìfero, moléculas proteináceas, para produzir uma fração enriquecida em uma molécula proteinácea, e para fracionar uma mistura que contém moléculas proteináceas, fração, e, usos de uma fração ou composição, e de eritropoietina recombinantemente produzìvel em uma célula de mamìfero |
| CA2468957C (en) | 2001-12-07 | 2011-07-12 | Crucell Holland B.V. | Methods of propagation of influenza virus in cell lines over expressing sialyl transferases |
| US20040248784A1 (en) * | 2003-06-03 | 2004-12-09 | Marco Filicori | Unitary combinations of FSH and hCG |
| US20080015142A1 (en) * | 2003-12-03 | 2008-01-17 | Defrees Shawn | Glycopegylated Follicle Stimulating Hormone |
| DK1711834T3 (da) | 2004-02-04 | 2010-11-29 | Centre Nat Rech Scient | Fremgangsmåde til screening af glycoform-specifikke antistoffer |
| CN1926242B (zh) | 2004-02-13 | 2013-01-16 | 格莱克托普有限公司 | 高活性糖蛋白加工条件及其有效生产方法 |
| TWI488640B (zh) | 2008-04-16 | 2015-06-21 | Ferring Int Ct Sa | 藥學製劑 |
| TWI604850B (zh) | 2009-10-05 | 2017-11-11 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| EP2417982A1 (en) | 2010-07-30 | 2012-02-15 | Ferring B.V. | Stabilization of gonadotropins |
| WO2012016575A1 (en) | 2010-08-03 | 2012-02-09 | King Saud University | Stoma coat |
| WO2012016576A1 (en) * | 2010-08-04 | 2012-02-09 | Glycotope Gmbh | Improved recombinant human follicle-stimulating hormone |
| HRP20150968T4 (hr) | 2010-09-29 | 2023-11-10 | Ferring B.V. | Pripravak za uporabu za liječenje neplodnosti |
| CA2831486A1 (en) | 2011-03-31 | 2012-10-04 | Ferring B.V. | Pharmaceutical preparation |
| AR090095A1 (es) | 2011-06-06 | 2014-10-22 | Ferring Bv | Preparacion farmaceutica que comprende hormona estimulante del foliculo recombinante |
| JO3092B1 (ar) | 2011-08-08 | 2017-03-15 | Ferring Bv | مركب لتحفيز مسيطر عليه للمبيض |
| US20170035854A1 (en) | 2014-04-18 | 2017-02-09 | Glycotope Gmbh | Controlled ovarian hyperstimulation with improved recombinant human follicle-stimulating hormone |
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2009
- 2009-04-15 TW TW098112483A patent/TWI488640B/zh active
- 2009-04-16 SI SI200932209T patent/SI4015527T1/sl unknown
- 2009-04-16 ES ES14178729.1T patent/ES2610277T3/es active Active
- 2009-04-16 LT LTEP16158141.8T patent/LT3045471T/lt unknown
- 2009-04-16 HU HUE16179121A patent/HUE068565T2/hu unknown
- 2009-04-16 EP EP16179121.5A patent/EP3098234B1/en active Active
- 2009-04-16 LT LTEP14178729.1T patent/LT2808340T/lt unknown
- 2009-04-16 CN CN201510933782.9A patent/CN105906702A/zh active Pending
- 2009-04-16 PT PT161791215T patent/PT3098234T/pt unknown
- 2009-04-16 PL PL16194925T patent/PL3144318T3/pl unknown
- 2009-04-16 PL PL16158141T patent/PL3045471T3/pl unknown
- 2009-04-16 BR BRPI0910461A patent/BRPI0910461B8/pt active IP Right Grant
- 2009-04-16 DK DK16194925.0T patent/DK3144318T3/da active
- 2009-04-16 ES ES16158141.8T patent/ES2629392T3/es active Active
- 2009-04-16 EP EP13193214.7A patent/EP2722339A1/en active Pending
- 2009-04-16 KR KR1020197022294A patent/KR102108377B1/ko active Active
- 2009-04-16 DK DK14178729.1T patent/DK2808340T3/en active
- 2009-04-16 LT LTEP21212873.0T patent/LT4015527T/lt unknown
- 2009-04-16 PT PT212128730T patent/PT4015527T/pt unknown
- 2009-04-16 PT PT141787291T patent/PT2808340T/pt unknown
- 2009-04-16 KR KR1020167012148A patent/KR20160056960A/ko not_active Ceased
- 2009-04-16 EP EP16194925.0A patent/EP3144318B1/en active Active
- 2009-04-16 HU HUE14178729A patent/HUE030652T4/en unknown
- 2009-04-16 AU AU2009237479A patent/AU2009237479B2/en active Active
- 2009-04-16 ES ES09733497.3T patent/ES2468318T3/es active Active
- 2009-04-16 DK DK16158141.8T patent/DK3045471T3/en active
- 2009-04-16 CA CA2725257A patent/CA2725257A1/en active Pending
- 2009-04-16 ES ES21212873T patent/ES3023526T3/es active Active
- 2009-04-16 JP JP2011504527A patent/JP2011519359A/ja active Pending
- 2009-04-16 HR HRP20241187TT patent/HRP20241187T1/hr unknown
- 2009-04-16 EP EP14178729.1A patent/EP2808340B1/en not_active Revoked
- 2009-04-16 DK DK16179121.5T patent/DK3098234T3/da active
- 2009-04-16 MX MX2010011343A patent/MX2010011343A/es active IP Right Grant
- 2009-04-16 SI SI200930931T patent/SI2268666T1/sl unknown
- 2009-04-16 NZ NZ588381A patent/NZ588381A/en unknown
- 2009-04-16 ES ES16179121T patent/ES2989729T3/es active Active
- 2009-04-16 SI SI200932094T patent/SI3144318T1/sl unknown
- 2009-04-16 MX MX2017007881A patent/MX355457B/es unknown
- 2009-04-16 PL PL16179121.5T patent/PL3098234T3/pl unknown
- 2009-04-16 US US12/988,218 patent/US8951967B2/en active Active
- 2009-04-16 CN CN200980121391XA patent/CN102066414A/zh active Pending
- 2009-04-16 HR HRP20140535AT patent/HRP20140535T1/hr unknown
- 2009-04-16 WO PCT/GB2009/000978 patent/WO2009127826A1/en not_active Ceased
- 2009-04-16 DK DK21212873.0T patent/DK4015527T3/da active
- 2009-04-16 PT PT161581418T patent/PT3045471T/pt unknown
- 2009-04-16 KR KR1020177026920A patent/KR20170110741A/ko not_active Ceased
- 2009-04-16 FI FIEP16179121.5T patent/FI3098234T3/fi active
- 2009-04-16 PL PL21212873.0T patent/PL4015527T3/pl unknown
- 2009-04-16 KR KR1020187023820A patent/KR20180095140A/ko not_active Ceased
- 2009-04-16 KR KR1020107025581A patent/KR101622944B1/ko active Active
- 2009-04-16 SI SI200931547A patent/SI2808340T1/sl unknown
- 2009-04-16 RU RU2010141908/10A patent/RU2537268C2/ru active
- 2009-04-16 HR HRP20250313TT patent/HRP20250313T1/hr unknown
- 2009-04-16 PL PL09733497T patent/PL2268666T3/pl unknown
- 2009-04-16 EP EP16158141.8A patent/EP3045471B1/en not_active Revoked
- 2009-04-16 EP EP09733497.3A patent/EP2268666B1/en not_active Revoked
- 2009-04-16 EP EP21212873.0A patent/EP4015527B1/en active Active
- 2009-04-16 RU RU2014141994A patent/RU2682270C2/ru active
- 2009-04-16 FI FIEP21212873.0T patent/FI4015527T3/fi active
- 2009-04-16 CN CN201510933827.2A patent/CN105906703A/zh active Pending
- 2009-04-16 SI SI200931670A patent/SI3045471T1/sl unknown
- 2009-04-16 LT LTEP16179121.5T patent/LT3098234T/lt unknown
- 2009-04-16 DK DK09733497.3T patent/DK2268666T3/da active
- 2009-04-16 PT PT97334973T patent/PT2268666E/pt unknown
- 2009-04-16 SI SI200932205T patent/SI3098234T1/sl unknown
- 2009-04-16 PT PT161949250T patent/PT3144318T/pt unknown
- 2009-04-16 PL PL14178729T patent/PL2808340T3/pl unknown
- 2009-04-16 MX MX2014011348A patent/MX348622B/es unknown
- 2009-04-16 HU HUE21212873A patent/HUE071059T2/hu unknown
- 2009-04-16 AR ARP090101333A patent/AR071479A1/es not_active Application Discontinuation
- 2009-04-16 HU HUE16158141A patent/HUE033830T2/en unknown
- 2009-04-18 SA SA109300228A patent/SA109300228B1/ar unknown
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2010
- 2010-10-07 IL IL208538A patent/IL208538A/en active Protection Beyond IP Right Term
- 2010-10-14 ZA ZA2010/07373A patent/ZA201007373B/en unknown
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2014
- 2014-01-21 IL IL230571A patent/IL230571A/en active IP Right Grant
- 2014-06-06 CY CY20141100402T patent/CY1115413T1/el unknown
- 2014-06-17 AU AU2014203277A patent/AU2014203277C1/en active Active
- 2014-11-14 US US14/541,852 patent/US9546204B2/en active Active
- 2014-12-25 JP JP2014262056A patent/JP2015120696A/ja active Pending
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2016
- 2016-08-16 US US15/238,362 patent/US9771407B2/en active Active
- 2016-10-07 JP JP2016198588A patent/JP6486310B2/ja active Active
- 2016-11-16 HR HRP20161520TT patent/HRP20161520T1/hr unknown
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2017
- 2017-05-30 HU HUS1700024C patent/HUS1700024I1/hu unknown
- 2017-05-31 HU HUS1700025C patent/HUS1700025I1/hu unknown
- 2017-06-05 LT LTPA2017018C patent/LTPA2017018I1/lt unknown
- 2017-06-06 FR FR17C1020C patent/FR17C1020I2/fr active Active
- 2017-06-06 NO NO2017025C patent/NO2017025I1/no unknown
- 2017-06-23 AU AU2017204258A patent/AU2017204258B2/en active Active
- 2017-06-23 AU AU2017204259A patent/AU2017204259B2/en active Active
- 2017-06-26 HR HRP20170958TT patent/HRP20170958T1/hr unknown
- 2017-08-01 JP JP2017148823A patent/JP6762916B2/ja active Active
- 2017-08-29 US US15/690,061 patent/US10995128B2/en active Active
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