JP2017532351A - がん治療のための医薬組成物の調製におけるデュロキセチン塩酸塩薬物の使用 - Google Patents
がん治療のための医薬組成物の調製におけるデュロキセチン塩酸塩薬物の使用 Download PDFInfo
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- JP2017532351A JP2017532351A JP2017522418A JP2017522418A JP2017532351A JP 2017532351 A JP2017532351 A JP 2017532351A JP 2017522418 A JP2017522418 A JP 2017522418A JP 2017522418 A JP2017522418 A JP 2017522418A JP 2017532351 A JP2017532351 A JP 2017532351A
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- cancer
- duloxetine hydrochloride
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Abstract
Description
各種がん細胞の作製
各種がん細胞株を継代培養した。これらのがん細胞の種類には、肺がん、胃がん、肝臓がん、直腸がん、皮膚がん、子宮頸がん、前立腺がん、膀胱がん、乳がん、白血病、すい臓がん、卵巣がん、舌がん、骨肉腫及び腎臓がんが含まれる。また、試験を行うための対象群としては、腎臓(HEK293(Kidney))及び肺上皮BEAS-2B(Lung Epithelial)の正常細胞を用いた(表1参照)。
96ウェルプレート中の培養液を除去した後、各ウェルに市販の薬物を濃度10μM、体積100μL添加し、72時間置いた。その後、各ウェルに希釈したWST−1溶液(希釈率は培養液とWST−1原液との体積比で9:1)100μLを加えた。よって各ウェルの最終的な体積は200μLとなった。その後、96ウェルプレートを37℃で30〜90分間置いた。そして、elisa reader(酵素結合免疫吸着検出器)を用いてOD450で吸光度を検出し、各がん細胞株の生存率を算出した。
胸部関連がん細胞に対するデュロキセチン塩酸塩の抑制効果の試験
「胸部関連がん細胞に対するデュロキセチン塩酸塩の抑制効果の試験」と題されたこの分析は、主に2種の肺がん細胞、即ちA549及びH1650がん細胞株に対して試験を行った。 各がん細胞の抑制実験を4回行い、平均値を計算した。その結果を以下の表2に示す。
「腹腔関連がん細胞に対するデュロキセチン塩酸塩の抑制効果の試験」と題されたこの分析は、主に、2種の腹腔関連がんに対して試験を行った。膀胱がん細胞株は、それぞれTSGH及びT24細胞株であった(表3)。子宮頸がん細胞株はそれぞれHeLa細胞株であった(表4)。腎臓がん細胞株は786‐O細胞株であった(表5)。各がん細胞の抑制実験を4回行い、平均値を計算した。結果を以下の表に示す。
「腹腔関連がん細胞に対するデュロキセチン塩酸塩の抑制効果の試験」と題されたこの分析は、主に3種の内分泌関連がんに対して試験を行った。前立腺がん細胞株は、それぞれPC‐3及びLNCap細胞株であった(表6)。乳がん細胞株は、それぞれMCF‐7及びMDA‐MB‐231細胞株であった(表7)。卵巣がん細胞株は、それぞれNIH‐OVCAR‐3及びTOV‐21G細胞株であった(表8)。各がん細胞の抑制実験を4回行い、平均値を計算した。結果を以下の表に示す。
「消化管関連がん細胞に対するデュロキセチン塩酸塩の抑制効果の試験」と題されたこの分析は、主に5種の消化管関連がんに対して行った。胃がん細胞株はそれぞれAGS及びMKN‐45細胞株であった(表9)。肝臓がん細胞株はそれぞれHepG2及びHep3B細胞株であった(表10)。大腸がん細胞株は、それぞれHCT116‐wt及びLoVo細胞株であった(表11)。すい臓がん細胞株は、それぞれAsPC及びBxPC細胞株であった(表12)。舌がん細胞株はSAS細胞株であった(表13)。各がん細胞の抑制実験を4回行い、平均値を計算した。結果を以下の表に示す。
他の種類のがんに対するデュロキセチン塩酸塩の分析を行った。 骨肉腫細胞株はU2OS細胞株であった(表14)。皮膚がん細胞株はそれぞれA375及びBCC細胞株であった(表15)。各がん細胞抑制実験を3回又は4回行い、平均値を計算した。結果を以下の表に示す。
正常細胞に対するデュロキセチン塩酸塩の抑制効果の試験
多種の正常細胞に対するデュロキセチン塩酸塩の分析を行った。正常腎臓細胞株はHEK293細胞株であった(表16)。正常肺上皮細胞株はBEAS‐2B細胞株であった(表17)。各細胞抑制実験を4回行い、平均値を計算した。結果を以下の表に示す。
この実験は、体重約21±1gの雌性BALB / cAnN.Cg-Foxn1nu / CrlNarlマウスをサンプルとして行った。肝臓がん細胞(HepG2)を皮下注射した後、正常対照群、低用量群(100mg/kg/日)、高用量群(200mg/kg/日)の3群に無作為に分けた。増殖した腫瘍が100mm3を超えた後、腹腔内注射によって毎日薬物投与した。そして、腫瘍の大きさを週に2回測定した。腫瘍の大きさを測定する数式は、(L×W2)であり、Lは腫瘍の最長直径を表し、Wは腫瘍の最短直径を表す。
各種がん細胞の作製
各種がん細胞株を継代培養した。これらのがん細胞の種類には、肺がん、胃がん、肝臓がん、大腸がん、皮膚がん、子宮頸がん、前立腺がん、膀胱がん、乳がん、白血病、すい臓がん、卵巣がん、舌がん、骨肉腫及び腎臓がんが含まれる。また、試験を行うための対象群としては、腎臓(HEK293(Kidney))及び肺上皮BEAS-2B(Lung Epithelial)の正常細胞を用いた(表1参照)。
「腹腔関連がん細胞に対するデュロキセチン塩酸塩の抑制効果の試験」と題されたこの分析は、主に、3種の腹腔関連がんに対して試験を行った。膀胱がん細胞株は、それぞれTSGH及びT24細胞株であった(表3)。子宮頸がん細胞株はそれぞれHeLa細胞株及びC‐33Aであった(表4)。腎臓がん細胞株は786‐O細胞株であった(表5)。各がん細胞の抑制実験を4回行い、平均値を計算した。結果を以下の表に示す。
「内分泌関連がん細胞に対するデュロキセチン塩酸塩の抑制効果の試験」と題されたこの分析は、主に3種の内分泌関連がんに対して試験を行った。前立腺がん細胞株は、それぞれPC‐3及びLNCap細胞株であった(表6)。乳がん細胞株は、それぞれMCF‐7及びMDA‐MB‐231細胞株であった(表7)。卵巣がん細胞株は、それぞれNIH‐OVCAR‐3及びTOV‐21G細胞株であった(表8)。各がん細胞の抑制実験を4回行い、平均値を計算した。結果を以下の表に示す。
「消化管関連がん細胞に対するデュロキセチン塩酸塩の抑制効果の試験」と題されたこの分析は、主に5種の消化管関連がんに対して行った。胃がん細胞株はそれぞれAGS及びMKN‐45細胞株であった(表9)。肝臓がん細胞株はそれぞれHepG2及びHep3B細胞株であった(表10)。大腸がん細胞株は、それぞれHCT116‐wt及びLoVo細胞株であった(表11)。すい臓がん細胞株は、それぞれAsPC‐1及びBxPC‐3細胞株であった(表12)。舌がん細胞株はSAS細胞株であった(表13)。各がん細胞の抑制実験を4回行い、平均値を計算した。結果を以下の表に示す。
この実験は、体重約21±1gの雌性BALB / cAnN.Cg-Foxn1nu / CrlNarlマウスをサンプルとして行った。肝臓がん細胞(HepG2)を皮下注射した後、正常対照群、低用量群(100mg/kg/日)、高用量群(200mg/kg/日)の3群に無作為に分けた。増殖した腫瘍が100mm3を超えた後、腹腔内注射によって毎日薬物投与した。そして、腫瘍の大きさを週に2回測定した。腫瘍の大きさを測定する数式は、(L×W2)/2であり、Lは腫瘍の最長直径を表し、Wは腫瘍の最短直径を表す。
Claims (8)
- がん治療のための医薬組成物の調製におけるデュロキセチン塩酸塩薬物の使用であって、前記医薬組成物は、有効用量のデュロキセチン塩酸塩及び医薬上許容される塩からなる群より選ばれることを特徴とする、デュロキセチン塩酸塩薬物の使用。
- 前記がんが、胸部関連がん、腹腔関連がん、内分泌関連がん又は消化管関連がんの内の1種以上のがんであることを特徴とする、請求項1に記載の使用。
- 前記がんが、骨肉腫関連がん、皮膚関連がん、白血病関連がんから選ばれる1種以上のがんであることを特徴とする請求項1に記載の使用。
- 前記胸部関連がんが肺がんであることを特徴とする請求項2に記載の使用。
- 前記腹腔関連がんが、膀胱がん又は/及び子宮頸がんであることを特徴とする請求項2に記載の使用。
- 前記内分泌関連がんが、前立腺がん、乳がん、卵巣がんから選ばれる1種以上のがんであることを特徴とする請求項2に記載の使用。
- 前記消化管関連がんが、胃がん、肝臓がん、大腸がん、すい臓がん、舌がんから選ばれる1種以上のがんであることを特徴とする請求項2に記載の使用。
- 前記有効用量が濃度にして20〜500mg/kg/日であることを特徴とする請求項1に記載の使用。
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