TW201615217A - 抗生素藥物臨床新應用 - Google Patents

抗生素藥物臨床新應用 Download PDF

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TW201615217A
TW201615217A TW104134908A TW104134908A TW201615217A TW 201615217 A TW201615217 A TW 201615217A TW 104134908 A TW104134908 A TW 104134908A TW 104134908 A TW104134908 A TW 104134908A TW 201615217 A TW201615217 A TW 201615217A
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antibiotic
hydrochloride
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cancer
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陳丘泓
莊秀美
蕭乃文
梁瑞岳
筱彤 陳
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朗齊生物醫學股份有限公司
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Abstract

本發明提供多種抗生素藥物的新臨床之應用。該多種抗生素藥物皆是經過衛生署通過核准上市的抗生素藥物。本發明提供多種抗生素藥物有效的抑制不同類型的癌細胞。

Description

抗生素藥物臨床新應用
本發明係為多種抗生素藥物的新適應症之應用，尤其該多種藥物為通過臨床實驗且具有抑制多種癌症之用途。
癌症長期高居全球死因之首，且罹患癌症人數更是逐年攀升，因此治療癌症儼然成為重要的課題。癌症的治療可區分為手術治療、放射線治療、化學治療及標靶治療。
一般來說，癌症藥物治療無論是化學治療或標靶治療，目的多是讓癌細胞無法複製、分裂，來阻斷腫瘤的蔓延擴張。在臨床治療選擇上，通常會結合一到數種化療藥物以及標靶治療，希望能藉由不同機制來殺死癌細胞以提高治療效果，但事實上，還是常遇到患者對於治療藥物的反應不佳。進一步，許多癌細胞相繼產生抗藥性，使藥物的使用成效大幅降低，最終導致癌症治療失敗。
抗生素(英語：antibiotic)由微生物(包括細菌、真菌、放線菌屬)所產生的具有抑制其它類微生物生長、生存的一類次級代謝產物，以及用化學方法合成或半合成的類似化合物。在 定義上是一較廣的概念，包括抗細菌抗生素、抗真菌抗生素以及對付其他微小病原之抗生素；但臨床實務中，抗生素常常是指抗細菌抗生素。
發明人依據長年的研究經驗，人類的癌症細胞常常 有與正常細胞具有不同的表現性狀，型態上的差異或是作用機轉的變化或許也有可能被視為一種外來的侵入者，而每一種癌症細胞所在的位置不同，變異的狀態又與所處的環境有關，因此，第一個提出使用抗生素藥物抑制癌症細胞的發明概念並且進行實驗。
相對的，在這些已經使用數十年抗生素，是早已被 FDA所認可的用藥，具有大量藥物機轉及人體研究成果資料，因此，若應用在癌症方面，這項新發展會更省時、減少成本，也能和其他治療方式結合來提高效果。
在發明人提出美國臨時申請案之後，亦有其他的教 授深入研究探討其可能性，近期亦陸續有相關的研究提出並證實發明人的發明內容，該教授根據內共生理論(Endosymbiotic Theory)提出相類似的假設，意即粒線體曾經是細菌，後來被大型細菌併吞後，在其細胞內與之共生，因此粒線體和一般細胞結構不太一樣，它有自己的基因，和原核生物(如細菌)比較接近。這種差異就也許就能被設計成像標靶治療一樣，單獨抑制癌症細胞的治療。
儘管如此，藥物開發依然是重要的醫學議題，必須經過繁複的臨床前試驗才能進入臨床試驗，根據統計，平均每一萬個新藥約只有五個能夠進入第一期臨床試驗。此外，除了藥物本身是否能大量製造的難題外，還需克服藥物安全性、病人篩選、試用劑量等問題，即便藥物已經通過FDA的核准並上市，亦有可能因上市後於人體發現不良反應而強制下架回收，由此可見藥物開發具有一定的困難程度。
為解決上述的問題，本發明係針對通過臨床實驗的多種藥物進行新適應症的研發，而達到老藥新用的目標。
經過實驗設計結果顯示抗生素藥物對正常細胞沒有或僅有微小的毒性，但至於抗生素在正常細胞與腫瘤細胞之間是否具有選擇性的影響，還待更多的研究釐清，而且並非所有的抗生素在相同的條件下均能有效的抑制腫瘤細胞，需要有許多的問題進行克服。
名詞定義
抗生素依據藥物的結構可以分為九大類，包含胺基配糖體抗生素、抗黴菌劑抗生素、頭孢子菌類抗生素、β-丙醯胺抗生素類、氯黴素抗生素、青黴素類抗生素、紅黴素類抗生素、四環 素類抗生素，與其他類。
1. 氨基糖苷類抗生素，氨基糖苷類抗生素是具有氨基 糖與氨基環醇結構的一類抗生素，在臨床主要用於對革蘭氏陰性菌、綠膿桿菌等感染的治療。本發明中的抗生素藥物包含在本類別的有Amikacin sulfate、Amikacin hydrate、Netilmicin Sulfate。
2. 抗黴菌劑抗生素，一系列抗黴菌的抗生素。本發 明中的抗生素藥物包含在本類別的有Posaconazole、Artemisinin、Fluconazole、Ketoconazole、Voriconazole、Natamycin(Pimaricin)、Clotrimazole(Canesten)、Amphotericin B(Abelcet)、Flucytosine(Ancobon)、Amorolfine Hydrochloride、Terbinafine(Lamisil,Terbinex)、Butoconazole nitrate、Chloroxine、Bifonazole、Tioconazole、Nystatin(Mycostatin)、Miconazole nitrate、Liranaftate、Isoconazole nitrate(Travogen)、Terbinafine hydrochloride(Lamisil)、Ciclopirox ethanolamine、Caspofungin acetate、Naftifine HCl、Sertaconazole nitrate、Pyrithione zinc、Sulconazole Nitrate、Climbazole、Valnemulin HCl。
3. 頭孢子菌類抗生素，頭孢菌素，又名先鋒霉素， 是一系列屬於β內醯胺類的抗生素。與頭黴素一併細分為頭孢烯。本發明中的抗生素藥物包含在本類別的有Cefdinir(Omnicef)、 Cefoperazone(Cefobid)、Cefditoren pivoxil、Cephalexin(Cefalexin)、Cefoselis sulfate、Ceftiofur hydrochloride、Cefaclor(Ceclor)、Ceftazidime Pentahydrate、Moxalactam Disodium、Cephapirin Sodium。
4. β-丙醯胺抗生素類，β-內醯胺類抗生素(Beta-lactam antibiotic)是一種種類很廣的抗生素，其中包括青黴素及其衍生物、頭孢菌素、單醯胺環類、碳青黴烯和青黴烯類酶抑制劑等。基本上所有在其分子結構中包括β-內醯胺核的抗生素均屬於β內醯胺類抗生素。它是現有的抗生素中使用最廣泛的一類。本發明中的抗生素藥物包含在本類別的有Doripenem Hydrate、Meropenem、Aztreonam、Sulbactam、Sulbactam sodium(Unasyn)、Biapenem。
5. 氯黴素抗生素，氯黴素有著很廣泛的活躍性，能有效對抗革蘭氏陽性菌，包括大部份的抗藥性金黃色葡萄球菌、革蘭氏陰性菌及厭氧性生物。本發明中的抗生素藥物包含在本類別的有Gatifloxacin、Daptomycin、Sulfapyridine(Dagenan)、Sulfameter(Bayrena)、Chloramphenicol(Chloromycetin)。
6. 青黴素類抗生素，青黴素(Penicillin，或音譯盤尼西林)是指分子中含有青黴烷、能破壞細菌的細胞壁並在細菌細 胞的繁殖期起殺菌作用的一類抗生素，是由青黴菌中提煉出的抗生素。青黴素屬於β-內醯胺類抗生素(β-lactams),β-內醯胺類抗生素包括青黴素、頭孢菌素、碳青黴烯類、單環類、頭黴素類等。 本發明中的抗生素藥物包含在本類別的有Amoxicillin sodium(Amox)、Ampicillin sodium、Carbenicillin disodium、Dicloxacillin Sodium、Ampicillin Trihydrate、Benzylpenicillin sodium、Mezlocillin Sodium、Piperacillin Sodium。
7. 紅黴素類抗生素，紅黴素(英文：Erythromycin)是一種大環內酯類的抗生素。抗菌範圍與青黴素相似；主要用於對青黴素已經產生耐藥性的葡萄球菌、鏈球菌、腹瀉等胃腸道反應。本發明中的抗生素藥物包含在本類別的有Teicoplanin、Linezolid(Zyvox)、Erythromycin(E-Mycin)、Erythromycin Ethylsuccinate、Spiramycin、Tilmicosin、Azithromycin Dihydrate、Dirithromycin、Fidaxomicin。
8. 四環素類抗生素，一個廣效抗生素(Broad-spectrum antibiotic)藥物家族的泛稱，因其氫化並四苯母核而得名。本類藥物抗菌譜廣，對革蘭氏陰性菌、革蘭氏陽性菌、螺旋體、衣原體、立克次氏體、支原體、放線菌和阿米巴原蟲都有較強的作用。本發明中的抗生素藥物包含在本類別的有 Marbofloxacin、Moxifloxacin hydrochloride、Oxytetracycline(Terramycin)、Tigecycline、Oxytetracycline dihydrate、Tetracycline HCl、Chlortetracycline HCl、Minocycline HCl、Rolitetracycline。
9. 其他類抗生素：Norfloxacin(Norxacin)、Enoxacin (Penetrex)、Pefloxacin mesylate、Sparfloxacin、Levofloxacin(Levaquin)、Sarafloxacin HCl、Nalidixic acid(NegGram)、Lomefloxacin hydrochloride(Maxaquin)、Enrofloxacin、Clinafloxacin(PD127391)、Orbifloxacin、Clinafoxacin HCl、Piromidic Acid、Cinoxacin、Difloxacin HC、Rifabutin(Mycobutin)、Rifapentine(Priftin)、Pyrazinamide(Pyrazinoic acid amide)、Rifampin(Rifadin,Rimactane)、Ethionamide、Rifaximin(Xifaxan)、Protionamide(Prothionamide)、Isoniazid(Tubizid)、D-Cycloserine、Streptomycin sulfate、Clofazimine、Nitrofurazone、Sulfanilamide、Sulfadiazine、Metronidazole(Flagyl)、Sulfamethoxazole、Sulfisoxazole、Sulfamethizole(Proklar)、Sulfadimethoxine、Clindamycin phosphate、Fenbendazole(Panacur)、Sulfadoxine(Sulphadoxine)、Secnidazole(Flagentyl)、Clindamycin palmitate HCl、Clindamycin、Sulfathiazole、Trimethoprim、Sulfamerazine、Pentamidine、Colistin Sulfate(polypeptide)、toltrazuril、tinidazoleMequinol、Bacitracin、 Cetylpyridinium Chloride、Sulfaguanidine、Paromomycin Sulfate、Domiphen Bromide、Chlorquinaldol、Furaltadone HCl、Primaquine Diphosphate、Carbadox、Colistimethate Sodium、Meclocycline Sulfosalicylate、Thiostrepton、Bekanamycin、Clofoctol、Ritonavir、Entecavir hydrate、Artemisinin、Megestrol Acetate、Lansoprazole、Lopinavir(ABT-378)、Ondansetron hydrochloride、Resveratrol、Stavudine、Tenofovir Disoproxil Fumarate、Tenofovir(Viread)、Cidofovir(Vistide)、Telaprevir(VX-950)、Saxagliptin(BMS-477118,Onglyza)、Darunavir Ethanolate(Prezista)、Docosanol(Abreva)、Amprenavir(Agenerase)、Telbivudine(Sebivo,Tyzeka)、Hydrocortisone(Cortisol)、Didanosine(Videx)、Emtricitabine(Emtriva)、Lamivudine(Epivir)、Adefovir Dipivoxil(Preveon,Hepsera)、Zalcitabine、Prednisolone(Hydroretrocortine)、Nevirapine(Viramune)、Trifluridine(Viroptic)、Vidarabine(Vira-A)、Acyclovir(Aciclovir)、Albendazole Oxide(Ricobendazole)、Chenodeoxycholic acid、Valaciclovir HCl、Ganciclovir、Idoxuridine、Crystal violet、Rimantadine(Flumadine)、Taurine(organic acid)、Diclazuril(anticoccidial drug)、Rebamipide、Orphenadrine citrate(Norflex)、Terazosin HCl(Hytrin)、Lafutidine、Dextrose、BIBR-1048 (Dabigatran)、Rosuvastatin calcium(Crestor)、Ammonium Glycyrrhizinate(AMGZ)、Amfebutamone(Bupropion)、Clonidine hydrochloride(Catapres)、Fluocinolone acetonide(Flucort-N)、Loperamide hydrochloride、Mycophenolic(Mycophenolate)、Olanzapine(Zyprexa)、Racecadotril(Acetorphan)、Rosiglitazone maleate、Salbutamol sulfate(Albuterol)、Tenoxicam(Mobiflex)、Vardenafil(Vivanza)、Dopamine hydrochloride(Inotropin)、Ritodrine hydrochloride(Yutopar)、Riboflavin(Vitamin B2)、Clomipramine hydrochloride(Anafranil)、Tiotropium Bromide hydrate、Isoprenaline hydrochloride、Medroxyprogesterone acetate、Xylometazoline HCl、Phenacetin、Trazodone hydrochloride(Desyrel)、Brompheniramine、Acemetacin(Emflex)、Dabrafenib(GSK2118436)、Paroxetine HCl、Zanamivir(Relenza)、Niflumic acid、Medetomidine HCl、Diclofenac Potassium、Ulipristal、Indacaterol Maleate、Biotin(Vitamin B7)、Sodium salicylate、Methylthiouracil、Darifenacin HBr、Benztropine mesylate、Abacavir sulfate、Antipyrine、Amitriptyline HCl、Azatadine dimaleate、Triflusal、Pemirolast(BMY 26517)potassium、Homatropine Bromide、Carbimazole、Spironolactone、Ropivacaine HCl、Escitalopram oxalate、Bismuth Subcitrate Potassium(mineral)、 Chlorpropamide、Nifuroxazide、Penciclovir、Salicylanilide、Betamipron、Ethacridine lactate monohydrate(aromatic compound)、Aminothiazole、Florfenicol、Cetrimonium Bromide(antiseptic)、Thonzonium Bromide(detergent)、Pasiniazid。
本發明提供一種抗生素藥物用於製備治療癌症之用途，其中該醫藥組合物係選自由一有效劑量的一抗生素及一藥物可接受的鹽類所組成。
本發明提供一種抗病毒藥物用於製備治療癌症之用途，其中該醫藥組合物係選自由一有效劑量的一抗病毒藥物及一藥物可接受的鹽類所組成。
本發明所述之抗生素係選自由胺基配糖體抗生素、抗黴菌劑抗生素、頭孢子菌類抗生素、β-丙醯胺抗生素類、氯黴素抗生素、紅黴素類抗生素、青黴素類抗生素、四環素類抗生素及其他抗生素所組成群組之抗生素。
本發明一實施例中，其中該胺基配糖體抗生素係選自由Amikacin sulfate、Amikacin hydrate、Netilmicin Sulfate所組成之藥物。
本發明一實施例中，其中該抗黴菌劑抗生素係選自由Posaconazole、Artemisinin、Fluconazole、Ketoconazole、 Voriconazole、Natamycin(Pimaricin)、Clotrimazole(Canesten)、Amphotericin B(Abelcet)、Flucytosine(Ancobon)、Amorolfine Hydrochloride、Terbinafine(Lamisil,Terbinex)、Butoconazole nitrate、Chloroxine、Bifonazole、Tioconazole、Nystatin(Mycostatin)、Miconazole nitrate、Liranaftate、Isoconazole nitrate(Travogen)、Terbinafine hydrochloride(Lamisil)、Ciclopirox ethanolamine、Caspofungin acetate、Naftifine HCl、Sertaconazole nitrate、Pyrithione zinc、Sulconazole Nitrate、Climbazole、Valnemulin HCl所組成之藥物。
本發明一實施例中，其中頭孢子菌類抗生素係選自 由Cefdinir(Omnicef)、Cefoperazone(Cefobid)、Cefditoren pivoxil、Cephalexin(Cefalexin)、Cefoselis sulfate、Ceftiofur hydrochloride、Cefaclor(Ceclor)、Ceftazidime Pentahydrate、Moxalactam Disodium、Cephapirin Sodium所組成之藥物。
本發明一實施例中，其中β-丙醯胺抗生素係選自由 Doripenem Hydrate、Meropenem、Aztreonam、Sulbactam、Sulbactam sodium(Unasyn)、Biapenem所組成之藥物。
本發明一實施例中，其中該氯黴素抗生素係選自由 Gatifloxacin、Daptomycin、Sulfapyridine(Dagenan)、Sulfameter (Bayrena)、Chloramphenicol(Chloromycetin)所組成之藥物。
本發明一實施例中，其中該青黴素類抗生素係選自 由Amoxicillin sodium(Amox)、Ampicillin sodium、Carbenicillin disodium、Dicloxacillin Sodium、Ampicillin Trihydrate、Benzylpenicillin sodium、Mezlocillin Sodium、Piperacillin Sodium所組成之藥物。
本發明一實施例中，其中該紅黴素類抗生素係選自 由Teicoplanin、Linezolid(Zyvox)、Erythromycin(E-Mycin)、Erythromycin Ethylsuccinate、Spiramycin、Tilmicosin、Azithromycin Dihydrate、Dirithromycin、Fidaxomicin所組成之藥物。
本發明一實施例中，其中該四環素類抗生素係選自 由Marbofloxacin、Moxifloxacin hydrochloride、Oxytetracycline(Terramycin)、Tigecycline、Oxytetracycline dihydrate、Tetracycline HCl、Chlortetracycline HCl、Minocycline HCl、Rolitetracycline。所組成之藥物。
本發明一實施例中，其中該其他抗生素係選自由 Norfloxacin(Norxacin)、Enoxacin(Penetrex)、Pefloxacin mesylate、Sparfloxacin、Levofloxacin(Levaquin)、Sarafloxacin HCl、Nalidixic acid(NegGram)、Lomefloxacin hydrochloride(Maxaquin)、 Enrofloxacin、Clinafloxacin(PD127391)、Orbifloxacin、Clinafoxacin HCl、Piromidic Acid、Cinoxacin、Difloxacin HCl、ifabutin(Mycobutin)、Rifapentine(Priftin)、Pyrazinamide(Pyrazinoic acid amide)、Rifampin(Rifadin,Rimactane)、Ethionamide、Rifaximin(Xifaxan)、Protionamide(Prothionamide)、Isoniazid(Tubizid)、D-Cycloserine、Streptomycin sulfate、Clofazimine、Nitrofurazone、Sulfanilamide、Sulfadiazine、Metronidazole(Flagyl)、Sulfamethoxazole、Sulfisoxazole、Sulfamethizole(Proklar)、Sulfadimethoxine、Clindamycin phosphate、Fenbendazole(Panacur)、Sulfadoxine(Sulphadoxine)、Secnidazole(Flagentyl)、Clindamycin palmitate HCl、Clindamycin、Sulfathiazole、Trimethoprim、Sulfamerazine、Pentamidine、Colistin Sulfate(polypeptide)、toltrazuril、tinidazoleMequinol、Bacitracin、Cetylpyridinium Chloride、Sulfaguanidine、Paromomycin Sulfate、Domiphen Bromide、Chlorquinaldol、Furaltadone HCl、Primaquine Diphosphate、Carbadox、Colistimethate Sodium、Meclocycline Sulfosalicylate、Thiostrepton、Bekanamycin、Clofoctol、Ritonavir、Entecavir hydrate、Artemisinin、Megestrol Acetate、Lansoprazole、Lopinavir(ABT-378)、Ondansetron hydrochloride、Resveratrol、 Stavudine、Tenofovir Disoproxil Fumarate、Tenofovir(Viread)、Cidofovir(Vistide)、Telaprevir(VX-950)、Saxagliptin(BMS-477118,Onglyza)、Darunavir Ethanolate(Prezista)、Docosanol(Abreva)、Amprenavir(Agenerase)、Telbivudine(Sebivo,Tyzeka)、Hydrocortisone(Cortisol)、Didanosine(Videx)、Emtricitabine(Emtriva)、Lamivudine(Epivir)、Adefovir Dipivoxil(Preveon,Hepsera)、Zalcitabine、Prednisolone(Hydroretrocortine)、Nevirapine(Viramune)、Trifluridine(Viroptic)、Vidarabine(Vira-A)、Acyclovir(Aciclovir)、Albendazole Oxide(Ricobendazole)、Chenodeoxycholic acid、Valaciclovir HCl、Ganciclovir、Idoxuridine、Crystal violet、Rimantadine(Flumadine)、Taurine(organic acid)、Diclazuril(anticoccidial drug)、Rebamipide、Orphenadrine citrate(Norflex)、Terazosin HCl(Hytrin)、Lafutidine、Dextrose、BIBR-1048(Dabigatran)、Rosuvastatin calcium(Crestor)、Ammonium Glycyrrhizinate(AMGZ)、Amfebutamone(Bupropion)、Clonidine hydrochloride(Catapres)、Fluocinolone acetonide(Flucort-N)、Loperamide hydrochloride、Mycophenolic(Mycophenolate)、Olanzapine(Zyprexa)、Racecadotril(Acetorphan)、Rosiglitazone maleate、Salbutamol sulfate(Albuterol)、Tenoxicam(Mobiflex)、 Vardenafil(Vivanza)、Dopamine hydrochloride(Inotropin)、Ritodrine hydrochloride(Yutopar)、Riboflavin(Vitamin B2)、Clomipramine hydrochloride(Anafranil)、Tiotropium Bromide hydrate、Isoprenaline hydrochloride、Medroxyprogesterone acetate、Xylometazoline HCl、Phenacetin、Trazodone hydrochloride(Desyrel)、Brompheniramine、Acemetacin(Emflex)、Dabrafenib(GSK2118436)、Paroxetine HCl、Zanamivir(Relenza)、Niflumic acid、Medetomidine HCl、Diclofenac Potassium、Ulipristal、Indacaterol Maleate、Biotin(Vitamin B7)、Sodium salicylate、Methylthiouracil、Darifenacin HBr、Benztropine mesylate、Abacavir sulfate、Antipyrine、Amitriptyline HCl、Azatadine dimaleate、Triflusal、Pemirolast(BMY 26517)potassium、Homatropine Bromide、Carbimazole、Spironolactone、Ropivacaine HCl、Escitalopram oxalate、Bismuth Subcitrate Potassium(mineral)、Chlorpropamide、Nifuroxazide、Penciclovir、Salicylanilide、Betamipron、Ethacridine lactate monohydrate(aromatic compound)、Aminothiazole、Florfenicol、Cetrimonium Bromide(antiseptic)、Thonzonium Bromide(detergent)、Pasiniazid所組成之藥物。
本發明一實施例中，其中該癌症係選自由肺癌、腸道癌、大腸直腸癌、前列腺癌、膀胱癌、子宮頸癌、乳癌及血癌所 組成之群組。
本發明一實施例中，其中該藥物的有效劑量濃度為20mg/kg/day。
現今癌症藥物費用動輒上萬至數百萬元，若未來更進一步證實抗生素對腫瘤的療效，對於無法負擔昂貴治療的患者們，這些便宜而歷史悠久的藥物，會是帶來健康的新希望。
第一圖顯示本發明抗生素用藥應用於抑制癌細胞分析結果
建立細胞株
請參考表一，將不同癌症類型的細胞株進行繼代培養，計算細胞數目後，回種2*106細胞數，然後加入培養該細胞株之培養液補至體積為10ml，繼續培養2-3天。之後將細胞計數，並分裝至96孔盤，其中每孔的細胞數目固定為3000顆，且體積為100ul。
細胞存活分析方法
將96孔盤中原有的培養液吸掉，每孔加入濃度10um、體積100ul的市售藥物，放置72小時後，每孔再加入100ul已稀釋的WST-1試劑，該稀釋比例為培養液與WST-1原液的體積比為9：1，最後每個孔盤的總體積為200ul，然後將96孔盤放置於37度30~90分鐘，利用elisa reader於OD450偵測吸光值，並計算各癌症細胞株之存活率。
抗生素用藥應用於抑制癌細胞分析結果
依據細胞存活分析方法針對取得的九大類抗生素藥物，包含胺基配糖體抗生素、抗黴菌劑抗生素、頭孢子菌類抗生素、β-丙醯胺抗生素類、氯黴素抗生素、青黴素類抗生素、紅黴素類抗生素、四環素類抗生素，以及抗病毒類藥物進行測試抑制癌細胞生長的效果。
實驗結果明顯的顯示有許多的抗生素並無法有效的抑制癌症的細胞的生長(表二)。
而相對的各種的抗生素藥物分子對於各種癌症細胞 的抑制效果也不盡相同(圖一)，經過發明人實驗結果，證實抗生素藥物藥物Ritonavir、Entecavir hydrate、Posaconazole、Artemisinin、Megestrol Acetate、Fluconazole、Gatifloxacin、Ketoconazole、Lansoprazole、Acitretin、Biapenem、Cefoselis sulfate、Daptomycin、Doripenem Hydrate、Lopinavir(ABT-378)、Meropenem、Ondansetron hydrochloride(Zofran)、Resveratrol、Stavudine、Teicoplanin、Tenofovir Disoproxil Fumarate、Tenofovir(Viread)、Tigecycline、Linezolid(Zyvox)、Voriconazole、Marbofloxacin、Moxifloxacin hydrochloride、Cefaclor(Ceclor)、Cephalexin(Cefalexin)、Aztreonam(Azactam,Cayston)、Norfloxacin(Norxacin)、Cidofovir(Vistide)、Natamycin(Pimaricin)、Telaprevir(VX-950)、Saxagliptin (BMS-477118,Onglyza)、Cefdinir(Omnicef)、Clotrimazole(Canesten)、Cefoperazone(Cefobid)、Sulfapyridine(Dagenan)、Sulfameter(Bayrena)、Darunavir Ethanolate(Prezista)、Erythromycin(E-Mycin)、Amphotericin B(Abelcet)、Docosanol(Abreva)、Amprenavir(Agenerase)、Nitrofurazone(Nitrofural)、Telbivudine(Sebivo,Tyzeka)、Flucytosine(Ancobon)、Amorolfine Hydrochloride、Chloramphenicol(Chloromycetin)、Sulfanilamide、Hydrocortisone(Cortisol)、Didanosine(Videx)、Emtricitabine(Emtriva)、Lamivudine(Epivir)、Adefovir Dipivoxil(Preveon,Hepsera)、Zalcitabine、Terbinafine(Lamisil,Terbinex)、Prednisolone(Hydroretrocortine)、Rifabutin(Mycobutin)、Nevirapine(Viramune)、Enoxacin(Penetrex)、Rifapentine(Priftin)、Pyrazinamide(Pyrazinoic acid amide)、Rifampin(Rifadin,Rimactane)、Cefditoren pivoxil、Sulfadiazine、Oxytetracycline(Terramycin)、Ethionamide、Trifluridine(Viroptic)、Vidarabine(Vira-A)、Rifaximin(Xifaxan)、Acyclovir(Aciclovir)、Butoconazole nitrate、Albendazole Oxide(Ricobendazole)、Chloroxine、Chenodeoxycholic acid、Bifonazole、Pefloxacin mesylate、Valaciclovir HCl、Ganciclovir、Protionamide (Prothionamide)、Idoxuridine、Sparfloxacin、Metronidazole(Flagyl)、Tioconazole、Sulfamethoxazole、Sulfisoxazole、Crystal violet、Nystatin(Mycostatin)、Isoniazid(Tubizid)、Levofloxacin(Levaquin)、Miconazole nitrate、Sulfamethizole(Proklar)、Sulbactam、Sulphadimethoxine、Rimantadine(Flumadine)、Sarafloxacin HCl、Liranaftate、D-Cycloserine、Taurine、Diclazuril、Rebamipide、Clindamycin phosphate、Oxytetracycline dihydrate、Orphenadrine citrate(Norflex)、Terazosin HCl(Hytrin)、Lafutidine、Dextrose(D-glucose)、BIBR-1048(Dabigatran)、Rosuvastatin calcium(Crestor)、Nalidixic acid(NegGram)、Ammonium Glycyrrhizinate(AMGZ)、Amfebutamone(Bupropion)、Clonidine hydrochloride(Catapres)、Fenbendazole(Panacur)、Fluocinolone acetonide(Flucort-N)、Loperamide hydrochloride、Mycophenolic(Mycophenolate)、Olanzapine(Zyprexa)、Racecadotril(Acetorphan)、Rosiglitazone maleate、Salbutamol sulfate(Albuterol)、Sulfadoxine(Sulphadoxine)、Tenoxicam(Mobiflex)、Vardenafil(Vivanza)、Dopamine hydrochloride(Inotropin)、Ritodrine hydrochloride(Yutopar)、Isoconazole nitrate(Travogen)、Secnidazole(Flagentyl)、 Lomefloxacin hydrochloride(Maxaquin)、Riboflavin(Vitamin B2)、Clomipramine hydrochloride(Anafranil)、Ceftiofur hydrochloride、Tiotropium Bromide hydrate、Sulbactam sodium(Unasyn)、Terbinafine hydrochloride(Lamisil)、Amoxicillin sodium(Amox)、Isoprenaline hydrochloride、Medroxyprogesterone acetate、Streptomycin sulfate、Tetracycline HCl、Xylometazoline HCl、Phenacetin、Trazodone hydrochloride(Desyrel)、Brompheniramine、Clindamycin palmitate HCl、Acemetacin(Emflex)、Dabrafenib(GSK2118436)、Clindamycin、Paroxetine HCl、Zanamivir(Relenza)、Niflumic acid、Ciclopirox ethanolamine、Enrofloxacin、Medetomidine HCl、Diclofenac Potassium、Amikacin sulfate、Caspofungin acetate、Ulipristal、Indacaterol Maleate、Sulfathiazole、Amikacin hydrate、Trimethoprim、Biotin(Vitamin B7)、Sulfamerazine、Sodium salicylate、Methylthiouracil、Darifenacin HBr、Naftifine HCl、Sertaconazole nitrate、Benztropine mesylate、Abacavir sulfate、Ampicillin sodium、Antipyrine、Carbenicillin disodium、Amitriptyline HCl、Azatadine dimaleate、Triflusal、Clinafloxacin(PD127391)、Pentamidine、Pemirolast(BMY 26517)potassium、Homatropine Bromide、Colistin Sulfate、toltrazuril、 Carbimazole、Netilmicin Sulfate、Spironolactone、Ropivacaine HCl、Erythromycin Ethylsuccinate、Escitalopram oxalate、tinidazole、Pyrithione zinc、Mequinol、Spiramycin、Bismuth Subcitrate Potassium、Clofazimine、Dicloxacillin Sodium、Sulconazole Nitrate、Tilmicosin、Bacitracin、Azithromycin Dihydrate、Ampicillin Trihydrate、Orbifloxacin、Chlortetracycline HCl、Benzylpenicillin sodium、Chlorpropamide、Cetylpyridinium Chloride、Sulfaguanidine、Climbazole、Mezlocillin Sodium、Nifuroxazide、Paromomycin Sulfate、Penciclovir、Domiphen Bromide、Salicylanilide、Betamipron、Chlorquinaldol、Ethacridine lactate monohydrate、Aminothiazole、Florfenicol、Furaltadone HCl、Dirithromycin、Valnemulin HCl、Piperacillin Sodium、Minocycline HCl、Fidaxomicin、Primaquine Diphosphate、Cetrimonium Bromide、Carbadox、Ceftazidime Pentahydrate、Clinafoxacin HCl、Colistimethate Sodium、Meclocycline Sulfosalicylate、Moxalactam Disodium、Piromidic Acid、Rolitetracycline、Thiostrepton、Thonzonium Bromide、Cinoxacin、Bekanamycin、Difloxacin HCl、Cephapirin Sodium、Clofoctol、Pasiniazid等藥物對於不同的癌症細胞有明顯的抑制效果。(表三)
上列詳細說明係針對本發明之一可行實施例之具體說明，惟該實施例並非用以限制本發明之專利範圍，凡未脫離本發明技藝精神所為之等效實施或變更，均應包含於本發明之專利範圍中。
重複性實驗
依據表三所示結果，針對對癌症細胞株有效之藥物進行重覆性實驗，其結果如表四所示。
表四、具抑制癌症細胞株之抗生素

Claims (12)

  1. 一種抗生素藥物用於製備治療癌症之用途，其中該醫藥組合物係選自由一有效劑量的一抗生素及一藥物可接受的鹽類所組成。
  2. 如申請專利範圍第1項所述之用途，其中該抗生素係選自由胺基配糖體抗生素、抗黴菌劑抗生素、頭孢子菌類抗生素、β-丙醯胺抗生素類、氯黴素抗生素、紅黴素類抗生素、青黴素類抗生素、四環素類抗生素及其他抗生素所組成群組之抗生素。
  3. 如申請專利範圍第2項所述之用途，其中該胺基配糖體抗生素係選自由Amikacin sulfate、Amikacin hydrate、Netilmicin Sulfate所組成之藥物。
  4. 如申請專利範圍第2項所述之用途，其中該抗黴菌劑抗生素係選自由Posaconazole、Artemisinin、Fluconazole、Ketoconazole、Voriconazole、Natamycin(Pimaricin)、Clotrimazole(Canesten)、Amphotericin B(Abelcet)、Flucytosine(Ancobon)、Amorolfine Hydrochloride、Terbinafine(Lamisil,Terbinex)、Butoconazole nitrate、Chloroxine、Bifonazole、Tioconazole、Nystatin(Mycostatin)、Miconazole nitrate、Liranaftate、Isoconazole nitrate(Travogen)、Terbinafine hydrochloride(Lamisil)、Ciclopirox ethanolamine、Caspofungin acetate、Naftifine HCl、Sertaconazole nitrate、Pyrithione zinc、Sulconazole Nitrate、Climbazole、Valnemulin HCl所組成之藥物。
  5. 如申請專利範圍第2項所述之用途，其中頭孢子菌類抗生素係選自由Cefdinir(Omnicef)、Cefoperazone(Cefobid)、Cefditoren pivoxil、Cephalexin(Cefalexin)、Cefoselis sulfate、Ceftiofur hydrochloride、Cefaclor(Ceclor)、Ceftazidime Pentahydrate、Moxalactam Disodium、Cephapirin Sodium所組成之藥物。
  6. 如申請專利範圍第2項所述之用途，其中β-丙醯胺抗生素係選自由Doripenem Hydrate、Meropenem、Aztreonam、Sulbactam、Sulbactam sodium(Unasyn)、Biapenem所組成之藥物。
  7. 如申請專利範圍第2項所述之用途，其中該氯黴素抗生素係選自由Gatifloxacin、Daptomycin、Sulfapyridine(Dagenan)、Sulfameter(Bayrena)、Chloramphenicol(Chloromycetin)所組成之藥物。
  8. 如申請專利範圍第2項所述之用途，其中該青黴素類抗生素係選自由Amoxicillin sodium(Amox)、Ampicillin sodium、Carbenicillin disodium、Dicloxacillin Sodium、Ampicillin Trihydrate、Benzylpenicillin sodium、Mezlocillin Sodium、Piperacillin Sodium所組成之藥物。
  9. 如申請專利範圍第2項所述之用途，其中該紅黴素類抗生素係選自由Teicoplanin、Linezolid(Zyvox)、Erythromycin(E-Mycin)、Erythromycin Ethylsuccinate、Spiramycin、Tilmicosin、Azithromycin Dihydrate、Dirithromycin、Fidaxomicin所組成之藥物。
  10. 如申請專利範圍第2項所述之用途，其中該四環素類抗生素係選自由Marbofloxacin、Moxifloxacin hydrochloride、Oxytetracycline(Terramycin)、Tigecycline、Oxytetracycline dihydrate、Tetracycline HCl、Chlortetracycline HCl、Minocycline HCl、Rolitetracycline所組成之藥物。
  11. 如申請專利範圍第2項所述之用途，其中該其他抗生素係選自由Norfloxacin(Norxacin)、Enoxacin(Penetrex)、Pefloxacin mesylate、Sparfloxacin、Levofloxacin(Levaquin)、Sarafloxacin HCl、Nalidixic acid(NegGram)、Lomefloxacin hydrochloride(Maxaquin)、Enrofloxacin、Clinafloxacin(PD127391)、Orbifloxacin、Clinafoxacin HCl、Piromidic Acid、Cinoxacin、Difloxacin HCl、Rifabutin(Mycobutin)、Rifapentine(Priftin)、Pyrazinamide(Pyrazinoic acid amide)、Rifampin(Rifadin,Rimactane)、Ethionamide、Rifaximin(Xifaxan)、Protionamide(Prothionamide)、Isoniazid(Tubizid)、D-Cycloserine、Streptomycin sulfate、Clofazimine、Nitrofurazone、Sulfanilamide、Sulfadiazine、Metronidazole(Flagyl)、Sulfamethoxazole、Sulfisoxazole、Sulfamethizole(Proklar)、Sulfadimethoxine、Clindamycin phosphate、Fenbendazole(Panacur)、Sulfadoxine(Sulphadoxine)、Secnidazole(Flagentyl)、Clindamycin palmitate HCl、Clindamycin、Sulfathiazole、Trimethoprim、Sulfamerazine、Pentamidine、Colistin Sulfate(polypeptide)、toltrazuril、tinidazoleMequinol、Bacitracin、Cetylpyridinium Chloride、Sulfaguanidine、Paromomycin Sulfate、Domiphen Bromide、Chlorquinaldol、Furaltadone HCl、Primaquine Diphosphate、Carbadox、Colistimethate Sodium、Meclocycline Sulfosalicylate、Thiostrepton、Bekanamycin、Clofoctol、Ritonavir、Entecavir hydrate、Artemisinin、Megestrol Acetate、Lansoprazole、Lopinavir(ABT-378)、Ondansetron hydrochloride、Resveratrol、Stavudine、Tenofovir Disoproxil Fumarate、Tenofovir(Viread)、Cidofovir(Vistide)、Telaprevir(VX-950)、Saxagliptin(BMS-477118,Onglyza)、Darunavir Ethanolate(Prezista)、Docosanol(Abreva)、Amprenavir(Agenerase)、Telbivudine(Sebivo,Tyzeka)、Hydrocortisone(Cortisol)、Didanosine(Videx)、Emtricitabine(Emtriva)、Lamivudine(Epivir)、Adefovir Dipivoxil(Preveon,Hepsera)、Zalcitabine、Prednisolone(Hydroretrocortine)、Nevirapine(Viramune)、Trifluridine(Viroptic)、Vidarabine(Vira-A)、Acyclovir(Aciclovir)、Albendazole Oxide(Ricobendazole)、Chenodeoxycholic acid、Valaciclovir HCl、Ganciclovir、Idoxuridine、Crystal violet、Rimantadine(Flumadine)、Taurine(organic acid)、Diclazuril(anticoccidial drug)、Rebamipide、Orphenadrine citrate(Norflex)、Terazosin HCl(Hytrin)、Lafutidine、Dextrose、BIBR-1048(Dabigatran)、Rosuvastatin calcium(Crestor)、Ammonium Glycyrrhizinate(AMGZ)、Amfebutamone(Bupropion)、Clonidine hydrochloride(Catapres)、Fluocinolone acetonide(Flucort-N)、Loperamide hydrochloride、Mycophenolic(Mycophenolate)、Olanzapine(Zyprexa)、Racecadotril(Acetorphan)、Rosiglitazone maleate、Salbutamol sulfate(Albuterol)、Tenoxicam(Mobiflex)、Vardenafil(Vivanza)、Dopamine hydrochloride(Inotropin)、Ritodrine hydrochloride(Yutopar)、Riboflavin(Vitamin B2)、Clomipramine hydrochloride (Anafranil)、Tiotropium Bromide hydrate、Isoprenaline hydrochloride、Medroxyprogesterone acetate、Xylometazoline HCl、Phenacetin、Trazodone hydrochloride(Desyrel)、Brompheniramine、Acemetacin(Emflex)、Dabrafenib(GSK2118436)、Paroxetine HCl、Zanamivir(Relenza)、Niflumic acid、Medetomidine HCl、Diclofenac Potassium、Ulipristal、Indacaterol Maleate、Biotin(Vitamin B7)、Sodium salicylate、Methylthiouracil、Darifenacin HBr、Benztropine mesylate、Abacavir sulfate、Antipyrine、Amitriptyline HCl、Azatadine dimaleate、Triflusal、Pemirolast(BMY 26517)potassium、Homatropine Bromide、Carbimazole、Spironolactone、Ropivacaine HCl、Escitalopram oxalate、Bismuth Subcitrate Potassium(mineral)、Chlorpropamide、Nifuroxazide、Penciclovir、Salicylanilide、Betamipron、Ethacridine lactate monohydrate(aromatic compound)、Aminothiazole、Florfenicol、Cetrimonium Bromide(antiseptic)、Thonzonium Bromide(detergent)、Pasiniazid所組成之藥物。
  12. 如申請專利範圍第1項所述之用途，其中該癌症係選自由肺癌、腸道癌、大腸直腸癌、前列腺癌、膀胱癌、子宮頸癌、乳癌及血癌所組成之群組。
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